Alfentanil (BioDeep_00000001883)

 

Secondary id: BioDeep_00000398415

human metabolite blood metabolite


代谢物信息卡片


N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide

化学式: C21H32N6O3 (416.2535762)
中文名称: 阿芬太尼
谱图信息: 最多检出来源 Homo sapiens(blood) 5.88%

分子结构信息

SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCN3C(=O)N(N=N3)CC)COC
InChI: InChI=1S/C21H32N6O3/c1-4-19(28)27(18-9-7-6-8-10-18)21(17-30-3)11-13-24(14-12-21)15-16-26-20(29)25(5-2)22-23-26/h6-10H,4-5,11-17H2,1-3H3

描述信息

A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. [PubChem]
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AH - Opioid anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics

同义名列表

13 个代谢物同义名

N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide; N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide; Janssen brand OF alfentanil hydrochloride; Esteve brand OF alfentanil hydrochloride; ICI brand OF alfentanil hydrochloride; alfentanil hydrochloride; Alfentanilum; Alfentanyl; ALFENTANIL; Fanaxal; Limifen; Alfenta; Rapifen



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark S Wallace. Effect of Pregabalin on the Median Effective Plasma Concentration of Intravenous Alfentanil in Capsaicin-Induced Pain. Pain medicine (Malden, Mass.). 2021 Dec; 22(12):3072-3079. doi: 10.1093/pm/pnab222. [PMID: 34329455]
  • Jean Jung, Allan Kolodziej, Elise Pape, Michael Bisch, Lucie Javot, Valérie Gibaja, Jean-Yves Jouzeau, Julien Scala-Bertola, Nicolas Gambier. Multiplex detection of 14 fentanyl analogues and U-47700 in biological samples: Application to a panel of French hospitalized patients. Forensic science international. 2020 Dec; 317(?):110437. doi: 10.1016/j.forsciint.2020.110437. [PMID: 33007729]
  • Robert J Brosnan, Bruno H Pypendop, Scott D Stanley. Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats. Journal of veterinary pharmacology and therapeutics. 2020 Nov; 43(6):533-537. doi: 10.1111/jvp.12886. [PMID: 32557697]
  • Haruka Tsutsui, Motohiro Kato, Shino Kuramoto, Nobuo Sekiguchi, Hidetoshi Shindoh, Kazuhisa Ozeki. Quantitative evaluation of hepatic and intestinal induction of CYP3A in clinical practice. Xenobiotica; the fate of foreign compounds in biological systems. 2020 Aug; 50(8):875-884. doi: 10.1080/00498254.2019.1710620. [PMID: 31885304]
  • Khaled Abduljalil, Xian Pan, Amita Pansari, Masoud Jamei, Trevor N Johnson. Preterm Physiologically Based Pharmacokinetic Model. Part II: Applications of the Model to Predict Drug Pharmacokinetics in the Preterm Population. Clinical pharmacokinetics. 2020 04; 59(4):501-518. doi: 10.1007/s40262-019-00827-4. [PMID: 31587145]
  • Jing-Yang Liou, Mei-Yung Tsou, Shinju Obara, Lu Yu, Chien-Kun Ting. Plasma concentration based response surface model predict better than effect-site concentration based model for wake-up time during gastrointestinal endoscopy sedation. Journal of the Formosan Medical Association = Taiwan yi zhi. 2019 Jan; 118(1 Pt 2):291-298. doi: 10.1016/j.jfma.2018.05.007. [PMID: 29803320]
  • Nina Hanke, Sebastian Frechen, Daniel Moj, Hannah Britz, Thomas Eissing, Thomas Wendl, Thorsten Lehr. PBPK Models for CYP3A4 and P-gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin. CPT: pharmacometrics & systems pharmacology. 2018 10; 7(10):647-659. doi: 10.1002/psp4.12343. [PMID: 30091221]
  • Carolyn Schifftner, Gery Schulteis, Mark S Wallace. Effect of Intravenous Alfentanil on Nonpainful Thermally Induced Hyperalgesia in Healthy Volunteers. Journal of clinical pharmacology. 2017 09; 57(9):1207-1214. doi: 10.1002/jcph.911. [PMID: 28464270]
  • M Roozekrans, E Olofsen, R van der Schrier, M Boom, R Mooren, A Dahan. Doxapram-mediated Increase in Cardiac Output Reduces Opioid Plasma Concentrations: A Pharmacokinetic/Pharmacodynamic-Pharmacokinetic/Pharmacodynamic Modeling Study in Healthy Volunteers. Clinical pharmacology and therapeutics. 2017 07; 102(1):115-122. doi: 10.1002/cpt.601. [PMID: 28001306]
  • Mohammad H Abou-Arab, Morten Rostrup, Tom Heier. Dose requirements of alfentanil to eliminate autonomic responses during rapid-sequence induction with thiopental 4 mg/kg and rocuronium 0.6 mg/kg. Journal of clinical anesthesia. 2016 Dec; 35(?):465-474. doi: 10.1016/j.jclinane.2016.09.026. [PMID: 27871575]
  • Pegah Zahedi, Saied Saeed Hosseiny Davarani, Hamid Reza Moazami, Saeed Nojavan. Surfactant assisted pulsed two-phase electromembrane extraction followed by GC analysis for quantification of basic drugs in biological samples. Journal of pharmaceutical and biomedical analysis. 2016 Jan; 117(?):485-91. doi: 10.1016/j.jpba.2015.10.002. [PMID: 26469297]
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  • Guillaume Baneyx, Neil Parrott, Christophe Meille, Athanassios Iliadis, Thierry Lavé. Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human: influence of time between substrate and inducer administration. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2014 Jun; 56(?):1-15. doi: 10.1016/j.ejps.2014.02.002. [PMID: 24530864]
  • B H Pypendop, R J Brosnan, C R Majewski-Tiedeken, S D Stanley, J E Ilkiw. Pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane-anesthetized cats. Journal of veterinary pharmacology and therapeutics. 2014 Feb; 37(1):13-7. doi: 10.1111/jvp.12047. [PMID: 23895731]
  • Min-Hsien Chiang, Shao-Chun Wu, Chia-Hsun You, Keng-Liang Wu, Yi-Chun Chiu, Chao-Wei Ma, Chin-Wei Kao, Kun-Chen Lin, Kuan-Hung Chen, Peng-Chih Wang, An-Kuo Chou. Target-controlled infusion vs. manually controlled infusion of propofol with alfentanil for bidirectional endoscopy: a randomized controlled trial. Endoscopy. 2013 Nov; 45(11):907-14. doi: 10.1055/s-0033-1344645. [PMID: 24165817]
  • N Sigmond, M Baechtold, P M Schumacher, V Hartwich, T W Schnider, M Luginbühl. Pharmacokinetic parameter sets of alfentanil revisited: optimal parameters for use in target controlled infusion and anaesthesia display systems. British journal of anaesthesia. 2013 Aug; 111(2):197-208. doi: 10.1093/bja/aet049. [PMID: 23512864]
  • Ali Reza Fakhari, Hadi Tabani, Saeed Nojavan. Miniaturized hollow fibre assisted liquid-phase microextraction and gas chromatography for determination of trace concentration of sufentanil and alfentanil in biological samples. Drug testing and analysis. 2013 Jul; 5(7):589-95. doi: 10.1002/dta.1387. [PMID: 22786780]
  • James R Miner, Johanna C Moore, David Plummer, Richard O Gray, Sagar Patel, Jeffrey D Ho. Randomized clinical trial of the effect of supplemental opioids in procedural sedation with propofol on serum catecholamines. Academic emergency medicine : official journal of the Society for Academic Emergency Medicine. 2013 Apr; 20(4):330-7. doi: 10.1111/acem.12110. [PMID: 23701339]
  • O Pérus, A Marsot, E Ramain, M Dahman, A Paci, M Raucoules-Aimé, N Simon. Performance of alfentanil target-controlled infusion in normal and morbidly obese female patients. British journal of anaesthesia. 2012 Oct; 109(4):551-60. doi: 10.1093/bja/aes211. [PMID: 22732112]
  • Marija Bosilkovska, Bernhard Walder, Marie Besson, Youssef Daali, Jules Desmeules. Analgesics in patients with hepatic impairment: pharmacology and clinical implications. Drugs. 2012 Aug; 72(12):1645-69. doi: 10.2165/11635500-000000000-00000. [PMID: 22867045]
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  • Joanne N Michou, Elizabeth A Leece, Jacqueline C Brearley. Comparison of pain on injection during induction of anaesthesia with alfaxalone and two formulations of propofol in dogs. Veterinary anaesthesia and analgesia. 2012 May; 39(3):275-81. doi: 10.1111/j.1467-2995.2012.00709.x. [PMID: 22414225]
  • E D Kharasch, D Whittington, D Ensign, C Hoffer, P S Bedynek, S Campbell, K Stubbert, A Crafford, A London, T Kim. Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics. Clinical pharmacology and therapeutics. 2012 Apr; 91(4):673-84. doi: 10.1038/clpt.2011.276. [PMID: 22398970]
  • Maiko Yamauchi-Satomoto, Yushi U Adachi, Tadayoshi Kurita, Koji Morita, Shigehito Sato. Cross-clamping of the descending thoracic aorta leads to the asymmetrical distribution of propofol during cardiopulmonary bypass surgery. Korean journal of anesthesiology. 2012 Apr; 62(4):327-31. doi: 10.4097/kjae.2012.62.4.327. [PMID: 22558498]
  • Kuntheavy Ing Lorenzini, Youssef Daali, Pierre Dayer, Jules Desmeules. Pharmacokinetic-pharmacodynamic modelling of opioids in healthy human volunteers. a minireview. Basic & clinical pharmacology & toxicology. 2012 Mar; 110(3):219-26. doi: 10.1111/j.1742-7843.2011.00814.x. [PMID: 21995512]
  • Evan D Kharasch, Pamela Sheffels Bedynek, Christine Hoffer, Alysa Walker, Dale Whittington. Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A). Anesthesiology. 2012 Feb; 116(2):432-47. doi: 10.1097/aln.0b013e3182423478. [PMID: 22273859]
  • Wan-hua Yang, Hong-bin Gu, Bing Chen, Juan Li, Qiu-wei Fan, Yong-fang Yuan, Xiangdong Wang. Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol. Journal of translational medicine. 2011 Nov; 9(?):187. doi: 10.1186/1479-5876-9-187. [PMID: 22044738]
  • Beena Parikh, Jyotsna Maliwad, Veena R Shah. Preventive analgesia: Effect of small dose of ketamine on morphine requirement after renal surgery. Journal of anaesthesiology, clinical pharmacology. 2011 Oct; 27(4):485-8. doi: 10.4103/0970-9185.86592. [PMID: 22096281]
  • Sabina Strano-Rossi, Iván Alvarez, María Jesús Tabernero, Pamela Cabarcos, Purificación Fernández, Ana María Bermejo. Determination of fentanyl, metabolite and analogs in urine by GC/MS. Journal of applied toxicology : JAT. 2011 Oct; 31(7):649-54. doi: 10.1002/jat.1613. [PMID: 21132842]
  • C Isles, S Robertson, A Almond, K Donaldson, D Clark. The challenges of renal replacement therapy and renal palliative care in the elderly. The journal of the Royal College of Physicians of Edinburgh. 2011 Sep; 41(3):238-43. doi: 10.4997/jrcpe.2011.313. [PMID: 21949923]
  • E D Kharasch, A Francis, A London, K Frey, T Kim, J Blood. Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction. Clinical pharmacology and therapeutics. 2011 Jul; 90(1):100-8. doi: 10.1038/clpt.2011.59. [PMID: 21562488]
  • Thomas Kim, Amy London, Evan D Kharasch. Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2011 Jun; 55(3):487-93. doi: 10.1016/j.jpba.2011.01.040. [PMID: 21382685]
  • Mohammad Saraji, Malihe Khalili Boroujeni, Ali Akbar Hajialiakbari Bidgoli. Comparison of dispersive liquid-liquid microextraction and hollow fiber liquid-liquid-liquid microextraction for the determination of fentanyl, alfentanil, and sufentanil in water and biological fluids by high-performance liquid chromatography. Analytical and bioanalytical chemistry. 2011 Jun; 400(7):2149-58. doi: 10.1007/s00216-011-4874-x. [PMID: 21442368]
  • E D Kharasch, S Vangveravong, N Buck, A London, T Kim, J Blood, R H Mach. Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. Clinical pharmacology and therapeutics. 2011 Apr; 89(4):562-70. doi: 10.1038/clpt.2010.313. [PMID: 21346758]
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