Trenbolone (BioDeep_00000001963)

   


代谢物信息卡片


(8S,13S,14S,17R)-17-hydroxy-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-one

化学式: C18H22O2 (270.1619712)
中文名称: 群勃龙, 17α-群勃龙
谱图信息: 最多检出来源 Viridiplantae(plant) 20.83%

分子结构信息

SMILES: CC12C=CC3=C4CCC(=O)C=C4CCC3C1CCC2O
InChI: InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-17,20H,2-7H2,1H3

描述信息

A 3-oxo-Delta(4) steroid that is estra-4,9,11-triene carrying an oxo group at position 3 and a hydroxy group at position 17beta. It is a synthetic anabolic steroid used for muscle growth in livestock.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D045930 - Anabolic Agents
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid
CONFIDENCE standard compound; INTERNAL_ID 2824
CONFIDENCE standard compound; INTERNAL_ID 8746
CONFIDENCE standard compound; INTERNAL_ID 787; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8822; ORIGINAL_PRECURSOR_SCAN_NO 8819
CONFIDENCE standard compound; INTERNAL_ID 787; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8842; ORIGINAL_PRECURSOR_SCAN_NO 8840
CONFIDENCE standard compound; INTERNAL_ID 787; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4804; ORIGINAL_PRECURSOR_SCAN_NO 4803
CONFIDENCE standard compound; INTERNAL_ID 787; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8845; ORIGINAL_PRECURSOR_SCAN_NO 8842
CONFIDENCE standard compound; INTERNAL_ID 787; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8903; ORIGINAL_PRECURSOR_SCAN_NO 8901
CONFIDENCE standard compound; INTERNAL_ID 787; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4774; ORIGINAL_PRECURSOR_SCAN_NO 4772
CONFIDENCE standard compound; INTERNAL_ID 787; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4796; ORIGINAL_PRECURSOR_SCAN_NO 4794
CONFIDENCE standard compound; INTERNAL_ID 787; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4817; ORIGINAL_PRECURSOR_SCAN_NO 4815
CONFIDENCE standard compound; INTERNAL_ID 787; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8823; ORIGINAL_PRECURSOR_SCAN_NO 8820
CONFIDENCE standard compound; INTERNAL_ID 787; DATASET 20200303_ENTACT_RP_MIX508; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4834; ORIGINAL_PRECURSOR_SCAN_NO 4832
CONFIDENCE standard compound; INTERNAL_ID 787; DATASET 20200303_ENTACT_RP_MIX500; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 8866; ORIGINAL_PRECURSOR_SCAN_NO 8863

同义名列表

4 个代谢物同义名

Trenbolone; (8S,13S,14S,17R)-17-hydroxy-13-methyl-2,6,7,8,14,15,16,17-octahydro-1H-cyclopenta[a]phenanthren-3-one; 17beta-Trenbolone; Trienbolone



数据库引用编号

36 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hua Tian, Rui Liu, Suqiu Zhang, Shuhui Wei, Wei Wang, Shaoguo Ru. 17β-Trenbolone binds to androgen receptor, decreases number of primordial germ cells, modulates expression of genes related to sexual differentiation, and affects sexual differentiation in zebrafish (Danio rerio). The Science of the total environment. 2022 Feb; 806(Pt 4):150959. doi: 10.1016/j.scitotenv.2021.150959. [PMID: 34662611]
  • Shaozhi Zhang, Xizeng Feng. Effect of 17β-trenbolone exposure during adolescence on the circadian rhythm in male mice. Chemosphere. 2022 Feb; 288(Pt 1):132496. doi: 10.1016/j.chemosphere.2021.132496. [PMID: 34627821]
  • Sabrina Liesenfeld, Panagiotis Steliopoulos, Svenja Wenig, Vera Gottstein, Gerd Hamscher. Comprehensive LC-HRMS metabolomics analyses for the estimation of environmental inputs of altrenogest in pig breeding. Chemosphere. 2022 Jan; 287(Pt 3):132353. doi: 10.1016/j.chemosphere.2021.132353. [PMID: 34826959]
  • Rafael Dal Forno Gianluppi, Matheus Schardong Lucca, Monike Quirino, Ana Paula Gonçalves Mellagi, Rafael da Rosa Ulguim, Fernando Pandolfo Bortolozzo. Altrenogest treatment during the last week of lactation on ovarian traits and subsequent reproductive performance of primiparous and multiparous sows. Theriogenology. 2021 Dec; 176(?):122-127. doi: 10.1016/j.theriogenology.2021.09.027. [PMID: 34601236]
  • Yanyan Li, Haifeng Yang, Liangyou Xia, Shuang Wang, Shijin Bu. Comparative pharmacokinetic study of two kinds of altrenogest oral solutions for sows. Animal biotechnology. 2021 Aug; 32(4):479-485. doi: 10.1080/10495398.2020.1723608. [PMID: 32180500]
  • Yanyan Li, Haifeng Yang, Shulei Qiu, Shuang Wang, Liangyou Xia, Shijin Bu. Investigations on residual elimination of altrenogest oral solution in pigs and the withdrawal time. Animal biotechnology. 2021 Jun; 32(3):310-317. doi: 10.1080/10495398.2019.1689989. [PMID: 31814507]
  • Ashley Gillon, Emmie N M Ho, George H M Chan, Alexia Kauff, Gillian Hughes, Rachel A Lund, Zoe Ashley, Terence S M Wan, Alison K Heather. Unravelling androgens in sport: Altrenogest shows strong activation of the androgen receptor in a mammalian cell bioassay. Drug testing and analysis. 2021 Mar; 13(3):523-528. doi: 10.1002/dta.2941. [PMID: 33037724]
  • J K Challis, S Sura, J Cantin, A W Curtis, K M Shade, T A McAllister, P D Jones, J P Giesy, F J Larney. Ractopamine and Other Growth-Promoting Compounds in Beef Cattle Operations: Fate and Transport in Feedlot Pens and Adjacent Environments. Environmental science & technology. 2021 02; 55(3):1730-1739. doi: 10.1021/acs.est.0c06450. [PMID: 33450151]
  • C C Reichhardt, A Ahmadpour, R G Christensen, N E Ineck, G K Murdoch, K J Thornton. Understanding the influence of trenbolone acetate and polyamines on proliferation of bovine satellite cells. Domestic animal endocrinology. 2021 01; 74(?):106479. doi: 10.1016/j.domaniend.2020.106479. [PMID: 32615508]
  • Ruoxin Jia, Xiaoyu Chen, Zhiwei Zhu, Jing Huang, Fuxian Yu, Liang Zhang, Atsuo Ogura, Jianzhi Pan. Improving ovulation in gilts using anti-inhibin serum treatment combined with fixed-time artificial insemination. Reproduction in domestic animals = Zuchthygiene. 2021 Jan; 56(1):112-119. doi: 10.1111/rda.13854. [PMID: 33152153]
  • Gerald T Ankley, Brett R Blackwell, Jenna E Cavallin, Jon A Doering, David J Feifarek, Kathleen M Jensen, Michael D Kahl, Carlie A LaLone, Shane T Poole, Eric C Randolph, Travis W Saari, Daniel L Villeneuve. Adverse Outcome Pathway Network-Based Assessment of the Interactive Effects of an Androgen Receptor Agonist and an Aromatase Inhibitor on Fish Endocrine Function. Environmental toxicology and chemistry. 2020 04; 39(4):913-922. doi: 10.1002/etc.4668. [PMID: 31965587]
  • Hongzhi Xiao, Pan Sun, Feifei Sun, Jicheng Qiu, Jie Wang, Jianzhong Wang, Yalong Lin, Xiaohui Gong, Lu Zhang, Suxia Zhang, Xingyuan Cao. Pharmacokinetics of altrenogest in gilts. Journal of veterinary pharmacology and therapeutics. 2019 Nov; 42(6):660-664. doi: 10.1111/jvp.12755. [PMID: 31222770]
  • Paweena Thuwanut, Janine L Brown, Pierre Comizzoli, Adrienne E Crosier. Responsiveness of the cheetah (Acinonyx jubatus) ovary to exogenous gonadotropins after preemptive oral progestin treatment. Theriogenology. 2019 Oct; 138(?):39-46. doi: 10.1016/j.theriogenology.2019.07.001. [PMID: 31284220]
  • Katie L Bidne, Matthew R Romoser, Jason W Ross, Lance H Baumgard, Aileen F Keating. Heat stress during the luteal phase decreases luteal size but does not affect circulating progesterone in gilts1. Journal of animal science. 2019 Oct; 97(10):4314-4322. doi: 10.1093/jas/skz251. [PMID: 31372640]
  • Sabrina Lehmann, Andreas Thomas, Karl-Heinz Schiwy-Bochat, Hans Geyer, Mario Thevis, Frank Glenewinkel, Markus Alexander Rothschild, Hilke Andresen-Streichert, Martin Juebner. Death after misuse of anabolic substances (clenbuterol, stanozolol and metandienone). Forensic science international. 2019 Oct; 303(?):109925. doi: 10.1016/j.forsciint.2019.109925. [PMID: 31499423]
  • Katelyn E Ellis, R McAlister Council-Troche, Karen A Von Dollen, Theresa M Beachler, C Scott Bailey, Jennifer L Davis, Sara K Lyle. Pharmacokinetics of Intrarectal Altrenogest in Horses. Journal of equine veterinary science. 2019 01; 72(?):41-46. doi: 10.1016/j.jevs.2018.10.001. [PMID: 30929782]
  • Vitória Müller, Bruna R Curcio, Ramiro E Toribio, Lorena S Feijó, Luciana A Borba, Igor F Canisso, Carlos E W Nogueira. Cortisol, progesterone, 17αOHprogesterone, and pregnenolone in foals born from mare's hormone-treated for experimentally induced ascending placentitis. Theriogenology. 2019 Jan; 123(?):139-144. doi: 10.1016/j.theriogenology.2018.06.024. [PMID: 30308389]
  • Katie L Bidne, Sara S Kvidera, Jason W Ross, Lance H Baumgard, Aileen F Keating. Impact of repeated lipopolysaccharide administration on ovarian signaling during the follicular phase of the estrous cycle in post-pubertal pigs. Journal of animal science. 2018 Sep; 96(9):3622-3634. doi: 10.1093/jas/sky226. [PMID: 29982469]
  • Zachary K Smith, Alex J Thompson, John P Hutcheson, Wade T Nichols, Bradley J Johnson. Evaluation of coated steroidal implants containing trenbolone acetate and estradiol-17β on live performance, carcass traits, and sera metabolites in finishing steers. Journal of animal science. 2018 May; 96(5):1704-1723. doi: 10.1093/jas/sky095. [PMID: 29534183]
  • Francesca Lega, Roberto Angeletti, Roberto Stella, Lorenzo Rigoni, Giancarlo Biancotto, Danilo Giusepponi, Simone Moretti, Giorgio Saluti, Roberta Galarini. Abuse of anabolic agents in beef cattle: Could bile be a possible alternative matrix?. Food chemistry. 2017 Aug; 229(?):188-197. doi: 10.1016/j.foodchem.2017.02.069. [PMID: 28372163]
  • Natalie K Karouna-Renier, Yu Chen, Paula F P Henry, Catherine M Maddox, Daniel T Sprague. Effects on Circulating Steroid Hormones and Gene Expression along the Hypothalamus-Pituitary-Gonadal Axis in Adult Japanese Quail Exposed to 17β-Trenbolone across Multiple Generations. Toxicological sciences : an official journal of the Society of Toxicology. 2017 05; 157(1):62-73. doi: 10.1093/toxsci/kfx016. [PMID: 28108667]
  • Joseph A Robinson, Qingli Ma, Jane P Staveley, Walter J Smolenski. Sorption and desorption of 17α-trenbolone and trendione on five soils. Environmental toxicology and chemistry. 2017 03; 36(3):613-620. doi: 10.1002/etc.3711. [PMID: 27958649]
  • Joseph A Robinson, Qingli Ma, Jane P Staveley, Walter J Smolenski, Jon Ericson. Degradation and transformation of 17α-estradiol in water-sediment systems under controlled aerobic and anaerobic conditions. Environmental toxicology and chemistry. 2017 03; 36(3):621-629. doi: 10.1002/etc.3383. [PMID: 26801177]
  • Joseph A Robinson, Qingli Ma, Jane P Staveley, Walter J Smolenski, Jon Ericson. Degradation and transformation of 17α-trenbolone in aerobic water-sediment systems. Environmental toxicology and chemistry. 2017 03; 36(3):630-635. doi: 10.1002/etc.3381. [PMID: 26800846]
  • A J Ziecik, J Klos, E Przygrodzka, R Milewski, B Jana. Aberrant effects of altrenogest and exposure to exogenous gonadotropins on follicular cysts appearance in gilts. Theriogenology. 2017 Feb; 89(?):250-254. doi: 10.1016/j.theriogenology.2016.10.028. [PMID: 28043359]
  • Daniel L Villeneuve, Kathleen M Jensen, Jenna E Cavallin, Elizabeth J Durhan, Natàlia Garcia-Reyero, Michael D Kahl, Richard L Leino, Elizabeth A Makynen, Leah C Wehmas, Edward J Perkins, Gerald T Ankley. Effects of the antimicrobial contaminant triclocarban, and co-exposure with the androgen 17β-trenbolone, on reproductive function and ovarian transcriptome of the fathead minnow (Pimephales promelas). Environmental toxicology and chemistry. 2017 01; 36(1):231-242. doi: 10.1002/etc.3531. [PMID: 27312088]
  • Claudia Zanardello, Katia Capello, Roberto Stella, Giancarlo Biancotto, Marta Vascellari. Semiquantitative immunohistochemical detection of progesterone receptors in male accessory sex glands as a screening assay for anabolic steroid use in bulls. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc. 2017 Jan; 29(1):35-40. doi: 10.1177/1040638716681047. [PMID: 28074716]
  • Satomi Mizukami-Murata, Katsuyuki Kishi-Kadota, Takashi Nishida. 17β-Trenbolone exposure programs metabolic dysfunction in larval medaka. Environmental toxicology. 2016 Nov; 31(11):1539-1551. doi: 10.1002/tox.22158. [PMID: 26040664]
  • Louisa B Harding, Irvin R Schultz, Denis A M da Silva, Gina M Ylitalo, Dave Ragsdale, Stephanie I Harris, Stephanie Bailey, Barry V Pepich, Penny Swanson. Wastewater treatment plant effluent alters pituitary gland gonadotropin mRNA levels in juvenile coho salmon (Oncorhynchus kisutch). Aquatic toxicology (Amsterdam, Netherlands). 2016 Sep; 178(?):118-31. doi: 10.1016/j.aquatox.2016.07.013. [PMID: 27475653]
  • F F McConaghy, L A Green, S Colgan, L H Morris. Studies of the pharmacokinetic profile, in vivo efficacy and safety of injectable altrenogest for the suppression of oestrus in mares. Australian veterinary journal. 2016 Jul; 94(7):248-55. doi: 10.1111/avj.12459. [PMID: 27349885]
  • Christine Akre, Masahiro Mizuno. A screening and determinative method for the analysis of natural and synthetic steroids, stilbenes and resorcyclic acid lactones in bovine urine. Drug testing and analysis. 2016 May; 8(5-6):448-57. doi: 10.1002/dta.2012. [PMID: 27443199]
  • Daniel G Donner, Grace E Elliott, Belinda R Beck, Andrew C Bulmer, Alfred K Lam, John P Headrick, Eugene F Du Toit. Trenbolone Improves Cardiometabolic Risk Factors and Myocardial Tolerance to Ischemia-Reperfusion in Male Rats With Testosterone-Deficient Metabolic Syndrome. Endocrinology. 2016 Jan; 157(1):368-81. doi: 10.1210/en.2015-1603. [PMID: 26584015]
  • Karen H Watanabe, Michael Mayo, Kathleen M Jensen, Daniel L Villeneuve, Gerald T Ankley, Edward J Perkins. Predicting Fecundity of Fathead Minnows (Pimephales promelas) Exposed to Endocrine-Disrupting Chemicals Using a MATLAB®-Based Model of Oocyte Growth Dynamics. PloS one. 2016; 11(1):e0146594. doi: 10.1371/journal.pone.0146594. [PMID: 26756814]
  • Dudu Demir, Nahit Gencer, Oktay Arslan. An alternative purification method for human serum paraoxonase 1 and its interactions with anabolic compounds. Journal of enzyme inhibition and medicinal chemistry. 2016; 31(2):247-52. doi: 10.3109/14756366.2015.1018242. [PMID: 25792501]
  • Sam Bircher, Marcella L Card, Guangshu Zhai, Yu-Ping Chin, Jerald L Schnoor. Sorption, uptake, and biotransformation of 17β-estradiol, 17α-ethinylestradiol, zeranol, and trenbolone acetate by hybrid poplar. Environmental toxicology and chemistry. 2015 Dec; 34(12):2906-13. doi: 10.1002/etc.3166. [PMID: 26184466]
  • Brett R Blackwell, Bradley J Johnson, Michael D Buser, George P Cobb, Philip N Smith. Transformation kinetics of trenbolone acetate metabolites and estrogens in urine and feces of implanted steers. Chemosphere. 2015 Nov; 138(?):901-7. doi: 10.1016/j.chemosphere.2014.10.091. [PMID: 25550108]
  • Tatiane Micheletti, Janine L Brown, Susan L Walker, Zalmir S Cubas, Priscila V Furtado, Sarah B Putman, Wanderlei de Moraes, Marcos J de Oliveira, Claudio A de Oliveira, Nei Moreira. The use of altrenogest to avoid hyperestrogenism after eCG-hCG ovulation induction in southern tigrina (Leopardus guttulus). Theriogenology. 2015 Sep; 84(4):575-82. doi: 10.1016/j.theriogenology.2015.04.015. [PMID: 26001599]
  • Sophie Massart, Baptiste Redivo, Enora Flamion, S N M Mandiki, Elodie Falisse, Sylvain Milla, Patrick Kestemont. The trenbolone acetate affects the immune system in rainbow trout, Oncorhynchus mykiss. Aquatic toxicology (Amsterdam, Netherlands). 2015 Jun; 163(?):109-20. doi: 10.1016/j.aquatox.2015.04.007. [PMID: 25889087]
  • Maxim A Yunin, Pavel S Metalnikov, Alexander A Komarov, Alexander N Panin. Development of a rapid method for the analysis of trenbolone, nortestosterone, and zeranol in bovine liver using liquid chromatography tandem mass spectrometry. Analytical and bioanalytical chemistry. 2015 Jun; 407(15):4363-71. doi: 10.1007/s00216-014-8346-y. [PMID: 25450054]
  • Daniel G Donner, Belinda R Beck, Andrew C Bulmer, Alfred K Lam, Eugene F Du Toit. Improvements in body composition, cardiometabolic risk factors and insulin sensitivity with trenbolone in normogonadic rats. Steroids. 2015 Feb; 94(?):60-9. doi: 10.1016/j.steroids.2014.12.017. [PMID: 25554582]
  • Brett R Blackwell, Tyson R Brown, Paul R Broadway, Michael D Buser, J Chance Brooks, Bradley J Johnson, George P Cobb, Philip N Smith. Characterization of trenbolone acetate and estradiol metabolite excretion profiles in implanted steers. Environmental toxicology and chemistry. 2014 Dec; 33(12):2850-8. doi: 10.1002/etc.2757. [PMID: 25244153]
  • S L Parr, T R Brown, F R B Ribeiro, K Y Chung, J P Hutcheson, B R Blackwell, P N Smith, B J Johnson. Biological responses of beef steers to steroidal implants and zilpaterol hydrochloride. Journal of animal science. 2014 Aug; 92(8):3348-63. doi: 10.2527/jas.2013-7221. [PMID: 24987078]
  • C Wynne Collins, Steven L Monfort, Mandi M Vick, Barbara A Wolfe, Rachael B Weiss, Carol L Keefer, Nucharin Songsasen. Oral and injectable synthetic progestagens effectively manipulate the estrous cycle in the Przewalski's horse (Equus ferus przewalskii). Animal reproduction science. 2014 Jul; 148(1-2):42-52. doi: 10.1016/j.anireprosci.2014.03.018. [PMID: 24856195]
  • Monica A Stoops, Gary D West, Terri L Roth, Nancy P Lung. Use of urinary biomarkers of ovarian function and altrenogest supplementation to enhance captive breeding success in the Indian rhinoceros (Rhinoceros unicornis). Zoo biology. 2014 Mar; 33(2):83-8. doi: 10.1002/zoo.21106. [PMID: 24375460]
  • E S M Silva, S C F Frade, F S Ignácio, J C F Pantoja, J N P Puoli Filho, C Meira. Supplementary corpora lutea monitoring allows progestin treatment interruption on day 70 of pregnancy in non-cyclic recipient mares. Animal reproduction science. 2014 Jan; 144(3-4):122-8. doi: 10.1016/j.anireprosci.2013.12.004. [PMID: 24380787]
  • S T Howard, D R Woerner, D J Vote, J A Scanga, R J Acheson, P L Chapman, T C Bryant, J D Tatum, K E Belk. Effects of ractopamine hydrochloride and zilpaterol hydrochloride supplementation on carcass cutability of calf-fed Holstein steers. Journal of animal science. 2014 Jan; 92(1):369-75. doi: 10.2527/jas.2013-7104. [PMID: 24243909]
  • Irvin R Schultz, James J Nagler, Penny Swanson, Dave Wunschel, Ann D Skillman, Vicki Burnett, Derek Smith, Richard Barry. Toxicokinetic, toxicodynamic, and toxicoproteomic aspects of short-term exposure to trenbolone in female fish. Toxicological sciences : an official journal of the Society of Toxicology. 2013 Dec; 136(2):413-29. doi: 10.1093/toxsci/kft220. [PMID: 24072461]
  • Yohana M Velasco-Santamaría, Poul Bjerregaard, Bodil Korsgaard. Evidence of small modulation of ethinylestradiol induced effects by concurrent exposure to trenbolone in male eelpout Zoarces viviparus. Environmental pollution (Barking, Essex : 1987). 2013 Jul; 178(?):189-96. doi: 10.1016/j.envpol.2013.03.011. [PMID: 23583938]
  • Mélanie Villeret, Sabrina Jolly, Laure Wiest, Emmanuelle Vulliet, Anne Bado-Nilles, Jean-Marc Porcher, Stéphane Betoulle, Christophe Minier, Wilfried Sanchez. A potential biomarker of androgen exposure in European bullhead (Cottus sp.) kidney. Fish physiology and biochemistry. 2013 Jun; 39(3):573-80. doi: 10.1007/s10695-012-9720-3. [PMID: 23010938]
  • B R Blackwell, A Karnjanapiboonwong, T A Anderson, P N Smith. Uptake of 17β-trenbolone and subsequent metabolite trendione by the pinto bean plant (Phaseolus vulgaris). Ecotoxicology and environmental safety. 2012 Nov; 85(?):110-4. doi: 10.1016/j.ecoenv.2012.08.006. [PMID: 22951338]
  • Shan Liu, Guang-Guo Ying, Rui-Quan Zhang, Li-Jun Zhou, Hua-Jie Lai, Zhi-Feng Chen. Fate and occurrence of steroids in swine and dairy cattle farms with different farming scales and wastes disposal systems. Environmental pollution (Barking, Essex : 1987). 2012 Nov; 170(?):190-201. doi: 10.1016/j.envpol.2012.07.016. [PMID: 22835499]
  • Sean C McCoy, Joshua F Yarrow, Christine F Conover, Paul A Borsa, Mark D Tillman, Bryan P Conrad, Jennifer E Pingel, Thomas J Wronski, Sally E Johnson, Hordur G Kristinsson, Fan Ye, Stephen E Borst. 17β-Hydroxyestra-4,9,11-trien-3-one (Trenbolone) preserves bone mineral density in skeletally mature orchiectomized rats without prostate enlargement. Bone. 2012 Oct; 51(4):667-73. doi: 10.1016/j.bone.2012.07.008. [PMID: 22842328]
  • Kenji Korosue, Harutaka Murase, Fumio Sato, Mutsuki Ishimaru, Takehiro Harada, Gen Watanabe, Kazuyoshi Taya, Yasuo Nambo. Successful induction of lactation in a barren Thoroughbred mare: growth of a foal raised on induced lactation and the corresponding maternal hormone profiles. The Journal of veterinary medical science. 2012 Aug; 74(8):995-1002. doi: 10.1292/jvms.12-0035. [PMID: 22467072]
  • K Kongsuwan, M R Knox, P G Allingham, R Pearson, B P Dalrymple. The effect of combination treatment with trenbolone acetate and estradiol-17β on skeletal muscle expression and plasma concentrations of oxytocin in sheep. Domestic animal endocrinology. 2012 Jul; 43(1):67-73. doi: 10.1016/j.domaniend.2012.02.004. [PMID: 22503145]
  • Barbara Wozniak, Iwona Matraszek-Zuchowska, Jan Zmudzki. LC-MS/MS fast analysis of androgenic steroids in urine. Analytical and bioanalytical chemistry. 2012 Jul; 403(10):2965-72. doi: 10.1007/s00216-012-5859-0. [PMID: 22392373]
  • Todd R Robeck, Claudia Gill, Bethany M Doescher, Jay Sweeney, Piet De Laender, Cornelis E Van Elk, Justine K O'Brien. Altrenogest and progesterone therapy during pregnancy in bottlenose dolphins (Tursiops truncatus) with progesterone insufficiency. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians. 2012 Jun; 43(2):296-308. doi: 10.1638/2011-0166.1. [PMID: 22779233]
  • Jinqing Jiang, Haitang Zhang, Guangling Li, Xuefeng Yang, Renfeng Li, Ziliang Wang, Jianhua Wang. Establishment and optimization of monoclonal antibody-based heterologous dcELISA for 19-nortestosterone residue in bovine edible tissue. Journal of food science. 2012 Apr; 77(4):T63-9. doi: 10.1111/j.1750-3841.2011.02578.x. [PMID: 22515255]
  • K S Schmidt, R Hackenberg, C S Stachel, P Gowik. Endogenous and synthetic steroids in bovine urine--preparation of in-house reference material, stability studies and results of a proficiency test. Analytica chimica acta. 2012 Mar; 717(?):85-91. doi: 10.1016/j.aca.2011.12.038. [PMID: 22304819]
  • Joshua F Yarrow, Luke A Beggs, Christine F Conover, Sean C McCoy, Darren T Beck, Stephen E Borst. Influence of androgens on circulating adiponectin in male and female rodents. PloS one. 2012; 7(10):e47315. doi: 10.1371/journal.pone.0047315. [PMID: 23071783]
  • Matthew J Geraci, Mario Cole, Peter Davis. New onset diabetes associated with bovine growth hormone and testosterone abuse in a young body builder. Human & experimental toxicology. 2011 Dec; 30(12):2007-12. doi: 10.1177/0960327111408152. [PMID: 21558143]
  • T W Geary, K J Wells, D M deAvila, J deAvila, V A Conforti, D J McLean, A J Roberts, R W Waterman, J J Reeves. Effects of immunization against luteinizing hormone-releasing hormone and treatment with trenbolone acetate on reproductive function of beef bulls and steers. Journal of animal science. 2011 Jul; 89(7):2086-95. doi: 10.2527/jas.2010-3565. [PMID: 21383041]
  • Nadia De Jager, Nicholas J Hudson, Antonio Reverter, Yong-Hong Wang, Shivashankar H Nagaraj, Linda M Cafe, Paul L Greenwood, Ross T Barnard, Kritaya P Kongsuwan, Brian P Dalrymple. Chronic exposure to anabolic steroids induces the muscle expression of oxytocin and a more than fiftyfold increase in circulating oxytocin in cattle. Physiological genomics. 2011 May; 43(9):467-78. doi: 10.1152/physiolgenomics.00226.2010. [PMID: 21325062]
  • Zhenhong Li, Kevin J Kroll, Kathleen M Jensen, Daniel L Villeneuve, Gerald T Ankley, Jayne V Brian, María S Sepúlveda, Edward F Orlando, James M Lazorchak, Mitchell Kostich, Brandon Armstrong, Nancy D Denslow, Karen H Watanabe. A computational model of the hypothalamic: pituitary: gonadal axis in female fathead minnows (Pimephales promelas) exposed to 17α-ethynylestradiol and 17β-trenbolone. BMC systems biology. 2011 May; 5(?):63. doi: 10.1186/1752-0509-5-63. [PMID: 21545743]
  • Michael J Hemmer, Kimberly A Salinas, Peggy S Harris. Application of protein expression profiling to screen chemicals for androgenic activity. Aquatic toxicology (Amsterdam, Netherlands). 2011 May; 103(1-2):71-8. doi: 10.1016/j.aquatox.2011.02.008. [PMID: 21392497]
  • Conrad Willmann, Gerhard Schuler, Bernd Hoffmann, Nahid Parvizi, Christine Aurich. Effects of age and altrenogest treatment on conceptus development and secretion of LH, progesterone and eCG in early-pregnant mares. Theriogenology. 2011 Feb; 75(3):421-8. doi: 10.1016/j.theriogenology.2010.05.009. [PMID: 21144568]
  • Drew R Ekman, Daniel L Villeneuve, Quincy Teng, Kimberly J Ralston-Hooper, Dalma Martinović-Weigelt, Michael D Kahl, Kathleen M Jensen, Elizabeth J Durhan, Elizabeth A Makynen, Gerald T Ankley, Timothy W Collette. Use of gene expression, biochemical and metabolite profiles to enhance exposure and effects assessment of the model androgen 17β-trenbolone in fish. Environmental toxicology and chemistry. 2011 Feb; 30(2):319-29. doi: 10.1002/etc.406. [PMID: 21082714]
  • Yuanyang Zhang, Fangyang He, Yuping Wan, Meng Meng, Jing Xu, Jian Yi, Yabin Wang, Caiwei Feng, Shanliang Wang, Rimo Xi. Generation of anti-trenbolone monoclonal antibody and establishment of an indirect competitive enzyme-linked immunosorbent assay for detection of trenbolone in animal tissues, feed and urine. Talanta. 2011 Jan; 83(3):732-7. doi: 10.1016/j.talanta.2010.10.020. [PMID: 21147313]
  • Jin Zhou, Xiao-Shan Zhu, Zhong-Hua Cai. Influences of DMP on the fertilization process and subsequent embryogenesis of abalone (Haliotis diversicolor supertexta) by gametes exposure. PloS one. 2011; 6(10):e25951. doi: 10.1371/journal.pone.0025951. [PMID: 22028799]
  • Gerald T Ankley, Kathleen M Jensen, Michael D Kahl, Elizabeth J Durhan, Elizabeth A Makynen, Jenna E Cavallin, Dalma Martinović, Leah C Wehmas, Nathaniel D Mueller, Daniel L Villeneuve. Use of chemical mixtures to differentiate mechanisms of endocrine action in a small fish model. Aquatic toxicology (Amsterdam, Netherlands). 2010 Sep; 99(3):389-96. doi: 10.1016/j.aquatox.2010.05.020. [PMID: 20573408]
  • Geraldine M Cripe, Becky L Hemmer, Sandy Raimondo, Larry R Goodman, Dannielle H Kulaw. Exposure of three generations of the estuarine sheepshead minnow (Cyprinodon variegatus) to the androgen, 17beta-trenbolone: effects on survival, development, and reproduction. Environmental toxicology and chemistry. 2010 Sep; 29(9):2079-87. doi: 10.1002/etc.261. [PMID: 20821666]
  • Timothy W Collette, Quincy Teng, Kathleen M Jensen, Michael D Kahl, Elizabeth A Makynen, Elizabeth J Durhan, Daniel L Villeneuve, Dalma Martinović-Weigelt, Gerald T Ankley, Drew R Ekman. Impacts of an anti-androgen and an androgen/anti-androgen mixture on the metabolite profile of male fathead minnow urine. Environmental science & technology. 2010 Sep; 44(17):6881-6. doi: 10.1021/es1011884. [PMID: 20687545]
  • Franziska M Palm, Ina Schenk, Stefanie Neuhauser, Daniel Schubert, Marc Machnik, Wilhelm Schänzer, Christine Aurich. Concentrations of altrenogest in plasma of mares and foals and in allantoic and amniotic fluid at parturition. Theriogenology. 2010 Jul; 74(2):229-35. doi: 10.1016/j.theriogenology.2010.02.006. [PMID: 20452000]
  • A Foisnet, C Farmer, C David, H Quesnel. Altrenogest treatment during late pregnancy did not reduce colostrum yield in primiparous sows. Journal of animal science. 2010 May; 88(5):1684-93. doi: 10.2527/jas.2009-2751. [PMID: 20118420]
  • R A Stewart, K M Pelican, J L Brown, D E Wildt, M A Ottinger, J G Howard. Oral progestin induces rapid, reversible suppression of ovarian activity in the cat. General and comparative endocrinology. 2010 Apr; 166(2):409-16. doi: 10.1016/j.ygcen.2009.12.016. [PMID: 20051246]
  • R J B Peters, J E Oosterink, A A M Stolker, C Georgakopoulos, M W F Nielen. Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. Analytical and bioanalytical chemistry. 2010 Apr; 396(7):2583-98. doi: 10.1007/s00216-010-3484-3. [PMID: 20155493]
  • Verena Christen, Silke Hickmann, Bettina Rechenberg, Karl Fent. Highly active human pharmaceuticals in aquatic systems: A concept for their identification based on their mode of action. Aquatic toxicology (Amsterdam, Netherlands). 2010 Feb; 96(3):167-81. doi: 10.1016/j.aquatox.2009.11.021. [PMID: 20053463]
  • Yohana M Velasco-Santamaría, Steffen S Madsen, Poul Bjerregaard, Bodil Korsgaard. Effects of 17beta-trenbolone in male eelpout Zoarces viviparus exposed to ethinylestradiol. Analytical and bioanalytical chemistry. 2010 Jan; 396(2):631-40. doi: 10.1007/s00216-009-3262-2. [PMID: 19902185]
  • Rainer W Stephany. Hormonal growth promoting agents in food producing animals. Handbook of experimental pharmacology. 2010; ?(195):355-67. doi: 10.1007/978-3-540-79088-4_16. [PMID: 20020373]
  • Jonathan J Lee, Irvin R Schultz. Sex differences in the uptake and disposition of perfluorooctanoic acid in fathead minnows after oral dosing. Environmental science & technology. 2010 Jan; 44(1):491-6. doi: 10.1021/es901838y. [PMID: 19961202]
  • Mara Gasparini, Michele Curatolo, Walter Assini, Eros Bozzoni, Nadia Tognoli, Guglielmo Dusi. Confirmatory method for the determination of nandrolone and trenbolone in urine samples using immunoaffinity cleanup and liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2009 Nov; 1216(46):8059-66. doi: 10.1016/j.chroma.2009.04.075. [PMID: 19447393]
  • T R Robeck, K J Steinman, M Greenwell, K Ramirez, W Van Bonn, M Yoshioka, E Katsumata, L Dalton, S Osborn, J K O'Brien. Seasonality, estrous cycle characterization, estrus synchronization, semen cryopreservation, and artificial insemination in the Pacific white-sided dolphin (Lagenorhynchus obliquidens). Reproduction (Cambridge, England). 2009 Aug; 138(2):391-405. doi: 10.1530/rep-08-0528. [PMID: 19494046]
  • S Neuhauser, F Palm, F Ambuehl, E Möstl, I Schwendenwein, C Aurich. Effect of altrenogest-treatment of mares in late gestation on adrenocortical function, blood count and plasma electrolytes in their foals. Equine veterinary journal. 2009 Jul; 41(6):572-7. doi: 10.2746/042516409x394481. [PMID: 19803053]
  • Marlo K Sellin, Daniel D Snow, Sarah T Gustafson, Galen E Erickson, Alan S Kolok. The endocrine activity of beef cattle wastes: do growth-promoting steroids make a difference?. Aquatic toxicology (Amsterdam, Netherlands). 2009 May; 92(4):221-7. doi: 10.1016/j.aquatox.2009.02.004. [PMID: 19269048]
  • Mario Thevis, Sven Guddat, Wilhelm Schänzer. Doping control analysis of trenbolone and related compounds using liquid chromatography-tandem mass spectrometry. Steroids. 2009 Mar; 74(3):315-21. doi: 10.1016/j.steroids.2008.10.004. [PMID: 19007801]
  • Xiaowei Zhang, Markus Hecker, June-Woo Park, Amber R Tompsett, Paul D Jones, John Newsted, Doris W T Au, Richard Kong, Rudolf S S Wu, John P Giesy. Time-dependent transcriptional profiles of genes of the hypothalamic-pituitary-gonadal axis in medaka (Oryzias latipes) exposed to fadrozole and 17beta-trenbolone. Environmental toxicology and chemistry. 2008 Dec; 27(12):2504-11. doi: 10.1897/08-082.1. [PMID: 18693774]
  • Limin He, Xianhui Huang, Binghu Fang, Shixin Huang, Ying Cao, Jianxin Chen, Zhenling Zeng, Zhangliu Chen. [Determination of eleven steroid hormones in animal muscle tissues and eggs using ultra-performance liquid chromatography-tandem mass spectrometry]. Se pu = Chinese journal of chromatography. 2008 Nov; 26(6):714-9. doi: . [PMID: 19253550]
  • K L Degenstein, R O'Donoghue, J L Patterson, E Beltranena, D J Ambrose, G R Foxcroft, M K Dyck. Synchronization of ovulation in cyclic gilts with porcine luteinizing hormone (pLH) and its effects on reproductive function. Theriogenology. 2008 Oct; 70(7):1075-85. doi: 10.1016/j.theriogenology.2008.06.027. [PMID: 18656251]
  • E Kamanga-Sollo, M E White, K Y Chung, B J Johnson, W R Dayton. Potential role of G-protein-coupled receptor 30 (GPR30) in estradiol-17beta-stimulated IGF-I mRNA expression in bovine satellite cell cultures. Domestic animal endocrinology. 2008 Oct; 35(3):254-62. doi: 10.1016/j.domaniend.2008.06.001. [PMID: 18650055]
  • E Kamanga-Sollo, M E White, M R Hathaway, K Y Chung, B J Johnson, W R Dayton. Roles of IGF-I and the estrogen, androgen and IGF-I receptors in estradiol-17beta- and trenbolone acetate-stimulated proliferation of cultured bovine satellite cells. Domestic animal endocrinology. 2008 Jul; 35(1):88-97. doi: 10.1016/j.domaniend.2008.02.003. [PMID: 18403176]
  • S Neuhauser, F Palm, F Ambuehl, C Aurich. Effects of altrenogest treatment of mares in late pregnancy on parturition and on neonatal viability of their foals. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2008 Jul; 116(7):423-8. doi: 10.1055/s-2008-1065367. [PMID: 18484066]
  • Yang Qin, Xin Liu, Zhanliang Wang, Moutian Wu. [Determination of three anabolic steroids by liquid chromatography-mass spectrometry]. Se pu = Chinese journal of chromatography. 2008 Jul; 26(4):465-8. doi: . [PMID: 18959243]
  • Michael J Hemmer, Geraldine M Cripe, Becky L Hemmer, Larry R Goodman, Kimberly A Salinas, John W Fournie, Calvin C Walker. Comparison of estrogen-responsive plasma protein biomarkers and reproductive endpoints in sheepshead minnows exposed to 17beta-trenbolone. Aquatic toxicology (Amsterdam, Netherlands). 2008 Jun; 88(2):128-36. doi: 10.1016/j.aquatox.2008.04.001. [PMID: 18495259]
  • M H Blokland, P W Zoontjes, S S Sterk, R W Stephany, J Zweigenbaum, L A van Ginkel. Confirmatory analysis of Trenbolone using accurate mass measurement with LC/TOF-MS. Analytica chimica acta. 2008 Jun; 618(1):86-93. doi: 10.1016/j.aca.2008.04.040. [PMID: 18501249]
  • Tiia Kuuranne, Kati-Henna Pystynen, Mario Thevis, Antii Leinonen, Wilhelm Schänzer, Risto Kostiainen. Screening of in vitro synthesised metabolites of 4,9,11-trien-3-one steroids by liquid chromatography mass spectrometry. European journal of mass spectrometry (Chichester, England). 2008; 14(3):181-9. doi: 10.1255/ejms.923. [PMID: 18708698]
  • D K Walker, E C Titgemeyer, E K Sissom, K R Brown, J J Higgins, G A Andrews, B J Johnson. Effects of steroidal implantation and ractopamine-HCl on nitrogen retention, blood metabolites and skeletal muscle gene expression in Holstein steers. Journal of animal physiology and animal nutrition. 2007 Oct; 91(9-10):439-47. doi: 10.1111/j.1439-0396.2007.00675.x. [PMID: 17845252]
  • Hari Kosanam, P K Sai Prakash, C R Yates, D D Miller, Suma Ramagiri. Rapid screening of doping agents in human urine by vacuum MALDI-linear ion trap mass spectrometry. Analytical chemistry. 2007 Aug; 79(15):6020-6. doi: 10.1021/ac070118z. [PMID: 17602668]
  • Marlice Aparecida Sípoli Marques, Henrique Marcelo Gualberto Pereira, Monica Costa Padilha, Francisco Radler de Aquino Neto. Analysis of synthetic 19-norsteroids trenbolone, tetrahydrogestrinone and gestrinone by gas chromatography-mass spectrometry. Journal of chromatography. A. 2007 May; 1150(1-2):215-25. doi: 10.1016/j.chroma.2006.08.032. [PMID: 16963059]
  • Antoni Rúbies, Albert Cabrera, Francesc Centrich. Determination of synthetic hormones in animal urine by high-performance liquid chromatography/mass spectrometry. Journal of AOAC International. 2007 Mar; 90(2):626-32. doi: 10.1093/jaoac/90.2.626. [PMID: 17474533]
  • K R Smith, S K Duckett, M J Azain, R N Sonon, T D Pringle. The effect of anabolic implants on intramuscular lipid deposition in finished beef cattle. Journal of animal science. 2007 Feb; 85(2):430-40. doi: 10.2527/jas.2006-280. [PMID: 17235028]