CNQX (BioDeep_00001875165)
Main id: BioDeep_00000009498
代谢物信息卡片
6-Cyano-7-nitroquinoxaline-2,3-dione
化学式: C9H4N4O4 (232.0233)
中文名称: CNQX
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N
InChI: InChI=1S/C9H4N4O4/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5/h1-2H,(H,11,14)(H,12,15)
描述信息
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC50s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist[1]. CNQX blocks the expression of fear-potentiated startle in rats[5].
同义名列表
4 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:34468
- KEGG: C13668
- PubChem: 3721046
- ChEMBL: CHEMBL222418
- MeSH: 6-Cyano-7-nitroquinoxaline-2,3-dione
- CAS: 114828-88-5
- CAS: 115066-14-3
- PubChem: 586261
- PDB-CCD: DQC
- NIKKAJI: J126.315C
- RefMet: CNQX
- medchemexpress: HY-15066
- KNApSAcK: 34468
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yun Qiu, Fen Zheng, Chao Ye, Ai-Dong Chen, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Angiotensin Type 1 Receptors and Superoxide Anion Production in Hypothalamic Paraventricular Nucleus Contribute to Capsaicin-Induced Excitatory Renal Reflex and Sympathetic Activation.
Neuroscience bulletin.
2020 May; 36(5):463-474. doi:
10.1007/s12264-019-00460-y. [PMID: 31989424] - Haruna Tamano, Naoya Oneta, Aoi Shioya, Paul A Adlard, Ashley I Bush, Atsushi Takeda. In vivo synaptic activity-independent co-uptakes of amyloid β1-42 and Zn2+ into dentate granule cells in the normal brain.
Scientific reports.
2019 04; 9(1):6498. doi:
10.1038/s41598-019-43012-0. [PMID: 31019269] - Victor Mathis, Brigitte Cosquer, Alexandra Barbelivien, Karine Herbeaux, Béatrice Bothorel, Dominique Sage-Ciocca, Vincent-Joseph Poirel, Chantal Mathis, Lucas Lecourtier. The lateral habenula interacts with the hypothalamo-pituitary adrenal axis response upon stressful cognitive demand in rats.
Behavioural brain research.
2018 04; 341(?):63-70. doi:
10.1016/j.bbr.2017.12.016. [PMID: 29248667] - Ezia Guatteo, Francesca Romana Rizzo, Mauro Federici, Alberto Cordella, Ada Ledonne, Laura Latini, Annalisa Nobili, Maria Teresa Viscomi, Filippo Biamonte, Kerstin K Landrock, Alessandro Martini, Daniela Aversa, Chiara Schepisi, Marcello D'Amelio, Nicola Berretta, Nicola B Mercuri. Functional alterations of the dopaminergic and glutamatergic systems in spontaneous α-synuclein overexpressing rats.
Experimental neurology.
2017 Jan; 287(Pt 1):21-33. doi:
10.1016/j.expneurol.2016.10.009. [PMID: 27771352] - Yumi Takemoto. Central cardiovascular actions of L-homocysteine microinjected into ventrolateral medullary autonomic areas of the rat.
Amino acids.
2016 09; 48(9):2215-25. doi:
10.1007/s00726-016-2259-3. [PMID: 27178024] - L Hondebrink, A H A Verboven, W S Drega, S Schmeink, M W G D M de Groot, R G D M van Kleef, F M J Wijnolts, A de Groot, J Meulenbelt, R H S Westerink. Neurotoxicity screening of (illicit) drugs using novel methods for analysis of microelectrode array (MEA) recordings.
Neurotoxicology.
2016 07; 55(?):1-9. doi:
10.1016/j.neuro.2016.04.020. [PMID: 27149913] - Jing Ding, Chen Huang, Zhong Peng, Yuxuan Xie, Shining Deng, Yan-Zhen Nie, Tian-Le Xu, Wei-Hong Ge, Wei-Guang Li, Fei Li. Electrophysiological characterization of methyleugenol: a novel agonist of GABA(A) receptors.
ACS chemical neuroscience.
2014 Sep; 5(9):803-11. doi:
10.1021/cn500022e. [PMID: 24980777] - Hui-Fang Chiu, Jen-Kun Cheng, Pu-Hua Lin, Jung-Chen Chang, I-Ming Chen, Ching-I Lin, Wei-Pin Chang, Chia-Hsien Lin. A mechanistic study on urine retention in d-amphetamine addicts.
The Chinese journal of physiology.
2014 Aug; 57(4):171-81. doi:
10.4077/cjp.2014.bac198. [PMID: 25246058] - Graciela L Mazzone, Andrea Nistri. S100β as an early biomarker of excitotoxic damage in spinal cord organotypic cultures.
Journal of neurochemistry.
2014 Aug; 130(4):598-604. doi:
10.1111/jnc.12748. [PMID: 24766228] - V-S Eckle, B Antkowiak. ALX 1393 inhibits spontaneous network activity by inducing glycinergic tonic currents in the spinal ventral horn.
Neuroscience.
2013 Dec; 253(?):165-71. doi:
10.1016/j.neuroscience.2013.08.042. [PMID: 23994185] - Janet L Fisher, Paul R Housley. Agonist binding to the GluK5 subunit is sufficient for functional surface expression of heteromeric GluK2/GluK5 kainate receptors.
Cellular and molecular neurobiology.
2013 Nov; 33(8):1099-108. doi:
10.1007/s10571-013-9976-x. [PMID: 23975096] - Idaira Oliva, Miriam Fernández, Eduardo D Martín. Dopamine release regulation by astrocytes during cerebral ischemia.
Neurobiology of disease.
2013 Oct; 58(?):231-41. doi:
10.1016/j.nbd.2013.06.007. [PMID: 23800715] - Walid Jalabi, Cornelia Kopp-Scheinpflug, Paul D Allen, Emanuele Schiavon, Rita R DiGiacomo, Ian D Forsythe, Stephen M Maricich. Sound localization ability and glycinergic innervation of the superior olivary complex persist after genetic deletion of the medial nucleus of the trapezoid body.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013 Sep; 33(38):15044-9. doi:
10.1523/jneurosci.2604-13.2013. [PMID: 24048834] - Gulcan Akgul, Lonnie P Wollmuth. Synapse-associated protein 97 regulates the membrane properties of fast-spiking parvalbumin interneurons in the visual cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013 Jul; 33(31):12739-50. doi:
10.1523/jneurosci.0040-13.2013. [PMID: 23904610] - Shengyuan Ding, Li Li, Fu-Ming Zhou. Presynaptic serotonergic gating of the subthalamonigral glutamatergic projection.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2013 Mar; 33(11):4875-85. doi:
10.1523/jneurosci.4111-12.2013. [PMID: 23486958] - Hua Yin, Dong Hyu Cho, Soo Joung Park, Seong Kyu Han. GABA-mimetic actions of Withania somnifera on substantia gelatinosa neurons of the trigeminal subnucleus caudalis in mice.
The American journal of Chinese medicine.
2013; 41(5):1043-51. doi:
10.1142/s0192415x13500705. [PMID: 24117067] - Richardson N Leão, Sanja Mikulovic, Katarina E Leão, Hermany Munguba, Henrik Gezelius, Anders Enjin, Kalicharan Patra, Anders Eriksson, Leslie M Loew, Adriano B L Tort, Klas Kullander. OLM interneurons differentially modulate CA3 and entorhinal inputs to hippocampal CA1 neurons.
Nature neuroscience.
2012 Nov; 15(11):1524-30. doi:
10.1038/nn.3235. [PMID: 23042082] - Cornelia Schöne, Zhen Fang Huang Cao, John Apergis-Schoute, Antoine Adamantidis, Takeshi Sakurai, Denis Burdakov. Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Sep; 32(36):12437-43. doi:
10.1523/jneurosci.0706-12.2012. [PMID: 22956835] - Ayelet Orenbuch, Lee Shalev, Vincenzo Marra, Isaac Sinai, Yotam Lavy, Joy Kahn, Jemima J Burden, Kevin Staras, Daniel Gitler. Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2012 Mar; 32(12):3969-80. doi:
10.1523/jneurosci.5058-11.2012. [PMID: 22442064] - Natsuko Kumamoto, Yan Gu, Jia Wang, Stephen Janoschka, Ken-Ichi Takemaru, Joel Levine, Shaoyu Ge. A role for primary cilia in glutamatergic synaptic integration of adult-born neurons.
Nature neuroscience.
2012 Feb; 15(3):399-405, S1. doi:
10.1038/nn.3042. [PMID: 22306608] - Chessa S Scullin, Lawrence C Tafoya, Michael C Wilson, L Donald Partridge. Presynaptic residual calcium and synaptic facilitation at hippocampal synapses of mice with altered expression of SNAP-25.
Brain research.
2012 Jan; 1431(?):1-12. doi:
10.1016/j.brainres.2011.10.035. [PMID: 22119397] - Eiji Shigetomi, Xiaoping Tong, Kelvin Y Kwan, David P Corey, Baljit S Khakh. TRPA1 channels regulate astrocyte resting calcium and inhibitory synapse efficacy through GAT-3.
Nature neuroscience.
2011 Dec; 15(1):70-80. doi:
10.1038/nn.3000. [PMID: 22158513] - Alfredo J Garcia, Shakil A Khan, Ganesh K Kumar, Nanduri R Prabhakar, Jan-Marino Ramirez. Hydrogen peroxide differentially affects activity in the pre-Bötzinger complex and hippocampus.
Journal of neurophysiology.
2011 Dec; 106(6):3045-55. doi:
10.1152/jn.00550.2010. [PMID: 21849609] - Chul-Kyu Park, Ning Lü, Zhen-Zhong Xu, Tong Liu, Charles N Serhan, Ru-Rong Ji. Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011 Oct; 31(42):15072-85. doi:
10.1523/jneurosci.2443-11.2011. [PMID: 22016541] - Erwan Michard, Pedro T Lima, Filipe Borges, Ana Catarina Silva, Maria Teresa Portes, João E Carvalho, Matthew Gilliham, Lai-Hua Liu, Gerhard Obermeyer, José A Feijó. Glutamate receptor-like genes form Ca2+ channels in pollen tubes and are regulated by pistil D-serine.
Science (New York, N.Y.).
2011 Apr; 332(6028):434-7. doi:
10.1126/science.1201101. [PMID: 21415319] - Adam W Hantman, Thomas M Jessell. Clarke's column neurons as the focus of a corticospinal corollary circuit.
Nature neuroscience.
2010 Oct; 13(10):1233-9. doi:
10.1038/nn.2637. [PMID: 20835249] - Nahoko Kasai, Chandra S Ramanujan, Ichiro Fujimoto, Akiyoshi Shimada, John F Ryan, Keiichi Torimitsu. AFM observation of single, functioning ionotropic glutamate receptors reconstituted in lipid bilayers.
Biochimica et biophysica acta.
2010 Jul; 1800(7):655-61. doi:
10.1016/j.bbagen.2010.03.002. [PMID: 20307628] - Luigi Bozzo, Jean-Yves Chatton. Inhibitory effects of (2S, 3S)-3-[3-[4-(trifluoromethyl)benzoylamino]benzyloxy]aspartate (TFB-TBOA) on the astrocytic sodium responses to glutamate.
Brain research.
2010 Feb; 1316(?):27-34. doi:
10.1016/j.brainres.2009.12.028. [PMID: 20026319] - Ibolya Bodnár, Zsuzsanna Bánky, Dóra Zelena, Béla Halász. Glutamate receptor antagonist infused into the hypothalamic suprachiasmatic nuclei interferes with the diurnal fluctuations in plasma prolactin and corticosterone levels and injected into the mesencephalic dorsal raphe nucleus attenuates the suckling stimulus-induced release of prolactin of the rat.
Brain research bulletin.
2009 Aug; 80(1-2):9-16. doi:
10.1016/j.brainresbull.2009.06.005. [PMID: 19539728] - Thomas P Jensen, Lucy E Buckby, Ruth M Empson. Reduced expression of the 'fast' calcium transporter PMCA2a during homeostatic plasticity.
Molecular and cellular neurosciences.
2009 Jul; 41(3):364-72. doi:
10.1016/j.mcn.2009.04.011. [PMID: 19410650] - Claudie Hooper, Fleur Pinteaux-Jones, Victoria A H Fry, Ioanna G Sevastou, David Baker, Simon J Heales, Jennifer M Pocock. Differential effects of albumin on microglia and macrophages; implications for neurodegeneration following blood-brain barrier damage.
Journal of neurochemistry.
2009 May; 109(3):694-705. doi:
10.1111/j.1471-4159.2009.05953.x. [PMID: 19187440] - Katie R Famous, Vidhya Kumaresan, Ghazaleh Sadri-Vakili, Heath D Schmidt, Dale F Mierke, Jang-Ho J Cha, R Christopher Pierce. Phosphorylation-dependent trafficking of GluR2-containing AMPA receptors in the nucleus accumbens plays a critical role in the reinstatement of cocaine seeking.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Oct; 28(43):11061-70. doi:
10.1523/jneurosci.1221-08.2008. [PMID: 18945913] - Craig N Morrell, Henry Sun, Masahiro Ikeda, Jean-Claude Beique, Anne Marie Swaim, Emily Mason, Tanika V Martin, Laura E Thompson, Oguz Gozen, David Ampagoomian, Rolf Sprengel, Jeffrey Rothstein, Nauder Faraday, Richard Huganir, Charles J Lowenstein. Glutamate mediates platelet activation through the AMPA receptor.
The Journal of experimental medicine.
2008 Mar; 205(3):575-84. doi:
10.1084/jem.20071474. [PMID: 18283118] - Winyoo Chowanadisai, Bo Lönnerdal, Shannon L Kelleher. Zip6 (LIV-1) regulates zinc uptake in neuroblastoma cells under resting but not depolarizing conditions.
Brain research.
2008 Mar; 1199(?):10-9. doi:
10.1016/j.brainres.2008.01.015. [PMID: 18272141] - Jing-Jer Ke, Hsiun-Ing Chen, Chauying J Jen, Yu-Min Kuo, Chianfang G Cherng, Yen-Ping N Tsai, Ming-Che Ho, Chia-Wen Tsai, Lung Yu. Mutual enhancement of central neurotoxicity induced by ketamine followed by methamphetamine.
Toxicology and applied pharmacology.
2008 Mar; 227(2):239-47. doi:
10.1016/j.taap.2007.10.017. [PMID: 18076959] - Wei-Zhong Wang, Li-Gang Wang, Lie Gao, Wei Wang. Contribution of AMPA/kainate receptors in the rostral ventrolateral medulla to the hypotensive and sympathoinhibitory effects of clonidine.
American journal of physiology. Regulatory, integrative and comparative physiology.
2007 Sep; 293(3):R1232-8. doi:
10.1152/ajpregu.00233.2007. [PMID: 17581836] - Nanping Wu, Carlos Cepeda, Xiaoxi Zhuang, Michael S Levine. Altered corticostriatal neurotransmission and modulation in dopamine transporter knock-down mice.
Journal of neurophysiology.
2007 Jul; 98(1):423-32. doi:
10.1152/jn.00971.2006. [PMID: 17522168] - Long Chen, Joseph D Bohanick, Makoto Nishihara, Jeremy K Seamans, Charles R Yang. Dopamine D1/5 receptor-mediated long-term potentiation of intrinsic excitability in rat prefrontal cortical neurons: Ca2+-dependent intracellular signaling.
Journal of neurophysiology.
2007 Mar; 97(3):2448-64. doi:
10.1152/jn.00317.2006. [PMID: 17229830] - Marko Kreft, Mija Blaganje, Sonja Grilc, Marjan Rupnik, Robert Zorec. Glutamate stimulation increases hormone release in rat melanotrophs.
Neuroscience letters.
2006 Sep; 404(3):299-302. doi:
10.1016/j.neulet.2006.06.021. [PMID: 16814468] - Noreen F Rossi, Haiping Chen. Aminopropionic acid receptors in paraventricular nucleus mediate pressor and vasopressin responses to endothelin-1 in subfornical organ.
Experimental biology and medicine (Maywood, N.J.).
2006 Jun; 231(6):1075-80. doi:
. [PMID: 16741052] - Mark C Farso, Fiona Y Carroll, Philip M Beart. Establishment of primary cultures of rat olfactory bulb under serum-free conditions for studies of cellular injury.
Cell and tissue research.
2006 Feb; 323(2):343-9. doi:
10.1007/s00441-005-0056-5. [PMID: 16189719] - Ibolya Bodnár, Zsuzsanna Bánky, Béla Halász. Non-NMDA glutamate receptor antagonist injected into the hypothalamic paraventricular nucleus inhibits the prolactin response to formalin stress of male rats.
Neurochemical research.
2006 Feb; 31(2):201-8. doi:
10.1007/s11064-005-9009-3. [PMID: 16518578] - Vanessa Schubert, Jorge Santos Da Silva, Carlos G Dotti. Localized recruitment and activation of RhoA underlies dendritic spine morphology in a glutamate receptor-dependent manner.
The Journal of cell biology.
2006 Jan; 172(3):453-67. doi:
10.1083/jcb.200506136. [PMID: 16449195] - Kerstin Wirkner, Attila Köfalvi, Wolfgang Fischer, Albrecht Günther, Heike Franke, Helke Gröger-Arndt, Wolfgang Nörenberg, Emília Madarász, E Sylvester Vizi, Dietmar Schneider, Beáta Sperlágh, Peter Illes. Supersensitivity of P2X receptors in cerebrocortical cell cultures after in vitro ischemia.
Journal of neurochemistry.
2005 Dec; 95(5):1421-37. doi:
10.1111/j.1471-4159.2005.03465.x. [PMID: 16313518] - Sotirios Keros, John J Hablitz. Subtype-specific GABA transporter antagonists synergistically modulate phasic and tonic GABAA conductances in rat neocortex.
Journal of neurophysiology.
2005 Sep; 94(3):2073-85. doi:
10.1152/jn.00520.2005. [PMID: 15987761] - Helga Susanne E Haas, Roswitha Pfragner, Veronika Siegl, Elisabeth Ingolic, Elfgard Heintz, Konrad Schauenstein. Glutamate receptor-mediated effects on growth and morphology of human histiocytic lymphoma cells.
International journal of oncology.
2005 Sep; 27(3):867-74. doi:
NULL. [PMID: 16077940] - Tai-Xiang Xu, Neng Gong, Tian-Le Xu. Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission.
Neuroreport.
2005 Aug; 16(11):1227-31. doi:
10.1097/00001756-200508010-00019. [PMID: 16012354] - Agathe Roubertie, Hassan Boukhaddaoui, Victor Sieso, Anne de Saint-Martin, Arielle Lellouch-Tubiana, Edouard Hirsch, Bernard Echenne, Jean Valmier. Antiglial cell autoantibodies and childhood epilepsy: a case report.
Epilepsia.
2005 Aug; 46(8):1308-12. doi:
10.1111/j.1528-1167.2005.53004.x. [PMID: 16060945] - Ibolya Bodnár, Zsuzsanna Bánky, György M Nagy, Béla Halász. Non-NMDA glutamate receptor antagonist injected into the hypothalamic paraventricular nucleus blocks the suckling stimulus-induced release of prolactin.
Brain research bulletin.
2005 Mar; 65(2):163-8. doi:
10.1016/j.brainresbull.2005.01.001. [PMID: 15763183] - Zafer Soygüder. NMDA and AMPA/KA receptors are involved in the c-Fos expression following mustard oil activation of C-fibres.
Journal of chemical neuroanatomy.
2004 Nov; 28(3):163-9. doi:
10.1016/j.jchemneu.2004.06.003. [PMID: 15482902] - Hiroyuki W Kitamura, Hiroki Hamanaka, Masahiko Watanabe, Koji Wada, Chiharu Yamazaki, Shinobu C Fujita, Toshiya Manabe, Nobuyuki Nukina. Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E.
Neuroscience letters.
2004 Oct; 369(3):173-8. doi:
10.1016/j.neulet.2004.07.084. [PMID: 15464259] - Ernst Seiffert, Jens P Dreier, Sebastian Ivens, Ingo Bechmann, Oren Tomkins, Uwe Heinemann, Alon Friedman. Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2004 Sep; 24(36):7829-36. doi:
10.1523/jneurosci.1751-04.2004. [PMID: 15356194] - Rachel Hopper, Barrie Lancaster, John Garthwaite. On the regulation of NMDA receptors by nitric oxide.
The European journal of neuroscience.
2004 Apr; 19(7):1675-82. doi:
10.1111/j.1460-9568.2004.03306.x. [PMID: 15078541] - Susumu Tomita, Masaki Fukata, Roger A Nicoll, David S Bredt. Dynamic interaction of stargazin-like TARPs with cycling AMPA receptors at synapses.
Science (New York, N.Y.).
2004 Mar; 303(5663):1508-11. doi:
10.1126/science.1090262. [PMID: 15001777] - Charles L Howe, Allan J Bieber, Arthur E Warrington, Larry R Pease, Moses Rodriguez. Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody.
Neurobiology of disease.
2004 Feb; 15(1):120-31. doi:
10.1016/j.nbd.2003.09.002. [PMID: 14751777] - Linda M Chicoine, Vishnu Suppiramaniam, Thirumalini Vaithianathan, Gerald Gianutsos, Ben A Bahr. Sulfate- and size-dependent polysaccharide modulation of AMPA receptor properties.
Journal of neuroscience research.
2004 Feb; 75(3):408-16. doi:
10.1002/jnr.10871. [PMID: 14743454] - Sang Jeong Kim, Yu Shin Kim, Joseph P Yuan, Ronald S Petralia, Paul F Worley, David J Linden. Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1.
Nature.
2003 Nov; 426(6964):285-91. doi:
10.1038/nature02162. [PMID: 14614461] - Do-Hoon Kim, Yoo-Sun Moon, Jun-Sub Jung, Hong-Won Suh, Dong-Keun Song. Route-dependent effects of the non-NMDA receptor antagonist CNQX on plasma corticosterone levels in mice.
Progress in neuro-psychopharmacology & biological psychiatry.
2003 Sep; 27(6):1055-8. doi:
10.1016/s0278-5846(03)00147-7. [PMID: 14499323] - Rudi D'Hooge, Gerda Van de Vijver, Pierre-Paul Van Bogaert, Bart Marescau, Raymond Vanholder, Peter P De Deyn. Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins.
Kidney international.
2003 May; 63(5):1764-75. doi:
10.1046/j.1523-1755.2003.00912.x. [PMID: 12675852] - M A Belenky, N Sagiv, J-M Fritschy, Y Yarom. Presynaptic and postsynaptic GABAA receptors in rat suprachiasmatic nucleus.
Neuroscience.
2003; 118(4):909-23. doi:
10.1016/s0306-4522(03)00062-9. [PMID: 12732237] - Asa Laestadius, Agneta Richter-Dahlfors, Anita Aperia. Dual effects of Escherichia coli alpha-hemolysin on rat renal proximal tubule cells.
Kidney international.
2002 Dec; 62(6):2035-42. doi:
10.1046/j.1523-1755.2002.00661.x. [PMID: 12427127] - Seong-Soo Choi, Eun-Jung Han, Tae-Hee Lee, Jin-Koo Lee, Ki-Jung Han, Han-Kyu Lee, Hong-Won Suh. Antinociceptive mechanisms of platycodin D administered intracerebroventricularly in the mouse.
Planta medica.
2002 Sep; 68(9):794-8. doi:
10.1055/s-2002-34396. [PMID: 12357389] - M C Arufe, R Durán, D Perez-Vences, M Alfonso. Endogenous excitatory amino acid neurotransmission regulates thyroid-stimulating hormone and thyroid hormone secretion in conscious freely moving male rats.
Endocrine.
2002 Apr; 17(3):193-7. doi:
10.1385/endo:17:3:193. [PMID: 12108519] - Elena Alberdi, María Victoria Sánchez-Gómez, Aida Marino, Carlos Matute. Ca(2+) influx through AMPA or kainate receptors alone is sufficient to initiate excitotoxicity in cultured oligodendrocytes.
Neurobiology of disease.
2002 Mar; 9(2):234-43. doi:
10.1006/nbdi.2001.0457. [PMID: 11895374] - G S McGillem, R F Dacheux. Rabbit cone bipolar cells: correlation of their morphologies with whole-cell recordings.
Visual neuroscience.
2001 Sep; 18(5):675-85. doi:
10.1017/s0952523801185019. [PMID: 11925003] - D P Li, D B Averill, H L Pan. Differential roles for glutamate receptor subtypes within commissural NTS in cardiac-sympathetic reflex.
American journal of physiology. Regulatory, integrative and comparative physiology.
2001 Sep; 281(3):R935-43. doi:
10.1152/ajpregu.2001.281.3.r935. [PMID: 11507011] - J M Langosch, X Y Zhou, M Heinen, S S Chatterjee, M Nöldner, J Walden. Effects of Hypericum perforatum L. on evoked potentials in guinea pig hippocampal slices.
Pharmacopsychiatry.
2001 Jul; 34 Suppl 1(?):S83-8. doi:
10.1055/s-2001-15511. [PMID: 11518083] - A Köfalvi, B Sperlágh, T Zelles, E S Vizi. Long-lasting facilitation of 4-amino-n-[2,3-(3)H]butyric acid ([(3)H]GABA) release from rat hippocampal slices by nicotinic receptor activation.
The Journal of pharmacology and experimental therapeutics.
2000 Nov; 295(2):453-62. doi:
NULL. [PMID: 11046076] - J Y Chatton, P Marquet, P J Magistretti. A quantitative analysis of L-glutamate-regulated Na+ dynamics in mouse cortical astrocytes: implications for cellular bioenergetics.
The European journal of neuroscience.
2000 Nov; 12(11):3843-53. doi:
10.1046/j.1460-9568.2000.00269.x. [PMID: 11069579] - J A Moguilevsky, B Szwarcfarb, S Carbone, D Rondina, O Ponzo, P Scacchi. Interrelationships of GABAergic, serotoninergic and excitatory amino acid systems in its regulatory effect on prolactin secretion in prepubertal rats.
Endocrine research.
2000 Aug; 26(3):399-410. doi:
10.3109/07435800009066176. [PMID: 11019904] - S Nishimura, M Iizuka, M Wakamori, I Akiba, K Imoto, E L Barsoumian. Stable expression of human homomeric and heteromeric AMPA receptor subunits in HEK293 cells.
Receptors & channels.
2000; 7(2):139-50. doi:
NULL. [PMID: 10952090] - I I Kruman, W A Pedersen, J E Springer, M P Mattson. ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis.
Experimental neurology.
1999 Nov; 160(1):28-39. doi:
10.1006/exnr.1999.7190. [PMID: 10630188] - I Mook-Jung, J E Shin, S H Yun, K Huh, J Y Koh, H K Park, S S Jew, M W Jung. Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity.
Journal of neuroscience research.
1999 Nov; 58(3):417-25. doi:
10.1002/(sici)1097-4547(19991101)58:3<417::aid-jnr7>3.0.co;2-g. [PMID: 10518115] - E Y Kim, J Y Koh, Y H Kim, S Sohn, E Joe, B J Gwag. Zn2+ entry produces oxidative neuronal necrosis in cortical cell cultures.
The European journal of neuroscience.
1999 Jan; 11(1):327-34. doi:
10.1046/j.1460-9568.1999.00437.x. [PMID: 9987035] - A N van den Pol, K Obrietan, A B Belousov, Y Yang, H C Heller. Early synaptogenesis in vitro: role of axon target distance.
The Journal of comparative neurology.
1998 Oct; 399(4):541-60. doi:
10.1002/(sici)1096-9861(19981005)399:4<541::aid-cne7>3.3.co;2-u. [PMID: 9741482] - C Vicario-Abejón, C Collin, R D McKay, M Segal. Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1998 Sep; 18(18):7256-71. doi:
10.1523/jneurosci.18-18-07256.1998. [PMID: 9736647] - M A DeCoster, P K Mukherjee, R J Davis, N G Bazan. Platelet-activating factor is a downstream messenger of kainate-induced activation of mitogen-activated protein kinases in primary hippocampal neurons.
Journal of neuroscience research.
1998 Aug; 53(3):297-303. doi:
10.1002/(sici)1097-4547(19980801)53:3<297::aid-jnr3>3.0.co;2-5. [PMID: 9698157] - K S Butcher, D F Cechetto. Receptors in lateral hypothalamic area involved in insular cortex sympathetic responses.
The American journal of physiology.
1998 08; 275(2):H689-96. doi:
10.1152/ajpheart.1998.275.2.h689. [PMID: 9683459] - H L Gaspary, W Wang, G B Richerson. Carrier-mediated GABA release activates GABA receptors on hippocampal neurons.
Journal of neurophysiology.
1998 Jul; 80(1):270-81. doi:
10.1152/jn.1998.80.1.270. [PMID: 9658049] - M E Morrison, C A Mason. Granule neuron regulation of Purkinje cell development: striking a balance between neurotrophin and glutamate signaling.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1998 May; 18(10):3563-73. doi:
10.1523/jneurosci.18-10-03563.1998. [PMID: 9570788] - L M Console-Bram, D H Baird, S G Fitzpatrick-McElligott, J G McElligott. Modulation of GAP-43 mRNA by GABA and glutamate in cultured cerebellar granule cells.
Brain research.
1998 Feb; 783(2):316-25. doi:
10.1016/s0006-8993(97)01386-3. [PMID: 9507175] - C D Weaver, V Gundersen, T A Verdoorn. A high affinity glutamate/aspartate transport system in pancreatic islets of Langerhans modulates glucose-stimulated insulin secretion.
The Journal of biological chemistry.
1998 Jan; 273(3):1647-53. doi:
10.1074/jbc.273.3.1647. [PMID: 9430708] - J Verweij, M Kamermans, K Negishi, H Spekreijse. GABA sensitivity of spectrally classified horizontal cells in goldfish retina.
Visual neuroscience.
1998 Jan; 15(1):77-86. doi:
10.1017/s0952523898151039. [PMID: 9456507] - J A Larm, N S Cheung, P M Beart. Apoptosis induced via AMPA-selective glutamate receptors in cultured murine cortical neurons.
Journal of neurochemistry.
1997 Aug; 69(2):617-22. doi:
10.1046/j.1471-4159.1997.69020617.x. [PMID: 9231719] - F W Holtsberg, M R Steiner, K Furukawa, J N Keller, M P Mattson, S M Steiner. Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium.
Journal of neurochemistry.
1997 Jul; 69(1):68-75. doi:
10.1046/j.1471-4159.1997.69010068.x. [PMID: 9202295] - A Ameri, T Peters. Calcium-dependent, sustained enhancement of excitability during washout of aconitine in rat hippocampal slices.
Experimental brain research.
1997 May; 114(3):518-24. doi:
10.1007/pl00005661. [PMID: 9187288] - K Cauley, V Kukekov, D Young. Kainate/AMPA receptors expressed on human fetal astrocytes in long-term culture.
Journal of neuroscience research.
1997 Feb; 47(3):311-21. doi:
10.1002/(sici)1097-4547(19970201)47:3<311::aid-jnr9>3.0.co;2-l. [PMID: 9039653] - Y Paas, M Eisenstein, F Medevielle, V I Teichberg, A Devillers-Thiéry. Identification of the amino acid subsets accounting for the ligand binding specificity of a glutamate receptor.
Neuron.
1996 Nov; 17(5):979-90. doi:
10.1016/s0896-6273(00)80228-7. [PMID: 8938129] - R A Hall, V Vodyanoy, A Quan, S Sinnarajah, V Suppiramaniam, M Kessler, B A Bahr. Effects of heparin on the properties of solubilized and reconstituted rat brain AMPA receptors.
Neuroscience letters.
1996 Oct; 217(2-3):179-83. doi:
10.1016/0304-3940(96)12984-0. [PMID: 8916102] - O Nagata, W M Li, A Sato. Glutamate N-methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists administered into the brain stem depress the renal sympathetic reflex discharges evoked by single shock of somatic afferents in anesthetized rats.
Neuroscience letters.
1995 Dec; 201(2):111-4. doi:
10.1016/0304-3940(95)12133-1. [PMID: 8848230] - J M Dubinsky, B S Kristal, M Elizondo-Fournier. An obligate role for oxygen in the early stages of glutamate-induced, delayed neuronal death.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1995 Nov; 15(11):7071-8. doi:
10.1523/jneurosci.15-11-07071.1995. [PMID: 7472462] - M A Cousin, D G Nicholls, J M Pocock. Modulation of ion gradients and glutamate release in cultured cerebellar granule cells by ouabain.
Journal of neurochemistry.
1995 May; 64(5):2097-104. doi:
10.1046/j.1471-4159.1995.64052097.x. [PMID: 7536807] - C K Tygesen, M Jørgensen, P H Andersen. The importance of two specific domains in ligand binding to the AMPA/kainate glutamate receptors GluR2 and GluR6.
FEBS letters.
1995 Apr; 363(1-2):184-8. doi:
10.1016/0014-5793(95)00315-z. [PMID: 7537225] - R E Twyman, L C Gahring, J Spiess, S W Rogers. Glutamate receptor antibodies activate a subset of receptors and reveal an agonist binding site.
Neuron.
1995 Apr; 14(4):755-62. doi:
10.1016/0896-6273(95)90219-8. [PMID: 7718238] - L C Gahring, R E Twyman, J E Greenlee, S W Rogers. Autoantibodies to neuronal glutamate receptors in patients with paraneoplastic neurodegenerative syndrome enhance receptor activation.
Molecular medicine (Cambridge, Mass.).
1995 Mar; 1(3):245-53. doi:
10.1007/bf03401549. [PMID: 8529103] - C Zona, M T Ciotti, P Calissano. Human recombinant IGF-I induces the functional expression of AMPA/kainate receptors in cerebellar granule cells.
Neuroscience letters.
1995 Feb; 186(2-3):75-8. doi:
10.1016/0304-3940(95)11284-4. [PMID: 7777202] - M Riepe, A Ludolph, M Seelig, P S Spencer, A C Ludolph. Increase of ATP levels by glutamate antagonists is unrelated to neuroprotection.
Neuroreport.
1994 Oct; 5(16):2130-2. doi:
10.1097/00001756-199410270-00035. [PMID: 7865761] - T A Verdoorn, T H Johansen, J Drejer, E O Nielsen. Selective block of recombinant glur6 receptors by NS-102, a novel non-NMDA receptor antagonist.
European journal of pharmacology.
1994 Sep; 269(1):43-9. doi:
10.1016/0922-4106(94)90024-8. [PMID: 7828657] - G M Yan, B Ni, M Weller, K A Wood, S M Paul. Depolarization or glutamate receptor activation blocks apoptotic cell death of cultured cerebellar granule neurons.
Brain research.
1994 Sep; 656(1):43-51. doi:
10.1016/0006-8993(94)91364-1. [PMID: 7804844]
