Azactam (BioDeep_00001870263)
Main id: BioDeep_00000006355
代谢物信息卡片
Urobactam
化学式: C13H17N5O8S2 (435.0518522)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(C(=O)N1S(=O)(=O)[O-])NC(=O)C(=NOC(C)(C)C(=O)O)C2=CSC(=[NH+]2)N
InChI: InChI=1S/C13H17N5O8S2/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25)/b17-8-/t5-,7-/m0/s1
描述信息
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:161680
- KEGG: C06840
- KEGGdrug: D00240
- PubChem: 135398736
- DrugBank: DB00355
- MeSH: Monobactams
- MeSH: Aztreonam
- PubChem: 9058
- CAS: 78110-38-0
- NIKKAJI: J20.598B
- KNApSAcK: 161680
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gabriela Kroneislová, Jan Závora, Vanda Gabriela Adámková, Anna Rýdlová, Václava Adámková. In vitro activity of antibiotics potentially effective against difficult-to-treat strains of Gram-negative rods: retrospective study.
Scientific reports.
2024 04; 14(1):8310. doi:
10.1038/s41598-024-59036-0. [PMID: 38594467] - Sun Miao, Yanyan Zhang, Cong Men, Yiou Mao, Jiane Zuo. A combined evaluation of the characteristics and antibiotic resistance induction potential of antibiotic wastewater during the treatment process.
Journal of environmental sciences (China).
2024 Apr; 138(?):626-636. doi:
10.1016/j.jes.2023.04.002. [PMID: 38135426] - Ruixian Guo, Xinyan Ma, Huibo Xu, Yuanyuan Ma, Rui Zhang, Xinyan Liu, Binan Lu, Jingpu Zhang, Ying Han. In silico prediction and a systematic toxicology-based in vivo investigation uncovering the mechanism of aquatic toxicity caused by beta-lactam antibiotics.
Chemosphere.
2024 Feb; 349(?):140884. doi:
10.1016/j.chemosphere.2023.140884. [PMID: 38065262] - Jiankang Zhao, Danni Pu, Ziyao Li, Xinmeng Liu, Yulin Zhang, Yongli Wu, Feilong Zhang, Chen Li, Xianxia Zhuo, Binghuai Lu, Bin Cao. In vitro activity of cefiderocol, a siderophore cephalosporin, against carbapenem-resistant hypervirulent Klebsiella pneumoniae in China.
Antimicrobial agents and chemotherapy.
2023 12; 67(12):e0073523. doi:
10.1128/aac.00735-23. [PMID: 38014944] - Jian-Guo Li, Xiao-Feng Chen, Ting-Yin Lu, Jing Zhang, Shu-He Dai, Jian Sun, Ya-Hong Liu, Xiao-Ping Liao, Yu-Feng Zhou. Increased Activity of β-Lactam Antibiotics in Combination with Carvacrol against MRSA Bacteremia and Catheter-Associated Biofilm Infections.
ACS infectious diseases.
2023 Dec; 9(12):2482-2493. doi:
10.1021/acsinfecdis.3c00338. [PMID: 38019707] - Lujie Liang, Lan-Lan Zhong, Lin Wang, Dianrong Zhou, Yaxin Li, Jiachen Li, Yong Chen, Wanfei Liang, Wenjing Wei, Chenchen Zhang, Hui Zhao, Lingxuan Lyu, Nicole Stoesser, Yohei Doi, Fang Bai, Siyuan Feng, Guo-Bao Tian. A new variant of the colistin resistance gene MCR-1 with co-resistance to β-lactam antibiotics reveals a potential novel antimicrobial peptide.
PLoS biology.
2023 Dec; 21(12):e3002433. doi:
10.1371/journal.pbio.3002433. [PMID: 38091366] - Hye-Ri Jung, Yu Jin Lee, Serim Hong, Sunghyun Yoon, Suk-Kyung Lim, Young Ju Lee. Current status of β-lactam antibiotic use and characterization of β-lactam-resistant Escherichia coli from commercial farms by integrated broiler chicken operations in Korea.
Poultry science.
2023 Dec; 102(12):103091. doi:
10.1016/j.psj.2023.103091. [PMID: 37839166] - Sayani Bhattacharyya. In vitro/In vivo Evaluation of Elastic Nano-lipid Carriers of Aztreonam for Pneumonic Lungs.
Pharmaceutical nanotechnology.
2023 Jun; 11(3):294-302. doi:
10.2174/2211738511666230223141759. [PMID: 36815648] - Yu-Hang Yan, Hao-Sheng Ding, Kai-Rong Zhu, Bin-Song Mu, Yang Zheng, Meng-Yi Huang, Cong Zhou, Wen-Fang Li, Zhenling Wang, Yong Wu, Guo-Bo Li. Metal binding pharmacophore click-derived discovery of new broad-spectrum metallo-β-lactamase inhibitors.
European journal of medicinal chemistry.
2023 May; 257(?):115473. doi:
10.1016/j.ejmech.2023.115473. [PMID: 37209449] - Qiang Ma, Guilai Wang, Na Li, Xin Wang, Xinyun Kang, Yanni Mao, Guiqin Wang. Insights into the Effects and Mechanism of Andrographolide-Mediated Recovery of Susceptibility of Methicillin-Resistant Staphylococcus aureus to β-Lactam Antibiotics.
Microbiology spectrum.
2023 Feb; 11(1):e0297822. doi:
10.1128/spectrum.02978-22. [PMID: 36602386] - Mohamed Abdel-Monem El-Sakhawy. Combinational Effect of Selected Medicinal Plants and Antibiotics Against Pathogenic Bacteria.
Pakistan journal of biological sciences : PJBS.
2023 Feb; 26(3):108-118. doi:
10.3923/pjbs.2023.108.118. [PMID: 37480267] - Yixin Kang, Lu Xie, Jiyong Yang, Junchang Cui. Optimal treatment of ceftazidime-avibactam and aztreonam-avibactam against bloodstream infections or lower respiratory tract infections caused by extensively drug-resistant or pan drug-resistant (XDR/PDR) Pseudomonas aeruginosa.
Frontiers in cellular and infection microbiology.
2023; 13(?):1023948. doi:
10.3389/fcimb.2023.1023948. [PMID: 37457958] - Muriel Masi, Julia Vergalli, Ishan Ghai, Andrea Barba-Bon, Thérèse Schembri, Werner M Nau, Daniel Lafitte, Mathias Winterhalter, Jean-Marie Pagès. Cephalosporin translocation across enterobacterial OmpF and OmpC channels, a filter across the outer membrane.
Communications biology.
2022 10; 5(1):1059. doi:
10.1038/s42003-022-04035-y. [PMID: 36198902] - Keith A Rodvold, Mark H Gotfried, Vipul Gupta, Amanda Ek, Praveen Srivastava, Angela Talley, Jon Bruss. Plasma and Intrapulmonary Concentrations of Tebipenem following Oral Administration of Tebipenem Pivoxil Hydrobromide to Healthy Adult Subjects.
Antimicrobial agents and chemotherapy.
2022 Jul; 66(7):e0059022. doi:
10.1128/aac.00590-22. [PMID: 35762796] - Gina Patel, Keith A Rodvold, Vipul K Gupta, Jon Bruss, Leanne Gasink, Floni Bajraktari, Yang Lei, Akash Jain, Praveen Srivastava, Angela K Talley. Pharmacokinetics of Oral Tebipenem Pivoxil Hydrobromide in Subjects with Various Degrees of Renal Impairment.
Antimicrobial agents and chemotherapy.
2022 05; 66(5):e0240721. doi:
10.1128/aac.02407-21. [PMID: 35420493] - Gabriele Bianco, Matteo Boattini, Sara Comini, Roberto Casale, Marco Iannaccone, Rossana Cavallo, Cristina Costa. Occurrence of multi-carbapenemases producers among carbapenemase-producing Enterobacterales and in vitro activity of combinations including cefiderocol, ceftazidime-avibactam, meropenem-vaborbactam, and aztreonam in the COVID-19 era.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2022 Apr; 41(4):573-580. doi:
10.1007/s10096-022-04408-5. [PMID: 35061145] - Yahui Li, Minghua Yuan, Dong Ding, Xiong Jiang, Qing Ye, Fujiang Guo. Isolation and structural characterization of eight impurities in aztreonam.
Journal of pharmaceutical and biomedical analysis.
2022 Feb; 210(?):114587. doi:
10.1016/j.jpba.2022.114587. [PMID: 35026590] - Anna Olsson, Marcus Hong, Hissa Al-Farsi, Christian G Giske, Pernilla Lagerbäck, Thomas Tängdén. Interactions of Polymyxin B in Combination with Aztreonam, Minocycline, Meropenem, and Rifampin against Escherichia coli Producing NDM and OXA-48-Group Carbapenemases.
Antimicrobial agents and chemotherapy.
2021 11; 65(12):e0106521. doi:
10.1128/aac.01065-21. [PMID: 34516251] - Freddy Frost, Gregory R Young, Laura Wright, Nahida Miah, Darren L Smith, Craig Winstanley, Martin J Walshaw, Joanne L Fothergill, Dilip Nazareth. The clinical and microbiological utility of inhaled aztreonam lysine for the treatment of acute pulmonary exacerbations of cystic fibrosis: An open-label randomised crossover study (AZTEC-CF).
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
2021 11; 20(6):994-1002. doi:
10.1016/j.jcf.2020.12.012. [PMID: 33358119] - Kun Feng, Nan Jia, Peijuan Zhu, Serubbabel Sy, Yanfei Liu, Dandan Dong, Shixing Zhu, Jiayuan Zhang, Yuwei Liu, Frederico S Martins, Hugh Gong, Zhihua Lv, Mingming Yu, Sherwin K B Sy, Yuanqi Zhu. Aztreonam/avibactam effect on pharmacodynamic indices for mutant selection of Escherichia coli and Klebsiella pneumoniae harbouring serine- and New Delhi metallo-β-lactamases.
The Journal of antimicrobial chemotherapy.
2021 10; 76(11):2875-2883. doi:
10.1093/jac/dkab292. [PMID: 34383928] - Wen-Jung Lu, Pang-Hung Hsu, Hong-Ting Victor Lin. A Novel Cooperative Metallo-β-Lactamase Fold Metallohydrolase from Pathogen Vibrio vulnificus Exhibits β-Lactam Antibiotic-Degrading Activities.
Antimicrobial agents and chemotherapy.
2021 08; 65(9):e0032621. doi:
10.1128/aac.00326-21. [PMID: 34228542] - Punit J Shah, Thuytram Tran, Francis Emelogu, Farheen Tariq. Aztreonam, Ceftazidime/Avibactam, and Colistin Combination for the Management of Carbapenemase-Producing Klebsiella Pneumoniae Bacteremia: A Case Report.
Journal of pharmacy practice.
2021 Aug; 34(4):653-657. doi:
10.1177/0897190019882262. [PMID: 31698984] - Francesco Perrotta, Marco Paolo Perrini. Successful Treatment of Klebsiella pneumoniae NDM Sepsis and Intestinal Decolonization with Ceftazidime/Avibactam Plus Aztreonam Combination in a Patient with TTP Complicated by SARSCoV-2 Nosocomial Infection.
Medicina (Kaunas, Lithuania).
2021 Apr; 57(5):. doi:
10.3390/medicina57050424. [PMID: 33924769] - Eleonora Camilleri, Niccolò Maggini, Matteo Piccica, Annarita Botta, Daniela Poli. A rare case of prothrombin time prolongation.
Internal and emergency medicine.
2021 01; 16(1):237-239. doi:
10.1007/s11739-020-02408-x. [PMID: 32557092] - Andrew Billnitzer, Peter W Kaplan. Generalized Periodic Discharges With Triphasic Morphology in the Setting of Aztreonam Neurotoxicity.
Clinical EEG and neuroscience.
2021 Jan; 52(1):66-68. doi:
10.1177/1550059420917842. [PMID: 32401538] - Edurne Peña-Mendizabal, Sergi Morais, Ángel Maquieira. Boosting the sensitivity of in vitroβ-lactam allergy diagnostic tests.
Chemical communications (Cambridge, England).
2020 Oct; 56(80):11973-11976. doi:
10.1039/d0cc04903d. [PMID: 33033809] - Edurne Peña-Mendizabal, Sergi Morais, Ángel Maquieira. Neo-antigens for the serological diagnosis of IgE-mediated drug allergic reactions to antibiotics cephalosporin, carbapenem and monobactam.
Scientific reports.
2020 09; 10(1):16037. doi:
10.1038/s41598-020-73109-w. [PMID: 32994501] - Ying Sun, Xueyuan Liao, Zhigang Huang, Yaliu Xie, Yanbin Liu, Cuicui Ma, Boguang Jiang, Li Zhang, Yuhang Yan, Guobo Li, Xingjun Cheng, Qi Yin, Charles Z Ding, Liang Shen, Jian Li, Shuhui Chen, Yuquan Wei, Zhenling Wang, Xiawei Wei. Therapeutic Effect and Mechanisms of the Novel Monosulfactam 0073.
Antimicrobial agents and chemotherapy.
2020 09; 64(10):. doi:
10.1128/aac.00529-20. [PMID: 32718961] - Ling Song, Zhiheng Yu, Yifan Xu, Xiaobei Li, Xuanlin Liu, Dongyang Liu, Tianyan Zhou. Preliminary physiologically based pharmacokinetic modeling of renally cleared drugs in Chinese pregnant women.
Biopharmaceutics & drug disposition.
2020 Jun; 41(6):248-267. doi:
10.1002/bdd.2243. [PMID: 32520400] - Deepjyoti Paul, Debadatta Dhar Chanda, Atanu Chakravarty, Amitabha Bhattacharjee. An insight into analysis and elimination of plasmids encoding metallo-β-lactamases in Pseudomonas aeruginosa.
Journal of global antimicrobial resistance.
2020 06; 21(?):3-7. doi:
10.1016/j.jgar.2019.09.002. [PMID: 31518725] - David González, Eibhlin Gallagher, Teresa Zúñiga, José Leiva, Ana Isabel Vitas. Prevalence and characterization of β-lactamase-producing Enterobacteriaceae in healthy human carriers.
International microbiology : the official journal of the Spanish Society for Microbiology.
2020 May; 23(2):171-177. doi:
10.1007/s10123-019-00087-z. [PMID: 31218538] - Paul B Eckburg, Troy Lister, Susannah Walpole, Tim Keutzer, Luke Utley, John Tomayko, Ellen Kopp, Nicholas Farinola, Scott Coleman. Safety, Tolerability, Pharmacokinetics, and Drug Interaction Potential of SPR741, an Intravenous Potentiator, after Single and Multiple Ascending Doses and When Combined with β-Lactam Antibiotics in Healthy Subjects.
Antimicrobial agents and chemotherapy.
2019 09; 63(9):. doi:
10.1128/aac.00892-19. [PMID: 31262767] - W J Weiss, M E Pulse, P Nguyen, E J Growcott. In Vivo Efficacy of Novel Monobactam LYS228 in Murine Models of Carbapenemase-Producing Klebsiella pneumoniae Infection.
Antimicrobial agents and chemotherapy.
2019 04; 63(4):. doi:
10.1128/aac.02214-18. [PMID: 30642927] - Edyta Konecka, Joanna Mokracka, Sylwia Krzymińska, Adam Kaznowski. Evaluation of The Pathogenic Potential of Insecticidal Serratia marcescens Strains to Humans.
Polish journal of microbiology.
2019; 68(2):185-191. doi:
10.21307/pjm-2019-018. [PMID: 31257791] - E J Growcott, T A Cariaga, L Morris, X Zang, S Lopez, D A Ansaldi, J Gold, L Gamboa, T Roth, R L Simmons, C S Osborne. Pharmacokinetics and pharmacodynamics of the novel monobactam LYS228 in a neutropenic murine thigh model of infection.
The Journal of antimicrobial chemotherapy.
2019 01; 74(1):108-116. doi:
10.1093/jac/dky404. [PMID: 30325447] - Alan E Gross, Hongmei Xu, Diansong Zhou, Nidal Al-Huniti. Simplified Aztreonam Dosing in Patients with End-Stage Renal Disease: Results of a Monte Carlo Simulation.
Antimicrobial agents and chemotherapy.
2018 11; 62(11):. doi:
10.1128/aac.01066-18. [PMID: 30150467] - Wenxia Zhang, Yan Guo, Jiayin Li, Yiyuan Zhang, Yang Yang, Dong Dong, Demei Zhu, Ping He, Fupin Hu. In vitro and in vivo bactericidal activity of ceftazidime-avibactam against Carbapenemase-producing Klebsiella pneumoniae.
Antimicrobial resistance and infection control.
2018; 7(?):142. doi:
10.1186/s13756-018-0435-9. [PMID: 30479755] - Barry J Plant, Damian G Downey, Joe A Eustace, Cedric Gunaratnam, Charles S Haworth, Andrew M Jones, Edward F McKone, Daniel G Peckham, R Ian Ketchell, Diana Bilton. A treatment evaluator tool to monitor the real-world effectiveness of inhaled aztreonam lysine in cystic fibrosis.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society.
2017 Nov; 16(6):695-701. doi:
10.1016/j.jcf.2017.02.006. [PMID: 28392014] - Yusuke Yamanaka, Akira Shimabukuro. Septic abortion presenting as a right lower trapezius abscess secondary to Bacteroides fragilis bacteraemia.
BMJ case reports.
2017 Aug; 2017(?):. doi:
10.1136/bcr-2016-219135. [PMID: 28827296] - Mark E Obrenovich, MaryAnn Tima, Alex Polinkovsky, Renliang Zhang, Steven N Emancipator, Curtis J Donskey. Targeted Metabolomics Analysis Identifies Intestinal Microbiota-Derived Urinary Biomarkers of Colonization Resistance in Antibiotic-Treated Mice.
Antimicrobial agents and chemotherapy.
2017 08; 61(8):. doi:
10.1128/aac.00477-17. [PMID: 28584146] - Benjamin Davido, Aurelien Dinh, Olivia Senard, Ruxandra Calin, Sabrina Makhloufi, Jerome Salomon. Repurposing an old drug: aztreonam as a new treatment strategy for gonorrhoea.
The Journal of antimicrobial chemotherapy.
2017 05; 72(5):1466-1468. doi:
10.1093/jac/dkw589. [PMID: 28137938] - Liang Tan, Yunliang Tao, Ting Wang, Feng Zou, Shuhua Zhang, Qunhuan Kou, Ao Niu, Qian Chen, Wenjing Chu, Xiaoyan Chen, Haidong Wang, Yushe Yang. Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.
Journal of medicinal chemistry.
2017 04; 60(7):2669-2684. doi:
10.1021/acs.jmedchem.6b01261. [PMID: 28287720] - Hongmei Xu, Wangda Zhou, Diansong Zhou, Jianguo Li, Nidal Al-Huniti. Evaluation of Aztreonam Dosing Regimens in Patients With Normal and Impaired Renal Function: A Population Pharmacokinetic Modeling and Monte Carlo Simulation Analysis.
Journal of clinical pharmacology.
2017 03; 57(3):336-344. doi:
10.1002/jcph.810. [PMID: 27530649] - Nuggehally R Srinivas. Interspecies scaling of excretory amounts using allometry - retrospective analysis with rifapentine, aztreonam, carumonam, pefloxacin, miloxacin, trovafloxacin, doripenem, imipenem, cefozopran, ceftazidime, linezolid for urinary excretion and rifapentine, cabotegravir, and dolutegravir for fecal excretion.
Xenobiotica; the fate of foreign compounds in biological systems.
2016 Sep; 46(9):784-92. doi:
10.3109/00498254.2015.1121554. [PMID: 26711252] - Maria F Mojica, Christopher P Ouellette, Amy Leber, M Brian Becknell, Monica I Ardura, Federico Perez, Masako Shimamura, Robert A Bonomo, Samuel L Aitken, Samuel A Shelburne. Successful Treatment of Bloodstream Infection Due to Metallo-β-Lactamase-Producing Stenotrophomonas maltophilia in a Renal Transplant Patient.
Antimicrobial agents and chemotherapy.
2016 09; 60(9):5130-4. doi:
10.1128/aac.00264-16. [PMID: 27551008] - Marion Straubinger, Holger Blenk, Kurt G Naber, Florian M E Wagenlehner. Urinary Concentrations and Antibacterial Activity of BAL30072, a Novel Siderophore Monosulfactam, against Uropathogens after Intravenous Administration in Healthy Subjects.
Antimicrobial agents and chemotherapy.
2016 06; 60(6):3309-15. doi:
10.1128/aac.02425-15. [PMID: 26976871] - Sandrine Marchand, Nicolas Grégoire, Julien Brillault, Isabelle Lamarche, Patrice Gobin, William Couet. Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats. 4. Aztreonam.
Antimicrobial agents and chemotherapy.
2016 05; 60(5):3196-8. doi:
10.1128/aac.00165-16. [PMID: 26926626] - Debasish Kar, Samiran Bandyopadhyay, Debaraj Bhattacharyya, Indranil Samanta, Achintya Mahanti, Pramod K Nanda, Bimalendu Mondal, Premanshu Dandapat, Arun K Das, Tapan K Dutta, Subhasish Bandyopadhyay, Raj Kumar Singh. Molecular and phylogenetic characterization of multidrug resistant extended spectrum beta-lactamase producing Escherichia coli isolated from poultry and cattle in Odisha, India.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.
2015 Jan; 29(?):82-90. doi:
10.1016/j.meegid.2014.11.003. [PMID: 25445661] - Jann-Tay Wang, Pei-Chen Chen, Shan-Chwen Chang, Yih-Ru Shiau, Hui-Ying Wang, Jui-Fen Lai, I-Wen Huang, Mei-Chen Tan, Tsai-Ling Yang Lauderdale. Antimicrobial susceptibilities of Proteus mirabilis: a longitudinal nationwide study from the Taiwan surveillance of antimicrobial resistance (TSAR) program.
BMC infectious diseases.
2014 Sep; 14(?):486. doi:
10.1186/1471-2334-14-486. [PMID: 25192738] - Wen-Wu Sun, Pei Cao, Ren-Qiang Mei, Yue Li, Yuan-Liang Ma, Bin Wu. Palladium-catalyzed unactivated C(sp3)-H bond activation and intramolecular amination of carboxamides: a new approach to β-lactams.
Organic letters.
2014 Jan; 16(2):480-3. doi:
10.1021/ol403364k. [PMID: 24341538] - Matthew F Brown, Mark J Mitton-Fry, Joel T Arcari, Rose Barham, Jeffrey Casavant, Brian S Gerstenberger, Seungil Han, Joel R Hardink, Thomas M Harris, Thuy Hoang, Michael D Huband, Manjinder S Lall, M Megan Lemmon, Chao Li, Jian Lin, Sandra P McCurdy, Eric McElroy, Craig McPherson, Eric S Marr, John P Mueller, Lisa Mullins, Antonia A Nikitenko, Mark C Noe, Joseph Penzien, Mark S Plummer, Brandon P Schuff, Veerabahu Shanmugasundaram, Jeremy T Starr, Jianmin Sun, Andrew Tomaras, Jennifer A Young, Richard P Zaniewski. Pyridone-conjugated monobactam antibiotics with gram-negative activity.
Journal of medicinal chemistry.
2013 Jul; 56(13):5541-52. doi:
10.1021/jm400560z. [PMID: 23755848] - Rosalind E Jenkins, Fiazia S Yaseen, Manal M Monshi, Paul Whitaker, Xiaoli Meng, John Farrell, Jane Hamlett, Joseph P Sanderson, Sabah El-Ghaiesh, Daniel Peckham, Munir Pirmohamed, B Kevin Park, Dean J Naisbitt. β-Lactam antibiotics form distinct haptenic structures on albumin and activate drug-specific T-lymphocyte responses in multiallergic patients with cystic fibrosis.
Chemical research in toxicology.
2013 Jun; 26(6):963-75. doi:
10.1021/tx400124m. [PMID: 23668298] - Hans-Peter Lipp. [Revival of selected well-tried antibiotics. Special features of the antiinfective agents penicillin G, fosfomycin, aztreonam and colistin].
Medizinische Monatsschrift fur Pharmazeuten.
2012 Oct; 35(10):367-77. doi:
. [PMID: 23094579] - Kristen Zeitler, Brian Salvas, Vanessa Stevens, Jack Brown. Aztreonam lysine for inhalation: new formulation of an old antibiotic.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
2012 Jan; 69(2):107-15. doi:
10.2146/ajhp100624. [PMID: 22215356] - Antonino Romano, Francesco Gaeta, Rocco Luigi Valluzzi, Cristiano Caruso, Gabriele Rumi, Philippe Jean Bousquet. IgE-mediated hypersensitivity to cephalosporins: cross-reactivity and tolerability of penicillins, monobactams, and carbapenems.
The Journal of allergy and clinical immunology.
2010 Nov; 126(5):994-9. doi:
10.1016/j.jaci.2010.06.052. [PMID: 20888035] - Jürgen B Bulitta, Stephen B Duffull, Cornelia B Landersdorfer, Martina Kinzig, Ulrike Holzgrabe, Ulrich Stephan, George L Drusano, Fritz Sörgel. Comparison of the pharmacokinetics and pharmacodynamic profile of carumonam in cystic fibrosis patients and healthy volunteers.
Diagnostic microbiology and infectious disease.
2009 Oct; 65(2):130-41. doi:
10.1016/j.diagmicrobio.2009.06.018. [PMID: 19748423] - Shekman L Wong, Fritz Sörgel, Martina Kinzig, Michael R Goldberg, Michael M Kitt, Steven L Barriere. Lack of pharmacokinetic drug interactions following concomitant administration of telavancin with aztreonam or piperacillin/tazobactam in healthy participants.
Journal of clinical pharmacology.
2009 Jul; 49(7):816-23. doi:
10.1177/0091270009337133. [PMID: 19443680] - Daniel Marcano, Fernando Pasterán, Melina Rapoport, Diego Faccone, Carmen Ugarte, Nuris Salgado, Daisy Payares, Enza Spadola, Yoanna López, Graziela Maggi, Marcelo Galas, Damarys Sánchez. First isolation of a VIM-producing Klebsiella pneumoniae from a seven-year-old child in Venezuela.
Journal of infection in developing countries.
2008 Jun; 2(3):241-4. doi:
10.3855/jidc.270. [PMID: 19738358] - Hitoshi Kawazoe, Yoshiharu Takiguchi, Tatsuya Inoue, Kazunori Yamaguchi, Hiroaki Tanaka, Masato Kaji, Shigeko Tsuji, Masaki Ninomiya, Noriyasu Fukuoka, Hiroaki Ohnishi, Toshihiko Ishida, Hitoshi Houchi. [Infection treatment caused by multiple-drug-resistant Pseudomonas aeruginosa in a patient undergoing allogeneic hematopoietic stem cell transplantation].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2008 Apr; 128(4):657-61. doi:
10.1248/yakushi.128.657. [PMID: 18379184] - B J Denny, P W J West, T C Mathew. Antagonistic interactions between the flavonoids hesperetin and naringenin and beta-lactam antibiotics against Staphylococcus aureus.
British journal of biomedical science.
2008; 65(3):145-7. doi:
10.1080/09674845.2008.11732819. [PMID: 18986103] - Neelam Taneja, Pooja Rao, Jitender Arora, Ashok Dogra. Occurrence of ESBL & Amp-C beta-lactamases & susceptibility to newer antimicrobial agents in complicated UTI.
The Indian journal of medical research.
2008 Jan; 127(1):85-8. doi:
NULL. [PMID: 18316858] - George Z Retsch-Bogart, Jane L Burns, Kelly L Otto, Theodore G Liou, Karen McCoy, Christopher Oermann, Ronald L Gibson. A phase 2 study of aztreonam lysine for inhalation to treat patients with cystic fibrosis and Pseudomonas aeruginosa infection.
Pediatric pulmonology.
2008 Jan; 43(1):47-58. doi:
10.1002/ppul.20736. [PMID: 18041081] - Pang-Hsin Hsieh, Yu-Han Chang, Shih-Hao Chen, Steve W N Ueng, Chun-Hsiung Shih. High concentration and bioactivity of vancomycin and aztreonam eluted from Simplex cement spacers in two-stage revision of infected hip implants: a study of 46 patients at an average follow-up of 107 days.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society.
2006 Aug; 24(8):1615-21. doi:
10.1002/jor.20214. [PMID: 16788986] - Ronald L Gibson, George Z Retsch-Bogart, Christopher Oermann, Carlos Milla, Joseph Pilewski, Cori Daines, Richard Ahrens, Kevin Leon, Morty Cohen, Sharon McNamara, Tracy L Callahan, Richard Markus, Jane L Burns. Microbiology, safety, and pharmacokinetics of aztreonam lysinate for inhalation in patients with cystic fibrosis.
Pediatric pulmonology.
2006 Jul; 41(7):656-65. doi:
10.1002/ppul.20429. [PMID: 16703579] - Mario Perotti, Nicasio Mancini, Annalisa Cavallero, Silvia Carletti, Filippo Canducci, Roberto Burioni, Massimo Clementi. Quantitation of Bacillus clausii in biological samples by real-time polymerase chain reaction.
Journal of microbiological methods.
2006 Jun; 65(3):632-6. doi:
10.1016/j.mimet.2005.10.010. [PMID: 16318892] - Helio S Sader, Ronald N Jones. Comprehensive in vitro evaluation of cefepime combined with aztreonam or ampicillin/sulbactam against multi-drug resistant Pseudomonas aeruginosa and Acinetobacter spp.
International journal of antimicrobial agents.
2005 May; 25(5):380-4. doi:
10.1016/j.ijantimicag.2005.01.011. [PMID: 15848291] - Soichiro Kimura, Masaji Ishiguro, Yoshikazu Ishii, Jimena Alba, Keizo Yamaguchi. Role of a mutation at position 167 of CTX-M-19 in ceftazidime hydrolysis.
Antimicrobial agents and chemotherapy.
2004 May; 48(5):1454-60. doi:
10.1128/aac.48.5.1454-1460.2004. [PMID: 15105092] - Rajesh K Goel, Mohinder P Mahajan, Shrinivas K Kulkarni. Evaluation of anti-hyperglycemic activity of some novel monocyclic beta lactams.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2004 Apr; 7(1):80-3. doi:
NULL. [PMID: 15144739] - George Adamis, Maria G Papaioannou, Evangelos J Giamarellos-Bourboulis, Panayotis Gargalianos, John Kosmidis, Helen Giamarellou. Pharmacokinetic interactions of ceftazidime, imipenem and aztreonam with amikacin in healthy volunteers.
International journal of antimicrobial agents.
2004 Feb; 23(2):144-9. doi:
10.1016/j.ijantimicag.2003.07.001. [PMID: 15013039] - Rajiv Gupta, Shariq J Rauf, Sonali Singh, Jason Smith, Mahendra L Agraharkar. Sepsis in a renal transplant recipient due to Citrobacter braakii.
Southern medical journal.
2003 Aug; 96(8):796-8. doi:
10.1097/01.smj.0000051068.52066.e2. [PMID: 14515921] - Takeshi Yamaryo, Kazunori Oishi, Hiroyuki Yoshimine, Yoshiko Tsuchihashi, Kouji Matsushima, Tsuyoshi Nagatake. Fourteen-member macrolides promote the phosphatidylserine receptor-dependent phagocytosis of apoptotic neutrophils by alveolar macrophages.
Antimicrobial agents and chemotherapy.
2003 Jan; 47(1):48-53. doi:
10.1128/aac.47.1.48-53.2003. [PMID: 12499168] - Mar Marín, Francesc Gudiol. [beta-Lactam antibiotics].
Enfermedades infecciosas y microbiologia clinica.
2003 Jan; 21(1):42-55. doi:
10.1016/s0213-005x(03)72873-0. [PMID: 12550043] - Brad A Feltis, David A Lee, Gregory J Beilman. Mycotic aneurysm of the descending thoracic aorta caused by Pseudomonas aeruginosa in a solid organ transplant recipient: case report and review.
Surgical infections.
2002; 3(1):29-33. doi:
10.1089/109629602753681131. [PMID: 12593697] - S Colpaert, Z Liu, B De Greef, P Rutgeerts, J L Ceuppens, K Geboes. Effects of anti-tumour necrosis factor, interleukin-10 and antibiotic therapy in the indometacin-induced bowel inflammation rat model.
Alimentary pharmacology & therapeutics.
2001 Nov; 15(11):1827-36. doi:
10.1046/j.1365-2036.2001.01111.x. [PMID: 11683697] - P F Smith, C H Ballow, B M Booker, A Forrest, J J Schentag. Pharmacokinetics and pharmacodynamics of aztreonam and tobramycin in hospitalized patients.
Clinical therapeutics.
2001 Aug; 23(8):1231-44. doi:
10.1016/s0149-2918(01)80103-x. [PMID: 11558860] - P Voutsinas, E Kavouklis, D Voutsinas, K Kontoghiorgi, H Giamarellou. The effect of acetazolamide on the kinetics of four newer beta-lactams in the aqueous humor.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2001 Feb; 7(2):70-4. doi:
10.1046/j.1469-0691.2001.00205.x. [PMID: 11298145] - T Teshager, I A Herrero, M C Porrero, J Garde, M A Moreno, L Domínguez. Surveillance of antimicrobial resistance in Escherichia coli strains isolated from pigs at Spanish slaughterhouses.
International journal of antimicrobial agents.
2000 Jul; 15(2):137-42. doi:
10.1016/s0924-8579(00)00153-9. [PMID: 10854810] - M Pereira, M Perilli, E Mantengoli, F Luzzaro, A Toniolo, G M Rossolini, G Amicosante. PER-1 extended-spectrum beta-lactamase production in an Alcaligenes faecalis clinical isolate resistant to expanded-spectrum cephalosporins and monobactams from a hospital in Northern Italy.
Microbial drug resistance (Larchmont, N.Y.).
2000; 6(1):85-90. doi:
10.1089/mdr.2000.6.85. [PMID: 10868812] - T L Sisson, G L Jungbluth, N K Hopkins. A pharmacokinetic evaluation of concomitant administration of linezolid and aztreonam.
Journal of clinical pharmacology.
1999 Dec; 39(12):1277-82. doi:
10.1177/00912709922011962. [PMID: 10586394] - D S Burgess, K K Summers, T C Hardin. Pharmacokinetics and pharmacodynamics of aztreonam administered by continuous intravenous infusion.
Clinical therapeutics.
1999 Nov; 21(11):1882-9. doi:
10.1016/s0149-2918(00)86736-3. [PMID: 10890260] - E J Ernst, S Hashimoto, J Guglielmo, T Sawa, J F Pittet, H Kropp, J J Jackson, J P Wiener-Kronish. Effects of antibiotic therapy on Pseudomonas aeruginosa-induced lung injury in a rat model.
Antimicrobial agents and chemotherapy.
1999 Oct; 43(10):2389-94. doi:
10.1128/aac.43.10.2389. [PMID: 10508012] - A P MacGowan, K E Bowker. Continuous infusion of beta-lactam antibiotics.
Clinical pharmacokinetics.
1998 Nov; 35(5):391-402. doi:
10.2165/00003088-199835050-00004. [PMID: 9839090] - E S Moland, C C Sanders, K S Thomson. Can results obtained with commercially available MicroScan microdilution panels serve as an indicator of beta-lactamase production among escherichia coli and Klebsiella isolates with hidden resistance to expanded-spectrum cephalosporins and aztreonam?.
Journal of clinical microbiology.
1998 Sep; 36(9):2575-9. doi:
10.1128/jcm.36.9.2575-2579.1998. [PMID: 9705395] - P D Lister, W E Sanders, C C Sanders. Cefepime-aztreonam: a unique double beta-lactam combination for Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy.
1998 Jul; 42(7):1610-9. doi:
10.1128/aac.42.7.1610. [PMID: 9660993] - G Raponi, M C Ghezzi, M T Lun, C Mancini. Balance of proinflammatory and antiinflammatory cytokines in mice immunized with Escherichia coli and correlation with mortality after lethal challenge.
Medical microbiology and immunology.
1998 Jun; 187(1):11-6. doi:
10.1007/s004300050069. [PMID: 9749978] - M A Mercer-Jones, D J Hadjiminas, M Heinzelmann, J Peyton, M Cook, W G Cheadle. Continuous antibiotic treatment for experimental abdominal sepsis: effects on organ inflammatory cytokine expression and neutrophil sequestration.
The British journal of surgery.
1998 Mar; 85(3):385-9. doi:
10.1046/j.1365-2168.1998.00580.x. [PMID: 9529499] - A Fishman, M Chowers, M Altaras, Y Beyth, R Lang. Aztreonam plus piperacillin--empiric treatment of neutropenic fever in gynecology-oncology patients receiving cisplatin-based chemotherapy.
European journal of gynaecological oncology.
1998; 19(2):126-9. doi:
. [PMID: 9611050] - J Zapardiel, E Nieto, F Soriano. Evaluation of a new selective medium for the isolation of Corynebacterium urealyticum.
Journal of medical microbiology.
1998 Jan; 47(1):79-83. doi:
10.1099/00222615-47-1-79. [PMID: 9449953] - E E Cornwell, H Belzberg, T V Berne, M A Gill, D Theodorou, J W Kern, W Yu, J Asensio, D Demetriades. Pharmacokinetics of aztreonam in critically ill surgical patients.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.
1997 Mar; 54(5):537-40. doi:
10.1093/ajhp/54.5.537. [PMID: 9066861] - A Turcotte, M Simard, N J Morin, D Beauchamp, M G Bergeron. Differential distributions in tissues and efficacies of aztreonam and ceftazidime and in vivo bacterial morphological changes following treatment.
Antimicrobial agents and chemotherapy.
1997 Feb; 41(2):401-9. doi:
10.1128/aac.41.2.401. [PMID: 9021198] - F Soriano, P García-Corbeira, C Ponte, R Fernández-Roblas, I Gadea. Correlation of pharmacodynamic parameters of five beta-lactam antibiotics with therapeutic efficacies in an animal model.
Antimicrobial agents and chemotherapy.
1996 Dec; 40(12):2686-90. doi:
10.1128/aac.40.12.2686. [PMID: 9124823] - D S McKindley, B A Boucher, M M Hess, M A Croce, T C Fabian. Pharmacokinetics of aztreonam and imipenem in critically ill patients with pneumonia.
Pharmacotherapy.
1996 Sep; 16(5):924-31. doi:
NULL. [PMID: 8888088] - G Dufort, C Ventura, T Olivé, J J Ortega. Teicoplanin pharmacokinetics in pediatric patients.
The Pediatric infectious disease journal.
1996 Jun; 15(6):494-8. doi:
10.1097/00006454-199606000-00005. [PMID: 8783345] - D S McKindley, T C Fabian, B A Boucher, M A Croce, K G Proctor. Antibiotic pharmacokinetics following fluid resuscitation from traumatic shock.
Archives of surgery (Chicago, Ill. : 1960).
1995 Dec; 130(12):1321-8; discussion 1328. doi:
10.1001/archsurg.1995.01430120075012. [PMID: 7492281] - M Dan, D Zabeeda, F Poch. Comparative serum bactericidal activity against Pseudomonas aeruginosa of six antipseudomonal agents.
Chemotherapy.
1995 Sep; 41(5):323-9. doi:
10.1159/000239362. [PMID: 8521732] - A M Castelao, K Soto, J M Grinyó, S Gilvernet, D Serón, J Torras, L Riera, J M Cruzado, J Alsina. Prophylaxis of urinary tract infection in renal transplantation: comparison of three different protocols using ceftriaxone-cloxacillin, aztreonam-cloxacillin, or aztreonam-amoxycillin-clavulanic acid.
Transplantation proceedings.
1995 Aug; 27(4):2277-9. doi:
. [PMID: 7652804] - G Alván, C E Nord. Adverse effects of monobactams and carbapenems.
Drug safety.
1995 May; 12(5):305-13. doi:
10.2165/00002018-199512050-00003. [PMID: 7669260] - M Ford, J D Perry, F K Gould. Use of cephalexin-aztreonam-arabinose agar for selective isolation of Enterococcus faecium.
Journal of clinical microbiology.
1994 Dec; 32(12):2999-3001. doi:
10.1128/jcm.32.12.2999-3001.1994. [PMID: 7883889] - L V Friedrich, R L White, M B Kays, D S Burgess. Drug degradation during HPLC analysis of aztreonam: effect on pharmacokinetic parameter estimation.
The Annals of pharmacotherapy.
1994 Apr; 28(4):444-6. doi:
10.1177/106002809402800402. [PMID: 8038462]