Astemizole (BioDeep_00000001891)
Secondary id: BioDeep_00001867674
human metabolite blood metabolite
代谢物信息卡片
1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-1,3-benzodiazol-2-amine
化学式: C28H31FN4O (458.2482)
中文名称: 阿司咪唑
谱图信息:
最多检出来源 Homo sapiens(general) 20.11%
分子结构信息
SMILES: COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F
InChI: InChI=1S/C28H31FN4O/c1-34-25-12-8-21(9-13-25)14-17-32-18-15-24(16-19-32)30-28-31-26-4-2-3-5-27(26)33(28)20-22-6-10-23(29)11-7-22/h2-13,24H,14-20H2,1H3,(H,30,31)
描述信息
Astemizole is a long-acting, non-sedating second generation antihistamine used in the treatment of allergy symptoms. It was withdrawn from market by the manufacturer in 1999 due to the potential to cause arrhythmias at high doses, especially when when taken with CYP inhibitors or grapefruit juice.
R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist
D018926 - Anti-Allergic Agents
Astemizole (R 43512), a second-generation antihistamine agent to diminish allergic symptoms with a long duration of action, is a histamine H1-receptor antagonist, with an IC50 of 4 nM. Astemizole also shows potent hERG K+ channel blocking activity with an IC50 of 0.9 nM. Astemizole has antipruritic effects[1][2].
同义名列表
69 个代谢物同义名
1-[(4-fluorophenyl)methyl]-N-{1-[2-(4-methoxyphenyl)ethyl]piperidin-4-yl}-1H-1,3-benzodiazol-2-amine; 1-(p-Fluorobenzyl)-2-((1-(2-(p-methoxyphenyl)ethyl)piperid-4-yl)amino)benzimidazole; 1-(p-Fluorobenzyl)-2-((1-(p-methoxyphenethyl)-4-piperidyl)amino)benzimidazole; Reig jofre brand OF astemizole; Ratiopharm brand OF astemizole; Senosiain brand OF astemizole; Medinsa brand OF astemizole; Smaller brand OF astemizole; Janssen brand OF astemizole; Astemizole ratiopharm brand; Fustery brand OF astemizole; Astemizole senosiain brand; Alacan brand OF astemizole; Esteve brand OF astemizole; Urbion brand OF astemizole; Alonga brand OF astemizole; McNeil brand OF astemizole; Merck brand OF astemizole; Septa brand OF astemizole; Elfar brand OF astemizole; Lesvi brand OF astemizole; Astemizole janssen brand; Astemizole fustery brand; Vita brand OF astemizole; Astemizole smaller brand; Diba brand OF astemizole; Astemizole medinsa brand; Astemizole mcneil brand; Astemizole alacan brand; Byk brand OF astemizole; Astemizole urbion brand; ICN brand OF astemizole; Astemizole alonga brand; Astemizole esteve brand; Astemizole merck brand; Astemizole elfar brand; Astemizole septa brand; Astemizole lesvi brand; Ratiopharm, astemizol; Astemizole diba brand; Astemizole vita brand; Astemizol ratiopharm; Astemizole icn brand; Astemizole byk brand; Alonga, astemizol; Astemizol alonga; Fustermizol; Astemizolum; Paralergin; Hubermizol; astemizole; Histaminos; Alermizol; Astemison; Astemizol; Astemina; Hismanal; Laridal; Simprox; Esmacen; Romadin; Rifedot; Retolen; Astesen; Rimbol; Urdrim; Emdar; R 43512; Astemizole
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:2896
- KEGG: C06832
- KEGGdrug: D00234
- PubChem: 2247
- HMDB: HMDB0014775
- Metlin: METLIN1122
- DrugBank: DB00637
- ChEMBL: CHEMBL296419
- Wikipedia: Astemizole
- MeSH: Astemizole
- chemspider: 2160
- CAS: 68844-77-9
- PMhub: MS000001397
- PubChem: 9050
- PDB-CCD: XB7
- NIKKAJI: J18.595G
- RefMet: Astemizole
- medchemexpress: HY-12532
- KNApSAcK: 2896
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiangjun Wang, Jiayu Lu, Shuai Ge, Yajing Hou, Tian Hu, Yuexin Lv, Cheng Wang, Huaizhen He. Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro.
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10.1093/toxsci/kfx098. [PMID: 28521025] - Jia-Nan Tian, Xiao-Dong Shi, Xiao-Kun Wang, Shuang Wang, Jing-Xue Xu, Chun-Xiao Yang. Astemizole protects against human umbilical vein endothelial cell injury induced by hydrogen peroxide via the p53 signaling pathway.
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