m-Chlorophenylbiguanide (BioDeep_00001869222)
Main id: BioDeep_00000009493
代谢物信息卡片
m-Chlorophenylbiguanide
化学式: C8H10ClN5 (211.0625)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=CC(=C1)Cl)N=C(N)N=C(N)N
InChI: InChI=1S/C8H10ClN5/c9-5-2-1-3-6(4-5)13-8(12)14-7(10)11/h1-4H,(H6,10,11,12,13,14)
描述信息
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
D007004 - Hypoglycemic Agents > D001645 - Biguanides
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:32347
- KEGG: C13646
- PubChem: 1354
- ChEMBL: CHEMBL13790
- CAS: 48144-44-1
- PubChem: 586256
- NIKKAJI: J341.557K
- KNApSAcK: 32347
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Saeed Amiri Gheshlaghi, Razieh Mohammad Jafari, Mohammad Algazo, Nastaran Rahimi, Hussein Alshaib, Ahmad Reza Dehpour. Genistein modulation of seizure: involvement of estrogen and serotonin receptors.
Journal of natural medicines.
2017 Jul; 71(3):537-544. doi:
10.1007/s11418-017-1088-3. [PMID: 28439683] - Yoshiyuki Kimura, Maho Sumiyoshi. Effects of an Atractylodes lancea rhizome extract and a volatile component β-eudesmol on gastrointestinal motility in mice.
Journal of ethnopharmacology.
2012 May; 141(1):530-6. doi:
10.1016/j.jep.2012.02.031. [PMID: 22374082] - Koilmani Emmanuvel Rajan, Hemant K Singh, Arunagiri Parkavi, Prisila Dulcy Charles. Attenuation of 1-(m-chlorophenyl)-biguanide induced hippocampus-dependent memory impairment by a standardised extract of Bacopa monniera (BESEB CDRI-08).
Neurochemical research.
2011 Nov; 36(11):2136-44. doi:
10.1007/s11064-011-0538-7. [PMID: 21735137] - Irina P Voronova, Vladimir S Naumenko, Galina M Khramova, Tamara V Kozyreva, Nina K Popova. Central 5-HT3 receptor-induced hypothermia is associated with reduced metabolic rate and increased heat loss.
Neuroscience letters.
2011 Oct; 504(3):209-14. doi:
10.1016/j.neulet.2011.09.024. [PMID: 21964386] - Asunción Morán, Ana-Vega Ortiz de Urbina, María-Luisa Martín, Alicia Rodríguez-Barbero, Luis San Román. Characterization of the contractile 5-hydroxytryptamine receptor in the autoperfused kidney of L-NAME hypertensive rats.
European journal of pharmacology.
2009 Oct; 620(1-3):90-6. doi:
10.1016/j.ejphar.2009.08.026. [PMID: 19699736] - Daniele G Machado, Luis E B Bettio, Mauricio P Cunha, Juliano C Capra, Juliana B Dalmarco, Moacir G Pizzolatti, Ana Lúcia S Rodrigues. Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system.
Progress in neuro-psychopharmacology & biological psychiatry.
2009 Jun; 33(4):642-50. doi:
10.1016/j.pnpbp.2009.03.004. [PMID: 19286446] - Ashraf A Rahman, Maha Khalifa Daoud, Małgorzata Dukat, Katharine Herrick-Davis, Anil Purohit, Milt Teitler, Antonia Taveres do Amaral, Alberto Malvezzi, Richard A Glennon. Conformationally-restricted analogues and partition coefficients of the 5-HT3 serotonin receptor ligands meta-chlorophenylbiguanide (mCPBG) and meta-chlorophenylguanidine (mCPG).
Bioorganic & medicinal chemistry letters.
2003 Mar; 13(6):1119-23. doi:
10.1016/s0960-894x(03)00044-1. [PMID: 12643925] - C A Brady, I M Stanford, I Ali, L Lin, J M Williams, A E Dubin, A G Hope, N M Barnes. Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors.
Neuropharmacology.
2001 Aug; 41(2):282-4. doi:
10.1016/s0028-3908(01)00074-0. [PMID: 11489465] - S Mochizuki, T Watanabe, A Miyake, M Saito, K Furuichi. Cloning, expression, and characterization of ferret 5-HT(3) receptor subunit.
European journal of pharmacology.
2000 Jul; 399(2-3):97-106. doi:
10.1016/s0014-2999(00)00371-x. [PMID: 10884508] - A D Spier, S C Lummis. The role of tryptophan residues in the 5-Hydroxytryptamine(3) receptor ligand binding domain.
The Journal of biological chemistry.
2000 Feb; 275(8):5620-5. doi:
10.1074/jbc.275.8.5620. [PMID: 10681544] - A C Hargreaves, M J Gunthorpe, C W Taylor, S C Lummis. Direct inhibition of 5-hydroxytryptamine3 receptors by antagonists of L-type Ca2+ channels.
Molecular pharmacology.
1996 Nov; 50(5):1284-94. doi:
. [PMID: 8913360] - A G Hope, J A Peters, A M Brown, J J Lambert, T P Blackburn. Characterization of a human 5-hydroxytryptamine3 receptor type A (h5-HT3R-AS) subunit stably expressed in HEK 293 cells.
British journal of pharmacology.
1996 Jul; 118(5):1237-45. doi:
10.1111/j.1476-5381.1996.tb15529.x. [PMID: 8818349] - A Miyake, S Mochizuki, Y Takemoto, S Akuzawa. Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.
Molecular pharmacology.
1995 Sep; 48(3):407-16. doi:
. [PMID: 7565620] - A D Campbell, D E Womer, J R Simon. The 5-HT3 receptor agonist 1-(m-chlorophenyl)-biguanide interacts with the dopamine transporter in rat brain synaptosomes.
European journal of pharmacology.
1995 Jul; 290(2):157-62. doi:
10.1016/0922-4106(95)90029-2. [PMID: 8575531] - J A Richter, D J Bare, H Yu, B Ghetti, J R Simon. Dopamine transporter-dependent and -independent endogenous dopamine release from weaver mouse striatum in vitro.
Journal of neurochemistry.
1995 Jan; 64(1):191-8. doi:
10.1046/j.1471-4159.1995.64010191.x. [PMID: 7798913] - A C Hargreaves, S C Lummis, C W Taylor. Ca2+ permeability of cloned and native 5-hydroxytryptamine type 3 receptors.
Molecular pharmacology.
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