Olsalazine (BioDeep_00001868368)
Main id: BioDeep_00000006470
代谢物信息卡片
Olsalazine
化学式: C14H10N2O6 (302.0539)
中文名称: 奥沙拉嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC(=C(C=C1N=NC2=CC(=C(C=C2)O)C(=O)O)C(=O)O)O
InChI: InChI=1S/C14H10N2O6/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22/h1-6,17-18H,(H,19,20)(H,21,22)
描述信息
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents > A07E - Intestinal antiinflammatory agents > A07EC - Aminosalicylic acid and similar agents
D000893 - Anti-Inflammatory Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D012459 - Salicylates
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D005765 - Gastrointestinal Agents
D018501 - Antirheumatic Agents
同义名列表
2 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:7770
- KEGG: C07323
- KEGGdrug: D08295
- PubChem: 22419
- DrugBank: DB01250
- ChEMBL: CHEMBL1208644
- ChEMBL: CHEMBL425
- CAS: 1004301-38-5
- CAS: 15722-48-2
- PubChem: 9531
- PDB-CCD: JBC
- NIKKAJI: J227.692E
- RefMet: Olsalazine
- KNApSAcK: 7770
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yanfen Niu, Pingfen Yang, Hongjian Li, Qiang Li, Hua Lin, Lihui Gao, Ling Li. Olsalazine Sodium Increases Renal Urate Excretion by Modulating Urate Transporters in Hyperuricemic Animals.
Biological & pharmaceutical bulletin.
2020 Nov; 43(11):1653-1659. doi:
10.1248/bpb.b20-00362. [PMID: 32863294] - Sandra Cortez-Maya, Luis Daniel Pedro-Hernández, Elena Martínez-Klimova, Teresa Ramírez-Ápan, Marcos Martínez-García. Anticancer Activity of Water-Soluble Olsalazine-PAMAM-Dendrimer-Salicylic Acid-Conjugates.
Biomolecules.
2019 08; 9(8):. doi:
10.3390/biom9080360. [PMID: 31412571] - Youtian Hu, Lu Wang, Xu Han, Yueyang Zhou, Tonghui Zhang, Li Wang, Ting Hong, Wei Zhang, Xun-Xiang Guo, Jielin Sun, Yingxin Qi, Jing Yu, Hong Liu, Fang Wu. Discovery of a Bioactive Inhibitor with a New Scaffold for Cystathionine γ-Lyase.
Journal of medicinal chemistry.
2019 02; 62(3):1677-1683. doi:
10.1021/acs.jmedchem.8b01720. [PMID: 30562026] - Yanfen Niu, Hongjian Li, Lihui Gao, Hua Lin, Hsiangfu Kung, Marie Chia-Mi Lin, Kwong-Sak Leung, Man-Hon Wong, Wenyong Xiong, Ling Li. Old drug, new indication: Olsalazine sodium reduced serum uric acid levels in mice via inhibiting xanthine oxidoreductase activity.
Journal of pharmacological sciences.
2017 Nov; 135(3):114-120. doi:
10.1016/j.jphs.2017.10.007. [PMID: 29132796] - Eleni Karatza, Maria Vertzoni, Uwe Muenster, Christos Reppas. The Impact of Handling and Storage of Human Fecal Material on Bacterial Activity.
Journal of pharmaceutical sciences.
2016 11; 105(11):3458-3461. doi:
10.1016/j.xphs.2016.07.010. [PMID: 27544433] - O A El-Kawy, I T Ibrahim, K Farah. Technetium-99 m labeling and evaluation of olsalazine: a novel agent for ulcerative colitis imaging.
Journal of labelled compounds & radiopharmaceuticals.
2015 Jun; 58(8):336-41. doi:
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Life sciences.
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The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.
2011 Oct; 22(5):486-93. doi:
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International journal of pharmaceutics.
2011 Jul; 413(1-2):81-6. doi:
10.1016/j.ijpharm.2011.04.028. [PMID: 21540091] - Yue-meng Wan, You-qing Zhu, Bing Xia, Jun Luo. [Probiotic therapy using live combined bifidobacterium, lactobacillus and enterococcus for experimental colitis in rats model].
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World journal of gastroenterology.
2004 Aug; 10(16):2311-7. doi:
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Inflammatory bowel diseases.
2003 Jan; 9(1):10-7. doi:
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2003 Jan; 17(1):29-42. doi:
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Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2003 Jan; 6(1):33-66. doi:
. [PMID: 12753729] - U Knoll, P Strauhs, G Schusser, F R Ungemach. Study of the plasma pharmacokinetics and faecal excretion of the prodrug olsalazine and its metabolites after oral administration to horses.
Journal of veterinary pharmacology and therapeutics.
2002 Apr; 25(2):135-43. doi:
10.1046/j.1365-2885.2002.00395.x. [PMID: 12000534] - N Mahmud, D O'Toole, N O'Hare, P J Freyne, D G Weir, D Kelleher. Evaluation of renal function following treatment with 5-aminosalicylic acid derivatives in patients with ulcerative colitis.
Alimentary pharmacology & therapeutics.
2002 Feb; 16(2):207-15. doi:
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Inflammatory bowel diseases.
2000 Nov; 6(4):275-9. doi:
10.1002/ibd.3780060404. [PMID: 11149559] - N Mahmud, D G Weir, D Kelleher. Systemic levels of free 5-aminosalicylic acid depend on the nature of the 5-aminosalicyclic acid derivative and not on disease activity or extent in patients with inflammatory bowel disease.
Irish journal of medical science.
1999 Oct; 168(4):228-32. doi:
10.1007/bf02944345. [PMID: 10624358] - G Støa-Birketvedt, J Florholmen. The systemic load and efficient delivery of active 5-aminosalicylic acid in patients with ulcerative colitis on treatment with olsalazine or mesalazine.
Alimentary pharmacology & therapeutics.
1999 Mar; 13(3):357-61. doi:
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Australian and New Zealand journal of medicine.
1998 Jun; 28(3):346. doi:
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Clinical nephrology.
1998 Apr; 49(4):265-7. doi:
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Alimentary pharmacology & therapeutics.
1996 Dec; 10(6):941-7. doi:
10.1046/j.1365-2036.1996.85257000.x. [PMID: 8971292] - D G Karamanolis, G V Papatheodoridis, V Xourgias. Systemic absorption of 5-aminosalicylic acid in patients with inactive ulcerative colitis treated with olsalazine and mesalazine.
European journal of gastroenterology & hepatology.
1996 Nov; 8(11):1083-8. doi:
10.1097/00042737-199611000-00010. [PMID: 8944370] - P Gionchetti, M Campieri, A Venturi, F Rizzello, M Ferretti, C Brignola, M Miglioli. Systemic availability of 5-aminosalicylic acid: comparison of delayed release and an azo-bond preparation.
Alimentary pharmacology & therapeutics.
1996 Aug; 10(4):601-5. doi:
10.1046/j.1365-2036.1996.26168000.x. [PMID: 8853765] - K Ewe, K Becker, B Ueberschaer. Systemic uptake of 5-aminosalicylic acid from olsalazine and eudragit L coated mesalazine in patients with ulcerative colitis in remission.
Zeitschrift fur Gastroenterologie.
1996 Apr; 34(4):225-9. doi:
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Alimentary pharmacology & therapeutics.
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10.1111/j.1365-2036.1994.tb00290.x. [PMID: 7918923] - L G Miller, J M Hopkinson, K J Motil, J E Corboy, S Andersson. Disposition of olsalazine and metabolites in breast milk.
Journal of clinical pharmacology.
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Gut.
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European journal of drug metabolism and pharmacokinetics.
1988 Oct; 13(4):261-5. doi:
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The American journal of gastroenterology.
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Scandinavian journal of gastroenterology. Supplement.
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Scandinavian journal of gastroenterology. Supplement.
1988; 148(?):61-9. doi:
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European journal of clinical pharmacology.
1988; 34(5):481-8. doi:
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Scandinavian journal of gastroenterology.
1988 Jan; 23(1):107-12. doi:
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Gut.
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