Carteolol (BioDeep_00000001928)

 

Secondary id: BioDeep_00000408906

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydroquinolin-2-one

化学式: C16H24N2O3 (292.1787)
中文名称: 卡替洛尔
谱图信息: 最多检出来源 Homo sapiens(blood) 13.84%

分子结构信息

SMILES: CC(C)(C)NCC(COC1=CC=CC2=C1CCC(=O)N2)O
InChI: InChI=1S/C16H24N2O3/c1-16(2,3)17-9-11(19)10-21-14-6-4-5-13-12(14)7-8-15(20)18-13/h4-6,11,17,19H,7-10H2,1-3H3,(H,18,20)

描述信息

Carteolol is only found in individuals that have used or taken this drug. It is a beta-adrenergic antagonist used as an anti-arrhythmia agent, an anti-angina agent, an antihypertensive agent, and an antiglaucoma agent. [PubChem]The primary mechanism of the ocular hypotensive action of carteolol in reducing intraocular pressure is most likely a decrease in aqueous humor production. This process is initiated by the non-selective beta1 and beta2 adrenergic receptor blockade.
C - Cardiovascular system > C07 - Beta blocking agents > C07A - Beta blocking agents > C07AA - Beta blocking agents, non-selective
S - Sensory organs > S01 - Ophthalmologicals > S01E - Antiglaucoma preparations and miotics > S01ED - Beta blocking agents
C78272 - Agent Affecting Nervous System > C29747 - Adrenergic Agent > C72900 - Adrenergic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013565 - Sympatholytics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D018674 - Adrenergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents

同义名列表

8 个代谢物同义名

5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydroquinolin-2-one; Monohydrochloride, carteolol; Carteolol monohydrochloride; Hydrochloride, carteolol; Carteolol hydrochloride; Carteololum; CARTEOLOL; Carteolol



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AXIN2, BCL2, BCL2L1, CDKN2A, CYP1A1, CYP2D6, CYP3A4, EDN1, NOX4
Peripheral membrane protein 2 CYP1A1, CYP1B1
Endoplasmic reticulum membrane 6 BCL2, CYP1A1, CYP1B1, CYP2D6, CYP3A4, NOX4
Mitochondrion membrane 1 BCL2L1
Nucleus 5 AXIN2, BCL2, CDKN2A, LMNB1, NOX4
cytosol 4 AXIN2, BCL2, BCL2L1, CDKN2A
dendrite 1 HTR1A
centrosome 2 AXIN2, BCL2L1
nucleoplasm 2 CDKN2A, LMNB1
Cell membrane 3 ADRB3, HTR1A, NOX4
Cytoplasmic side 1 BCL2L1
Multi-pass membrane protein 4 ADRB3, CACNA1I, HTR1A, NOX4
Synapse 1 HTR1A
Golgi membrane 1 INS
mitochondrial inner membrane 2 BCL2L1, CYP1A1
Cytoplasm, cytosol 1 BCL2L1
plasma membrane 7 ADRB3, AXIN2, CACNA1I, HTR1A, KNG1, NOX4, REN
synaptic vesicle membrane 1 BCL2L1
Membrane 8 BCL2, CACNA1I, CYP1B1, CYP2D6, CYP3A4, LMNB1, NOX4, REN
extracellular exosome 1 KNG1
endoplasmic reticulum 4 BCL2, BCL2L1, CYP2D6, NOX4
extracellular space 7 CXCL8, EDN1, IL10, IL6, INS, KNG1, REN
perinuclear region of cytoplasm 1 NOX4
mitochondrion 7 BCL2, BCL2L1, CDKN2A, CYP1A1, CYP1B1, CYP2D6, NOX4
protein-containing complex 2 BCL2, CDKN2A
intracellular membrane-bounded organelle 4 CYP1A1, CYP1B1, CYP2D6, CYP3A4
Microsome membrane 4 CYP1A1, CYP1B1, CYP2D6, CYP3A4
Secreted 6 CXCL8, EDN1, IL10, IL6, INS, REN
extracellular region 7 CXCL8, EDN1, IL10, IL6, INS, KNG1, REN
Mitochondrion outer membrane 2 BCL2, BCL2L1
Single-pass membrane protein 3 BCL2, BCL2L1, CYP2D6
mitochondrial outer membrane 2 BCL2, BCL2L1
basal part of cell 1 EDN1
Mitochondrion matrix 1 BCL2L1
mitochondrial matrix 2 BCL2L1, CDKN2A
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 BCL2L1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 BCL2L1
Nucleus membrane 2 BCL2, BCL2L1
Bcl-2 family protein complex 2 BCL2, BCL2L1
nuclear membrane 3 BCL2, BCL2L1, LMNB1
beta-catenin destruction complex 1 AXIN2
nucleolus 2 CDKN2A, NOX4
apical part of cell 1 REN
Cytoplasm, perinuclear region 1 NOX4
Mitochondrion inner membrane 1 CYP1A1
pore complex 1 BCL2
Cell junction, focal adhesion 1 NOX4
focal adhesion 1 NOX4
collagen-containing extracellular matrix 1 KNG1
intermediate filament 1 LMNB1
nuclear inner membrane 1 LMNB1
receptor complex 1 ADRB3
[Isoform 5]: Cytoplasm 1 NOX4
Secreted, extracellular space 1 KNG1
Nucleus, nucleolus 2 CDKN2A, NOX4
blood microparticle 1 KNG1
nuclear envelope 1 LMNB1
endosome lumen 1 INS
Nucleus, nucleoplasm 1 CDKN2A
Cell projection, dendrite 1 HTR1A
myelin sheath 1 BCL2
[Isoform 3]: Cytoplasm 1 NOX4
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, KNG1
nuclear matrix 1 LMNB1
platelet alpha granule lumen 1 KNG1
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 2 EDN1, INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
perinuclear endoplasmic reticulum 1 NOX4
nuclear lamina 1 LMNB1
[Isoform 4]: Nucleus 1 NOX4
Nucleus lamina 1 LMNB1
lamin filament 1 LMNB1
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
NADPH oxidase complex 1 NOX4
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[Isoform 6]: Cytoplasm 1 NOX4
senescence-associated heterochromatin focus 1 CDKN2A
[Isoform Bcl-X(L)]: Mitochondrion inner membrane 1 BCL2L1
[Isoform smARF]: Mitochondrion 1 CDKN2A


文献列表

  • Riku Arai, Daisuke Fukamachi, Masaki Monden, Naotaka Akutsu, Nobuhiro Murata, Yasuo Okumura. Bradycardia Shock Caused by the Combined Use of Carteolol Eye Drops and Verapamil in an Elderly Patient with Atrial Fibrillation and Chronic Kidney Disease. Internal medicine (Tokyo, Japan). 2021 Jan; 60(1):79-83. doi: 10.2169/internalmedicine.5598-20. [PMID: 32830185]
  • Dzmitry Shcharbin, Maria Bryszewska, Serge Mignani, Xiangyang Shi, Jean-Pierre Majoral. Phosphorus dendrimers as powerful nanoplatforms for drug delivery, as fluorescent probes and for liposome interaction studies: A concise overview. European journal of medicinal chemistry. 2020 Dec; 208(?):112788. doi: 10.1016/j.ejmech.2020.112788. [PMID: 32883637]
  • Jia Wu, Xue Xiao, Zhenqun Li, Li Jia. Enantioseparation of chiral β-blockers using polynorepinephrine-coated nanoparticles and chiral capillary electrophoresis. Analytical and bioanalytical chemistry. 2019 Apr; 411(10):2121-2129. doi: 10.1007/s00216-019-01641-4. [PMID: 30734853]
  • Dongsheng Xu, Huikai Shao, Rongying Luo, Qiqin Wang, Elena Sánchez-López, Salvatore Fanali, Maria Luisa Marina, Zhengjin Jiang. A facile and efficient single-step approach for the fabrication of vancomycin functionalized polymer-based monolith as chiral stationary phase for nano-liquid chromatography. Journal of chromatography. A. 2018 Jul; 1557(?):43-50. doi: 10.1016/j.chroma.2018.05.004. [PMID: 29739612]
  • Ming Shan, Ting-Jun Fan. Cytotoxicity of carteolol to human corneal epithelial cells by inducing apoptosis via triggering the Bcl-2 family protein-mediated mitochondrial pro-apoptotic pathway. Toxicology in vitro : an international journal published in association with BIBRA. 2016 Sep; 35(?):36-42. doi: 10.1016/j.tiv.2016.05.008. [PMID: 27216471]
  • Qing Yao, Xianyong Yu, Tongyin Zheng, Heting Liu, Ying Yang, Pinggui Yi. Spectroscopic studies on the interaction of carteolol hydrochloride and urea-induced bovine serum albumin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2013 Sep; 113(?):447-51. doi: 10.1016/j.saa.2013.04.129. [PMID: 23747387]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Imju Jeong, Bok Hee Choi, Shin Hee Yoon, Sang June Hahn. Carvedilol blocks the cloned cardiac Kv1.5 channels in a β-adrenergic receptor-independent manner. Biochemical pharmacology. 2012 Feb; 83(4):497-505. doi: 10.1016/j.bcp.2011.11.019. [PMID: 22146582]
  • V A Badar, Sachin K Hiware, Meena P Shrivastava, V R Thawani, M M Hardas. Comparison of nebivolol and atenolol on blood pressure, blood sugar, and lipid profile in patients of essential hypertension. Indian journal of pharmacology. 2011 Jul; 43(4):437-40. doi: 10.4103/0253-7613.83117. [PMID: 21845001]
  • Ling Zou, Ashwin Nair, Hong Weng, Yi-Ting Tsai, Zhibing Hu, Liping Tang. Intraocular pressure changes: an important determinant of the biocompatibility of intravitreous implants. PloS one. 2011; 6(12):e28720. doi: 10.1371/journal.pone.0028720. [PMID: 22194895]
  • Kazuhide Kawase, Tetsuya Yamamoto, Tomoyuki Muramatsu, Junji Ono, Toru Nakajima, Atsuko Matsuhisa, Torao Sugiura, Masayoshi Migita, Yuji Ishikawa. [Long-acting carteolol hydrochloride 2\% ophthalmic solution phase IV study--investigation of the effectiveness, safety and plasma concentration]. Nippon Ganka Gakkai zasshi. 2010 Nov; 114(11):976-82. doi: NULL. [PMID: 21141077]
  • Kwou-Yeung Wu, Cheng-Hsien Chang, Hwei-Zu Wang, Show-Jen Hong. Mechanism of carteolol-induced cytosolic Ca2+ mobilization in cultured vascular smooth muscle cells. Vascular pharmacology. 2010 Sep; 53(3-4):88-93. doi: 10.1016/j.vph.2010.04.003. [PMID: 20416399]
  • Li Zhang, Xiaoli Su, Chenggong Zhang, Li Ouyang, Qingji Xie, Ming Ma, Shouzhuo Yao. Extraction and preconcentration of beta-blockers in human urine for analysis with high performance liquid chromatography by means of carrier-mediated liquid phase microextraction. Talanta. 2010 Aug; 82(3):984-92. doi: 10.1016/j.talanta.2010.06.003. [PMID: 20678656]
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  • Takahiro Horinouchi, Shigeru Morishima, Yoshio Tanaka, Katsuo Koike, Soichi Miwa, Ikunobu Muramatsu. Pharmacological evaluation of ocular beta-adrenoceptors in rabbit by tissue segment binding method. Life sciences. 2009 Jan; 84(5-6):181-7. doi: 10.1016/j.lfs.2008.11.016. [PMID: 19087880]
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  • Masayo Higashiyama, Tetsuya Tajika, Katsuhiro Inada, Akira Ohtori. Improvement of the ocular bioavailability of carteolol by ion pair. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2006 Oct; 22(5):333-9. doi: 10.1089/jop.2006.22.333. [PMID: 17076627]
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  • P Renard, J L Kovalski, I Cochereau, S Jaulerry, W Williamson, P P Elena, M Lablache Combier, C Allaire, R Siou-Mermet. Comparison of carteolol plasmatic levels after repeated instillations of long-acting and regular formulations of carteolol 2\% in glaucoma patients. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2005 Dec; 243(12):1221-7. doi: 10.1007/s00417-005-0024-5. [PMID: 16003515]
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  • Yoko Ishii, Koichi Nakamura, Shunji Matsuki, Naoto Uemura, Ryoko Muraguchi, Mikiko Nakagawa, Shigeyuki Nakano, Kazuo Nakatsuka. Pharmacokinetic and pharmacodynamic differences between ocular and nasal instillation of carteolol on intraocular pressure and heart rate in Japanese men with high CYP2D6 activity. Journal of clinical pharmacology. 2002 Sep; 42(9):1020-6. doi: . [PMID: 12211218]
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  • G E Mirza, S Karaküçük, E Temel. Comparison of the effects of 0.5\% timolol maleate, 2\% carteolol hydrochloride, and 0.3\% metipranolol on intraocular pressure and perimetry findings and evaluation of their ocular and systemic effects. Journal of glaucoma. 2000 Feb; 9(1):45-50. doi: 10.1097/00061198-200002000-00009. [PMID: 10708231]
  • J D Bartlett, M Olivier, T Richardson, R Whitaker, D Pensyl, M R Wilson. Central nervous system and plasma lipid profiles associated with carteolol and timolol in postmenopausal black women. Journal of glaucoma. 1999 Dec; 8(6):388-95. doi: . [PMID: 10604299]
  • T Sugiyama, I Azuma, M Araie, S Fujisawa, H Urashima, M Nagasawa. Effect of continuous intravenous infusion of carteolol chloride on tissue blood flow in rabbit optic nerve head. Japanese journal of ophthalmology. 1999 Nov; 43(6):490-4. doi: 10.1016/s0021-5155(99)00107-0. [PMID: 10672877]
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