2-Me 5-HT (BioDeep_00001875892)
Main id: BioDeep_00000009496
代谢物信息卡片
2-Methyl-5-hydroxytryptamine
化学式: C11H14N2O (190.1106)
中文名称: 2-甲基5-羟色胺盐酸盐
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C2=C(N1)C=CC(=C2)O)CCN
InChI: InChI=1S/C11H14N2O/c1-7-9(4-5-12)10-6-8(14)2-3-11(10)13-7/h2-3,6,13-14H,4-5,12H2,1H3
描述信息
2-Methyl-5-HT (2-Methyl-5-hydroxytryptamine) is a potent and selective 5-HT3 receptor agonist. 2-Methyl-5-HT is shown to display anti-depressive-like effects[1].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:31085
- KEGG: C13665
- PubChem: 1574
- ChEMBL: CHEMBL266591
- CAS: 78263-90-8
- PubChem: 586258
- NIKKAJI: J258.445J
- medchemexpress: HY-19358
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Katherine C Faulkner, Katherine A Hurley, Douglas B Weibel. 5-Alkyloxytryptamines are membrane-targeting, broad-spectrum antibiotics.
Bioorganic & medicinal chemistry letters.
2016 11; 26(22):5539-5544. doi:
10.1016/j.bmcl.2016.10.004. [PMID: 27765507] - François Reichardt, Charlotte Baudry, Lisa Gruber, Gemma Mazzuoli, Raphaël Moriez, Christian Scherling, Patrick Kollmann, Hannelore Daniel, Sigrid Kisling, Dirk Haller, Michel Neunlist, Michael Schemann. Properties of myenteric neurones and mucosal functions in the distal colon of diet-induced obese mice.
The Journal of physiology.
2013 Oct; 591(20):5125-39. doi:
10.1113/jphysiol.2013.262733. [PMID: 23940384] - Mari Gabrielsen, Aina Westrheim Ravna, Kurt Kristiansen, Ingebrigt Sylte. Substrate binding and translocation of the serotonin transporter studied by docking and molecular dynamics simulations.
Journal of molecular modeling.
2012 Mar; 18(3):1073-85. doi:
10.1007/s00894-011-1133-1. [PMID: 21670993] - Yung-Chih Lai, Yih Ho, Kai-Han Huang, Li Hsueh Tsai. Effects of serotonin on acid secretion in isolated rat stomach: the role of 5-HT3 receptors.
The Chinese journal of physiology.
2009 Nov; 52(5 Suppl):395-405. doi:
10.4077/cjp.2009.amk037. [PMID: 20359130] - Xiang-Qun Hu, David M Lovinger. Role of aspartate 298 in mouse 5-HT3A receptor gating and modulation by extracellular Ca2+.
The Journal of physiology.
2005 Oct; 568(Pt 2):381-96. doi:
10.1113/jphysiol.2005.092866. [PMID: 16096341] - Gareth A Hicks, Jonathan R Coldwell, Marcus Schindler, Philip A Bland Ward, David Jenkins, Penny A Lynn, Patrick P A Humphrey, L Ashley Blackshaw. Excitation of rat colonic afferent fibres by 5-HT(3) receptors.
The Journal of physiology.
2002 11; 544(3):861-9. doi:
10.1113/jphysiol.2002.025452. [PMID: 12411529] - Kenji Seo, Naoshi Fujiwara, James W Hu, Brian E Cairns, Genji Someya. Intrathecal administration of 5-HT(3) receptor agonist modulates jaw muscle activity evoked by injection of mustard oil into the temporomandibular joint in the rat.
Brain research.
2002 May; 934(2):157-61. doi:
10.1016/s0006-8993(02)02367-3. [PMID: 11955479] - X W Fu, D Wang, J Pan, S M Farragher, V Wong, E Cutz. Neuroepithelial bodies in mammalian lung express functional serotonin type 3 receptor.
American journal of physiology. Lung cellular and molecular physiology.
2001 Oct; 281(4):L931-40. doi:
10.1152/ajplung.2001.281.4.l931. [PMID: 11557597] - S Mochizuki, T Watanabe, A Miyake, M Saito, K Furuichi. Cloning, expression, and characterization of ferret 5-HT(3) receptor subunit.
European journal of pharmacology.
2000 Jul; 399(2-3):97-106. doi:
10.1016/s0014-2999(00)00371-x. [PMID: 10884508] - G Campiani, E Morelli, S Gemma, V Nacci, S Butini, M Hamon, E Novellino, G Greco, A Cagnotto, M Goegan, L Cervo, F Dalla Valle, C Fracasso, S Caccia, T Mennini. Pyrroloquinoxaline derivatives as high-affinity and selective 5-HT(3) receptor agonists: synthesis, further structure-activity relationships, and biological studies.
Journal of medicinal chemistry.
1999 Oct; 42(21):4362-79. doi:
10.1021/jm990151g. [PMID: 10543880] - L W Fu, J C Longhurst. Role of 5-HT3 receptors in activation of abdominal sympathetic C fibre afferents during ischaemia in cats.
The Journal of physiology.
1998 Jun; 509 ( Pt 3)(?):729-40. doi:
10.1111/j.1469-7793.1998.729bm.x. [PMID: 9596795] - G Campiani, A Cappelli, V Nacci, M Anzini, S Vomero, M Hamon, A Cagnotto, C Fracasso, C Uboldi, S Caccia, S Consolo, T Mennini. Novel and highly potent 5-HT3 receptor agonists based on a pyrroloquinoxaline structure.
Journal of medicinal chemistry.
1997 Oct; 40(22):3670-8. doi:
10.1021/jm970376w. [PMID: 9357534] - J E Leysen, W Gommeren, L Heylen, W H Luyten, I Van de Weyer, P Vanhoenacker, G Haegeman, A Schotte, P Van Gompel, R Wouters, A S Lesage. Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan.
Molecular pharmacology.
1996 Dec; 50(6):1567-80. doi:
. [PMID: 8967979] - Y Sugimoto, J Yamada, T Yoshikawa, K Horisaka. The effects of peripheral serotonin2 (5-HT2) and serotonin3 (5-HT3) receptor agonists on blood glucose levels in rats.
Biological & pharmaceutical bulletin.
1996 Oct; 19(10):1384-6. doi:
10.1248/bpb.19.1384. [PMID: 8913520] - A G Hope, J A Peters, A M Brown, J J Lambert, T P Blackburn. Characterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cells.
British journal of pharmacology.
1996 Jul; 118(5):1237-45. doi:
10.1111/j.1476-5381.1996.tb15529.x. [PMID: 8818349] - A Miyake, S Mochizuki, Y Takemoto, S Akuzawa. Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.
Molecular pharmacology.
1995 Sep; 48(3):407-16. doi:
. [PMID: 7565620] - A D Levy, Q Li, P A Rittenhouse, L D Van de Kar. Investigation of the role of 5-HT3 receptors in the secretion of prolactin, ACTH and renin.
Neuroendocrinology.
1993 Jul; 58(1):65-70. doi:
10.1159/000126513. [PMID: 8264857] - J S Petersen, C Hinojosa-Laborde, G F DiBona. Sympathoinhibitory responses to 2-methylserotonin during changes in sodium intake.
Hypertension (Dallas, Tex. : 1979).
1993 Jun; 21(6 Pt 2):1000-4. doi:
10.1161/01.hyp.21.6.1000. [PMID: 8505083] - N Adham, H T Kao, L E Schecter, J Bard, M Olsen, D Urquhart, M Durkin, P R Hartig, R L Weinshank, T A Branchek. Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.
Proceedings of the National Academy of Sciences of the United States of America.
1993 Jan; 90(2):408-12. doi:
10.1073/pnas.90.2.408. [PMID: 8380639]
