Fomepizole (BioDeep_00001867803)
Main id: BioDeep_00000003469
代谢物信息卡片
4-Methyl-1H-pyrazole
化学式: C4H6N2 (82.0531)
中文名称: 4-甲基-1H-吡唑, 4-甲基吡唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CNN=C1
InChI: InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
描述信息
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AB - Antidotes
D020011 - Protective Agents > D000931 - Antidotes
D004791 - Enzyme Inhibitors
C471 - Enzyme Inhibitor
同义名列表
4 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:5141
- KEGG: C07837
- KEGGdrug: D00707
- PubChem: 3406
- DrugBank: DB01213
- ChEMBL: CHEMBL1308
- MeSH: Fomepizole
- CAS: 615557-09-0
- CAS: 7554-65-6
- PubChem: 10039
- PDB-CCD: 4PZ
- NIKKAJI: J35.396E
- RefMet: Fomepizole
- KNApSAcK: 5141
分类词条
相关代谢途径
Reactome(0)
BioCyc(5)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Linsong Wang, Chenglei Qin, Qunqun Guo, Yi Han, Guicai Du, Ronggui Li. Transcriptome Study of Bursaphelenchus xylophilus Treated with Fomepizole Reveals a Serine/Threonine-Protein Phosphatase Gene that Is Substantially Linked with Vitality and Pathogenicity.
Phytopathology.
2024 Mar; 114(3):630-640. doi:
10.1094/phyto-04-23-0113-r. [PMID: 38457135] - Jianlong Ma, Xiaofeng Lu, Mingyao Hao, Yumeng Wang, Yong Guo, Zhijun Wang. Real-time visualization the pH fluctuations of living cells with a ratiometric near-infrared fluorescent probe.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2023 Oct; 306(?):123572. doi:
10.1016/j.saa.2023.123572. [PMID: 37922853] - Jessie Beaulieu, Darren M Roberts, Sophie Gosselin, Robert S Hoffman, Valery Lavergne, Knut Erik Hovda, Bruno Megarbane, Derrick Lung, Ruben Thanacoody, Marc Ghannoum. Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review.
Clinical toxicology (Philadelphia, Pa.).
2022 07; 60(7):784-797. doi:
10.1080/15563650.2022.2049810. [PMID: 35311442] - Sasha K Kaiser, Richard C Dart. The Roles of Antidotes in Emergency Situations.
Emergency medicine clinics of North America.
2022 May; 40(2):381-394. doi:
10.1016/j.emc.2022.01.008. [PMID: 35461629] - Yvonne E Lao, Trond Vartdal, Sten Froeyshov, Brian Latimer, Christiane Kvaerner, Marija Mataric, Peter Holm, Siri Foreid, Dag Jacobsen, Kenneth McMartin, Knut Erik Hovda. Fomepizole dosing during continuous renal replacement therapy - an observational study.
Clinical toxicology (Philadelphia, Pa.).
2022 Apr; 60(4):451-457. doi:
10.1080/15563650.2021.1980581. [PMID: 34585641] - Jephte Y Akakpo, Anup Ramachandran, Steven C Curry, Barry H Rumack, Hartmut Jaeschke. Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
Archives of toxicology.
2022 02; 96(2):453-465. doi:
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Human & experimental toxicology.
2022 Jan; 41(?):9603271211061502. doi:
10.1177/09603271211061502. [PMID: 35023765] - Kenneth McMartin, Jeffrey Brent. Analysis of Fomepizole Elimination in Methanol- and Ethylene Glycol-Poisoned Patients.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2022 01; 18(1):19-29. doi:
10.1007/s13181-021-00862-3. [PMID: 34697779] - P M Emeka, H I M Ibrahim, I A Alhaider, M A Morsy, M E Mohamed. Subchronic administration of mitoxantrone and the influence of enzyme inhibitors on its induced cardiotoxicity in mice: role of NRF-2/CYP2E1.
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2021 Oct; 25(20):6295-6299. doi:
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Nga T Nguyen, Jephte Y Akakpo, James L Weemhoff, Anup Ramachandran, Wen-Xing Ding, Hartmut Jaeschke. Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice.
Archives of toxicology.
2021 04; 95(4):1463-1473. doi:
10.1007/s00204-021-02985-6. [PMID: 33458793] - Jephte Y Akakpo, Anup Ramachandran, Hilmi Orhan, Steven C Curry, Barry H Rumack, Hartmut Jaeschke. 4-methylpyrazole protects against acetaminophen-induced acute kidney injury.
Toxicology and applied pharmacology.
2020 12; 409(?):115317. doi:
10.1016/j.taap.2020.115317. [PMID: 33157119] - Riana Rasamison, Hélène Besson, Marie-Pierre Berleur, Azzurra Schicchi, Bruno Mégarbane. Analysis of fomepizole safety based on a 16-year post-marketing experience in France.
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2020 07; 58(7):742-747. doi:
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Lakartidningen.
2020 05; 117(?):. doi:
NULL. [PMID: 32453856] - A Min Kang, Angela Padilla-Jones, Erik S Fisher, Jephte Y Akakpo, Hartmut Jaeschke, Barry H Rumack, Richard D Gerkin, Steven C Curry. The Effect of 4-Methylpyrazole on Oxidative Metabolism of Acetaminophen in Human Volunteers.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2020 04; 16(2):169-176. doi:
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Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Jephte Y Akakpo, Anup Ramachandran, Luqi Duan, Matthew A Schaich, Matthew W Jaeschke, Bret D Freudenthal, Wen-Xing Ding, Barry H Rumack, Hartmut Jaeschke. Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase.
Toxicological sciences : an official journal of the Society of Toxicology.
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Journal of medicinal food.
2010 Aug; 13(4):985-91. doi:
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BMJ case reports.
2010 Jul; 2010(?):. doi:
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Clinical toxicology (Philadelphia, Pa.).
2010 Jun; 48(5):401-6. doi:
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Human & experimental toxicology.
2010 Jun; 29(6):507-12. doi:
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Electrolyte & blood pressure : E & BP.
2010 Jun; 8(1):32-7. doi:
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Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2010 Jun; 6(2):131-4. doi:
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Alcohol (Fayetteville, N.Y.).
2010 Mar; 44(2):157-69. doi:
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Annals of emergency medicine.
2010 Feb; 55(2):198-200. doi:
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Pharmacotherapy.
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AoB PLANTS.
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Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology.
2009 Dec; 22(4):293-300. doi:
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Clinical toxicology (Philadelphia, Pa.).
2009 Nov; 47(9):859-69. doi:
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Clinical toxicology (Philadelphia, Pa.).
2009 Jul; 47(6):525-35. doi:
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Clinical toxicology (Philadelphia, Pa.).
2009 Mar; 47(3):239-42. doi:
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Experimental oncology.
2008 Dec; 30(4):306-14. doi:
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Free radical biology & medicine.
2008 Dec; 45(11):1542-50. doi:
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Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2008 Dec; 4(4):275-6. doi:
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
2008 Jul; 52(1):181-7. doi:
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Phytotherapy research : PTR.
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BMC emergency medicine.
2008 Apr; 8(?):5. doi:
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Journal of hepatology.
2008 Apr; 48(4):614-27. doi:
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Acta medica Indonesiana.
2008 Apr; 40(2):84-8. doi:
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Endocrinology.
2008 Apr; 149(4):1748-56. doi:
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Clinical toxicology (Philadelphia, Pa.).
2008 Mar; 46(3):181-6. doi:
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Plant signaling & behavior.
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Clinical journal of the American Society of Nephrology : CJASN.
2008 Jan; 3(1):208-25. doi:
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Hepatology (Baltimore, Md.).
2008 Jan; 47(1):59-70. doi:
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Clinical toxicology (Philadelphia, Pa.).
2007 Sep; 45(6):701-4. doi:
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Journal of medical toxicology : official journal of the American College of Medical Toxicology.
2007 Sep; 3(3):125-8. doi:
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Nature clinical practice. Nephrology.
2007 Sep; 3(9):515-20. doi:
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Journal of plant physiology.
2007 Aug; 164(8):1013-8. doi:
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Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
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Clinical toxicology (Philadelphia, Pa.).
2007 Jun; 45(5):516-21. doi:
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Acta paediatrica (Oslo, Norway : 1992).
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Alcoholism, clinical and experimental research.
2006 Jul; 30(7):1126-31. doi:
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