Cyproheptadine (BioDeep_00000001940)

 

Secondary id: BioDeep_00000405791

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


1-methyl-4-{tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-ylidene}piperidine

化学式: C21H21N (287.1674)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 28.61%

分子结构信息

SMILES: CN1CC/C(CC1)=C2C3=CC=CC=C3C=CC4=CC=CC=C/24
InChI: InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3

描述信息

Cyproheptadine is only found in individuals that have used or taken this drug. It is a serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc. [PubChem]Cyproheptadine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. Cyproheptadine also competes with serotonin at receptor sites in smooth muscle in the intestines and other locations. Antagonism of serotonin on the appetite center of the hypothalamus may account for Cyproheptadines ability to stimulate appetite.
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D003879 - Dermatologic Agents > D000982 - Antipruritics
D005765 - Gastrointestinal Agents
D018926 - Anti-Allergic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Cyproheptadine is a potent and orally active 5-HT2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders[1][2].

同义名列表

17 个代谢物同义名

1-methyl-4-{tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,9,11,13-heptaen-2-ylidene}piperidine; 1-Methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine; 4-(5H-Dibenzo(a,D)cyclohepten-5-ylidene)-1-methylpiperidine; 4-(5-Dibenzo(a,D)cyclohepten-5-ylidine)-1-methylpiperidine; 5-(1-Methylpiperidylidene-4)-5H-dibenzo(a,D)cyclopheptene; 1-Methyl-4-(5H-dibenzo(a,D)cycloheptenylidene)piperidine; 4-Dibenzo[a,D]cyclohepten-5-ylidene-1-methyl-piperidine; Cyproheptadinum; Ciproheptadina; CYPROHEPTADINE; Periactin; Dihexazin; Ciprovit; Viternum; Antergan; Peritol; Cyproheptadine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 HTR2B, POMC, PRL
Peripheral membrane protein 1 RDX
Endoplasmic reticulum membrane 1 CD4
Nucleus 2 PRL, SETD7
cytosol 1 SST
dendrite 3 HTR2A, HTR2B, HTR2C
nucleoplasm 3 HTR2B, PRL, SETD7
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 7 ADRB3, CD4, HTR2A, HTR2B, HTR2C, RDX, TNF
Cytoplasmic side 1 RDX
Cleavage furrow 1 RDX
lamellipodium 1 RDX
Cell projection, axon 1 HTR2A
Multi-pass membrane protein 5 ADRB3, CACNA1I, HTR2A, HTR2B, HTR2C
Synapse 3 CRH, HTR2B, HTR2C
cell surface 1 TNF
dendritic shaft 1 HTR2A
glutamatergic synapse 1 HTR2A
Golgi membrane 1 INS
neuronal cell body 3 HTR2A, SST, TNF
presynaptic membrane 1 HTR2A
Presynapse 1 HTR2A
plasma membrane 10 ADRB3, CACNA1I, CD4, GCG, HTR2A, HTR2B, HTR2C, KNG1, RDX, TNF
Membrane 2 CACNA1I, RDX
apical plasma membrane 1 RDX
axon 1 HTR2A
caveola 1 HTR2A
extracellular exosome 2 KNG1, RDX
extracellular space 12 CRH, GCG, IL2, IL4, IL5, INS, KNG1, POMC, PRL, RDX, SST, TNF
adherens junction 1 RDX
filopodium 1 RDX
Single-pass type I membrane protein 1 CD4
Secreted 10 CRH, GCG, IL2, IL4, IL5, INS, POMC, PRL, SST, TRH
extracellular region 12 CRH, GCG, IL2, IL4, IL5, INS, KNG1, POMC, PRL, SST, TNF, TRH
external side of plasma membrane 2 CD4, TNF
varicosity 1 CRH
T-tubule 1 RDX
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
cytoplasmic vesicle 1 HTR2A
nucleolus 1 SETD7
midbody 1 RDX
Early endosome 1 CD4
apical part of cell 1 RDX
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 HTR2A
Membrane raft 2 CD4, TNF
Cytoplasm, cytoskeleton 1 RDX
focal adhesion 1 RDX
GABA-ergic synapse 1 SST
collagen-containing extracellular matrix 1 KNG1
secretory granule 2 POMC, TRH
receptor complex 1 ADRB3
chromatin 1 PRL
cell projection 1 RDX
phagocytic cup 1 TNF
cell periphery 1 RDX
Chromosome 1 SETD7
cytoskeleton 1 RDX
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
endosome lumen 2 INS, PRL
microvillus 1 RDX
Membrane, caveola 1 HTR2A
Cell projection, stereocilium 1 RDX
Cell projection, microvillus 1 RDX
cell body fiber 1 HTR2A
Cell projection, dendrite 1 HTR2A
secretory granule lumen 3 GCG, INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 CD4, GCG, INS, KNG1
cortical actin cytoskeleton 1 RDX
platelet alpha granule lumen 1 KNG1
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 SST
cell tip 1 RDX
neurofilament 1 HTR2A
clathrin-coated endocytic vesicle membrane 1 CD4
Synapse, synaptosome 1 HTR2B
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
G protein-coupled serotonin receptor complex 3 HTR2A, HTR2B, HTR2C
stereocilium base 1 RDX
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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