Monoethylglycinexylidide (BioDeep_00001873765)
代谢物信息卡片
Monoethylglycinexylidide
化学式: C12H18N2O (206.1419)
中文名称: 盐酸利多卡因杂质-d5
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCNCC(=O)NC1=C(C=CC=C1C)C
InChI: InChI=1S/C12H18N2O/c1-4-13-8-11(15)14-12-9(2)6-5-7-10(12)3/h5-7,13H,4,8H2,1-3H3,(H,14,15)
描述信息
Amino acid amide formed from 2,6-dimethylaniline and N-ethylglycine components; an active metabolite of lidocaine, formed by oxidative deethylation. Used as an indicator of hepatic function.
同义名列表
2 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:222828
- PubChem: 24415
- ChEMBL: CHEMBL1028
- CAS: 1216698-89-3
- CAS: 1246819-83-9
- CAS: 7728-40-7
- MetaboLights: MTBLC222828
- RefMet: Monoethylglycinexylidide
- KEGG: C16561
- PubChem: 51090890
- KNApSAcK: 222828
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lawrence R Soma, Youwen You, Mary A Robinson, Raymond C Boston. Pharmacokinetics of intravenous, subcutaneous, and topical administration of lidocaine hydrochloride and metabolites 3-hydroxylidocaine, monoethylglycinexylidide, and 4-hydroxylidocaine in horse.
Journal of veterinary pharmacology and therapeutics.
2018 Dec; 41(6):825-837. doi:
10.1111/jvp.12695. [PMID: 30028024] - Bridget Martell, Harvey Kushner, Elaine Richardson, Amy Mize, Philip Mayer. Pharmacokinetics of Lidocaine and Its Metabolites Following Vaginal Administration of Lidocaine Gel to Healthy Female Subjects.
Clinical pharmacology in drug development.
2017 Jan; 6(1):27-35. doi:
10.1002/cpdd.286. [PMID: 27297519] - Giorgio Saluti, Danilo Giusepponi, Simone Moretti, Alessandra Di Salvo, Roberta Galarini. Flexible Method for Analysis of Lidocaine and Its Metabolite in Biological Fluids.
Journal of chromatographic science.
2016 Aug; 54(7):1193-200. doi:
10.1093/chromsci/bmw051. [PMID: 27060111] - Yan-Hong Feng, Xiang-Dong Hu, Lin Zhai, Ji-Bin Liu, Lan-Yan Qiu, Yuan Zu, Si Liang, Yu Gui, Lin-Xue Qian. Shear wave elastography results correlate with liver fibrosis histology and liver function reserve.
World journal of gastroenterology.
2016 May; 22(17):4338-44. doi:
10.3748/wjg.v22.i17.4338. [PMID: 27158202] - Cora Wunder, Jens Meier, Christian Reyher, Verena Könitz, Alexander Paulke, Kai Zacharowski, Stefan W Toennes. Use of lidocaine in endotracheal intubation. Blood and urine concentrations in patients and deceased after unsuccessful resuscitation.
Forensic science international.
2014 Nov; 244(?):259-62. doi:
10.1016/j.forsciint.2014.09.008. [PMID: 25291527] - Georgette Oni, Yvonne Rasko, Jeffrey Kenkel. Topical lidocaine enhanced by laser pretreatment: a safe and effective method of analgesia for facial rejuvenation.
Aesthetic surgery journal.
2013 Aug; 33(6):854-61. doi:
10.1177/1090820x13496248. [PMID: 23908302] - Bruno Laviolle, Cédric Basquin, David Aguillon, Philippe Compagnon, Isabelle Morel, Valérie Turmel, Philippe Seguin, Karim Boudjema, Eric Bellissant, Yannick Mallédant. Effect of an anesthesia with propofol compared with desflurane on free radical production and liver function after partial hepatectomy.
Fundamental & clinical pharmacology.
2012 Dec; 26(6):735-42. doi:
10.1111/j.1472-8206.2011.00958.x. [PMID: 21692846] - Georgette Oni, Spencer Brown, Jeffrey Kenkel. Comparison of five commonly-available, lidocaine-containing topical anesthetics and their effect on serum levels of lidocaine and its metabolite monoethylglycinexylidide (MEGX).
Aesthetic surgery journal.
2012 May; 32(4):495-503. doi:
10.1177/1090820x12442672. [PMID: 22452841] - Nitsupa Wattanachai, Wichittra Tassaneeyakul, Andrew Rowland, David J Elliot, Kushari Bowalgaha, Kathleen M Knights, John O Miners. Effect of albumin on human liver microsomal and recombinant CYP1A2 activities: impact on in vitro-in vivo extrapolation of drug clearance.
Drug metabolism and disposition: the biological fate of chemicals.
2012 May; 40(5):982-9. doi:
10.1124/dmd.111.044057. [PMID: 22331994] - Colleen K Lambertz, Christopher J Johnson, Paul G Montgomery, James R Maxwell, Stefanie J Fry. Toxicity of topical lidocaine applied to the breasts to reduce discomfort during screening mammography.
Journal of anaesthesiology, clinical pharmacology.
2012 Apr; 28(2):200-4. doi:
10.4103/0970-9185.94859. [PMID: 22557743] - Juciene Aparecida Caris, Bruno José Gonçalves Silva, Elaine Christine Dantas Moisés, Vera Lúcia Lanchote, Maria Eugênia Costa Queiroz. Automated analysis of lidocaine and its metabolite in plasma by in-tube solid-phase microextraction coupled with LC-UV for pharmacokinetic study.
Journal of separation science.
2012 Mar; 35(5-6):734-41. doi:
10.1002/jssc.201100872. [PMID: 22318808] - E A Hewitt, G Armstrong, N Beg, S Katz, T G Vancaillie. Lignocaine plasma levels following topical gel application in laparoscopic and hysteroscopic procedures.
Anaesthesia and intensive care.
2012 Mar; 40(2):292-6. doi:
10.1177/0310057x1204000212. [PMID: 22417024] - Georgette Oni, Spencer A Brown, Jeffrey M Kenkel. Can fractional lasers enhance transdermal absorption of topical lidocaine in an in vivo animal model?.
Lasers in surgery and medicine.
2012 Feb; 44(2):168-74. doi:
10.1002/lsm.21130. [PMID: 22302761] - E ter Weijden, M P H van den Broek, F F T Ververs. Easy and fast LC-MS/MS determination of lidocaine and MEGX in plasma for therapeutic drug monitoring in neonates with seizures.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Jan; 881-882(?):111-4. doi:
10.1016/j.jchromb.2011.11.030. [PMID: 22192875] - Robert Werdehausen, David Kremer, Timo Brandenburger, Lukas Schlösser, Janusz Jadasz, Patrick Küry, Inge Bauer, Carmen Aragón, Volker Eulenburg, Henning Hermanns. Lidocaine metabolites inhibit glycine transporter 1: a novel mechanism for the analgesic action of systemic lidocaine?.
Anesthesiology.
2012 Jan; 116(1):147-58. doi:
10.1097/aln.0b013e31823cf233. [PMID: 22133759] - Jiongran Chen, Murray R Woodbury, Jane Alcorn, Ali Honaramooz. Dietary supplementation of female rats with elk velvet antler improves physical and neurological development of offspring.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):640680. doi:
10.1155/2012/640680. [PMID: 22550542] - Qing-Tao Meng, Zhong-Yuan Xia, Jin Liu, Douglas A Bayliss, Xiangdong Chen. Local anesthetic inhibits hyperpolarization-activated cationic currents.
Molecular pharmacology.
2011 May; 79(5):866-73. doi:
10.1124/mol.110.070227. [PMID: 21303986] - Luciana de Barros Duarte, Elaine Cristine Dantas Móises, Ricardo Carvalho Cavalli, Vera Lucia Lanchote, Geraldo Duarte, Sérgio Pereira da Cunha. Distribution of bupivacaine enantiomers and lidocaine and its metabolite in the placental intervillous space and in the different maternal and fetal compartments in term pregnant women.
Journal of clinical pharmacology.
2011 Feb; 51(2):212-7. doi:
10.1177/0091270010365551. [PMID: 20400649] - B E Pérez-Guillé, F Villegas-Alvarez, A Toledo-López, M A Jiménez-Bravo, J F González-Zamora, M C Carrasco-Portugal, F J Flores-Murrieta, R E Soriano-Rosales. Pharmacokinetics of lidocaine and its metabolite as a hepatic function marker in dogs.
Proceedings of the Western Pharmacology Society.
2011; 54(?):62-5. doi:
. [PMID: 22423583] - Georgette Oni, Spencer Brown, Clint Burrus, Lorin Grant, Jeff Watkins, Matthew Kenkel, Fritz Barton, Jeffrey Kenkel. Effect of 4\% topical lidocaine applied to the face on the serum levels of lidocaine and its metabolite, monoethylglycinexylidide.
Aesthetic surgery journal.
2010 Nov; 30(6):853-8. doi:
10.1177/1090820x10386944. [PMID: 21131461] - Jin Xiang, Cheng Zhang, Qin Yu, Mao-Zhi Liang, Yong-Ping Qin, Feng Nan. [Determination of lidocaine and its metabolites in human plasma by liquid chromatography in combination with tandem mass spectrometry].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2010 Jul; 41(4):696-9. doi:
. [PMID: 20848799] - Christian Probst, Frank Hildebrand, Martijn van Griensven, Hellmut Baur, Lutz Mahlke, Christian Krettek, Hans-Christoph Pape, Martin Rolf Wolfgang Grotz. Is dopexamine superior to dopamine in the treatment of multiple trauma patients--a prospective, double-blind, randomised study.
Injury.
2010 May; 41(5):499-505. doi:
10.1016/j.injury.2009.06.018. [PMID: 19595327] - Daniel A Hatef, Spencer A Brown, Avron H Lipschitz, Jeffrey M Kenkel. Efficacy of lidocaine for pain control in subcutaneous infiltration during liposuction.
Aesthetic surgery journal.
2009 Mar; 29(2):122-8. doi:
10.1016/j.asj.2009.01.014. [PMID: 19371843] - J C H Ko, L K Maxwell, L A Abbo, A B Weil. Pharmacokinetics of lidocaine following the application of 5\% lidocaine patches to cats.
Journal of veterinary pharmacology and therapeutics.
2008 Aug; 31(4):359-67. doi:
10.1111/j.1365-2885.2008.00967.x. [PMID: 18638297] - E J Dickey, H C McKenzie, K A Brown, C N de Solis. Serum concentrations of lidocaine and its metabolites after prolonged infusion in healthy horses.
Equine veterinary journal.
2008 Jun; 40(4):348-52. doi:
10.2746/042516408x284664. [PMID: 18267881] - Zhenxia Wang, Ruiming Zhang, Wei Cao, Xiaohui Ouyang, Haiping Zhao, Peide Dong, Xingkai Meng. [Determination of monoethylglycinexylidide concentration in serum using solid phase extraction and capillary gas chromatography-mass spectrometry].
Se pu = Chinese journal of chromatography.
2008 May; 26(3):310-3. doi:
NULL. [PMID: 18724665] - Satish Balkrishna Bhise, Remeth Jacky Dias. Effect of erythromycin and rifampicin on monoethylglycinexylidide test.
Indian journal of pharmacology.
2008 Mar; 40(2):84-6. doi:
10.4103/0253-7613.41044. [PMID: 21279172] - Satish B Bhise, Remeth J Dias. Monoethylglycinexylidide (MEGX) as a liver function test in cirrhosis.
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology.
2007 Jul; 26(4):167-9. doi:
. [PMID: 17986743] - Satish B Bhise, Remeth J Dias, Kailas K Mali. Prognostic value of the monoethylglycinexylidide test in alcoholic cirrhosis.
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association.
2007 Jul; 13(3):118-23. doi:
10.4103/1319-3767.33462. [PMID: 19858627] - A Maes, L Weiland, C Sandersen, F Gasthuys, P De Backer, S Croubels. Determination of lidocaine and its two N-desethylated metabolites in dog and horse plasma by high-performance liquid chromatography combined with electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2007 Jun; 852(1-2):180-7. doi:
10.1016/j.jchromb.2007.01.010. [PMID: 17296334] - Ulrich Brennscheidt, Ulrike Brunnmüller, Dietfried Proppe, Peter Thomann, Klaus-Ulrich Seiler. Pharmacokinetics of tilidine and naloxone in patients with severe hepatic impairment.
Arzneimittel-Forschung.
2007; 57(2):106-11. doi:
10.1055/s-0031-1296591. [PMID: 17396621] - Sara De Martin, Rocco Orlando, Massimo Bertoli, Paola Pegoraro, Pietro Palatini. Differential effect of chronic renal failure on the pharmacokinetics of lidocaine in patients receiving and not receiving hemodialysis.
Clinical pharmacology and therapeutics.
2006 Dec; 80(6):597-606. doi:
10.1016/j.clpt.2006.08.020. [PMID: 17178261] - Mika H Isohanni, Pertti J Neuvonen, Klaus T Olkkola. Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine.
Basic & clinical pharmacology & toxicology.
2006 Aug; 99(2):168-72. doi:
10.1111/j.1742-7843.2006.pto_482.x. [PMID: 16918719] - Małgorzata Mokrzycka, Andrzej Pawlik, Maria Kałdońska, Barbara Millo. Assessment of liver function in children with acute lymphoblastic leukemia in remission.
Annales Academiae Medicae Stetinensis.
2006; 52(3):61-5; discussion 65. doi:
. [PMID: 17385349] - M H Isohanni, J Ahonen, P J Neuvonen, K T Olkkola. Effect of ciprofloxin on the pharmacokinetics of intravenous lidocaine.
European journal of anaesthesiology.
2005 Oct; 22(10):795-9. doi:
10.1017/s0265021505001316. [PMID: 16211753] - Sara M Thomasy, Bruno H Pypendop, Jan E Ilkiw, Scott D Stanley. Pharmacokinetics of lidocaine and its active metabolite, monoethylglycinexylidide, after intravenous administration of lidocaine to awake and isoflurane-anesthetized cats.
American journal of veterinary research.
2005 Jul; 66(7):1162-6. doi:
10.2460/ajvr.2005.66.1162. [PMID: 16111153] - Nenad Sarapa, Margaret R Britto, Michelle B Mainka, Kourosh Parivar. The effect of mild and moderate hepatic impairment on the pharmacokinetics of valdecoxib, a selective COX-2 inhibitor.
European journal of clinical pharmacology.
2005 Jun; 61(4):247-56. doi:
10.1007/s00228-005-0909-6. [PMID: 15887009] - Klaus T Olkkola, Mika H Isohanni, Katri Hamunen, Pertti J Neuvonen. The effect of erythromycin and fluvoxamine on the pharmacokinetics of intravenous lidocaine.
Anesthesia and analgesia.
2005 May; 100(5):1352-1356. doi:
10.1213/01.ane.0000148123.79437.f9. [PMID: 15845683] - Bruno H Pypendop, Jan E Ilkiw. Assessment of the hemodynamic effects of lidocaine administered IV in isoflurane-anesthetized cats.
American journal of veterinary research.
2005 Apr; 66(4):661-8. doi:
10.2460/ajvr.2005.66.661. [PMID: 15900948] - Alexander Valverde, Thomas J Doherty, Jorge Hernández, Wendy Davies. Effect of lidocaine on the minimum alveolar concentration of isoflurane in dogs.
Veterinary anaesthesia and analgesia.
2004 Oct; 31(4):264-71. doi:
10.1111/j.1467-2995.2004.00165.x. [PMID: 15509291] - Mika H Isohanni, Pertti J Neuvonen, Klaus T Olkkola. Effect of itraconazole on the pharmacokinetics of inhaled lidocaine.
Basic & clinical pharmacology & toxicology.
2004 Sep; 95(3):120-3. doi:
10.1111/j.1742-7843.2004.950303.x. [PMID: 15447735] - Jadwiga Piwowarska, Julita Kuczyñska, Jan Pachecka. Liquid chromatographic method for the determination of lidocaine and monoethylglycine xylidide in human serum containing various concentrations of bilirubin for the assessment of liver function.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Jun; 805(1):1-5. doi:
10.1016/j.jchromb.2004.01.030. [PMID: 15113532] - Ortrud Vargas Hein, Renate Ohring, Andreas Schilling, Michael Oellerich, Victor W Armstrong, Wolfgang J Kox, Claudia Spies. N-acetylcysteine decreases lactate signal intensities in liver tissue and improves liver function in septic shock patients, as shown by magnetic resonance spectroscopy: extended case report.
Critical care (London, England).
2004 Apr; 8(2):R66-71. doi:
10.1186/cc2426. [PMID: 15025780] - Rocco Orlando, Pierpaolo Piccoli, Sara De Martin, Roberto Padrini, Maura Floreani, Pietro Palatini. Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function.
Clinical pharmacology and therapeutics.
2004 Jan; 75(1):80-8. doi:
10.1016/j.clpt.2003.09.007. [PMID: 14749694] - Magnus S Anderson, Bing Lu, Mohamed Abdel-Rehim, Sverker Blomberg, Lars G Blomberg. Utility of nonaqueous capillary electrophoresis for the determination of lidocaine and its metabolites in human plasma: a comparison of ultraviolet and mass spectrometric detection.
Rapid communications in mass spectrometry : RCM.
2004; 18(22):2612-8. doi:
10.1002/rcm.1666. [PMID: 15481095] - Fumio Moriya, Yoshiaki Hashimoto. Tissue distribution of lidocaine in critical care patients after intubation.
Forensic science international.
2003 Nov; 137(2-3):183-7. doi:
10.1016/s0379-0738(03)00333-5. [PMID: 14609655] - Edoardo Giannini, Federica Botta, Paolo Borro, Federica Malfatti, Alessandra Fumagalli, Emanuela Testa, Elena Podestà, Bruno Chiarbonello, Simone Polegato, Mario Mamone, Roberto Testa. Relationship between thrombopoietin serum levels and liver function in patients with chronic liver disease related to hepatitis C virus infection.
The American journal of gastroenterology.
2003 Nov; 98(11):2516-20. doi:
10.1111/j.1572-0241.2003.08665.x. [PMID: 14638357] - Tomoharu Funao, Yutaka Oda, Katsuaki Tanaka, Akira Asada. The P-glycoprotein inhibitor quinidine decreases the threshold for bupivacaine-induced, but not lidocaine-induced, convulsions in rats.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2003 Oct; 50(8):805-11. doi:
10.1007/bf03019376. [PMID: 14525819] - Barbara Gawrońska-Szklarz, David H Musiał, Andrzej Pawlik, Bartosz Paprota. Effect of experimental diabetes on pharmacokinetic parameters of lidocaine and MEGX in rats.
Polish journal of pharmacology.
2003 Jul; 55(4):619-24. doi:
NULL. [PMID: 14581721] - Taeko Fukuda, Yoshihiro Kakiuchi, Masayuki Miyabe, Shinichi Kihara, Yukinao Kohda, Hidenori Toyooka. Free lidocaine concentrations during continuous epidural anesthesia in geriatric patients.
Regional anesthesia and pain medicine.
2003 May; 28(3):215-20. doi:
10.1053/rapm.2003.50131. [PMID: 12772139] - Bernhard Kumle, Joachim Boldt, Stefan W Suttner, Swen N Piper, Andreas Lehmann, Markus Blome. Influence of prolonged cardiopulmonary bypass times on splanchnic perfusion and markers of splanchnic organ function.
The Annals of thoracic surgery.
2003 May; 75(5):1558-64. doi:
10.1016/s0003-4975(02)04903-2. [PMID: 12735579] - Alexander Zipprich, Norbert Steudel, Curd Behrmann, Frank Meiss, Ursula Sziegoleit, Wolfgang E Fleig, Gerhard Kleber. Functional significance of hepatic arterial flow reserve in patients with cirrhosis.
Hepatology (Baltimore, Md.).
2003 Feb; 37(2):385-92. doi:
10.1053/jhep.2003.50065. [PMID: 12540789] - C Mischiati, A C Puviani, M Brogli, S Guarniero, A Sereni, L Breda, D Ricci, D Galavotti, E Morsiani, R Gambari. Modulation of pro-apoptotic (Bax) and anti-apoptotic (Bcl-2) gene expression in isolated porcine hepatocytes perfused within a radial-flow bioreactor after low-temperature storing.
The International journal of artificial organs.
2003 Feb; 26(2):139-48. doi:
10.1177/039139880302600208. [PMID: 12653348] - Rocco Orlando, Pierpaolo Piccoli, Sara De Martin, Roberto Padrini, Pietro Palatini. Effect of the CYP3A4 inhibitor erythromycin on the pharmacokinetics of lignocaine and its pharmacologically active metabolites in subjects with normal and impaired liver function.
British journal of clinical pharmacology.
2003 Jan; 55(1):86-93. doi:
10.1046/j.1365-2125.2003.01718.x. [PMID: 12534644] - F Botta, E Giannini, P Romagnoli, A Fasoli, F Malfatti, B Chiarbonello, E Testa, D Risso, G Colla, R Testa. MELD scoring system is useful for predicting prognosis in patients with liver cirrhosis and is correlated with residual liver function: a European study.
Gut.
2003 Jan; 52(1):134-9. doi:
10.1136/gut.52.1.134. [PMID: 12477775] - Federico Pea, Maurizia Licari, Marco Baldassarre, Mario Furlanut. MEGX disposition in critically-ill trauma patients: subsequent assessments during the first week following trauma.
Fundamental & clinical pharmacology.
2002 Dec; 16(6):519-25. doi:
10.1046/j.1472-8206.2002.00108.x. [PMID: 12685511] - Y Kakiuchi, T Fukuda, M Miyabe, M Homma, H Toyooka, Y Kohda. Chromatographic determination of free lidocaine and its active metabolites in plasma from patients under epidural anesthesia.
International journal of clinical pharmacology and therapeutics.
2002 Nov; 40(11):493-8. doi:
10.5414/cpp40493. [PMID: 12698986] - Masayuki Miyabe, Yoshihiro Kakiuchi, Shinichi Inomata, Yoshiko Ohsaka, Yukinao Kohda, Hidenori Toyooka. Epinephrine does not reduce the plasma concentration of lidocaine during continuous epidural infusion in children.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2002 Aug; 49(7):706-10. doi:
10.1007/bf03017450. [PMID: 12193490] - Yi-Shin Huang, Jen-Huey Chiang, Jaw-Ching Wu, Full-Young Chang, Shou-Dong Lee. Risk of hepatic failure after transcatheter arterial chemoembolization for hepatocellular carcinoma: predictive value of the monoethylglycinexylidide test.
The American journal of gastroenterology.
2002 May; 97(5):1223-7. doi:
10.1111/j.1572-0241.2002.05709.x. [PMID: 12014732] - M Waheed Rana, Marc J Shapiro, M Arif Ali, Yao-Jan Chang, William H Taylor. Deferoxamine and hespan complex as a resuscitative adjuvant in hemorrhagic shock rat model.
Shock (Augusta, Ga.).
2002 Apr; 17(4):339-42. doi:
10.1097/00024382-200204000-00018. [PMID: 11954838] - David S McKindley, Judah Boulet, Karuna Sachdeva, Ping Wang, Clinton Chichester. Endotoxic shock alters the pharmacokinetics of lidocaine and monoethylglycinexylidide.
Shock (Augusta, Ga.).
2002 Mar; 17(3):199-204. doi:
10.1097/00024382-200203000-00007. [PMID: 11900338] - P Nisse, M Lhermitte, V Dherbecourt, C Fourier, F Leclerc, N Houdret, M Mathieu-Nolf. [Fatal intoxication after accidental ingestion of viscous 2\% lidocaine in a young child].
Acta clinica Belgica.
2002; 57 Suppl 1(?):51-3. doi:
. [PMID: 11974445] - Andrea Leopold, Stephen Wilson, Joel S Weaver, Amr M Moursi. Pharmacokinetics of lidocaine delivered from a transmucosal patch in children.
Anesthesia progress.
2002; 49(3):82-7. doi:
NULL. [PMID: 15384296] - E Giannini, A Fasoli, P Borro, B Chiarbonello, F Malfatti, P Romagnoli, F Botta, E Testa, A Fumagalli, S Polegato, V Savarino, R Testa. Impairment of cytochrome P-450-dependent liver activity in cirrhotic patients with Helicobacter pylori infection.
Alimentary pharmacology & therapeutics.
2001 Dec; 15(12):1967-73. doi:
10.1046/j.1365-2036.2001.01117.x. [PMID: 11736728] - S Inomata, E Tanaka, M Miyabe, Y Kakiuchi, A Nagashima, Y Yamasaki, S Nakayama, Y Baba, H Toyooka, K Okuyama, Y Kohda. Plasma lidocaine concentrations during continuous thoracic epidural anesthesia after clonidine premedication in children.
Anesthesia and analgesia.
2001 Nov; 93(5):1147-51. doi:
10.1097/00000539-200111000-00016. [PMID: 11682384] - S W Suttner, C Sürder, K Lang, S N Piper, B Kumle, J Boldt. Does age affect liver function and the hepatic acute phase response after major abdominal surgery?.
Intensive care medicine.
2001 Nov; 27(11):1762-9. doi:
10.1007/s00134-001-1126-0. [PMID: 11810120] - E Morsiani, M Brogli, D Galavotti, T Bellini, D Ricci, P Pazzi, A C Puviani. Long-term expression of highly differentiated functions by isolated porcine hepatocytes perfused in a radial-flow bioreactor.
Artificial organs.
2001 Sep; 25(9):740-8. doi:
10.1046/j.1525-1594.2001.06669.x. [PMID: 11722353] - H Kern, T Schröder, M Kaulfuss, M Martin, W J Kox, C D Spies. Enoximone in contrast to dobutamine improves hepatosplanchnic function in fluid-optimized septic shock patients.
Critical care medicine.
2001 Aug; 29(8):1519-25. doi:
10.1097/00003246-200108000-00004. [PMID: 11505119] - J Boldt, C Brosch, S N Piper, S Suttner, A Lehmann, C Werling. Influence of prophylactic use of pentoxifylline on postoperative organ function in elderly cardiac surgery patients.
Critical care medicine.
2001 May; 29(5):952-8. doi:
10.1097/00003246-200105000-00008. [PMID: 11378603] - H Ping, C Zhen-Fu, X Shao-Qing, L Ming, W Jian, Z Guo-Qing, Z Lin, L Lin-Fang, W Meng-Chao. An in vivo rat model for assessment of extrahepatic metabolism.
Journal of pharmacological and toxicological methods.
2001 May; 45(3):181-5. doi:
10.1016/s1056-8719(01)00135-6. [PMID: 11755380] - M Oellerich, V W Armstrong. The MEGX test: a tool for the real-time assessment of hepatic function.
Therapeutic drug monitoring.
2001 Apr; 23(2):81-92. doi:
10.1097/00007691-200104000-00001. [PMID: 11294522] - E Giannini, A Fasoli, F Botta, E Testa, P Romagnoli, P Ceppa, R Testa. Long-term follow up of chronic hepatitis C patients after alpha-interferon treatment: a functional study.
Journal of gastroenterology and hepatology.
2001 Apr; 16(4):399-405. doi:
10.1046/j.1440-1746.2001.02463.x. [PMID: 11354278] - D A Gremse, L J Sindel, C J Hoff, D J Wells, R C Boerth. Assessment of hepatic function in cystic fibrosis by lidocaine metabolism.
Journal of pediatric gastroenterology and nutrition.
2001 Apr; 32(4):434-7. doi:
10.1097/00005176-200104000-00008. [PMID: 11396809] - H Kaneko, Y Otsuka, M Katagiri, T Maeda, M Tsuchiya, A Tamura, T Ishii, S Takagi, T Shiba. Reassessment of monoethylglycinexylidide as preoperative liver function test in a rat model of liver cirrhosis and man.
Clinical and experimental medicine.
2001 Mar; 1(1):19-26. doi:
10.1007/s10238-001-8005-4. [PMID: 11467398] - M Giuliani, G B Grossi, M Pileri, C Lajolo, G Casparrini. Could local anesthesia while breast-feeding be harmful to infants?.
Journal of pediatric gastroenterology and nutrition.
2001 Feb; 32(2):142-4. doi:
10.1097/00005176-200102000-00009. [PMID: 11321382] - N Rank, C Michel, C Haertel, A Lenhart, M Welte, A Meier-Hellmann, C Spies. N-acetylcysteine increases liver blood flow and improves liver function in septic shock patients: results of a prospective, randomized, double-blind study.
Critical care medicine.
2000 Dec; 28(12):3799-807. doi:
10.1097/00003246-200012000-00006. [PMID: 11153617] - A A Igonin, V W Armstrong, M Shipkova, V G Kukes, M Oellerich. The monoethylglycinexylidide (MEGX) test as a marker of hepatic dysfunction in septic patients with pneumonia.
Clinical chemistry and laboratory medicine.
2000 Nov; 38(11):1125-8. doi:
10.1515/cclm.2000.169. [PMID: 11156341] - T Rygnestad, F Samdal. Plasma concentrations of monoethylglycinexylidide during and after breast augmentation.
Plastic and reconstructive surgery.
2000 Sep; 106(3):728-31. doi:
10.1097/00006534-200009030-00036. [PMID: 10987485] - P Palatini, M Floreani, R Padrini, P Piccoli, M Bertoli, L Calò, R Orlando. Effects of chronic renal failure and hemodialysis on the monoethylglycinexylidide liver function test.
Clinical chemistry.
2000 Sep; 46(9):1406-8. doi:
10.1093/clinchem/46.9.1406. [PMID: 10973873] - Y Momota, A A Artru, K M Powers, D S Mautz, Y Ueda. Concentrations of lidocaine and monoethylglycine xylidide in brain, cerebrospinal fluid, and plasma during lidocaine-induced epileptiform electroencephalogram activity in rabbits: the effects of epinephrine and hypocapnia.
Anesthesia and analgesia.
2000 Aug; 91(2):362-8. doi:
10.1097/00000539-200008000-00024. [PMID: 10910849] - S W Suttner, C C Schmidt, J Boldt, I Hüttner, B Kumle, S N Piper. Low-flow desflurane and sevoflurane anesthesia minimally affect hepatic integrity and function in elderly patients.
Anesthesia and analgesia.
2000 Jul; 91(1):206-12. doi:
10.1097/00000539-200007000-00039. [PMID: 10866914] - R Testa, R Franceschini, E Giannini, A Cataldi, F Botta, A Fasoli, P Tenerelli, E Rolandi, T Barreca. Serum leptin levels in patients with viral chronic hepatitis or liver cirrhosis.
Journal of hepatology.
2000 Jul; 33(1):33-7. doi:
10.1016/s0168-8278(00)80156-7. [PMID: 10905583] - T Fukuda, Y Kakiuchi, M Miyabe, N Okubo, Y Yaguchi, Y Kohda, H Toyooka. Plasma lidocaine, monoethylglycinexylidide, and glycinexylidide concentrations after epidural administration in geriatric patients.
Regional anesthesia and pain medicine.
2000 May; 25(3):268-73. doi:
10.1016/s1098-7339(00)90009-9. [PMID: 10834781] - G Ercolani, G L Grazi, R Callivà, F Pierangeli, M Cescon, A Cavallari, A Mazziotti. The lidocaine (MEGX) test as an index of hepatic function: its clinical usefulness in liver surgery.
Surgery.
2000 Apr; 127(4):464-71. doi:
10.1067/msy.2000.104743. [PMID: 10776439] - G Marx, M Leuwer, M Höltje, A Bornscheuer, H Herrmann, K H Mahr, B Vangerow, J Heine, S Piepenbrock, H Rueckoldt. Low-dose dopexamine in patients undergoing hemihepatectomy: an evaluation of effects on reduction of hepatic dysfunction and ischaemic liver injury.
Acta anaesthesiologica Scandinavica.
2000 Apr; 44(4):410-6. doi:
10.1034/j.1399-6576.2000.440409.x. [PMID: 10757573] - J Rózański. [The effect of hyperlipidemia on metabolism, distribution and secretion of lidocaine in patients with primary hyperlipidemia].
Annales Academiae Medicae Stetinensis.
2000; 46(?):177-87. doi:
. [PMID: 11712303] - T Sato, T Ono, M Ozaki, H Sakio, S Yasuda. [Lidocaine metabolism associated with epidural anesthesia in patients for hepatic surgery].
Masui. The Japanese journal of anesthesiology.
1999 Dec; 48(12):1318-22. doi:
. [PMID: 10658411] - Y Kakiuchi, Y Kohda, M Miyabe, Y Momose. Effect of plasma alpha1-acid glycoprotein concentration on the accumulation of lidocaine metabolites during continuous epidural anesthesia in infants and children.
International journal of clinical pharmacology and therapeutics.
1999 Oct; 37(10):493-8. doi:
NULL. [PMID: 10543316] - E Giannini, F Botta, A Fasoli, P Ceppa, D Risso, P B Lantieri, G Celle, R Testa. Progressive liver functional impairment is associated with an increase in AST/ALT ratio.
Digestive diseases and sciences.
1999 Jun; 44(6):1249-53. doi:
10.1023/a:1026609231094. [PMID: 10389705] - R Testa, U Valente, D Risso, S Caglieris, E Giannini, A Fasoli, F Botta, G Dardano, P B Lantieri, G Celle. Can the MEGX test and serum bile acids improve the prognostic ability of Child-Pugh's score in liver cirrhosis?.
European journal of gastroenterology & hepatology.
1999 May; 11(5):559-63. doi:
10.1097/00042737-199905000-00016. [PMID: 10755262] - T Rygnestad, K Zahlsen, O Bergslien, O Dale. Focus on mobilisation after lower abdominal surgery. A double-blind randomised comparison of epidural bupivacaine with morphine vs. lidocaine with morphine for postoperative analgesia.
Acta anaesthesiologica Scandinavica.
1999 Apr; 43(4):380-7. doi:
10.1034/j.1399-6576.1999.430403.x. [PMID: 10225069] - E S El Desoky, A M Ahmed, M A Nafeh, H A Ahmed, E Schütz, V W Armstrong, M Oellerich. Assessment of liver function by the MEGX test in patients with schistosomiasis and cirrhosis.
Clinical biochemistry.
1999 Apr; 32(3):207-12. doi:
10.1016/s0009-9120(99)00007-7. [PMID: 10383082] - A E Muñoz, C Miguez, M Rubio, M Bartellini, D Levi, A Podestá, V Niselman, R Terg. Lidocaine and monoethylglycinexylidide serum determinations to analyze liver function of cirrhotic patients after oral administration.
Digestive diseases and sciences.
1999 Apr; 44(4):789-95. doi:
10.1023/a:1026630313038. [PMID: 10219840] - M H Isohanni, P J Neuvonen, K T Olkkola. Effect of erythromycin and itraconazole on the pharmacokinetics of oral lignocaine.
Pharmacology & toxicology.
1999 Mar; 84(3):143-6. doi:
10.1111/j.1600-0773.1999.tb00890.x. [PMID: 10193676] - L Fabris, R M Jemmolo, G Toffolo, D Paleari, S Viaggi, M Rigon, F Casagrande, F Lirussi, M Strazzabosco, C Cobelli, L Okolicsanyi. The monoethylglycinexylidide test for grading of liver cirrhosis.
Alimentary pharmacology & therapeutics.
1999 Jan; 13(1):67-75. doi:
10.1046/j.1365-2036.1999.00431.x. [PMID: 9892881] - H S Ong, K C Soo, V T Joseph, S Y Tan, P R Jeyaraj. The viability of liver graft for transplantation after prolonged warm ischaemia.
Annals of the Academy of Medicine, Singapore.
1999 Jan; 28(1):25-30. doi:
NULL. [PMID: 10374022] - S Gruttadauria, G Marino, A Gentile, A V Sgroi, A Fonti, S Libra, G Gruttadauria. [Unreliability of the lidocaine test as a prognostic indicator of acute liver failure: an experimental study in swine].
Il Giornale di chirurgia.
1999 Jan; 20(1-2):53-6. doi:
. [PMID: 10097458] - V Kupcová, L Turecký, M Szántová, K Schmidtová. [Monoethylglycinexylidide--a metabolite of lidocaine--as an index of liver function in chronic hepatic parenchymal diseases].
Bratislavske lekarske listy.
1999 Jan; 100(1):12-24. doi:
. [PMID: 10492993] - P Aita, I Robieux, R Sorio, S Tumolo, G Corona, R Cannizzaro, A M Colussi, M Boiocchi, G Toffoli. Pharmacokinetics of oral etoposide in patients with hepatocellular carcinoma.
Cancer chemotherapy and pharmacology.
1999; 43(4):287-94. doi:
10.1007/s002800050897. [PMID: 10071979]
