THIORPHAN (BioDeep_00001868906)

Main id: BioDeep_00000004725

 


代谢物信息卡片


THIORPHAN

化学式: C12H15NO3S (253.0773)
中文名称: 3-巯基-2苄基丙基甘氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C=C1)CC(CS)C(=O)NCC(=O)O
InChI: InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)

描述信息

D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors

同义名列表

2 个代谢物同义名

THIORPHAN; Thiorphan



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ACE, ADM, ALB, ANPEP, EDN1, MME, NPPA, POMC
Endosome membrane 1 ECE1
Nucleus 1 ALB
cytosol 1 ALB
dendrite 2 MME, PDYN
trans-Golgi network 1 MME
centrosome 1 ALB
Cell membrane 5 ACE, ANPEP, ECE1, MME, OPRD1
Multi-pass membrane protein 1 OPRD1
Synapse 3 MME, PDYN, TAC1
cell surface 1 MME
Golgi apparatus 1 ALB
Golgi membrane 1 INS
lysosomal membrane 2 ANPEP, ECE1
neuronal cell body 3 MME, PDYN, TAC1
presynaptic membrane 1 OPRD1
synaptic vesicle 1 MME
Cytoplasmic vesicle, secretory vesicle 1 NTS
Lysosome 1 ACE
Presynapse 1 MME
endosome 2 ACE, ECE1
plasma membrane 9 ACE, ANPEP, CD160, ECE1, KNG1, MME, OPRD1, PDYN, REN
synaptic vesicle membrane 1 OPRD1
Membrane 5 ACE, ECE1, MME, OPRD1, REN
axon 2 MME, TAC1
brush border 1 MME
extracellular exosome 7 ACE, ALB, ANPEP, CPVL, ECE1, KNG1, MME
endoplasmic reticulum 1 ALB
extracellular space 13 ACE, ADM, ALB, ANPEP, EDN1, EDN3, INS, KNG1, NPPA, POMC, REN, TAC1, TAC3
perinuclear region of cytoplasm 1 ECE1
protein-containing complex 2 ALB, NPPA
intracellular membrane-bounded organelle 1 NTS
Single-pass type I membrane protein 1 ACE
Secreted 11 ACE, ADM, ALB, EDN1, EDN3, INS, NPPA, NTS, PDYN, POMC, REN
extracellular region 15 ACE, ADM, ALB, CD160, EDN1, EDN3, INS, KNG1, NPPA, NTS, PDYN, POMC, REN, TAC1, TAC3
basal part of cell 1 EDN1
hippocampal mossy fiber to CA3 synapse 1 PDYN
anchoring junction 1 ALB
external side of plasma membrane 3 ACE, ANPEP, ECE1
perikaryon 1 NPPA
cytoplasmic vesicle 1 MME
Early endosome 2 ECE1, MME
apical part of cell 1 REN
Single-pass type II membrane protein 3 ANPEP, ECE1, MME
vesicle 1 ECE1
Membrane raft 1 MME
focal adhesion 1 MME
collagen-containing extracellular matrix 2 KNG1, NPPA
secretory granule 1 POMC
neuron projection 1 OPRD1
ciliary basal body 1 ALB
cell projection 1 NPPA
centriole 1 ALB
Secreted, extracellular space 1 KNG1
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 2 ALB, KNG1
sperm midpiece 1 ACE
Lipid-anchor, GPI-anchor 1 CD160
endosome lumen 1 INS
side of membrane 1 CD160
basal plasma membrane 1 ACE
secretory granule lumen 2 INS, POMC
secretory granule membrane 2 ANPEP, MME
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, INS, KNG1
platelet alpha granule lumen 2 ALB, KNG1
axon terminus 3 NTS, OPRD1, PDYN
transport vesicle 3 EDN1, INS, NTS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 2 OPRD1, PDYN
endoplasmic reticulum-Golgi intermediate compartment 1 ANPEP
dendrite membrane 1 OPRD1
[CD160 antigen]: Cell membrane 1 CD160
[Long-acting natriuretic peptide]: Secreted 1 NPPA
[Vessel dilator]: Secreted 1 NPPA
[Kaliuretic peptide]: Secreted 1 NPPA
[Urodilatin]: Secreted 1 NPPA
[Atrial natriuretic peptide]: Secreted 1 NPPA
[Atriopeptin-3]: Secreted 1 NPPA
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 2 ECE1, EDN1
neuron projection terminus 1 MME
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
spine apparatus 1 OPRD1
ciliary transition fiber 1 ALB


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Lan Li, Chenlin Shen, Lian Tang, Yanxia Yu, Qin Zhou, Xiaohui Huang, Sudong Xue. Determination of thiorphan, a racecadotril metabolite, in human plasma by LC-MS/MS and its application to a bioequivalence study in Chinese subjects
. International journal of clinical pharmacology and therapeutics. 2020 Jul; 58(7):408-414. doi: 10.5414/cp203588. [PMID: 32352368]
  • Peter Serfozo, Jan Wysocki, Gvantca Gulua, Arndt Schulze, Minghao Ye, Pan Liu, Jing Jin, Michael Bader, Timo Myöhänen, J Arturo García-Horsman, Daniel Batlle. Ang II (Angiotensin II) Conversion to Angiotensin-(1-7) in the Circulation Is POP (Prolyloligopeptidase)-Dependent and ACE2 (Angiotensin-Converting Enzyme 2)-Independent. Hypertension (Dallas, Tex. : 1979). 2020 01; 75(1):173-182. doi: 10.1161/hypertensionaha.119.14071. [PMID: 31786979]
  • Vajir Malek, Nisha Sharma, Anil Bhanudas Gaikwad. Simultaneous inhibition of neprilysin and activation of ACE2 prevented diabetic cardiomyopathy. Pharmacological reports : PR. 2019 Oct; 71(5):958-967. doi: 10.1016/j.pharep.2019.05.008. [PMID: 31470292]
  • Vajir Malek, Nisha Sharma, Himanshu Sankrityayan, Anil Bhanudas Gaikwad. Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy. Life sciences. 2019 Mar; 221(?):159-167. doi: 10.1016/j.lfs.2019.02.027. [PMID: 30769114]
  • R Murray McKinnell, Paul Fatheree, Seok-Ki Choi, Roland Gendron, Keith Jendza, Brooke Olson Blair, Joe Budman, Craig M Hill, Laxminarayan G Hegde, Cecile Yu, Donavon McConn, Sharath S Hegde, Daniel G Marquess, Uwe Klein. Discovery of TD-0212, an Orally Active Dual Pharmacology AT1 Antagonist and Neprilysin Inhibitor (ARNI). ACS medicinal chemistry letters. 2019 Jan; 10(1):86-91. doi: 10.1021/acsmedchemlett.8b00462. [PMID: 30655952]
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  • Oliver Domenig, Arndt Manzel, Nadja Grobe, Eva Königshausen, Christopher C Kaltenecker, Johannes J Kovarik, Johannes Stegbauer, Susan B Gurley, Dunja van Oyen, Marlies Antlanger, Michael Bader, Daisy Motta-Santos, Robson A Santos, Khalid M Elased, Marcus D Säemann, Ralf A Linker, Marko Poglitsch. Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney. Scientific reports. 2016 09; 6(?):33678. doi: 10.1038/srep33678. [PMID: 27649628]
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  • Lodi C W Roksnoer, Richard van Veghel, René de Vries, Ingrid M Garrelds, Usha M Bhaggoe, Edith C H Friesema, Frank P J Leijten, Marko Poglitsch, Oliver Domenig, Marian C Clahsen-van Groningen, Ewout J Hoorn, A H Jan Danser, Wendy W Batenburg. Optimum AT1 receptor-neprilysin inhibition has superior cardioprotective effects compared with AT1 receptor blockade alone in hypertensive rats. Kidney international. 2015 Jul; 88(1):109-20. doi: 10.1038/ki.2015.107. [PMID: 25830765]
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  • Kanetaka Maeshiro, Shinzo Takamori, Hiroharu Mifune, Toshihiro Matsuo, Norman Y Kimura, Junichi Honda, Kazuo Shirouzu. Changes in A-type natriuretic peptide and its receptors induced by a neutral endopeptidase inhibitor in a rat model of sepsis. Surgery today. 2008; 38(2):130-4. doi: 10.1007/s00595-007-3586-5. [PMID: 18239869]
  • Fan Xu, Lingli Yang, Guili Xu. A rapid and validated HPLC method to quantify racecadotril metabolite, thiorphan, in human plasma using solid-phase extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2008 Jan; 861(1):130-5. doi: 10.1016/j.jchromb.2007.11.038. [PMID: 18083074]
  • Yu Xu, Jinchang Huang, Fei Liu, Shu Gao, Qingxiang Guo. Quantitative analysis of racecadotril metabolite in human plasma using a liquid chromatography/tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Jun; 852(1-2):101-7. doi: 10.1016/j.jchromb.2006.12.041. [PMID: 17241825]
  • Giovanni Sansoè, Manuela Aragno, Raffaella Mastrocola, Francesca Restivo, Giulio Mengozzi, Antonina Smedile, Floriano Rosina, Oliviero Danni, Maurizio Parola, Mario Rizzetto. Neutral endopeptidase (EC 3.4.24.11) in cirrhotic liver: a new target to treat portal hypertension?. Journal of hepatology. 2005 Nov; 43(5):791-8. doi: 10.1016/j.jhep.2005.04.017. [PMID: 16085334]
  • Christoph Schmid, Claudia Ghirlanda-Keller, Martina Gosteli-Peter. Ascorbic acid decreases neutral endopeptidase activity in cultured osteoblastic cells. Regulatory peptides. 2005 Aug; 130(1-2):57-66. doi: 10.1016/j.regpep.2005.03.007. [PMID: 15908023]
  • Marie-Hélène Fecteau, Jean-Claude Honoré, Mirco Plante, Julie Labonté, Giles A Rae, Pedro D'Orléans-Juste. Endothelin-1 (1-31) is an intermediate in the production of endothelin-1 after big endothelin-1 administration in vivo. Hypertension (Dallas, Tex. : 1979). 2005 Jul; 46(1):87-92. doi: 10.1161/01.hyp.0000170460.24604.23. [PMID: 15956117]
  • Anthony C Sulpizio, Mark A Pullen, Richard M Edwards, David P Brooks. The effect of acute angiotensin-converting enzyme and neutral endopeptidase 24.11 inhibition on plasma extravasation in the rat. The Journal of pharmacology and experimental therapeutics. 2004 Jun; 309(3):1141-7. doi: 10.1124/jpet.103.064105. [PMID: 14769834]
  • Catherine Rougeot, Michaël Messaoudi, Véronique Hermitte, Anne Gaëlle Rigault, Thierry Blisnick, Christophe Dugave, Didier Desor, François Rougeon. Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity. Proceedings of the National Academy of Sciences of the United States of America. 2003 Jul; 100(14):8549-54. doi: 10.1073/pnas.1431850100. [PMID: 12835417]
  • K S Park, Y Li, Y Zhang, A L Gerbes, H Liu, M G Swain, S S Lee. Effects of the neutral endopeptidase inhibitor thiorphan on cardiovascular and renal function in cirrhotic rats. British journal of pharmacology. 2003 May; 139(1):81-8. doi: 10.1038/sj.bjp.0705219. [PMID: 12746226]
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  • François Piquard, Ruddy Richard, Anne Charloux, Stephane Doutreleau, Thierry Hannedouche, Gabrielle Brandenberger, Bernard Geny. Hormonal, renal, hemodynamic responses to acute neutral endopeptidase inhibition in heart transplant patients. Journal of applied physiology (Bethesda, Md. : 1985). 2002 Aug; 93(2):569-75. doi: 10.1152/japplphysiol.00027.2002. [PMID: 12133866]
  • A Chevrier, J S Mort, P Crine, C D Hoemann, M D Buschmann. Soluble recombinant neprilysin induces aggrecanase-mediated cleavage of aggrecan in cartilage explant cultures. Archives of biochemistry and biophysics. 2001 Dec; 396(2):178-86. doi: 10.1006/abbi.2001.2608. [PMID: 11747295]
  • G Capasso, R Unwin, F Ciani, A Rizzo, F Russo, A Pica, N G De Santo. Inhibition of neutral endopeptidase potentiates the effects of atrial natriuretic peptide on acute cyclosporin-induced nephrotoxicity. Nephron. 2000 Nov; 86(3):298-305. doi: 10.1159/000045785. [PMID: 11096287]
  • E Salazar-Lindo, J Santisteban-Ponce, E Chea-Woo, M Gutierrez. Racecadotril in the treatment of acute watery diarrhea in children. The New England journal of medicine. 2000 Aug; 343(7):463-7. doi: 10.1056/nejm200008173430703. [PMID: 10944563]
  • G Freyer, P Rougier, R Bugat, J P Droz, M Marty, H Bleiberg, D Mignard, L Awad, P Herait, S Culine, V Trillet-Lenoir. Prognostic factors for tumour response, progression-free survival and toxicity in metastatic colorectal cancer patients given irinotecan (CPT-11) as second-line chemotherapy after 5FU failure. CPT-11 F205, F220, F221 and V222 study groups. British journal of cancer. 2000 Aug; 83(4):431-7. doi: 10.1054/bjoc.2000.1303. [PMID: 10945486]
  • Y Takeda, S Inaba, K Furukawa, A Fujimura, I Miyamori, H Mabuchi. Effects of chronic neutral endopeptidase inhibition in rats with cyclosporine-induced hypertension. Journal of hypertension. 2000 Jul; 18(7):927-33. doi: 10.1097/00004872-200018070-00015. [PMID: 10930191]
  • P Solter, D Sisson, W Thomas, L Goetze. Intrarenal effects of ecadotril during acute volume expansion in dogs with congestive heart failure. The Journal of pharmacology and experimental therapeutics. 2000 Jun; 293(3):989-95. doi: NULL. [PMID: 10869402]
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  • M B Pamnani, S Chen, H J Bryant, J F Schooley, F J Haddy, R D Ghai. Effects of a neutral endoprotease enzyme inhibitor, thiorphan, on hemodynamics and renal excretory function in four models of experimental hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993). 2000 Jan; 22(1):45-62. doi: 10.1081/ceh-100100061. [PMID: 10685724]
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