Arbaclofen (BioDeep_00001868423)

Main id: BioDeep_00000001426

 


代谢物信息卡片


(R)-Baclofen

化学式: C10H12ClNO2 (213.0557)
中文名称: (R)-巴氯芬(mM/ml)
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CC=C1C(CC(=O)O)CN)Cl
InChI: InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)/t8-/m0/s1

描述信息

C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant
(R)-Baclofen (Arbaclofen) is a selective GABAB receptor agonist[1].

同义名列表

3 个代谢物同义名

(R)-Baclofen; Arbaclofen; STX209



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CA1, CA3, FMR1, GABBR2, GRM5, GTPBP4, IKBKG, ITPR3
Endoplasmic reticulum membrane 3 GABBR1, GJB1, ITPR3
Nucleus 4 CDCA4, FMR1, GTPBP4, IKBKG
cytosol 8 CA1, CA3, CDCA4, FMR1, GTPBP4, IKBKG, PRKCQ, SST
dendrite 2 FMR1, GRM5
mitochondrial membrane 1 GABBR1
nucleoplasm 6 CD2, CDCA4, FMR1, GTPBP4, IKBKG, ITPR3
Cell membrane 7 CD2, FMR1, GABBR1, GABBR2, GJB1, GRID1, GRM5
Cell projection, axon 1 FMR1
Cell projection, growth cone 1 FMR1
Multi-pass membrane protein 8 CACNA1I, GABBR1, GABBR2, GJB1, GRID1, GRM5, ITPR3, KCNA3
Synapse 2 FMR1, TAC1
cell surface 1 CD2
dendritic shaft 2 GABBR1, GRM5
glutamatergic synapse 4 GABBR1, GRID1, GRM5, KCNA3
Golgi apparatus 1 CD2
growth cone 1 FMR1
neuronal cell body 5 GABBR1, GRM5, ITPR3, SST, TAC1
postsynapse 2 FMR1, GRM5
presynaptic membrane 3 FMR1, GABBR1, KCNA3
synaptic vesicle 1 GABBR1
Presynapse 1 FMR1
plasma membrane 10 CACNA1I, CD2, CDCA4, GABBR1, GABBR2, GRID1, GRM5, ITPR3, KCNA3, PRKCQ
Membrane 8 CACNA1I, FMR1, GABBR1, GABBR2, GRM5, GTPBP4, ITPR3, KCNA3
axon 4 CCK, FMR1, KCNA3, TAC1
brush border 1 ITPR3
extracellular exosome 2 CA1, GRID1
endoplasmic reticulum 1 ITPR3
extracellular space 4 CCK, GABBR1, SST, TAC1
perinuclear region of cytoplasm 3 FMR1, GTPBP4, KCNA3
Schaffer collateral - CA1 synapse 2 GABBR1, GRM5
protein-containing complex 2 CD2, IKBKG
postsynaptic density 1 FMR1
Single-pass type I membrane protein 1 CD2
Secreted 3 CCK, SST, VIP
extracellular region 5 CCK, CD2, SST, TAC1, VIP
cytoplasmic side of plasma membrane 1 CD2
centriolar satellite 1 PRKCQ
nuclear membrane 1 GTPBP4
external side of plasma membrane 1 CD2
dendritic spine 3 FMR1, GABBR1, GRM5
perikaryon 1 FMR1
nucleolus 3 FMR1, GTPBP4, ITPR3
apical part of cell 1 ITPR3
cell-cell junction 1 CD2
growth cone filopodium 1 FMR1
postsynaptic membrane 5 FMR1, GABBR1, GABBR2, GRID1, KCNA3
Cell projection, filopodium tip 1 FMR1
Cytoplasm, perinuclear region 1 FMR1
filopodium tip 1 FMR1
Membrane raft 1 KCNA3
axolemma 1 GABBR1
G protein-coupled GABA receptor complex 2 GABBR1, GABBR2
GABA-ergic synapse 3 GABBR1, GRID1, SST
sarcoplasmic reticulum 1 ITPR3
Cell projection, dendritic spine 1 FMR1
Cell junction, gap junction 1 GJB1
connexin complex 1 GJB1
lateral plasma membrane 1 GJB1
nuclear outer membrane 1 ITPR3
Postsynaptic cell membrane 4 FMR1, GABBR1, GABBR2, GRID1
receptor complex 1 ITPR3
Cell projection, neuron projection 1 FMR1
neuron projection 3 FMR1, GABBR2, VIP
cell projection 1 FMR1
mitotic spindle 1 IKBKG
Chromosome 1 FMR1
cytoplasmic ribonucleoprotein granule 1 FMR1
Nucleus, nucleolus 2 FMR1, GTPBP4
spindle pole 1 IKBKG
[Isoform 2]: Cell membrane 1 KCNA3
Chromosome, centromere 1 FMR1
Cell projection, dendrite 2 FMR1, GABBR1
Cytoplasm, Stress granule 1 FMR1
cytoplasmic stress granule 1 FMR1
Presynaptic cell membrane 1 FMR1
ubiquitin ligase complex 1 IKBKG
voltage-gated potassium channel complex 1 KCNA3
secretory granule membrane 1 ITPR3
axon terminus 1 FMR1
voltage-gated calcium channel complex 1 CACNA1I
postsynaptic density membrane 2 GRID1, GRM5
immunological synapse 1 PRKCQ
neuronal dense core vesicle 1 SST
aggresome 1 PRKCQ
chromosome, centromeric region 1 FMR1
calyx of Held 1 KCNA3
IkappaB kinase complex 1 IKBKG
Cajal body 1 FMR1
ribonucleoprotein complex 1 FMR1
platelet dense tubular network membrane 1 ITPR3
Synapse, synaptosome 1 FMR1
Cytoplasm, Cytoplasmic ribonucleoprotein granule 1 FMR1
[Isoform 1]: Cell membrane 1 KCNA3
intracellular non-membrane-bounded organelle 1 FMR1
chromocenter 1 FMR1
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
neuronal ribonucleoprotein granule 1 FMR1
Nucleus, Cajal body 1 FMR1
G protein-coupled receptor heterodimeric complex 2 GABBR1, GABBR2
GABA receptor complex 1 GABBR2
astrocyte projection 1 GRM5
glial cell projection 1 FMR1
transport vesicle membrane 1 ITPR3
[Isoform 6]: Cytoplasm 1 FMR1
dendritic filopodium 1 FMR1
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
[Isoform 9]: Cytoplasm 1 FMR1
[Isoform 10]: Nucleus 1 FMR1
[Isoform 11]: Nucleus 1 FMR1
[Isoform 1E]: Secreted 1 GABBR1


文献列表

  • Ritu Lal, Juthamas Sukbuntherng, Ezra H L Tai, Shubhra Upadhyay, Fenmei Yao, Mark S Warren, Wendy Luo, Lin Bu, Son Nguyen, Jeanelle Zamora, Ge Peng, Tracy Dias, Ying Bao, Maria Ludwikow, Thu Phan, Randall A Scheuerman, Hui Yan, Mark Gao, Quincey Q Wu, Thamil Annamalai, Stephen P Raillard, Kerry Koller, Mark A Gallop, Kenneth C Cundy. Arbaclofen placarbil, a novel R-baclofen prodrug: improved absorption, distribution, metabolism, and elimination properties compared with R-baclofen. The Journal of pharmacology and experimental therapeutics. 2009 Sep; 330(3):911-21. doi: 10.1124/jpet.108.149773. [PMID: 19502531]