Fludrocortisone acetate (BioDeep_00001868261)
Main id: BioDeep_00000397838
代谢物信息卡片
Fludrocortisone acetate
化学式: C23H31FO6 (422.2105)
中文名称: 醋酸氟氢可的松
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OCC(=O)C1(CCC2C1(CC(C3(C2CCC4=CC(=O)CCC43C)F)O)C)O
InChI: InChI=1S/C23H31FO6/c1-13(25)30-12-19(28)22(29)9-7-16-17-5-4-14-10-15(26)6-8-20(14,2)23(17,24)18(27)11-21(16,22)3/h10,16-18,27,29H,4-9,11-12H2,1-3H3/t16-,17-,18-,20-,21-,22-,23-/m0/s1
描述信息
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
2 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:5102
- KEGG: C08186
- KEGGdrug: D00986
- PubChem: 225609
- ChEMBL: CHEMBL1201010
- CAS: 514-36-3
- PubChem: 10386
- LipidMAPS: LMST02030122
- NIKKAJI: J6.287A
- RefMet: Fludrocortisone acetate
- KNApSAcK: 5102
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Y S Aleksandrovich, K V Pshenisnov, A S Ustinova, V V Kopylov, I V Aleksandrovich, V I Gordeev. [Sodium balance impairment in a child with severe traumatic brain injury].
Problemy endokrinologii.
2019 05; 65(1):39-45. doi:
10.14341/probl9668. [PMID: 31091049] - Yanbin Zhao, Kun Zhang, Karl Fent. Corticosteroid Fludrocortisone Acetate Targets Multiple End Points in Zebrafish (Danio rerio) at Low Concentrations.
Environmental science & technology.
2016 09; 50(18):10245-54. doi:
10.1021/acs.est.6b03436. [PMID: 27618422] - Ichiro Nakagawa, Yasuo Hironaka, Fumihiko Nishimura, Yasuhiro Takeshima, Ryosuke Matsuda, Shuichi Yamada, Yasushi Motoyama, Young-Su Park, Hiroyuki Nakase. Early inhibition of natriuresis suppresses symptomatic cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage.
Cerebrovascular diseases (Basel, Switzerland).
2013; 35(2):131-7. doi:
10.1159/000346586. [PMID: 23406891] - Luis E Okamoto, Satish R Raj, Amanda Peltier, Alfredo Gamboa, Cyndya Shibao, André Diedrich, Bonnie K Black, David Robertson, Italo Biaggioni. Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes.
Clinical science (London, England : 1979).
2012 Feb; 122(4):183-92. doi:
10.1042/cs20110200. [PMID: 21906029] - Riccardo Maria Fagugli, Chiara Taglioni. Changes in the perceived epidemiology of primary hyperaldosteronism.
International journal of hypertension.
2011; 2011(?):162804. doi:
10.4061/2011/162804. [PMID: 21837271] - Ichiro Nakagawa, Shinichiro Kurokawa, Katsutoshi Takayama, Takeshi Wada, Hiroyuki Nakase. [Increased urinary sodium excretion in the early phase of aneurysmal subarachnoid hemorrhage as a predictor of cerebral salt wasting syndrome].
Brain and nerve = Shinkei kenkyu no shinpo.
2009 Dec; 61(12):1419-23. doi:
. [PMID: 20034309] - Dong Ki Kim, Kwon Wook Joo. Hyponatremia in patients with neurologic disorders.
Electrolyte & blood pressure : E & BP.
2009 Dec; 7(2):51-7. doi:
10.5049/ebp.2009.7.2.51. [PMID: 21468186] - I Madhusudhana Reddy, Alka Beotra, S Jain, S Ahi. A simple and rapid ESI-LC-MS/MS method for simultaneous screening of doping agents in urine samples.
Indian journal of pharmacology.
2009 Apr; 41(2):80-6. doi:
10.4103/0253-7613.51347. [PMID: 20336223] - Sonja Hoeller, Andrea Sperger, Claudia Valenta. Lecithin based nanoemulsions: A comparative study of the influence of non-ionic surfactants and the cationic phytosphingosine on physicochemical behaviour and skin permeation.
International journal of pharmaceutics.
2009 Mar; 370(1-2):181-6. doi:
10.1016/j.ijpharm.2008.11.014. [PMID: 19073240] - Bing Shao, Xiaoliang Cui, Yi Yang, Jing Zhang, Yongnin Wu. Validation of a solid-phase extraction and ultra-performance liquid chromatographic tandem mass spectrometric method for the detection of 16 glucocorticoids in pig tissues.
Journal of AOAC International.
2009 Mar; 92(2):604-11. doi:
. [PMID: 19485221] - S C Djajadiningrat-Laanen, S Galac, S E Cammelbeeck, K J C van Laar, P Boer, H S Kooistra. Urinary aldosterone to creatinine ratio in cats before and after suppression with salt or fludrocortisone acetate.
Journal of veterinary internal medicine.
2008 Nov; 22(6):1283-8. doi:
10.1111/j.1939-1676.2008.0166.x. [PMID: 18775055] - Isamu Miyamori. [Synthetic mineralocorticoid].
Nihon rinsho. Japanese journal of clinical medicine.
2008 Jan; 66(1):125-9. doi:
. [PMID: 18193551] - Dong-Min Kim, Jong Hoon Chung, Sung Ho Yoon, Hyun Lee Kim. Effect of fludrocortisone acetate on reducing serum potassium levels in patients with end-stage renal disease undergoing haemodialysis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2007 Nov; 22(11):3273-6. doi:
10.1093/ndt/gfm386. [PMID: 17616536] - Cecilia Mattsson, William F Young. Primary aldosteronism: diagnostic and treatment strategies.
Nature clinical practice. Nephrology.
2006 Apr; 2(4):198-208; quiz, 1 p following 230. doi:
10.1038/ncpneph0151. [PMID: 16932426] - Oliviero Olivieri, Annalisa Castagna, Patrizia Guarini, Laura Chiecchi, Gherardo Sabaini, Francesca Pizzolo, Roberto Corrocher, Pier Giorgio Righetti. Urinary prostasin: a candidate marker of epithelial sodium channel activation in humans.
Hypertension (Dallas, Tex. : 1979).
2005 Oct; 46(4):683-8. doi:
10.1161/01.hyp.0000184108.12155.6b. [PMID: 16172430] - Miyoko Saito, Natasha J Olby, Leticia Obledo, Jody L Gookin. Muscle cramps in two standard poodles with hypoadrenocorticism.
Journal of the American Animal Hospital Association.
2002 Sep; 38(5):437-43. doi:
10.5326/0380437. [PMID: 12220028] - Ryuichi Furuya, Hiromichi Kumagai, Tadashi Sakao, Yukitaka Maruyama, Akira Hishida. Potassium-lowering effect of mineralocorticoid therapy in patients undergoing hemodialysis.
Nephron.
2002; 92(3):576-81. doi:
10.1159/000064116. [PMID: 12372940] - J Stonehewer, S Tasker. Hypoadrenocorticism in a cat.
The Journal of small animal practice.
2001 Apr; 42(4):186-90. doi:
10.1111/j.1748-5827.2001.tb01800.x. [PMID: 11327666] - Ishikawa Se, T Saito, A Fukagawa, M Higashiyama, T Nakamura, I Kusaka, S Nagasaka, K Honda, T Saito. Close association of urinary excretion of aquaporin-2 with appropriate and inappropriate arginine vasopressin-dependent antidiuresis in hyponatremia in elderly subjects.
The Journal of clinical endocrinology and metabolism.
2001 Apr; 86(4):1665-71. doi:
10.1210/jcem.86.4.7426. [PMID: 11297601] - R Taniguchi, H Koshiyama, M Yamauchi, S Tanaka, D Inoue, Y Sato, A Sugawa, Y Muramatsu, H Sasano. A case of aldosterone-producing adenoma with severe postoperative hyperkalemia.
The Tohoku journal of experimental medicine.
1998 Nov; 186(3):215-23. doi:
10.1620/tjem.186.215. [PMID: 10348217] - S Yamashiro, I Fuwa, H Seto, Y Ushio. Initial and postoperative hyponatremia associated with pituitary adenoma: a case report.
Acta neurochirurgica.
1997; 139(10):987-90; discussion 990. doi:
10.1007/bf01411311. [PMID: 9401662] - G G Krishna, S C Kapoor. Potassium supplementation ameliorates mineralocorticoid-induced sodium retention.
Kidney international.
1993 May; 43(5):1097-103. doi:
10.1038/ki.1993.154. [PMID: 8510388] - M Montrella-Waybill, J N Clore, A C Schoolwerth, C O Watlington. Evidence that high dose cortisol-induced Na+ retention in man is not mediated by the mineralocorticoid receptor.
The Journal of clinical endocrinology and metabolism.
1991 May; 72(5):1060-6. doi:
10.1210/jcem-72-5-1060. [PMID: 1850752] - D Hasan, K W Lindsay, E F Wijdicks, G D Murray, P J Brouwers, W H Bakker, J van Gijn, M Vermeulen. Effect of fludrocortisone acetate in patients with subarachnoid hemorrhage.
Stroke.
1989 Sep; 20(9):1156-61. doi:
10.1161/01.str.20.9.1156. [PMID: 2672426] - P Weidmann, D R Matter, E E Matter, M P Gnädinger, D E Uehlinger, S Shaw, C Hess. Glucocorticoid and mineralocorticoid stimulation of atrial natriuretic peptide release in man.
The Journal of clinical endocrinology and metabolism.
1988 Jun; 66(6):1233-9. doi:
10.1210/jcem-66-6-1233. [PMID: 2967304] - S E Ishikawa, T Saito, K Kaneko, K Okada, T Kuzuya. Hyponatremia responsive to fludrocortisone acetate in elderly patients after head injury.
Annals of internal medicine.
1987 Feb; 106(2):187-91. doi:
10.7326/0003-4819-106-2-187. [PMID: 3800181] - T Morise, I Miyamori, S Hifumi, S Okamoto, M Ikeda, Y Takeda, H Koshida, S Yasuhara, R Takeda. Effect of 9 alpha-fluorocortisol on the excretion of urinary digoxin-like substance in normotensive men.
Endocrinologia japonica.
1986 Jun; 33(3):279-83. doi:
10.1507/endocrj1954.33.279. [PMID: 3757920] - P Genard, M Palem-Vliers. Effect of 6-dehydro-DOCA and 6-dehydro-9 alpha-fluorocortisol acetate on the excretion of sodium and potassium in the rat.
Journal of steroid biochemistry.
1985 Nov; 23(5A):673-5. doi:
10.1016/0022-4731(85)90021-4. [PMID: 4079383] - O B Holland, H Brown, L Kuhnert, C Fairchild, M Risk, C E Gomez-Sanchez. Further evaluation of saline infusion for the diagnosis of primary aldosteronism.
Hypertension (Dallas, Tex. : 1979).
1984 Sep; 6(5):717-23. doi:
10.1161/01.hyp.6.5.717. [PMID: 6389337] - J Biollaz, J Dürr, H R Brunner, M Porchet, H Gavras. Escape from mineralocorticoid excess: the role of angiotensin II.
The Journal of clinical endocrinology and metabolism.
1982 Jun; 54(6):1187-93. doi:
10.1210/jcem-54-6-1187. [PMID: 6281293] - M D Lindheimer, R L Landau, S Oparil. Oral-contraceptive-induced hypertension after adrenalectomy and hypophysectomy.
Archives of internal medicine.
1976 Sep; 136(9):1029-31. doi:
NULL. [PMID: 962446] - M M Hoehn. Levodopa-induced postural hypotension. Treatment with fludrocortisone.
Archives of neurology.
1975 Jan; 32(1):50-1. doi:
10.1001/archneur.1975.00490430072013. [PMID: 1115660]
