Gabazine (BioDeep_00001869500)
Main id: BioDeep_00000009586
代谢物信息卡片
Gabazine
化学式: C15H17N3O3 (287.127)
中文名称: 1（6H）-哒嗪丁酸，6-亚氨基-3-（4-甲氧基苯基）
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC=C(C=C1)C2=NN(C(=N)C=C2)CCCC(=O)O
InChI: InChI=1S/C15H17N3O3/c1-21-12-6-4-11(5-7-12)13-8-9-14(16)18(17-13)10-2-3-15(19)20/h4-9,16H,2-3,10H2,1H3,(H,19,20)
描述信息
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018756 - GABA Antagonists
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:34968
- KEGG: C13796
- PubChem: 107896
- ChEMBL: CHEMBL32503
- CAS: 105538-73-6
- PubChem: 854041
- NIKKAJI: J331.170H
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Laura G Kammel, Weizheng Wei, Shekib A Jami, Rhonda R Voskuhl, Thomas J O'Dell. Enhanced GABAergic Tonic Inhibition Reduces Intrinsic Excitability of Hippocampal CA1 Pyramidal Cells in Experimental Autoimmune Encephalomyelitis.
Neuroscience.
2018 12; 395(?):89-100. doi:
10.1016/j.neuroscience.2018.11.003. [PMID: 30447391] - Damian M Cummings, Tiffanie A Benway, Hinze Ho, Angelo Tedoldi, Monica M Fernandes Freitas, Lion Shahab, Christina E Murray, Angela Richard-Loendt, Sebastian Brandner, Tammaryn Lashley, Dervis A Salih, Frances A Edwards. Neuronal and Peripheral Pentraxins Modify Glutamate Release and may Interact in Blood-Brain Barrier Failure.
Cerebral cortex (New York, N.Y. : 1991).
2017 06; 27(6):3437-3448. doi:
10.1093/cercor/bhx046. [PMID: 28334103] - Yonggang Gao, Jing-Jing Zhou, Yun Zhu, Therese Kosten, De-Pei Li. Chronic Unpredictable Mild Stress Induces Loss of GABA Inhibition in Corticotrophin-Releasing Hormone-Expressing Neurons through NKCC1 Upregulation.
Neuroendocrinology.
2017; 104(2):194-208. doi:
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Neuropharmacology.
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PloS one.
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The Journal of pharmacology and experimental therapeutics.
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2013 Mar; 33(11):4768-81. doi:
10.1523/jneurosci.5555-12.2013. [PMID: 23486948] - Hannah J Seong, Adam G Carter. D1 receptor modulation of action potential firing in a subpopulation of layer 5 pyramidal neurons in the prefrontal cortex.
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2012 Aug; 32(31):10516-21. doi:
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Nature neuroscience.
2009 Mar; 12(3):286-94. doi:
10.1038/nn.2265. [PMID: 19198604] - Guillermo Gonzalez-Burgos, Diana C Rotaru, Aleksey V Zaitsev, Nadezhda V Povysheva, David A Lewis. GABA transporter GAT1 prevents spillover at proximal and distal GABA synapses onto primate prefrontal cortex neurons.
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2009 Feb; 101(2):533-47. doi:
10.1152/jn.91161.2008. [PMID: 19073797] - France Rousseau, Karin R Aubrey, Stéphane Supplisson. The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Sep; 28(39):9755-68. doi:
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The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008 Jul; 28(29):7412-25. doi:
10.1523/jneurosci.0581-08.2008. [PMID: 18632945] - Ming-Kui Zhong, Zhen Shi, Li-Min Zhou, Juan Gao, Zhao-Hui Liao, Wei Wang, Xing-Ya Gao, Guo-Qing Zhu. Regulation of cardiac sympathetic afferent reflex by GABA(A) and GABA(B) receptors in paraventricular nucleus in rats.
The European journal of neuroscience.
2008 Jun; 27(12):3226-32. doi:
10.1111/j.1460-9568.2008.06261.x. [PMID: 18554298] - Christine M Pedroarena, Susanne Kamphausen. Glycinergic synaptic currents in the deep cerebellar nuclei.
Neuropharmacology.
2008 Apr; 54(5):784-95. doi:
10.1016/j.neuropharm.2007.12.005. [PMID: 18234240] - Ivan Marchionni, Azar Omrani, Enrico Cherubini. In the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cells.
The Journal of physiology.
2007 Jun; 581(Pt 2):515-28. doi:
10.1113/jphysiol.2006.125609. [PMID: 17317750] - Danka Pericić, Dubravka Svob Strac, Maja Jazvinsćak Jembrek, Josipa Vlainić. Allosteric uncoupling and up-regulation of benzodiazepine and GABA recognition sites following chronic diazepam treatment of HEK 293 cells stably transfected with alpha1beta2gamma2S subunits of GABA (A) receptors.
Naunyn-Schmiedeberg's archives of pharmacology.
2007 May; 375(3):177-87. doi:
10.1007/s00210-007-0152-z. [PMID: 17377772] - Marco Beato, Valeria Burzomato, Lucia G Sivilotti. The kinetics of inhibition of rat recombinant heteromeric alpha1beta glycine receptors by the low-affinity antagonist SR-95531.
The Journal of physiology.
2007 Apr; 580(Pt 1):171-9. doi:
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Diabetes.
2007 Feb; 56(2):320-7. doi:
10.2337/db06-0712. [PMID: 17259375] - Melissa R McCartney, Tarek Z Deeb, Tricia N Henderson, Tim G Hales. Tonically active GABAA receptors in hippocampal pyramidal neurons exhibit constitutive GABA-independent gating.
Molecular pharmacology.
2007 Feb; 71(2):539-48. doi:
10.1124/mol.106.028597. [PMID: 17090706] - Euguenia Bouairi, Harriet Kamendi, Xin Wang, Christopher Gorini, David Mendelowitz. Multiple types of GABAA receptors mediate inhibition in brain stem parasympathetic cardiac neurons in the nucleus ambiguus.
Journal of neurophysiology.
2006 Dec; 96(6):3266-72. doi:
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European journal of pharmacology.
2006 Jan; 530(1-2):15-22. doi:
10.1016/j.ejphar.2005.11.048. [PMID: 16375888] - Adriana Galvan, Rosa M Villalba, Sara M West, Nigel T Maidment, Larry C Ackerson, Yoland Smith, Thomas Wichmann. GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters.
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The Journal of experimental biology.
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