(20R)-20-hydroxypregn-4-en-3-one (BioDeep_00001868341)
Main id: BioDeep_00000637533
代谢物信息卡片
Pregn-4-en-3-one,20-hydroxy-, (20S)-
化学式: C21H32O2 (316.2402)
中文名称: 20β-二氢黄体酮, 二氢孕酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C)O
InChI: InChI=1S/C21H32O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12-13,16-19,22H,4-11H2,1-3H3/t13-,16+,17-,18+,19+,20+,21-/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D011372 - Progestins
同义名列表
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:36729
- ChEBI: CHEBI:28453
- KEGG: C04042
- PubChem: 92747
- PubChem: 8956
- ChEMBL: CHEMBL2112756
- ChEMBL: CHEMBL1583424
- MeSH: 20-alpha-Dihydroprogesterone
- CAS: 145-15-3
- CAS: 145-14-2
- MetaboLights: MTBLC28453
- PubChem: 6743
- LipidMAPS: LMST02030169
- 3DMET: B04922
- NIKKAJI: J6.126C
- KNApSAcK: 28453
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Cecilia Rustichelli, Emanuela Monari, Rossella Avallone, Elisa Bellei, Stefania Bergamini, Aldo Tomasi, Anna Ferrari. Dehydroepiandrosterone sulfate, dehydroepiandrosterone, 5α-dihydroprogesterone and pregnenolone in women with migraine: Analysis of serum levels and correlation with age, migraine years and frequency.
Journal of pharmaceutical and biomedical analysis.
2021 Nov; 206(?):114388. doi:
10.1016/j.jpba.2021.114388. [PMID: 34597839] - Kristina M Deligiannidis, Aimee R Kroll-Desrosiers, Yanglan Tan, Michelle L Dubuke, Scott A Shaffer. Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis.
Psychoneuroendocrinology.
2020 11; 121(?):104827. doi:
10.1016/j.psyneuen.2020.104827. [PMID: 32828068] - Jie Wang, Xiang-Zhong Gu, Li-Ming He, Chen-Chen Li, Wen-Wei Qiu. Synthesis of ursodeoxycholic acid from plant-source (20S)-21-hydroxy-20-methylpregn-4-en-3-one.
Steroids.
2020 05; 157(?):108600. doi:
10.1016/j.steroids.2020.108600. [PMID: 32068080] - Yu-Ling Wang, Wei Wu, Yong-Nan Su, Zhi-Peng Ai, Han-Chuan Mou, Luo-Sheng Wan, Ying Luo, Ming-Hua Qiu, Ji-Hong Zhang. Buxus alkaloid compound destabilizes mutant p53 through inhibition of the HSF1 chaperone axis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2020 Mar; 68(?):153187. doi:
10.1016/j.phymed.2020.153187. [PMID: 32097779] - Philippe Liere, Charlotte A Cornil, Marie Pierre de Bournonville, Antoine Pianos, Matthieu Keller, Michael Schumacher, Jacques Balthazart. Steroid profiles in quail brain and serum: Sex and regional differences and effects of castration with steroid replacement.
Journal of neuroendocrinology.
2019 02; 31(2):e12681. doi:
10.1111/jne.12681. [PMID: 30585662] - Gaia Cermenati, Silvia Giatti, Matteo Audano, Marzia Pesaresi, Roberto Spezzano, Donatella Caruso, Nico Mitro, Roberto Cosimo Melcangi. Diabetes alters myelin lipid profile in rat cerebral cortex: Protective effects of dihydroprogesterone.
The Journal of steroid biochemistry and molecular biology.
2017 04; 168(?):60-70. doi:
10.1016/j.jsbmb.2017.02.002. [PMID: 28167298] - Kristina M Deligiannidis, Aimee R Kroll-Desrosiers, Shunyan Mo, Hien P Nguyen, Abby Svenson, Nina Jaitly, Janet E Hall, Bruce A Barton, Anthony J Rothschild, Scott A Shaffer. Peripartum neuroactive steroid and γ-aminobutyric acid profiles in women at-risk for postpartum depression.
Psychoneuroendocrinology.
2016 08; 70(?):98-107. doi:
10.1016/j.psyneuen.2016.05.010. [PMID: 27209438] - Erin L Legacki, Elizabeth L Scholtz, Barry A Ball, Scott D Stanley, Trish Berger, Alan J Conley. The dynamic steroid landscape of equine pregnancy mapped by mass spectrometry.
Reproduction (Cambridge, England).
2016 Apr; 151(4):421-30. doi:
10.1530/rep-15-0547. [PMID: 26814209] - L V Bayunova. [THE EFFECT OF HORMONAL STIMULATION OF STERLET (ACIPENSER RUTHENUS L.) ON STEROID LEVELS IN TISSUE INCUBATES].
Zhurnal evoliutsionnoi biokhimii i fiziologii.
2016 Jan; 52(1):17-25. doi:
10.1134/s0022093016010026. [PMID: 27220236] - Donatella Caruso, Federico Abbiati, Silvia Giatti, Simone Romano, Letizia Fusco, Guido Cavaletti, Roberto Cosimo Melcangi. Patients treated for male pattern hair with finasteride show, after discontinuation of the drug, altered levels of neuroactive steroids in cerebrospinal fluid and plasma.
The Journal of steroid biochemistry and molecular biology.
2015 Feb; 146(?):74-9. doi:
10.1016/j.jsbmb.2014.03.012. [PMID: 24717976] - Nico Mitro, Gaia Cermenati, Elisabetta Brioschi, Federico Abbiati, Matteo Audano, Silvia Giatti, Maurizio Crestani, Emma De Fabiani, Inigo Azcoitia, Luis Miguel Garcia-Segura, Donatella Caruso, Roberto Cosimo Melcangi. Neuroactive steroid treatment modulates myelin lipid profile in diabetic peripheral neuropathy.
The Journal of steroid biochemistry and molecular biology.
2014 Sep; 143(?):115-21. doi:
10.1016/j.jsbmb.2014.02.015. [PMID: 24607810] - John P Wiebe, Guihua Zhang, Ian Welch, Heather-Anne T Cadieux-Pitre. Progesterone metabolites regulate induction, growth, and suppression of estrogen- and progesterone receptor-negative human breast cell tumors.
Breast cancer research : BCR.
2013 May; 15(3):R38. doi:
10.1186/bcr3422. [PMID: 25927181] - Nico Mitro, Gaia Cermenati, Silvia Giatti, Federico Abbiati, Marzia Pesaresi, Donato Calabrese, Luis Miguel Garcia-Segura, Donatella Caruso, Roberto C Melcangi. LXR and TSPO as new therapeutic targets to increase the levels of neuroactive steroids in the central nervous system of diabetic animals.
Neurochemistry international.
2012 May; 60(6):616-21. doi:
10.1016/j.neuint.2012.02.025. [PMID: 22406419] - Sonja Janmaat, Yvette Akwa, Mohamed Doulazmi, Joëlle Bakouche, Vanessa Gautheron, Philippe Liere, Bernard Eychenne, Antoine Pianos, Paul Luiten, Ton Groothuis, Etienne-Emile Baulieu, Jean Mariani, Rachel M Sherrard, Florence Frédéric. Age-related Purkinje cell death is steroid dependent: RORα haplo-insufficiency impairs plasma and cerebellar steroids and Purkinje cell survival.
Age (Dordrecht, Netherlands).
2011 Dec; 33(4):565-78. doi:
10.1007/s11357-010-9203-3. [PMID: 21222044] - Jason J Paris, Alicia A Walf, Cheryl A Frye. II. Cognitive performance of middle-aged female rats is influenced by capacity to metabolize progesterone in the prefrontal cortex and hippocampus.
Brain research.
2011 Mar; 1379(?):149-63. doi:
10.1016/j.brainres.2010.10.099. [PMID: 21044614] - Cheryl A Frye, Alicia Walf. Progesterone, administered before kainic acid, prevents decrements in cognitive performance in the Morris Water Maze.
Developmental neurobiology.
2011 Feb; 71(2):142-52. doi:
10.1002/dneu.20832. [PMID: 20715152] - Nasser Zangiabadi, Majid Asadi-Shekaari, Vahid Sheibani, Mandana Jafari, Mohammad Shabani, Ali Reza Asadi, Hale Tajadini, Morteza Jarahi. Date fruit extract is a neuroprotective agent in diabetic peripheral neuropathy in streptozotocin-induced diabetic rats: a multimodal analysis.
Oxidative medicine and cellular longevity.
2011; 2011(?):976948. doi:
10.1155/2011/976948. [PMID: 22191015] - Cheryl A Frye, Alicia A Walf, Jason J Paris. Conjugated equine estrogen, with medroxyprogesterone acetate, enhances formation of 5alpha-reduced progestogens and reduces anxiety-like behavior of middle-aged rats.
Behavioural pharmacology.
2010 Sep; 21(5-6):530-9. doi:
10.1097/fbp.0b013e32833e0a23. [PMID: 20679892] - Silvia Giatti, Giulia D'Intino, Omar Maschi, Marzia Pesaresi, Luis-Miguel Garcia-Segura, Laura Calza, Donatella Caruso, R C Melcangi. Acute experimental autoimmune encephalomyelitis induces sex dimorphic changes in neuroactive steroid levels.
Neurochemistry international.
2010 Jan; 56(1):118-27. doi:
10.1016/j.neuint.2009.09.009. [PMID: 19772882] - M Hill, A Pařízek, J E Jirásek, M Jirkovská, M Velíková, M Dušková, M Klímková, A Pasková, Z Zizka, A Germanová, M Koucký, M Kalousová, L Stárka. Is maternal progesterone actually independent of the fetal steroids?.
Physiological research.
2010; 59(2):211-224. doi:
10.33549/physiolres.931807. [PMID: 19537920] - K M Tripp, M Dubois, P Delahaut, J P Verstegen. Detection and identification of plasma progesterone metabolites in the female Florida manatee (Trichechus manatus latirostris) using GC/MS/MS.
Theriogenology.
2009 Aug; 72(3):365-71. doi:
10.1016/j.theriogenology.2009.03.004. [PMID: 19464047] - Cheryl A Frye, Alicia A Walf. Progesterone reduces depression-like behavior in a murine model of Alzheimer's Disease.
Age (Dordrecht, Netherlands).
2009 Jun; 31(2):143-53. doi:
10.1007/s11357-009-9091-6. [PMID: 19322681] - Rok Ocvirk, Keith B J Franklin, Beverley E Pearson Murphy. Measurement of ring A-reduced progesterone metabolites by enzyme-linked immunoassay with colorimetric detection: baseline levels of six metabolites, including pregnanolone, in male rat plasma.
Analytical chemistry.
2009 Feb; 81(3):1191-7. doi:
10.1021/ac801538c. [PMID: 19132927] - Yonghua Zhang, Mélanie Nadeau, Frédérick Faucher, Odette Lescelleur, Simon Biron, Marleen Daris, Caroline Rhéaume, Van Luu-The, André Tchernof. Progesterone metabolism in adipose cells.
Molecular and cellular endocrinology.
2009 Jan; 298(1-2):76-83. doi:
10.1016/j.mce.2008.09.034. [PMID: 18984031] - Pia Rantakari, Leena Strauss, Riku Kiviranta, Heidi Lagerbohm, Jenni Paviala, Irma Holopainen, Seppo Vainio, Pirjo Pakarinen, Matti Poutanen. Placenta defects and embryonic lethality resulting from disruption of mouse hydroxysteroid (17-beta) dehydrogenase 2 gene.
Molecular endocrinology (Baltimore, Md.).
2008 Mar; 22(3):665-75. doi:
10.1210/me.2007-0257. [PMID: 18048640] - Maho Ishida, Jae-hyek Choi, Keiji Hirabayashi, Takashi Matsuwaki, Masatoshi Suzuki, Keitaro Yamanouchi, Reiko Horai, Katsuko Sudo, Yoichiro Iwakura, Masugi Nishihara. Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.
The Journal of reproduction and development.
2007 Jun; 53(3):499-508. doi:
10.1262/jrd.18125. [PMID: 17272929] - Eileen Jea Chien, Ching-Fong Liao, Ching-Pang Chang, Hsiao-Fung Pu, Li-Ming Lu, Mei-Chi Shie, Dennis J-Y Hsieh, Ming-Ta Hsu. The non-genomic effects on Na+/H+-exchange 1 by progesterone and 20alpha-hydroxyprogesterone in human T cells.
Journal of cellular physiology.
2007 May; 211(2):544-50. doi:
10.1002/jcp.20962. [PMID: 17323380] - E Leonelli, R Bianchi, G Cavaletti, D Caruso, D Crippa, L M Garcia-Segura, G Lauria, V Magnaghi, I Roglio, R C Melcangi. Progesterone and its derivatives are neuroprotective agents in experimental diabetic neuropathy: a multimodal analysis.
Neuroscience.
2007 Feb; 144(4):1293-304. doi:
10.1016/j.neuroscience.2006.11.014. [PMID: 17187935] - Petra Brozic, Tina Smuc, Stanislav Gobec, Tea Lanisnik Rizner. Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1.
Molecular and cellular endocrinology.
2006 Oct; 259(1-2):30-42. doi:
10.1016/j.mce.2006.08.001. [PMID: 16962702] - L R G Nieminen, K K Makino, N Mehta, M Virkkunen, H Y Kim, J R Hibbeln. Relationship between omega-3 fatty acids and plasma neuroactive steroids in alcoholism, depression and controls.
Prostaglandins, leukotrienes, and essential fatty acids.
2006 Oct; 75(4-5):309-14. doi:
10.1016/j.plefa.2006.07.012. [PMID: 16959481] - John P Wiebe. Progesterone metabolites in breast cancer.
Endocrine-related cancer.
2006 Sep; 13(3):717-38. doi:
10.1677/erc.1.01010. [PMID: 16954427] - M Kucka, K Vagnerová, P Klusonová, I Miksík, J Pácha. Corticosterone metabolism in chicken tissues: evidence for tissue-specific distribution of steroid dehydrogenases.
General and comparative endocrinology.
2006 Jul; 147(3):377-83. doi:
10.1016/j.ygcen.2006.02.007. [PMID: 16574115] - Cheryl A Frye, Madeline E Rhodes. Progestin concentrations are increased following paced mating in midbrain, hippocampus, diencephalon, and cortex of rats in behavioral estrus, but only in midbrain of diestrous rats.
Neuroendocrinology.
2006; 83(5-6):336-47. doi:
10.1159/000096051. [PMID: 17028418] - K J Pawlak, G Zhang, J P Wiebe. Membrane 5alpha-pregnane-3,20-dione (5alphaP) receptors in MCF-7 and MCF-10A breast cancer cells are up-regulated by estradiol and 5alphaP and down-regulated by the progesterone metabolites, 3alpha-dihydroprogesterone and 20alpha-dihydroprogesterone, with associated changes in cell proliferation and detachment.
The Journal of steroid biochemistry and molecular biology.
2005 Nov; 97(3):278-88. doi:
10.1016/j.jsbmb.2005.05.014. [PMID: 16154741] - Madeline E Rhodes, Jayanth Talluri, Jacob P Harney, Cheryl A Frye. Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats.
Epilepsy & behavior : E&B.
2005 Sep; 7(2):231-9. doi:
10.1016/j.yebeh.2005.05.025. [PMID: 16054440] - Véronique Bellemare, Frédérick Faucher, Rock Breton, Van Luu-The. Characterization of 17alpha-hydroxysteroid dehydrogenase activity (17alpha-HSD) and its involvement in the biosynthesis of epitestosterone.
BMC biochemistry.
2005 Jul; 6(?):12. doi:
10.1186/1471-2091-6-12. [PMID: 16018803] - Walimuni Samantha Nilanthi Jayasekara, Tomohiro Yonezawa, Maho Ishida, Keitaro Yamanouchi, Masugi Nishihara. Expression and possible role of 20alpha-hydroxysteroid dehydrogenase in the placenta of the goat.
The Journal of reproduction and development.
2005 Apr; 51(2):265-72. doi:
10.1262/jrd.16074. [PMID: 15703459] - Karla Mazancová, Marek Kucka, Ivan Miksík, Jirí Pácha. Glucocorticoid metabolism and Na+ transport in chicken intestine.
Journal of experimental zoology. Part A, Comparative experimental biology.
2005 Feb; 303(2):113-22. doi:
10.1002/jez.a.132. [PMID: 15662663] - Li-wen Zhang, Ruo-bing Chao. [Determination of progesterone and its main metabolite in rat plasma and uterus using HPLC].
Yao xue xue bao = Acta pharmaceutica Sinica.
2004 Aug; 39(8):613-7. doi:
NULL. [PMID: 15563063] - Luisa Dalla Valle, Vania Toffolo, Silvia Vianello, Paola Belvedere, Lorenzo Colombo. Expression of cytochrome P450c17 and other steroid-converting enzymes in the rat kidney throughout the life-span.
The Journal of steroid biochemistry and molecular biology.
2004 Jun; 91(1-2):49-58. doi:
10.1016/j.jsbmb.2004.01.008. [PMID: 15261307] - G Pelletier, V Luu-The, S Li, L Ren, F Labrie. Sex-related expression of 20alpha-hydroxysteroid dehydrogenase mRNA in the adult mouse.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
2003 Nov; 51(11):1425-36. doi:
10.1177/002215540305101103. [PMID: 14566015] - S Maffei, S Del Ry, C Prontera, A Clerico. Increase in circulating levels of cardiac natriuretic peptides after hormone replacement therapy in postmenopausal women.
Clinical science (London, England : 1979).
2001 Nov; 101(5):447-53. doi:
NULL. [PMID: 11672449] - S Usuki, E Kotani. Effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on progestin biosynthesis in cultured luteal cells from rat ovary.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2001 Jun; 15(3):184-91. doi:
10.1080/gye.15.3.184.191. [PMID: 11447729] - J M Torres, E Ruiz, E Ortega. Effects of CRH and ACTH administration on plasma and brain neurosteroid levels.
Neurochemical research.
2001 May; 26(5):555-8. doi:
10.1023/a:1010925331768. [PMID: 11513484] - D S Reddy, H Y Kim, M A Rogawski. Neurosteroid withdrawal model of perimenstrual catamenial epilepsy.
Epilepsia.
2001 Mar; 42(3):328-36. doi:
10.1046/j.1528-1157.2001.10100.x. [PMID: 11442149] - K K Olson, L E Anderson, M C Wiltbank, D H Townson. Actions of prostaglandin F2alpha and prolactin on intercellular adhesion molecule-1 expression and monocyte/macrophage accumulation in the rat corpus luteum.
Biology of reproduction.
2001 Mar; 64(3):890-7. doi:
10.1095/biolreprod64.3.890. [PMID: 11207205] - M E Burczynski, G R Sridhar, N T Palackal, T M Penning. The reactive oxygen species--and Michael acceptor-inducible human aldo-keto reductase AKR1C1 reduces the alpha,beta-unsaturated aldehyde 4-hydroxy-2-nonenal to 1,4-dihydroxy-2-nonene.
The Journal of biological chemistry.
2001 Jan; 276(4):2890-7. doi:
10.1074/jbc.m006655200. [PMID: 11060293] - M Quinkler, S Johanssen, C Bumke-Vogt, W Oelkers, V Bähr, S Diederich. Enzyme-mediated protection of the mineralocorticoid receptor against progesterone in the human kidney.
Molecular and cellular endocrinology.
2001 Jan; 171(1-2):21-4. doi:
10.1016/s0303-7207(00)00429-9. [PMID: 11165007] - D Poirier, P Bydal, M R Tremblay, K M Sam, V Luu-The. Inhibitors of type II 17beta-hydroxysteroid dehydrogenase.
Molecular and cellular endocrinology.
2001 Jan; 171(1-2):119-28. doi:
10.1016/s0303-7207(00)00427-5. [PMID: 11165020] - J M Bowen, P L Keyes. Repeated exposure to prolactin is required to induce luteal regression in the hypophysectomized rat.
Biology of reproduction.
2000 Oct; 63(4):1179-84. doi:
10.1095/biolreprod63.4.1179. [PMID: 10993843] - C Y Pau, K Y Pau, M Berria, H G Spies. Ovarian influence on gonadotropin and prolactin release in mated rabbits.
Endocrine.
2000 Aug; 13(1):25-35. doi:
10.1385/endo:13:1:25. [PMID: 11051044] - P J Weiler, J P Wiebe. Plasma membrane receptors for the cancer-regulating progesterone metabolites, 5alpha-pregnane-3,20-dione and 3alpha-hydroxy-4-pregnen-20-one in MCF-7 breast cancer cells.
Biochemical and biophysical research communications.
2000 Jun; 272(3):731-7. doi:
10.1006/bbrc.2000.2847. [PMID: 10860824] - C A Manire, L E Rasmussen, T S Gross. Serum steroid hormones including 11-ketotestosterone, 11-ketoandrostenedione, and dihydroprogesterone in juvenile and adult bonnethead sharks, Sphyrna tiburo.
The Journal of experimental zoology.
1999 Oct; 284(5):595-603. doi:
10.1002/(sici)1097-010x(19991001)284:5<595::aid-jez15>3.0.co;2-6. [PMID: 10469997] - S Kurusu, K Tsukamoto, H Konishi, M Tachibana, M Kawaminami, I Hashimoto. Biphasic change in correlation between ovarian lipid peroxides and progestational activity during pseudopregnancy induced in immature rats.
The Journal of veterinary medical science.
1999 Sep; 61(9):1039-42. doi:
10.1292/jvms.61.1039. [PMID: 10535510] - O P Mgbonyebi, C T Smothers, J J Mrotek. Modulation of adrenal cell functions by cadmium salts. 5. Cadmium acetate and sulfate effects on basal and ACTH-stimulated steroidogenesis.
Cell biology and toxicology.
1998 Aug; 14(4):301-11. doi:
10.1023/a:1007491110595. [PMID: 9733285] - D A Stead, R G Reid, R B Taylor. Capillary electrochromatography of steroids increased sensitivity by on-line concentration and comparison with high-performance liquid chromatography.
Journal of chromatography. A.
1998 Mar; 798(1-2):259-67. doi:
10.1016/s0021-9673(97)00840-6. [PMID: 9542140] - S T Oh, E Yedidag, K Bielefeldt. Differential effects of progesterone and its analogues on the contractility of the murine jejunum in vitro.
The Journal of surgical research.
1998 Feb; 75(1):1-5. doi:
10.1006/jsre.1997.5152. [PMID: 9614849] - I Mayer, M Rand-Weaver, B Borg. Effects of gonadectomy and steroids on plasma and pituitary levels of somatolactin in Atlantic salmon, Salmo salar.
General and comparative endocrinology.
1998 Feb; 109(2):223-31. doi:
10.1006/gcen.1997.7015. [PMID: 9473366] - J N Garniera, D I Green, A R Pickard, H J Shaw, W V Holt. Non-invasive diagnosis of pregnancy in wild black rhinoceros (Diceros bicornis minor) by faecal steroid analysis.
Reproduction, fertility, and development.
1998; 10(6):451-8. doi:
10.1071/rd98118. [PMID: 10588374] - C A Beck, M Wolfe, L D Murphy, J P Wiebe. Acute, nongenomic actions of the neuroactive gonadal steroid, 3 alpha-hydroxy-4-pregnen-20-one (3 alpha HP), on FSH release in perifused rat anterior pituitary cells.
Endocrine.
1997 Jun; 6(3):221-9. doi:
10.1007/bf02820496. [PMID: 9368676] - J P Wiebe. Nongenomic actions of steroids on gonadotropin release.
Recent progress in hormone research.
1997; 52(?):71-99; discussion 99. doi:
NULL. [PMID: 9238848] - D P Uzunov, T B Cooper, E Costa, A Guidotti. Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography.
Proceedings of the National Academy of Sciences of the United States of America.
1996 Oct; 93(22):12599-604. doi:
10.1073/pnas.93.22.12599. [PMID: 8901628] - B J Waddell, G J Pepe, E D Albrecht. Progesterone and 20 alpha-hydroxypregn-4-en-3-one (20 alpha-OHP) in the pregnant baboon: selective placental secretion of 20 alpha-OHP into the fetal compartment.
Biology of reproduction.
1996 Oct; 55(4):854-9. doi:
10.1095/biolreprod55.4.854. [PMID: 8879500] - E Bjurulf, G Selstam. Rat luteinizing hormone receptor messenger ribonucleic acid expression and luteolysis: inhibition by prostaglandin F2 alpha.
Biology of reproduction.
1996 Jun; 54(6):1350-5. doi:
10.1095/biolreprod54.6.1350. [PMID: 8724364] - R C Melcangi, P Froelichsthal, L Martini, A L Vescovi. Steroid metabolizing enzymes in pluripotential progenitor central nervous system cells: effect of differentiation and maturation.
Neuroscience.
1996 May; 72(2):467-75. doi:
10.1016/0306-4522(95)00522-6. [PMID: 8737416] - B de Lignieres, L Dennerstein, T Backstrom. Influence of route of administration on progesterone metabolism.
Maturitas.
1995 Apr; 21(3):251-7. doi:
10.1016/0378-5122(94)00882-8. [PMID: 7616875] - P Stein, L E Bussmann, M Tesone. In vivo regulation of the steroidogenic activity of rat luteal cells by insulin.
The Journal of steroid biochemistry and molecular biology.
1995 Apr; 52(4):329-35. doi:
10.1016/0960-0760(94)00182-l. [PMID: 7734400] - T Sawada, M Hou, H Tamada, J Mori. Secretion of progesterone and 20 alpha-dihydroprogesterone during the estrous cycle in goats.
Steroids.
1994 Dec; 59(12):672-5. doi:
10.1016/0039-128x(94)90097-3. [PMID: 7900164] - M A Abdullah, D E Kime. Increased substrate concentration causes a shift from production of 11-oxygenated androgens to 17,20-dihydroxyprogestogens during the in vitro metabolism of 17-hydroxyprogesterone by goldfish testes.
General and comparative endocrinology.
1994 Oct; 96(1):129-39. doi:
10.1006/gcen.1994.1165. [PMID: 7843561] - E Bjurulf, G Selstam, J I Olofsson. Increased LH receptor mRNA and extended corpus luteum function induced by prolactin and indomethacin treatment in vivo in hysterectomized pseudopregnant rats.
Journal of reproduction and fertility.
1994 Sep; 102(1):139-45. doi:
10.1530/jrf.0.1020139. [PMID: 7799306] - T Sawada, T Nakatani, H Tamada, J Mori. Secretion of progesterone and 20 alpha-dihydroprogesterone during pregnancy in goats.
Steroids.
1994 Aug; 59(8):468-71. doi:
10.1016/0039-128x(94)90059-0. [PMID: 7985207] - R K Srivastava, V Luu-The, B L Marrone, S Harris-Hooker, R Sridaran. Inhibition of steroidogenesis by luteal cells of early pregnancy in the rat in response to in vitro administration of a gonadotropin-releasing hormone agonist.
The Journal of steroid biochemistry and molecular biology.
1994 May; 49(1):73-9. doi:
10.1016/0960-0760(94)90303-4. [PMID: 8003442] - J P Wiebe, G C De Gannes, M J Dallaire. Synthesis of the allylic regulatory steroid, 3 alpha-hydroxy-4-pregnen-20-one, by rat granulosa cells and its regulation by gonadotropins.
Biology of reproduction.
1994 Apr; 50(4):956-64. doi:
10.1095/biolreprod50.4.956. [PMID: 8199276] - J P Wiebe, S Dhanvantari, P H Watson, Y Huang. Suppression in gonadotropes of gonadotropin-releasing hormone-stimulated follicle-stimulating hormone release by the gonadal- and neurosteroid 3 alpha-hydroxy-4-pregnen-20-one involves cytosolic calcium.
Endocrinology.
1994 Jan; 134(1):377-82. doi:
10.1210/endo.134.1.8275953. [PMID: 8275953] - S Dhanvantari, J P Wiebe. Suppression of follicle-stimulating hormone by the gonadal- and neurosteroid 3 alpha-hydroxy-4-pregnen-20-one involves actions at the level of the gonadotrope membrane/calcium channel.
Endocrinology.
1994 Jan; 134(1):371-6. doi:
10.1210/endo.134.1.8275952. [PMID: 8275952] - O P Mgbonyebi, C T Smothers, J J Mrotek. Modulation of adrenal cell functions by cadmium salts. 1. Cadmium chloride effects on basal and ACTH-stimulated steroidogenesis.
Cell biology and toxicology.
1993 Jul; 9(3):223-34. doi:
10.1007/bf00755601. [PMID: 8299002] - J Yeh, G Y Lee, E Anderson. Presence of transforming growth factor-alpha messenger ribonucleic acid (mRNA) and absence of epidermal growth factor mRNA in rat ovarian granulosa cells, and the effects of these factors on steroidogenesis in vitro.
Biology of reproduction.
1993 May; 48(5):1071-81. doi:
10.1095/biolreprod48.5.1071. [PMID: 8481471] - J E Hindle, E Möstl, J K Hodges. Measurement of urinary oestrogens and 20 alpha-dihydroprogesterone during ovarian cycles of black (Diceros bicornis) and white (Ceratotherium simum) rhinoceroses.
Journal of reproduction and fertility.
1992 Jan; 94(1):237-49. doi:
10.1530/jrf.0.0940237. [PMID: 1552485] - R Tapia-Serrano, F J Jimenez-Balderas, S Murrieta, C Bravo-Gatica, R Guerra, G Mintz. Testicular function in active ankylosing spondylitis. Therapeutic response to human chorionic gonadotrophin.
The Journal of rheumatology.
1991 Jun; 18(6):841-8. doi:
NULL. [PMID: 1843848] - K Nahoul, M Gilbert. Plasma C-21 steroids in conscious pregnant and non-pregnant rabbits with chronic catheterization of the femoral artery and the portal and hepatic veins.
The Journal of steroid biochemistry and molecular biology.
1991 Jun; 38(6):753-8. doi:
10.1016/0960-0760(91)90089-n. [PMID: 2064991] - J P Wiebe, K J Barr, K D Buckingham. A radioimmunoassay for the regulatory allylic steroid, 3 alpha-hydroxy-4-pregnen-20-one (3 alpha HP).
The Journal of steroid biochemistry and molecular biology.
1991 Apr; 38(4):505-12. doi:
10.1016/0960-0760(91)90339-7. [PMID: 2031864] - T M Mills, V S Stopper. The use of perfused rabbit ovaries to investigate regional ovarian lymphatic flow.
Lymphology.
1991 Mar; 24(1):32-9. doi:
NULL. [PMID: 2051783] - S Usuki. The direct luteotropic effect of tokishakuyakusan in rats.
The American journal of Chinese medicine.
1991; 19(2):163-9. doi:
10.1142/s0192415x91000235. [PMID: 1816728] - J I Komorowski, B K Tsang. Divergent effects of 1-oleoyl-2-acetylglycerol and tumor-promoting phorbol ester on rat granulosa cell steroidogenesis in vitro.
Biology of reproduction.
1990 Jul; 43(1):73-9. doi:
10.1095/biolreprod43.1.73. [PMID: 2168218] - M Loir. Trout steroidogenic testicular cells in primary culture. I. Changes in free and conjugated androgen and progestagen secretions: effects of gonadotropin, serum, and lipoproteins.
General and comparative endocrinology.
1990 Jun; 78(3):374-87. doi:
10.1016/0016-6480(90)90027-j. [PMID: 2347487] - H Watanabe, K Hirato, M Hashino, T Kosaki, T Kimura, T Nakayama, T Yanaihara. Effects of DHA-S on placental 3 beta-hydroxysteroid dehydrogenase activity, progesterone and 20 alpha-dihydroprogesterone concentrations in placenta and serum.
Endocrinologia japonica.
1990 Feb; 37(1):69-77. doi:
10.1507/endocrj1954.37.69. [PMID: 2143469] - C Kadota, M Ohta, M Takahashi. Effects of androgen on progesterone secretion from granulosa cells obtained from antral follicles of rats.
Endocrinologia japonica.
1990 Feb; 37(1):113-20. doi:
10.1507/endocrj1954.37.113. [PMID: 2166653] - L F Fanjul, F Estévez, A Déniz Cáceres, I Marrero, L Benitez, I Centol, J Quintana, J González, L Llanes, C M Ruiz de Galarreta. The androgen receptor does not mediate progestin regulation of progesterone biosynthesis in cultured rat granulosa cells.
Biochemistry international.
1989 Nov; 19(5):977-84. doi:
NULL. [PMID: 2534567] - S Iida, V Papadopoulos, P F Hall. The influence of exogenous free cholesterol on steroid synthesis in cultured adrenal cells.
Endocrinology.
1989 May; 124(5):2619-24. doi:
10.1210/endo-124-5-2619. [PMID: 2539983] - P Saragüeta, A R Krimer, E H Charreau, M Tesone. Insulin regulation of steroidogenic activity in rat culture luteal cells.
Journal of steroid biochemistry.
1989 Mar; 32(3):393-7. doi:
10.1016/0022-4731(89)90212-4. [PMID: 2468046] - J T Uilenbroek, P J Woutersen, P D van der Vaart. Steroid concentrations in rat corpora lutea isolated during the oestrous cycle and pseudopregnancy: effect of induction of ovulation at dioestrus.
The Journal of endocrinology.
1989 Feb; 120(2):325-30. doi:
10.1677/joe.0.1200325. [PMID: 2926304] - E Kawamura, M Hashino, T Akiyama, T Kosaki, T Yanaihara, T Nakayama, H Mori, T Yamaguchi. [Serum concentrations of delta 5C21 steroids during pregnancy and at delivery].
Nihon Naibunpi Gakkai zasshi.
1989 Jan; 65(1):42-54. doi:
10.1507/endocrine1927.65.1_42. [PMID: 2721780] - I C McMillen, G Jenkin, A S Haji-Baba, C A Browne, G D Thorburn. Effect of gamma 3 or gamma 2 melanocyte stimulating hormone on steroidogenesis in the fetal sheep during late gestation.
Life sciences.
1989; 44(8):563-9. doi:
10.1016/0024-3205(89)90618-8. [PMID: 2927260] - S L Monfort, K D Dahl, N M Czekala, L Stevens, M Bush, D E Wildt. Monitoring ovarian function and pregnancy in the giant panda (Ailuropoda melanoleuca) by evaluating urinary bioactive FSH and steroid metabolites.
Journal of reproduction and fertility.
1989 Jan; 85(1):203-12. doi:
10.1530/jrf.0.0850203. [PMID: 2492603] - L A Walker, L Cornell, K D Dahl, N M Czekala, C M Dargen, B Joseph, A J Hsueh, B L Lasley. Urinary concentrations of ovarian steroid hormone metabolites and bioactive follicle-stimulating hormone in killer whales (Orcinus orchus) during ovarian cycles and pregnancy.
Biology of reproduction.
1988 Dec; 39(5):1013-20. doi:
10.1095/biolreprod39.5.1013. [PMID: 3146355] - S Saito, S Matsuyama, K Shiota, M Takahashi. Involvement of splenocytes in the control of corpus luteum function in the rat.
Endocrinologia japonica.
1988 Dec; 35(6):891-8. doi:
10.1507/endocrj1954.35.891. [PMID: 3250864] - K Takagi. [Effects of prostaglandin F2 alpha on steroidogenesis of the PMSG-hCG primed rat ovary in luteolysis].
Nihon Naibunpi Gakkai zasshi.
1988 Oct; 64(10):1024-37. doi:
10.1507/endocrine1927.64.10_1024. [PMID: 3208916] - K M Orstead, D L Hess, H G Spies. Pulsatile patterns of gonadotropins and ovarian steroids during estrus and pseudopregnancy in the rabbit.
Biology of reproduction.
1988 May; 38(4):733-43. doi:
10.1095/biolreprod38.4.733. [PMID: 3135850] - J A Carnegie, R Byard, I Dardick, B K Tsang. Culture of granulosa cells in collagen gels: the influence of cell shape on steroidogenesis.
Biology of reproduction.
1988 May; 38(4):881-90. doi:
10.1095/biolreprod38.4.881. [PMID: 3401543]
