Azactam (BioDeep_00001870263)
Main id: BioDeep_00000006355
代谢物信息卡片
Urobactam
化学式: C13H17N5O8S2 (435.0518522)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(C(=O)N1S(=O)(=O)[O-])NC(=O)C(=NOC(C)(C)C(=O)O)C2=CSC(=[NH+]2)N
InChI: InChI=1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:161680
- KEGG: C06840
- KEGGdrug: D00240
- PubChem: 135398736
- DrugBank: DB00355
- MeSH: Monobactams
- MeSH: Aztreonam
- PubChem: 9058
- CAS: 78110-38-0
- NIKKAJI: J20.598B
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gabriela Kroneislová, Jan Závora, Vanda Gabriela Adámková, Anna Rýdlová, Václava Adámková. In vitro activity of antibiotics potentially effective against difficult-to-treat strains of Gram-negative rods: retrospective study.
Scientific reports.
2024 04; 14(1):8310. doi:
10.1038/s41598-024-59036-0. [PMID: 38594467] - Sun Miao, Yanyan Zhang, Cong Men, Yiou Mao, Jiane Zuo. A combined evaluation of the characteristics and antibiotic resistance induction potential of antibiotic wastewater during the treatment process.
Journal of environmental sciences (China).
2024 Apr; 138(?):626-636. doi:
10.1016/j.jes.2023.04.002. [PMID: 38135426] - Ruixian Guo, Xinyan Ma, Huibo Xu, Yuanyuan Ma, Rui Zhang, Xinyan Liu, Binan Lu, Jingpu Zhang, Ying Han. In silico prediction and a systematic toxicology-based in vivo investigation uncovering the mechanism of aquatic toxicity caused by beta-lactam antibiotics.
Chemosphere.
2024 Feb; 349(?):140884. doi:
10.1016/j.chemosphere.2023.140884. [PMID: 38065262] - Jiankang Zhao, Danni Pu, Ziyao Li, Xinmeng Liu, Yulin Zhang, Yongli Wu, Feilong Zhang, Chen Li, Xianxia Zhuo, Binghuai Lu, Bin Cao. In vitro activity of cefiderocol, a siderophore cephalosporin, against carbapenem-resistant hypervirulent Klebsiella pneumoniae in China.
Antimicrobial agents and chemotherapy.
2023 12; 67(12):e0073523. doi:
10.1128/aac.00735-23. [PMID: 38014944] - Jian-Guo Li, Xiao-Feng Chen, Ting-Yin Lu, Jing Zhang, Shu-He Dai, Jian Sun, Ya-Hong Liu, Xiao-Ping Liao, Yu-Feng Zhou. Increased Activity of β-Lactam Antibiotics in Combination with Carvacrol against MRSA Bacteremia and Catheter-Associated Biofilm Infections.
ACS infectious diseases.
2023 Dec; 9(12):2482-2493. doi:
10.1021/acsinfecdis.3c00338. [PMID: 38019707] - Lujie Liang, Lan-Lan Zhong, Lin Wang, Dianrong Zhou, Yaxin Li, Jiachen Li, Yong Chen, Wanfei Liang, Wenjing Wei, Chenchen Zhang, Hui Zhao, Lingxuan Lyu, Nicole Stoesser, Yohei Doi, Fang Bai, Siyuan Feng, Guo-Bao Tian. A new variant of the colistin resistance gene MCR-1 with co-resistance to β-lactam antibiotics reveals a potential novel antimicrobial peptide.
PLoS biology.
2023 Dec; 21(12):e3002433. doi:
10.1371/journal.pbio.3002433. [PMID: 38091366] - Hye-Ri Jung, Yu Jin Lee, Serim Hong, Sunghyun Yoon, Suk-Kyung Lim, Young Ju Lee. Current status of β-lactam antibiotic use and characterization of β-lactam-resistant Escherichia coli from commercial farms by integrated broiler chicken operations in Korea.
Poultry science.
2023 Dec; 102(12):103091. doi:
10.1016/j.psj.2023.103091. [PMID: 37839166] - Sayani Bhattacharyya. In vitro/In vivo Evaluation of Elastic Nano-lipid Carriers of Aztreonam for Pneumonic Lungs.
Pharmaceutical nanotechnology.
2023 Jun; 11(3):294-302. doi:
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European journal of medicinal chemistry.
2023 May; 257(?):115473. doi:
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Microbiology spectrum.
2023 Feb; 11(1):e0297822. doi:
10.1128/spectrum.02978-22. [PMID: 36602386] - Mohamed Abdel-Monem El-Sakhawy. Combinational Effect of Selected Medicinal Plants and Antibiotics Against Pathogenic Bacteria.
Pakistan journal of biological sciences : PJBS.
2023 Feb; 26(3):108-118. doi:
10.3923/pjbs.2023.108.118. [PMID: 37480267] - Yixin Kang, Lu Xie, Jiyong Yang, Junchang Cui. Optimal treatment of ceftazidime-avibactam and aztreonam-avibactam against bloodstream infections or lower respiratory tract infections caused by extensively drug-resistant or pan drug-resistant (XDR/PDR) Pseudomonas aeruginosa.
Frontiers in cellular and infection microbiology.
2023; 13(?):1023948. doi:
10.3389/fcimb.2023.1023948. [PMID: 37457958] - Muriel Masi, Julia Vergalli, Ishan Ghai, Andrea Barba-Bon, Thérèse Schembri, Werner M Nau, Daniel Lafitte, Mathias Winterhalter, Jean-Marie Pagès. Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane.
Communications biology.
2022 10; 5(1):1059. doi:
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Antimicrobial agents and chemotherapy.
2022 Jul; 66(7):e0059022. doi:
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Antimicrobial agents and chemotherapy.
2022 05; 66(5):e0240721. doi:
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European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2022 Apr; 41(4):573-580. doi:
10.1007/s10096-022-04408-5. [PMID: 35061145] - Yahui Li, Minghua Yuan, Dong Ding, Xiong Jiang, Qing Ye, Fujiang Guo. Isolation and structural characterization of eight impurities in aztreonam.
Journal of pharmaceutical and biomedical analysis.
2022 Feb; 210(?):114587. doi:
10.1016/j.jpba.2022.114587. [PMID: 35026590] - Anna Olsson, Marcus Hong, Hissa Al-Farsi, Christian G Giske, Pernilla Lagerbäck, Thomas Tängdén. Interactions of Polymyxin B in Combination with Aztreonam, Minocycline, Meropenem, and Rifampin against Escherichia coli Producing NDM and OXA-48-Group Carbapenemases.
Antimicrobial agents and chemotherapy.
2021 11; 65(12):e0106521. doi:
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Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
2021 11; 20(6):994-1002. doi:
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The Journal of antimicrobial chemotherapy.
2021 10; 76(11):2875-2883. doi:
10.1093/jac/dkab292. [PMID: 34383928] - Wen-Jung Lu, Pang-Hung Hsu, Hong-Ting Victor Lin. A Novel Cooperative Metallo-β-Lactamase Fold Metallohydrolase from Pathogen Vibrio vulnificus Exhibits β-Lactam Antibiotic-Degrading Activities.
Antimicrobial agents and chemotherapy.
2021 08; 65(9):e0032621. doi:
10.1128/aac.00326-21. [PMID: 34228542] - Punit J Shah, Thuytram Tran, Francis Emelogu, Farheen Tariq. Aztreonam, Ceftazidime/Avibactam, and Colistin Combination for the Management of Carbapenemase-Producing Klebsiella Pneumoniae Bacteremia: A Case Report.
Journal of pharmacy practice.
2021 Aug; 34(4):653-657. doi:
10.1177/0897190019882262. [PMID: 31698984] - Francesco Perrotta, Marco Paolo Perrini. Successful Treatment of Klebsiella pneumoniae NDM Sepsis and Intestinal Decolonization with Ceftazidime/Avibactam Plus Aztreonam Combination in a Patient with TTP Complicated by SARSCoV-2 Nosocomial Infection.
Medicina (Kaunas, Lithuania).
2021 Apr; 57(5):. doi:
10.3390/medicina57050424. [PMID: 33924769] - Eleonora Camilleri, Niccolò Maggini, Matteo Piccica, Annarita Botta, Daniela Poli. A rare case of prothrombin time prolongation.
Internal and emergency medicine.
2021 01; 16(1):237-239. doi:
10.1007/s11739-020-02408-x. [PMID: 32557092] - Andrew Billnitzer, Peter W Kaplan. Generalized Periodic Discharges With Triphasic Morphology in the Setting of Aztreonam Neurotoxicity.
Clinical EEG and neuroscience.
2021 Jan; 52(1):66-68. doi:
10.1177/1550059420917842. [PMID: 32401538] - Edurne Peña-Mendizabal, Sergi Morais, Ángel Maquieira. Boosting the sensitivity of in vitroβ-lactam allergy diagnostic tests.
Chemical communications (Cambridge, England).
2020 Oct; 56(80):11973-11976. doi:
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Scientific reports.
2020 09; 10(1):16037. doi:
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Antimicrobial agents and chemotherapy.
2020 09; 64(10):. doi:
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Biopharmaceutics & drug disposition.
2020 Jun; 41(6):248-267. doi:
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Journal of global antimicrobial resistance.
2020 06; 21(?):3-7. doi:
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2020 May; 23(2):171-177. doi:
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Antimicrobial agents and chemotherapy.
2019 09; 63(9):. doi:
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Antimicrobial agents and chemotherapy.
2019 04; 63(4):. doi:
10.1128/aac.02214-18. [PMID: 30642927] - Edyta Konecka, Joanna Mokracka, Sylwia Krzymińska, Adam Kaznowski. Evaluation of The Pathogenic Potential of Insecticidal Serratia marcescens Strains to Humans.
Polish journal of microbiology.
2019; 68(2):185-191. doi:
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The Journal of antimicrobial chemotherapy.
2019 01; 74(1):108-116. doi:
10.1093/jac/dky404. [PMID: 30325447] - Alan E Gross, Hongmei Xu, Diansong Zhou, Nidal Al-Huniti. Simplified Aztreonam Dosing in Patients with End-Stage Renal Disease: Results of a Monte Carlo Simulation.
Antimicrobial agents and chemotherapy.
2018 11; 62(11):. doi:
10.1128/aac.01066-18. [PMID: 30150467] - Wenxia Zhang, Yan Guo, Jiayin Li, Yiyuan Zhang, Yang Yang, Dong Dong, Demei Zhu, Ping He, Fupin Hu. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae.
Antimicrobial resistance and infection control.
2018; 7(?):142. doi:
10.1186/s13756-018-0435-9. [PMID: 30479755] - Barry J Plant, Damian G Downey, Joe A Eustace, Cedric Gunaratnam, Charles S Haworth, Andrew M Jones, Edward F McKone, Daniel G Peckham, R Ian Ketchell, Diana Bilton. A treatment evaluator tool to monitor the real-world effectiveness of inhaled aztreonam lysine in cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
2017 Nov; 16(6):695-701. doi:
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Antimicrobial agents and chemotherapy.
2017 08; 61(8):. doi:
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The Journal of antimicrobial chemotherapy.
2017 05; 72(5):1466-1468. doi:
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Journal of medicinal chemistry.
2017 04; 60(7):2669-2684. doi:
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Journal of clinical pharmacology.
2017 03; 57(3):336-344. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2016 Sep; 46(9):784-92. doi:
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Antimicrobial agents and chemotherapy.
2016 09; 60(9):5130-4. doi:
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Antimicrobial agents and chemotherapy.
2016 06; 60(6):3309-15. doi:
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Antimicrobial agents and chemotherapy.
2016 05; 60(5):3196-8. doi:
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BMC infectious diseases.
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Organic letters.
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Chemical research in toxicology.
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2012 Oct; 35(10):367-77. doi:
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American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2012 Jan; 69(2):107-15. doi:
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The Journal of allergy and clinical immunology.
2010 Nov; 126(5):994-9. doi:
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Diagnostic microbiology and infectious disease.
2009 Oct; 65(2):130-41. doi:
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Journal of clinical pharmacology.
2009 Jul; 49(7):816-23. doi:
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Journal of infection in developing countries.
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