Indicaxanthin (BioDeep_00000019557)
Secondary id: BioDeep_00000006849, BioDeep_00000403109, BioDeep_00000911264, BioDeep_00001869974
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
化学式: C14H16N2O6 (308.1008)
中文名称:
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 42.28%
分子结构信息
SMILES: C1CC([N+](=CC=C2CC(NC(=C2)C(=O)O)C(=O)O)C1)C(=O)[O-]
InChI: InChI=1S/C14H16N2O6/c17-12(18)9-6-8(7-10(15-9)13(19)20)3-5-16-4-1-2-11(16)14(21)22/h3,5-6,10-11H,1-2,4,7H2,(H3,17,18,19,20,21,22)
描述信息
Indicaxanthin is found in fruits. Indicaxanthin is a constituent of the fruits of Opuntia ficus-indica (Indian fig) Indicaxanthin is a type of betaxanthin, a plant pigment present in beets, prickly pear cactus, and a powerful antioxidant. It is also found in red dragonfruit
D004396 - Coloring Agents > D050858 - Betalains
同义名列表
5 个代谢物同义名
(1E)-1-{2-[(4E)-2,6-dicarboxy-1,2,3,4-tetrahydropyridin-4-ylidene]ethylidene}-1λ⁵-pyrrolidin-1-ylium-2-carboxylate; (1E)-1-{2-[(4E)-2,6-dicarboxy-2,3-dihydro-1H-pyridin-4-ylidene]ethylidene}-1λ⁵-pyrrolidin-1-ylium-2-carboxylate; 4-[2-(2-Carboxy-1-pyrrolidinyl)ethenyl]-2,3-dihydro-2,6-pyridinedicarboxylic acid, 9ci; Indicaxanthin; Indicaxanthin
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:5896
- KEGG: C08549
- PubChem: 76552239
- PubChem: 6096870
- PubChem: 4480892
- HMDB: HMDB0029386
- ChEMBL: CHEMBL4453776
- Wikipedia: Indicaxanthin
- KNApSAcK: C00001591
- foodb: FDB000466
- chemspider: 3678858
- CAS: 2181-75-1
- PMhub: MS000020002
- PubChem: 10742
- 3DMET: B02217
- NIKKAJI: J412.456A
- RefMet: Indicaxanthin
- KNApSAcK: 5896
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Nikolaos Tsafantakis, Efrosini S Katsanou, Katerina Kyriakopoulou, Eirini-Christina Psarou, Iliana Raptaki, Alexios L Skaltsounis, Marc Audebert, Kyriaki A Machera, Nikolas Fokialakis. Comparative UHPLC-HRMS Profiling, Toxicological Assessment, and Protection Against H2O2-Induced Genotoxicity of Different Parts of Opuntia ficus indica.
Journal of medicinal food.
2019 Dec; 22(12):1280-1293. doi:
10.1089/jmf.2019.0032. [PMID: 31584314] - M Alejandra Guerrero-Rubio, Samanta Hernández-García, Francisco García-Carmona, Fernando Gandía-Herrero. Extension of life-span using a RNAi model and in vivo antioxidant effect of Opuntia fruit extracts and pure betalains in Caenorhabditis elegans.
Food chemistry.
2019 Feb; 274(?):840-847. doi:
10.1016/j.foodchem.2018.09.067. [PMID: 30373018] - Alessandro Attanzio, Anna Frazzitta, Rosalia Busa', Luisa Tesoriere, Maria A Livrea, Mario Allegra. Indicaxanthin from Opuntia ficus indica (L. Mill) Inhibits Oxidized LDL-Mediated Human Endothelial Cell Dysfunction through Inhibition of NF-κB Activation.
Oxidative medicine and cellular longevity.
2019; 2019(?):3457846. doi:
10.1155/2019/3457846. [PMID: 30911345] - José A Fernández-López, María J Roca, José M Angosto, José M Obón. Betaxanthin-Rich Extract from Cactus Pear Fruits as Yellow Water-Soluble Colorant with Potential Application in Foods.
Plant foods for human nutrition (Dordrecht, Netherlands).
2018 Jun; 73(2):146-153. doi:
10.1007/s11130-018-0664-3. [PMID: 29666973] - Tom Clifford, Costas M Constantinou, Karen M Keane, Daniel J West, Glyn Howatson, Emma J Stevenson. The plasma bioavailability of nitrate and betanin from Beta vulgaris rubra in humans.
European journal of nutrition.
2017 Apr; 56(3):1245-1254. doi:
10.1007/s00394-016-1173-5. [PMID: 26873098] - A Mata, J P Ferreira, C Semedo, T Serra, C M M Duarte, M R Bronze. Contribution to the characterization of Opuntia spp. juices by LC-DAD-ESI-MS/MS.
Food chemistry.
2016 Nov; 210(?):558-65. doi:
10.1016/j.foodchem.2016.04.033. [PMID: 27211682] - Luisa Tesoriere, Alessandro Attanzio, Mario Allegra, Maria A Livrea. Dietary indicaxanthin from cactus pear (Opuntia ficus-indica L. Mill) fruit prevents eryptosis induced by oxysterols in a hypercholesterolaemia-relevant proportion and adhesion of human erythrocytes to endothelial cell layers.
The British journal of nutrition.
2015 Aug; 114(3):368-75. doi:
10.1017/s0007114515002111. [PMID: 26169206] - Flores Naselli, Luisa Tesoriere, Fabio Caradonna, Daniele Bellavia, Alessandro Attanzio, Carla Gentile, Maria A Livrea. Anti-proliferative and pro-apoptotic activity of whole extract and isolated indicaxanthin from Opuntia ficus-indica associated with re-activation of the onco-suppressor p16(INK4a) gene in human colorectal carcinoma (Caco-2) cells.
Biochemical and biophysical research communications.
2014 Jul; 450(1):652-8. doi:
10.1016/j.bbrc.2014.06.029. [PMID: 24937448] - Mario Allegra, Angela Ianaro, Mariaroberta Tersigni, Elisabetta Panza, Luisa Tesoriere, Maria Antonia Livrea. Indicaxanthin from cactus pear fruit exerts anti-inflammatory effects in carrageenin-induced rat pleurisy.
The Journal of nutrition.
2014 Feb; 144(2):185-92. doi:
10.3945/jn.113.183657. [PMID: 24306215] - M Allegra, F D'Acquisto, L Tesoriere, A Attanzio, M A Livrea. Pro-oxidant activity of indicaxanthin from Opuntia ficus indica modulates arachidonate metabolism and prostaglandin synthesis through lipid peroxide production in LPS-stimulated RAW 264.7 macrophages.
Redox biology.
2014; 2(?):892-900. doi:
10.1016/j.redox.2014.07.004. [PMID: 25180166] - Luisa Tesoriere, Alessandro Attanzio, Mario Allegra, Carla Gentile, Maria A Livrea. Phytochemical indicaxanthin suppresses 7-ketocholesterol-induced THP-1 cell apoptosis by preventing cytosolic Ca(2+) increase and oxidative stress.
The British journal of nutrition.
2013 Jul; 110(2):230-40. doi:
10.1017/s000711451200493x. [PMID: 23228674] - L Tesoriere, C Gentile, F Angileri, A Attanzio, M Tutone, M Allegra, M A Livrea. Trans-epithelial transport of the betalain pigments indicaxanthin and betanin across Caco-2 cell monolayers and influence of food matrix.
European journal of nutrition.
2013 Apr; 52(3):1077-87. doi:
10.1007/s00394-012-0414-5. [PMID: 22806766] - S Baldassano, L Tesoriere, A Rotondo, R Serio, M A Livrea, F Mulè. Inhibition of the mechanical activity of mouse ileum by cactus pear (Opuntia Ficus Indica, L, Mill.) fruit extract and its pigment indicaxanthin.
Journal of agricultural and food chemistry.
2010 Jul; 58(13):7565-71. doi:
10.1021/jf100434e. [PMID: 20518499] - Maria Liria Turco Liveri, Luciana Sciascia, Mario Allegra, Luisa Tesoriere, Maria A Livrea. Partition of indicaxanthin in membrane biomimetic systems. A kinetic and modeling approach.
Journal of agricultural and food chemistry.
2009 Nov; 57(22):10959-63. doi:
10.1021/jf902266m. [PMID: 19919126] - L Tesoriere, M Allegra, D Butera, C Gentile, M A Livrea. Kinetics of the lipoperoxyl radical-scavenging activity of indicaxanthin in solution and unilamellar liposomes.
Free radical research.
2007 Feb; 41(2):226-33. doi:
10.1080/10715760601026614. [PMID: 17364949] - L Tesoriere, M Allegra, D Butera, C Gentile, M A Livrea. Cytoprotective effects of the antioxidant phytochemical indicaxanthin in beta-thalassemia red blood cells.
Free radical research.
2006 Jul; 40(7):753-61. doi:
10.1080/10715760600554228. [PMID: 16984002] - C Gentile, L Tesoriere, M Allegra, M A Livrea, P D'Alessio. Antioxidant betalains from cactus pear (Opuntia ficus-indica) inhibit endothelial ICAM-1 expression.
Annals of the New York Academy of Sciences.
2004 Dec; 1028(?):481-6. doi:
10.1196/annals.1322.057. [PMID: 15650274] - Luisa Tesoriere, Mario Allegra, Daniela Butera, Maria A Livrea. Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: potential health effects of betalains in humans.
The American journal of clinical nutrition.
2004 Oct; 80(4):941-5. doi:
10.1093/ajcn/80.4.941. [PMID: 15447903] - . .
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