Dinitrochlorobenzene (BioDeep_00001871322)
Main id: BioDeep_00000003648
代谢物信息卡片
1-chloro-2,4-dinitrobenzene
化学式: C6H3ClN2O4 (201.9781)
中文名称: 1-氯-2,4-二硝基苯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1[N+](=O)[O-])[N+](=O)[O-])Cl
InChI: InChI=1S/C6H3ClN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
C308 - Immunotherapeutic Agent > C2139 - Immunostimulant
D009676 - Noxae > D007509 - Irritants
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:34718
- KEGG: C14397
- PubChem: 6
- DrugBank: DB11831
- ChEMBL: CHEMBL292687
- MeSH: Dinitrochlorobenzene
- CAS: 347840-12-4
- CAS: 97-00-7
- PubChem: 17395397
- NIKKAJI: J3.974H
分类词条
相关代谢途径
Reactome(4)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jing Nie, Xiaoyuan Jiang, Guomi Wang, Yanan Xu, Rui Pan, Wantao Yu, Yuanwen Li, Jingxiao Wang. Yu-Ping-Feng-San alleviates inflammation in atopic dermatitis mice by TLR4/MyD88/NF-κB pathway.
Journal of ethnopharmacology.
2024 Jul; 329(?):118092. doi:
10.1016/j.jep.2024.118092. [PMID: 38604509] - Wei Wu, Le Song, Hong Wang, Lu Feng, Zhenkai Li, Yanqing Li, Le Li, Li Peng. Supercritical CO2 fluid extract from Stellariae Radix ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by inhibit M1 macrophages polarization via AMPK activation.
Environmental toxicology.
2024 May; 39(5):3188-3197. doi:
10.1002/tox.24145. [PMID: 38356236] - YuJiao Meng, Yu Liu, Jianning Guo, Xiaoyao Guo, Xuyang Han, Lu Zhang, Tingting Di, Jingxia Zhao, Yan Wang, Ping Li. Qing-Re-Chu-shi decoction ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice through anti-inflammation and immunoregulatory mechanisms.
Journal of ethnopharmacology.
2024 Apr; 323(?):117702. doi:
10.1016/j.jep.2024.117702. [PMID: 38176665] - Chenming Gu, Jiayuan Liu, Fei Qian, Wenchao Yu, Doudou Huang, Jingshan Shen, Chenguo Feng, Kaixian Chen, Yiming Li, Xiangrui Jiang, Yechun Xu, Liuqiang Zhang. Identification of Dihydrobenzofuran Neolignans as Novel PDE4 Inhibitors and Evaluation of Antiatopic Dermatitis Efficacy in DNCB-Induced Mice Model.
Journal of medicinal chemistry.
2024 Mar; 67(6):4855-4869. doi:
10.1021/acs.jmedchem.3c02424. [PMID: 38489246] - Myeongguk Jeong, Hyeokjin Kwon, Yeeun Kim, Hyunwoo Jin, Go-Eun Choi, Kyung-Yae Hyun. Erigeron annuus Extract Improves DNCB-Induced Atopic Dermatitis in a Mouse Model via the Nrf2/HO-1 Pathway.
Nutrients.
2024 Feb; 16(3):. doi:
10.3390/nu16030451. [PMID: 38337735] - Yun Sun, Defen Zhu, Lu Qu, Manping Li, Wenxia Du, Mingming Wang, Yi Zhang, Guifang Chen, Gaoxiong Rao, Xiaoling Yu, Xiangnong Wu, Feng Huang, Xiaoyun Tong. Inhibitory effects of catalpol on DNCB-induced atopic dermatitis and IgE-mediated mast cells reaction.
International immunopharmacology.
2024 Jan; 126(?):111274. doi:
10.1016/j.intimp.2023.111274. [PMID: 38041954] - Rebecca Riedl, Annika Kühn, Yvonne Hupfer, Betty Hebecker, Lukas K Peltner, Paul M Jordan, Oliver Werz, Stefan Lorkowski, Cornelia Wiegand, Maria Wallert. Characterization of Different Inflammatory Skin Conditions in a Mouse Model of DNCB-Induced Atopic Dermatitis.
Inflammation.
2023 Dec; ?(?):. doi:
10.1007/s10753-023-01943-x. [PMID: 38150167] - Jinkai Li, Jiawei Duan, Yujiao Wang, Peijie Zhou, Xuan Wang, Ning Xia, Jie Wang, Jia Li, Wenfei Wang, Xiao Wang, Jing Sun, Dongyan Guo, Junbo Zou, Xiaofei Zhang, Changli Wang. The JAK/STAT/NF-κB signaling pathway can be regulated by rosemary essential oil, thereby providing a potential treatment for DNCB-induced in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Dec; 168(?):115727. doi:
10.1016/j.biopha.2023.115727. [PMID: 37879216] - Krzysztof Sitko, Michał Starke, Stefan Tukaj. Heat shock protein 90 (Hsp90) inhibitor STA-9090 (Ganetespib) ameliorates inflammation in a mouse model of atopic dermatitis.
Cell stress & chaperones.
2023 Oct; ?(?):. doi:
10.1007/s12192-023-01387-0. [PMID: 37851180] - Pinglong Fan, Shuchun Xie, ZhiQian Zhang, Quan Yuan, Jiajiang He, Jie Zhang, Xinyue Liu, Xiaoyi Liu, Lieqiang Xu. Polygonum perfoliatum L. ethanol extract ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin inflammation.
Journal of ethnopharmacology.
2023 Oct; ?(?):117288. doi:
10.1016/j.jep.2023.117288. [PMID: 37827300] - Lian Yang, Qing Zhang, Yili Yang, Qun Wang. PYR-41, an inhibitor of ubiquitin-activating enzyme E1, attenuates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 10; 37(10):e23210. doi:
10.1096/fj.202200951rrr. [PMID: 37738047] - Zhao Yiding, Yan Xiaoning, Jiang Shanshan, Liu Yong, Dong Chun, Chi Huiyan, Mao Chaoyi. Zhenxin Anshen formula ameliorates atopic der-matitis-like skin dysfunction in mice and regulation of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 in Neural pathways.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 10; 43(5):887-896. doi:
10.19852/j.cnki.jtcm.20230802.003. [PMID: 37679976] - Zi-Wen Zhou, Xue-Yan Zhu, Shu-Ying Li, Si-En Lin, Yu-Han Zhu, Kunmei Ji, Jia-Jie Chen. Formononetin Inhibits Mast Cell Degranulation to Ameliorate Compound 48/80-Induced Pseudoallergic Reactions.
Molecules (Basel, Switzerland).
2023 Jul; 28(13):. doi:
10.3390/molecules28135271. [PMID: 37446928] - Gakyung Lee, Jinyoung Park, Hyunbeom Lee, Kyeong Seok Kim, Jae Hyeon Park, So Young Kyung, Hyung Sik Kim, Hyun Ok Yang, Byung Hwa Jung. Anti-inflammatory effect and metabolic mechanism of BS012, a mixture of Asarum sieboldii, Platycodon grandiflorum, and Cinnamomum cassia extracts, on atopic dermatitis in vivo and in vitro.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jul; 115(?):154818. doi:
10.1016/j.phymed.2023.154818. [PMID: 37187105] - Xinyu Bai, Xiuming Rao, Yuqi Wang, Hengyan Shen, Xuejun Jin. A homogeneous Lonicera japonica polysaccharide alleviates atopic dermatitis by promoting Nrf2 activation and NLRP3 inflammasome degradation via p62.
Journal of ethnopharmacology.
2023 Jun; 309(?):116344. doi:
10.1016/j.jep.2023.116344. [PMID: 36889421] - Ga-Yul Min, Tae In Kim, Ji-Hye Kim, Won-Kyung Cho, Ju-Hye Yang, Jin Yeul Ma. Anti-Atopic Effect of Isatidis Folium Water Extract in TNF-α/IFN-γ-Induced HaCaT Cells and DNCB-Induced Atopic Dermatitis Mouse Model.
Molecules (Basel, Switzerland).
2023 May; 28(9):. doi:
10.3390/molecules28093960. [PMID: 37175371] - Huan-Huan Yu, Wei Zhao, Bu-Xin Zhang, Ying Wang, Jie Li, Yu-Fu Fang. Morinda officinalis extract exhibits protective effects against atopic dermatitis by regulating the MALAT1/miR-590-5p/CCR7 axis.
Journal of cosmetic dermatology.
2023 May; 22(5):1602-1612. doi:
10.1111/jocd.15610. [PMID: 36639978] - Sojung Bae, Na-Hee Jeong, Young-Ae Choi, Byungheon Lee, Yong Hyun Jang, Soyoung Lee, Sang-Hyun Kim. Lupeol alleviates atopic dermatitis-like skin inflammation in 2,4-dinitrochlorobenzene/Dermatophagoides farinae extract-induced mice.
BMC pharmacology & toxicology.
2023 04; 24(1):27. doi:
10.1186/s40360-023-00668-9. [PMID: 37098554] - Zhehuan Wang, Huiru Zhang, Caihong Qi, Hui Guo, Xiangyue Jiao, Jia Yan, Yifei Wang, Qiangsheng Li, Mingming Zhao, Xinhao Guo, Baoluo Wan, Xiaotian Li. Ursolic acid ameliorates DNCB-induced atopic dermatitis-like symptoms in mice by regulating TLR4/NF-κB and Nrf2/HO-1 signaling pathways.
International immunopharmacology.
2023 Mar; 118(?):110079. doi:
10.1016/j.intimp.2023.110079. [PMID: 36996741] - Congying Huang, Siqi Li, Wenxin Guo, Ziyan Zhang, Xiangxi Meng, Xing Li, Bing Gao, Rong Wen, Hui Niu, Chunhong Zhang, Minhui Li. Cymbaria daurica L.: A Mongolian herbal medicine for treating eczema via natural killer cell-mediated cytotoxicity pathway.
Journal of ethnopharmacology.
2023 Feb; 308(?):116246. doi:
10.1016/j.jep.2023.116246. [PMID: 36791926] - Jia Liu, Yiwen Tao, Xuemei Zou, Qian Liu, Xianli Meng, Yi Zhang, Jinsong Su. In vitro and in vivo exploration of the anti-atopic dermatitis mechanism of action of Tibetan medicine Qi-Sai-Er-Sang-Dang-Song decoction.
Journal of ethnopharmacology.
2023 Jan; 306(?):116155. doi:
10.1016/j.jep.2023.116155. [PMID: 36634726] - Yanjie Wang, Ping Zhang, Jingyu Zhang, Tie Hong. Inhibitory Effect of Bisdemethoxycurcumin on DNCB-Induced Atopic Dermatitis in Mice.
Molecules (Basel, Switzerland).
2022 Dec; 28(1):. doi:
10.3390/molecules28010293. [PMID: 36615486] - Yi Zhang, Lu Qu, Yun Sun, YuPing Lin, Jing Zeng, LiXia He, Xiucun Li, Wen Gu, Jian Nie, Xiaoling Yu, XiaoYun Tong, Feng Huang. Daphnetin contributes to allergen-induced Th2 cytokine expression and type 2-immune responses in atopic dermatitis and asthma.
Food & function.
2022 Nov; 13(23):12383-12399. doi:
10.1039/d2fo02518c. [PMID: 36373505] - Hyun-Su Lee, Eun-Nam Kim, Gil-Saeng Jeong. Oral administration of Helianthus annuus leaf extract ameliorates atopic dermatitis by modulation of T cell activity in vivo.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Nov; 106(?):154443. doi:
10.1016/j.phymed.2022.154443. [PMID: 36108372] - Yunji Bae, Taeyoung Kim, Nojune Park, Sangho Choi, Dongkeun Yi, Silvia Soto, Nelson Zamora, Sunam Kim, Minhye Yang. Ameliorative Effects of Daphnopsis costaricensis Extract against Oxazolone-Induced Atopic Dermatitis-like Lesions in BALB/c Mice.
Nutrients.
2022 Oct; 14(21):. doi:
10.3390/nu14214521. [PMID: 36364783] - Tae-Kyeong Lee, Dae Won Kim, Ji Hyeon Ahn, Choong-Hyun Lee, Jae-Chul Lee, Soon Sung Lim, Il Jun Kang, Seongkweon Hong, Soo Young Choi, Moo-Ho Won, Joon Ha Park. Protective Effects of Topical Administration of Laminarin in Oxazolone-Induced Atopic Dermatitis-like Skin Lesions.
Marine drugs.
2022 Oct; 20(11):. doi:
10.3390/md20110669. [PMID: 36354992] - Seo Yeon Lee, Se Hyang Hong, Hyo In Kim, Jin Mo Ku, Yu-Jeong Choi, Min-Jeong Kim, Seong-Gyu Ko. Paeonia lactiflora Pallas extract alleviates antibiotics and DNCB-induced atopic dermatitis symptoms by suppressing inflammation and changing the gut microbiota composition in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Oct; 154(?):113574. doi:
10.1016/j.biopha.2022.113574. [PMID: 36057224] - Fahmida Akter, Shintaro Munemasa, Toshiyuki Nakamura, Yoshimasa Nakamura, Yoshiyuki Murata. Negative regulation of salicylic acid-induced stomatal closure by glutathione in Arabidopsis thaliana.
Bioscience, biotechnology, and biochemistry.
2022 Sep; 86(10):1378-1382. doi:
10.1093/bbb/zbac116. [PMID: 35867881] - Gu Qinwufeng, Lin Jiacheng, Lu Xiaoling, Chen Tingru, Wu Yunyang, Yang Yanlong. Jiu-Wei-Yong-An Formula suppresses JAK1/STAT3 and MAPK signaling alleviates atopic dermatitis-like skin lesions.
Journal of ethnopharmacology.
2022 Sep; 295(?):115428. doi:
10.1016/j.jep.2022.115428. [PMID: 35659915] - Lan Wang, Zhen Hu, Wen Yang, Steven King Fan Loo, Siu Po Ip, Yan-Fang Xian, Zhi-Xiu Lin. Anti-atopic dermatitis effect of a modified Huang-Lian-Jie-Du decoction and its active fraction on 2,4-dinitrobenzene and MC903-induced mouse models.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Sep; 104(?):154346. doi:
10.1016/j.phymed.2022.154346. [PMID: 35872445] - Ya-Chu Tsai, Hsun-Hao Chang, Sheng-Chieh Chou, Thomas W Chu, Yu-Jou Hsu, Chien-Yu Hsiao, Yuan-Hsin Lo, Nan-Lin Wu, Der-Chen Chang, Chi-Feng Hung. Evaluation of the Anti-Atopic Dermatitis Effects of α-Boswellic Acid on Tnf-α/Ifn-γ-Stimulated HaCat Cells and DNCB-Induced BALB/c Mice.
International journal of molecular sciences.
2022 Aug; 23(17):. doi:
10.3390/ijms23179863. [PMID: 36077254] - Hairong Zeng, Bei Zhao, Die Zhang, Xin Rui, Xudong Hou, Xingxing Chen, Benrui Zhang, Yi Yuan, Hongping Deng, Guangbo Ge. Viola yedoensis Makino formula alleviates DNCB-induced atopic dermatitis by activating JAK2/STAT3 signaling pathway and promoting M2 macrophages polarization.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Aug; 103(?):154228. doi:
10.1016/j.phymed.2022.154228. [PMID: 35689898] - Zhi-Wen Zeng, Jin-Quan Huang, Yong Chen, Xiao Yu, Wei Zhu, Dong-Shu Zhang. Acupoint Autohemotherapy Attenuates Atopic Dermatitis Lesions by Regulating Th1/Th2 Balance in DNCB-Induced BALB/c Mice.
Chinese journal of integrative medicine.
2022 Jul; 28(7):612-619. doi:
10.1007/s11655-022-3579-7. [PMID: 35776292] - Jin Ah Ryuk, Byoung-Seob Ko, Na Rang Moon, Sunmin Park. Pinus koraiensis needle or cone extracts alleviate atopic dermatitis symptoms by regulating immunity and suppressing inflammation in HaCaT cells and Nc/Nga mice.
Journal of food biochemistry.
2022 07; 46(7):e14135. doi:
10.1111/jfbc.14135. [PMID: 35301731] - Yun-Mi Kang, Hye-Min Kim, Hwan Lee, Dong-Sung Lee, Hyo-Jin An. Anti-inflammatory effects of Eclipta prostrata Linné on house dust mite-induced atopic dermatitis in vivo and in vitro.
Journal of ethnopharmacology.
2022 Jun; 292(?):115233. doi:
10.1016/j.jep.2022.115233. [PMID: 35346812] - Yajing Gu, Xinxin Wang, Fang Liu, Jin Zhang, Xiufang Zhang, Jiping Liu, Sijia Li, Decheng Wang, Hongquan Guan, Diandong Hou. Total flavonoids of sea buckthorn (Hippophae rhamnoides L.) improve MC903-induced atopic dermatitis-like lesions.
Journal of ethnopharmacology.
2022 Jun; 292(?):115195. doi:
10.1016/j.jep.2022.115195. [PMID: 35306042] - Guangxia Li, Huayan Wu, Liqin Sun, Kang Cheng, Zhi Lv, Kaixian Chen, Fei Qian, Yiming Li. (-)-α-Bisabolol Alleviates Atopic Dermatitis by Inhibiting MAPK and NF-κB Signaling in Mast Cell.
Molecules (Basel, Switzerland).
2022 Jun; 27(13):. doi:
10.3390/molecules27133985. [PMID: 35807237] - Xinyan Han, Ziyu Chen, Jinfeng Yuan, Gaorui Wang, Xiao Han, Hui Wu, Hailian Shi, Guixin Chou, Liu Yang, Xiaojun Wu. Artemisia annua water extract attenuates DNCB-induced atopic dermatitis by restraining Th2 cell mediated inflammatory responses in BALB/c mice.
Journal of ethnopharmacology.
2022 Jun; 291(?):115160. doi:
10.1016/j.jep.2022.115160. [PMID: 35245629] - Pei-Chin Chen, Yi-Hao Lo, Shi-Ying Huang, Hsin-Lu Liu, Zhi-Kang Yao, Chi-I Chang, Zhi-Hong Wen. The anti-inflammatory properties of ethyl acetate fraction in ethanol extract from Sarcodia suiae sp. alleviates atopic dermatitis-like lesion in mice.
Bioscience, biotechnology, and biochemistry.
2022 Apr; 86(5):646-654. doi:
10.1093/bbb/zbac028. [PMID: 35218182] - Sooyeon Hong, Eun-Young Kim, Seo-Eun Lim, Jae-Hyun Kim, Youngjoo Sohn, Hyuk-Sang Jung. Dendrobium nobile Lindley Administration Attenuates Atopic Dermatitis-like Lesions by Modulating Immune Cells.
International journal of molecular sciences.
2022 Apr; 23(8):. doi:
10.3390/ijms23084470. [PMID: 35457288] - Do Yoon Kim, Kyung-Jong Won, Dae Il Hwang, Nan Young Kim, Bokyung Kim, Hwan Myung Lee. 1-Iodohexadecane Alleviates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis in Mice: Possible Involvements of the Skin Barrier and Mast Cell SNARE Proteins.
Molecules (Basel, Switzerland).
2022 Feb; 27(5):. doi:
10.3390/molecules27051560. [PMID: 35268661] - Lan Wang, Yan-Fang Xian, Steven King Fan Loo, Siu Po Ip, Wen Yang, Wood Yee Chan, Zhi-Xiu Lin, Justin Che Yuen Wu. Baicalin ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in mice through modulating skin barrier function, gut microbiota and JAK/STAT pathway.
Bioorganic chemistry.
2022 02; 119(?):105538. doi:
10.1016/j.bioorg.2021.105538. [PMID: 34929516] - Se Hoon Lee, Jeesuk Yu, Sang Hyun Cho. Effect of a combination of Korean red ginseng extract and probiotics on the prevention of atopic dermatitis in a murine model.
Journal of ethnopharmacology.
2022 Jan; 283(?):114687. doi:
10.1016/j.jep.2021.114687. [PMID: 34600077] - Yung-Sen Chang, Chih-Chen Tsai, Pang-Yan Yang, Chih-Yu Tang, Bor-Luen Chiang. Topical Melatonin Exerts Immunomodulatory Effect and Improves Dermatitis Severity in a Mouse Model of Atopic Dermatitis.
International journal of molecular sciences.
2022 Jan; 23(3):. doi:
10.3390/ijms23031373. [PMID: 35163297] - Seon Gyeong Bak, Hyung-Jin Lim, Yeong-Seon Won, Soyoung Lee, Sun Hee Cheong, Seong Jin Lee, Eun Young Bae, Seung Woong Lee, Seung Jae Lee, Mun-Chual Rho. Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation.
BioMed research international.
2022; 2022(?):2475699. doi:
10.1155/2022/2475699. [PMID: 36158872] - Jin-Su Oh, Geum-Su Seong, Yong-Deok Kim, Se-Young Choung. Deacetylasperulosidic Acid Ameliorates Pruritus, Immune Imbalance, and Skin Barrier Dysfunction in 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis NC/Nga Mice.
International journal of molecular sciences.
2021 Dec; 23(1):. doi:
10.3390/ijms23010226. [PMID: 35008651] - Eun-Young Kim, Sooyeon Hong, Jae-Hyun Kim, Minsun Kim, Yujin Lee, Youngjoo Sohn, Hyuk-Sang Jung. Effects of chloroform fraction of Fritillariae Thunbergii Bulbus on atopic symptoms in a DNCB-induced atopic dermatitis-like skin lesion model and in vitro models.
Journal of ethnopharmacology.
2021 Dec; 281(?):114453. doi:
10.1016/j.jep.2021.114453. [PMID: 34314806] - Ga-Yul Min, Eun-Young Kim, Sooyeon Hong, Jae-Hyun Kim, Minsun Kim, Eom Ji Kim, Jae Ho Park, Youngjoo Sohn, Hyuk-Sang Jung. Lycopus lucidus Turcz ameliorates DNCB‑induced atopic dermatitis in BALB/c mice.
Molecular medicine reports.
2021 Dec; 24(6):. doi:
10.3892/mmr.2021.12467. [PMID: 34581418] - Hai Rong Zeng, Bei Zhao, Xing Rui, Gui Hua Jia, Yue Wu, Die Zhang, Hao Nao Yu, Ben Rui Zhang, Yi Yuan. A TCM formula VYAC ameliorates DNCB-induced atopic dermatitis via blocking mast cell degranulation and suppressing NF-κB pathway.
Journal of ethnopharmacology.
2021 Nov; 280(?):114454. doi:
10.1016/j.jep.2021.114454. [PMID: 34329716] - Pinglong Fan, Yanling Yang, Tao Liu, Xiaolu Lu, Hao Huang, Lei Chen, Ying Kuang. Anti-atopic effect of Viola yedoensis ethanol extract against 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin dysfunction.
Journal of ethnopharmacology.
2021 Nov; 280(?):114474. doi:
10.1016/j.jep.2021.114474. [PMID: 34332065] - Yoon Seon Kim, Gyeongyun Go, Chul-Won Yun, Ji-Hye Yea, Sungtae Yoon, Su-Yeon Han, Gaeun Lee, Mi-Young Lee, Sang Hun Lee. Topical Administration of Melatonin-Loaded Extracellular Vesicle-Mimetic Nanovesicles Improves 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis.
Biomolecules.
2021 10; 11(10):. doi:
10.3390/biom11101450. [PMID: 34680082] - Du Hyeon Hwang, Phil-Ok Koh, Changkeun Kang, Euikyung Kim. Rosa davurica Pall. improves DNCB-induced atopic dermatitis in mice and regulated TNF-Alpa/IFN-gamma-induced skin inflammatory responses in HaCaT cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Oct; 91(?):153708. doi:
10.1016/j.phymed.2021.153708. [PMID: 34455178] - Ju-Hye Yang, Kwang-Youn Kim, Young-Woo Kim, Kwang-Il Park. Artemisia anomala Herba Alleviates 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions in Mice and the Production of Pro-Inflammatory Mediators in Tumor Necrosis Factor Alpha-/Interferon Gamma-Induced HaCaT Cells.
Molecules (Basel, Switzerland).
2021 Sep; 26(17):. doi:
10.3390/molecules26175427. [PMID: 34500860] - Masashi Mizuno, Nobuaki Ohto, Hiroshige Kuwahara. Lactiplantibacillus plantarum 22A-3 isolated from pickle suppresses ovalbumin-induced food allergy in BALB/c mice and 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice.
Journal of bioscience and bioengineering.
2021 Sep; 132(3):271-278. doi:
10.1016/j.jbiosc.2021.05.001. [PMID: 34083121] - Bina Lee, Sooyeon Hong, Minsun Kim, Eun-Young Kim, Hi-Joon Park, Hyuk-Sang Jung, Jae-Hyun Kim, Youngjoo Sohn. Lycii radicis cortex inhibits glucocorticoid‑induced bone loss by downregulating Runx2 and BMP‑2 expression.
International journal of molecular medicine.
2021 Aug; 48(2):. doi:
10.3892/ijmm.2021.4988. [PMID: 34165156] - Lan Wang, Yan-Fang Xian, Zhen Hu, Steven King Fan Loo, Siu Po Ip, Wood Yee Chan, Zhi-Xiu Lin, Justin Che Yuen Wu. Efficacy and action mechanisms of a Chinese herbal formula on experimental models of atopic dermatitis.
Journal of ethnopharmacology.
2021 Jun; 274(?):114021. doi:
10.1016/j.jep.2021.114021. [PMID: 33716079] - Zhijie Yu, Ting Deng, Ping Wang, Tao Sun, Ying Xu. Ameliorative effects of total coumarins from the fructus of Cnidium monnieri (L.) Cuss. on 2,4-dinitrochlorobenzene-induced atopic dermatitis in rats.
Phytotherapy research : PTR.
2021 Jun; 35(6):3310-3324. doi:
10.1002/ptr.7052. [PMID: 33634904] - Seong Min Hong, Min Cheol Kang, Mirim Jin, Taek Hwan Lee, Beong Ou Lim, Sun Yeou Kim. Fermented blueberry and black rice containing Lactobacillus plantarum MG4221: a novel functional food for particulate matter (PM2.5)/dinitrochlorobenzene (DNCB)-induced atopic dermatitis.
Food & function.
2021 Apr; 12(8):3611-3623. doi:
10.1039/d0fo02966a. [PMID: 33900308] - Hyo In Kim, Se Hyang Hong, Seo Yeon Lee, Jin Mo Ku, Min Jeong Kim, Seong-Gyu Ko. Gardenia Jasminoides Ameliorates Antibiotic-Associated Aggravation of DNCB-Induced Atopic Dermatitis by Restoring the Intestinal Microbiome Profile.
Nutrients.
2021 Apr; 13(4):. doi:
10.3390/nu13041349. [PMID: 33919521] - Jonghwan Jegal, No-June Park, Beom-Geun Jo, Tae-Young Kim, Sim-Kyu Bong, Sangho Choi, Jin-Hyub Paik, Jung-Won Kim, Su-Nam Kim, Min Hye Yang. Wikstroemiaganpi Extract Improved Atopic Dermatitis-Like Skin Lesions via Suppression of Interleukin-4 in 2,4-Dinitrochlorobenzene-Induced SKH-1 Hairless Mice.
Molecules (Basel, Switzerland).
2021 Apr; 26(7):. doi:
10.3390/molecules26072016. [PMID: 33916154] - Boguen Kwon, Soo Yeon Hong, Eun-Young Kim, Jae-Hyun Kim, Minsun Kim, Jae Ho Park, Youngjoo Sohn, Hyuk-Sang Jung. Effect of Cone of Pinus densiflora on DNCB-Induced Allergic Contact Dermatitis-Like Skin Lesion in Balb/c Mice.
Nutrients.
2021 Mar; 13(3):. doi:
10.3390/nu13030839. [PMID: 33806628] - Johny Bajgai, Jing Xingyu, Ailyn Fadriquela, Rahima Begum, Dong Heui Kim, Cheol-Su Kim, Soo-Ki Kim, Kyu-Jae Lee. Effects of mineral complex material treatment on 2,4- dinitrochlorobenzene-induced atopic dermatitis like-skin lesions in mice model.
BMC complementary medicine and therapies.
2021 Mar; 21(1):82. doi:
10.1186/s12906-021-03259-5. [PMID: 33658026] - Yunlong Chen, Yan-Fang Xian, Steven Loo, Wood Yee Chan, Ling Liu, Zhi-Xiu Lin. Anti-atopic dermatitis effects of dictamni cortex: Studies on in vitro and in vivo experimental models.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Feb; 82(?):153453. doi:
10.1016/j.phymed.2020.153453. [PMID: 33450637] - Sheng-Shuai Liu, Yu-Sheng Xu, Ahunova Hilola, Nong Zhou, Miao He, Cheng-Gui Zhang, Heng Liu. Study on the effect of the treatment of Periplaneta americana L. extract Ento-B by Dinitrochlorobenzene combined with acetic acid induced UC in rats.
Acta cirurgica brasileira.
2021; 36(1):e360102. doi:
10.1590/acb360102. [PMID: 33605307] - Thomas Chu, Nan-Lin Wu, Chien-Yu Hsiao, Hsin-Ju Li, Tung-Yi Lin, Cheng-Hung Ku, Chi-Feng Hung. An isoflavone extract from soybean cake suppresses 2,4-dinitrochlorobenzene-induced contact dermatitis.
Journal of ethnopharmacology.
2020 Dec; 263(?):113037. doi:
10.1016/j.jep.2020.113037. [PMID: 32485302] - Youn-Hwan Hwang, Hyun-Kyung Song, Ami Lee, Hyunil Ha, Taesoo Kim. Laminaria japonica Suppresses the Atopic Dermatitis-Like Responses in NC/Nga Mice and Inflamed HaCaT Keratinocytes via the Downregulation of STAT1.
Nutrients.
2020 Oct; 12(11):. doi:
10.3390/nu12113238. [PMID: 33113891] - Sooyeon Hong, Bina Lee, Jae-Hyun Kim, Eun-Young Kim, Minsun Kim, Boguen Kwon, Hye-Rin Cho, Youngjoo Sohn, Hyuk-Sang Jung. Solanum nigrum Linne improves DNCB‑induced atopic dermatitis‑like skin disease in BALB/c mice.
Molecular medicine reports.
2020 Oct; 22(4):2878-2886. doi:
10.3892/mmr.2020.11381. [PMID: 32945415] - So-Eun Son, Soo-Jin Park, Jung-Min Koh, Dong-Soon Im. Free fatty acid receptor 4 (FFA4) activation ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis by increasing regulatory T cells in mice.
Acta pharmacologica Sinica.
2020 Oct; 41(10):1337-1347. doi:
10.1038/s41401-020-0435-1. [PMID: 32555509] - Hyun-Deok Moon, Bae-Hwan Kim. Inhibitory effects of Aristotelia chilensis water extract on 2,4-Dinitrochlorobenzene induced atopic-like dermatitis in BALB/c Mice.
Asian Pacific journal of allergy and immunology.
2020 Sep; 38(3):190-199. doi:
10.12932/ap-190418-0298. [PMID: 30903998] - Do-Youn Jeong, Myeong-Seon Ryu, Hee-Jong Yang, Seong-Yeop Jeong, Ting Zhang, Hye Jeong Yang, Min Jung Kim, Sunmin Park. Pediococcus acidilactici intake decreases the clinical severity of atopic dermatitis along with increasing mucin production and improving the gut microbiome in Nc/Nga mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Sep; 129(?):110488. doi:
10.1016/j.biopha.2020.110488. [PMID: 32768968] - Xinxin Wang, Sijia Li, Jiping Liu, Dongning Kong, Xiaowei Han, Ping Lei, Ming Xu, Hongquan Guan, Diandong Hou. Ameliorative effects of sea buckthorn oil on DNCB induced atopic dermatitis model mice via regulation the balance of Th1/Th2.
BMC complementary medicine and therapies.
2020 Aug; 20(1):263. doi:
10.1186/s12906-020-02997-2. [PMID: 32843010] - Eui Jeong Han, Ilekuttige Priyan Shanura Fernando, Hyun-Soo Kim, You-Jin Jeon, Dissanayaka Mudiyanselage Dinesh Madusanka, Mawalle Kankanamge Hasitha Madhawa Dias, Youngheun Jee, Ginnae Ahn. Oral Administration of Sargassum horneri Improves the HDM/DNCB-Induced Atopic Dermatitis in NC/Nga Mice.
Nutrients.
2020 Aug; 12(8):. doi:
10.3390/nu12082482. [PMID: 32824648] - Laura Morello, Tommaso Tiroli, Francesca Aretino, Stefano Morandi, Diego Breviario. Preliminary Results, Perspectives, and Proposal for a Screening Method of In Vitro Susceptibility of Prototheca Species to Antimicrotubular Agents.
Antimicrobial agents and chemotherapy.
2020 02; 64(3):. doi:
10.1128/aac.01392-19. [PMID: 31871079] - Yonghyeon Lee, Hyeon Kyeong Choi, Kaudjhis Patrick Ulrich N'deh, Young-Jin Choi, Meiqi Fan, Eun-Kyung Kim, Kang-Hyun Chung, And Jeung Hee An. Inhibitory Effect of Centella asiatica Extract on DNCB-Induced Atopic Dermatitis in HaCaT Cells and BALB/c Mice.
Nutrients.
2020 Feb; 12(2):. doi:
10.3390/nu12020411. [PMID: 32033291] - Na-Hee Jeong, Soyoung Lee, Jin Kyeong Choi, Young-Ae Choi, Min-Jong Kim, Hyun-Shik Lee, Tae-Yong Shin, Yong Hyun Jang, Kyung-Sik Song, Sang-Hyun Kim. Polyozellin alleviates atopic dermatitis-like inflammatory and pruritic responses in activated keratinocytes and mast cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Feb; 122(?):109743. doi:
10.1016/j.biopha.2019.109743. [PMID: 31918284] - Sung Ho Kim, Geum Su Seong, Se Young Choung. Fermented Morinda citrifolia (Noni) Alleviates DNCB-Induced Atopic Dermatitis in NC/Nga Mice through Modulating Immune Balance and Skin Barrier Function.
Nutrients.
2020 Jan; 12(1):. doi:
10.3390/nu12010249. [PMID: 31963703] - So-Yeon Lee, No-June Park, Jonghwan Jegal, Beom-Geun Jo, Sangho Choi, Sang Woo Lee, Md Salah Uddin, Su-Nam Kim, Min Hye Yang. Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract.
Nutrients.
2020 Jan; 12(1):. doi:
10.3390/nu12010173. [PMID: 31936273] - Chieh-Shan Wu, Shih-Chao Lin, Shiming Li, Yu-Chih Chiang, Nicole Bracci, Caitlin W Lehman, Kuo-Tung Tang, Chi-Chien Lin. Phloretin alleviates dinitrochlorobenzene-induced dermatitis in BALB/c mice.
International journal of immunopathology and pharmacology.
2020 Jan; 34(?):2058738420929442. doi:
10.1177/2058738420929442. [PMID: 32571120] - Sullim Lee, Hyun Jegal, Sim-Kyu Bong, Kyeong-No Yoon, No-June Park, Myoung-Sook Shin, Min Hye Yang, Yong Kee Kim, Su-Nam Kim. Anti-Atopic Effect of Acorn Shell Extract on Atopic Dermatitis-Like Lesions in Mice and Its Active Phytochemicals.
Biomolecules.
2019 12; 10(1):. doi:
10.3390/biom10010057. [PMID: 31905797] - Xue Yang, Jinchi Wei, Zhihai Wu, Jie Gao. Effects of Substrate-Binding Site Residues on the Biochemical Properties of a Tau Class Glutathione S-Transferase from Oryza sativa.
Genes.
2019 12; 11(1):. doi:
10.3390/genes11010025. [PMID: 31878175] - Bina Lee, Jun Heo, SooYeon Hong, Eun-Young Kim, Young Joo Sohn, Hyuk-Sang Jung. dl-Malic acid as a component of α-hydroxy acids: effect on 2,4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in vitro and in vivo.
Immunopharmacology and immunotoxicology.
2019 Dec; 41(6):614-621. doi:
10.1080/08923973.2019.1680688. [PMID: 31645147] - Tae-Young Kim, No-June Park, Jonghwan Jegal, Sangho Choi, Sang Woo Lee, Jin Hang, Su-Nam Kim, Min Hye Yang. Chamaejasmine Isolated from Wikstroemia dolichantha Diels Suppresses 2,4-Dinitrofluoro-benzene-Induced Atopic Dermatitis in SKH-1 Hairless Mice.
Biomolecules.
2019 11; 9(11):. doi:
10.3390/biom9110697. [PMID: 31694198] - Ji-Ye Lim, Ji-Hyun Lee, Dong-Hyun Lee, Jeong-Heon Lee, Dae-Ki Kim. Umbelliferone reduces the expression of inflammatory chemokines in HaCaT cells and DNCB/DFE-induced atopic dermatitis symptoms in mice.
International immunopharmacology.
2019 Oct; 75(?):105830. doi:
10.1016/j.intimp.2019.105830. [PMID: 31437788] - Bowen Tang, Wu Dai, Lijun Qi, Qi Zhang, Chunni Zhang. Identification and Functional Analysis of a Delta Class Glutathione S-Transferase Gene Associated with Insecticide Detoxification in Bradysia odoriphaga.
Journal of agricultural and food chemistry.
2019 Sep; 67(36):9979-9988. doi:
10.1021/acs.jafc.9b02874. [PMID: 31411878] - Ju-Hyoung Park, Eun-Kyung Ahn, Hye-Jin Ko, Jae Yeon Lee, Seung-Mi Hwang, SeonMi Ko, Joa Sub Oh. Korean red ginseng water extract alleviates atopic dermatitis-like inflammatory responses by negative regulation of mitogen-activated protein kinase signaling pathway in vivo.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Sep; 117(?):109066. doi:
10.1016/j.biopha.2019.109066. [PMID: 31226639] - Hui-Jie Fan, Xiao-Shan Zhao, Zhang-Bin Tan, Bin Liu, Hong-Lin Xu, Yu-Ting Wu, Ling-Peng Xie, Yi-Ming Bi, Yi-Gui Lai, Hong-Feng Liang, Ying-Chun Zhou. Effects and mechanism of action of Huang-Lian-Jie-Du-Tang in atopic dermatitis-like skin dysfunction in vivo and in vitro.
Journal of ethnopharmacology.
2019 Aug; 240(?):111937. doi:
10.1016/j.jep.2019.111937. [PMID: 31075381] - Ravi Raj Pal, Poonam Parashar, Indu Singh, Shubhini A Saraf. Tamanu oil potentiated novel sericin emulgel of levocetirizine: repurposing for topical delivery against DNCB-induced atopic dermatitis, QbD based development and in vivo evaluation.
Journal of microencapsulation.
2019 Aug; 36(5):432-446. doi:
10.1080/02652048.2019.1637474. [PMID: 31238752] - Young-Ae Choi, Ju-Hee Yu, Hong Dae Jung, Soyoung Lee, Pil-Hoon Park, Hyun-Shik Lee, Taeg Kyu Kwon, Tae-Yong Shin, Seung Woong Lee, Mun-Chul Rho, Yong Hyun Jang, Sang-Hyun Kim. Inhibitory effect of ethanol extract of Ampelopsis brevipedunculata rhizomes on atopic dermatitis-like skin inflammation.
Journal of ethnopharmacology.
2019 Jun; 238(?):111850. doi:
10.1016/j.jep.2019.111850. [PMID: 30953820] - Huan He, Xiaoxiao Gao, Xiaomin Wang, Xin Li, Xiaoxue Jiang, Zhehui Xie, Ke Ma, Jun Ma, Kazuo Umezawa, Yuyang Zhang. Comparison of anti-atopic dermatitis activities between DHMEQ and tacrolimus ointments in mouse model without stratum corneum.
International immunopharmacology.
2019 Jun; 71(?):43-51. doi:
10.1016/j.intimp.2019.03.015. [PMID: 30877873] - Jonghwan Jegal, No-June Park, Tae-Young Kim, Sangho Choi, Sang Woo Lee, Jin Hang, Su-Nam Kim, Min Hye Yang. Effect of Topically Applied Wikstroemia dolichantha Diels on the Development of Atopic Dermatitis-Like Skin Symptoms in Mice.
Nutrients.
2019 Apr; 11(4):. doi:
10.3390/nu11040914. [PMID: 31018627] - Laura Ceballos, Candela Canton, Gabriela Cadenazzi, Guillermo Virkel, Paula Dominguez, Laura Moreno, Carlos Lanusse, Luis Alvarez. Oxfendazole kinetics in pigs: In vivo assessment of its pattern of accumulation in Ascaris suum.
Experimental parasitology.
2019 Apr; 199(?):52-58. doi:
10.1016/j.exppara.2019.02.017. [PMID: 30831078] - Yujiao Meng, Zhengrong Liu, Chunyan Zhai, Tingting Di, Lu Zhang, Lei Zhang, Xinran Xie, Yan Lin, Ning Wang, Jingxia Zhao, Yan Wang, Ping Li. Paeonol inhibits the development of 1‑chloro‑2,4‑dinitrobenzene‑induced atopic dermatitis via mast and T cells in BALB/c mice.
Molecular medicine reports.
2019 Apr; 19(4):3217-3229. doi:
10.3892/mmr.2019.9985. [PMID: 30816506] - Hye Ryeon Yang, Hyunkyoung Lee, Jong-Hyun Kim, Il-Hwa Hong, Du Hyeon Hwang, Il Rae Rho, Gon Sup Kim, Euikyung Kim, Changkeun Kang. Therapeutic Effect of Rumex japonicus Houtt. on DNCB-Induced Atopic Dermatitis-Like Skin Lesions in Balb/c Mice and Human Keratinocyte HaCaT Cells.
Nutrients.
2019 Mar; 11(3):. doi:
10.3390/nu11030573. [PMID: 30866501] - KyoHee Cho, Min Cheol Kang, Amna Parveen, Silvia Yumnam, Sun Yeou Kim. Anti-Inflammatory Effect of Chloroform Fraction of Pyrus Ussuriensis Maxim. Leaf Extract on 2, 4-Dinitrochlorobenzene-Induced Atopic Dermatitis in nc/nga Mice.
Nutrients.
2019 Jan; 11(2):. doi:
10.3390/nu11020276. [PMID: 30691219] - Kyung-Jae Cha, Ayesha Kashif, Min Hwa Hong, Geunyeong Kim, Ji-Sook Lee, In Sik Kim. Poncirus Trifoliata (L.) Raf. Extract Inhibits the Development of Atopic Dermatitis-like Lesions in Human Keratinocytes and NC/Nga mice.
International journal of medical sciences.
2019; 16(8):1116-1122. doi:
10.7150/ijms.34323. [PMID: 31523174] - Kyung-Jae Cha, Chang-Seob Song, Ji-Sook Lee, Ayesha Kashif, Min Hwa Hong, Geunyeong Kim, In Sik Kim. Chaenomeles sinensis Koehne extract suppresses the development of atopic dermatitis-like lesions by regulating cytokine and filaggrin expression in NC/Nga mice.
International journal of medical sciences.
2019; 16(12):1604-1613. doi:
10.7150/ijms.37854. [PMID: 31839748] - Guang-Wei Li, Xiu-Lin Chen, Xiang-Li Xu, Jun-Xiang Wu. Degradation of sex pheromone and plant volatile components by an antennal glutathione S-transferase in the oriental fruit moth,Grapholita molesta Busck (Lepidoptera: Tortricidae).
Archives of insect biochemistry and physiology.
2018 Dec; 99(4):e21512. doi:
10.1002/arch.21512. [PMID: 30387866] - Se Hyang Hong, Jin Mo Ku, Hyo In Kim, Sol Ji Lee, Ye Seul Lim, Hye Sook Seo, Yong Cheol Shin, Seong-Gyu Ko. Oral administration of Cervus nippon mantchuricus extract suppresses 2,4-dinitrochlorobenzene-induced atopic dermatitis in BALB/c mice and inflammatory effects in mast cells.
International journal of molecular medicine.
2018 Nov; 42(5):2961-2971. doi:
10.3892/ijmm.2018.3856. [PMID: 30226556] - Na-Ra Han, Phil-Dong Moon, Hyung-Min Kim, Hyun-Ja Jeong. Cordycepin ameliorates skin inflammation in a DNFB-challenged murine model of atopic dermatitis.
Immunopharmacology and immunotoxicology.
2018 Oct; 40(5):401-407. doi:
10.1080/08923973.2018.1510964. [PMID: 30183461]
