chlorothiazide (BioDeep_00001867782)
Main id: BioDeep_00000002343
代谢物信息卡片
chlorothiazide
化学式: C7H6ClN3O4S2 (294.9488)
中文名称: 氯噻嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2
InChI: InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)
描述信息
C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain
D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D049990 - Membrane Transport Modulators
同义名列表
2 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:3640
- KEGG: C07461
- KEGGdrug: D00519
- KEGGdrug: D89501
- PubChem: 2720
- DrugBank: DB00880
- ChEMBL: CHEMBL3392493
- ChEMBL: CHEMBL842
- MeSH: Chlorothiazide
- CAS: 58-94-6
- PubChem: 9664
- NIKKAJI: J2.807J
- RefMet: Chlorothiazide
- KNApSAcK: 3640
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kristen M Ahlschwede, Edward Ofori, Terrick Andey, Anita Osei, John S Somberg. Formulation, Characterization, and the Diuretic Effects of a New Intravenous Metolazone Emulsion.
Drug research.
2022 Jul; 72(6):299-305. doi:
10.1055/a-1813-9489. [PMID: 35537450] - Summer R Record, Aaron A Harthan, Sandeep Tripathi. Use of Furosemide and Chlorothiazide Combination Continuous Infusion in Furosemide-Refractory Patients in the Pediatric Intensive Care Unit: A Retrospective Cohort Study.
Paediatric drugs.
2021 Nov; 23(6):575-582. doi:
10.1007/s40272-021-00472-0. [PMID: 34632558] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Taylor D Steuber, Kristin M Janzen, Meredith L Howard. A Systematic Review and Meta-Analysis of Metolazone Compared to Chlorothiazide for Treatment of Acute Decompensated Heart Failure.
Pharmacotherapy.
2020 09; 40(9):924-935. doi:
10.1002/phar.2440. [PMID: 32639593] - Zachary L Cox, Rebecca Hung, Daniel J Lenihan, Jeffrey M Testani. Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial.
JACC. Heart failure.
2020 03; 8(3):157-168. doi:
10.1016/j.jchf.2019.09.012. [PMID: 31838029] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Brady S Moffett, Rocky Tsang, Curt Kennedy, Ron A Bronicki, Ayse Akcan-Arikan, Paul A Checchia. Efficacy of sequential nephron blockade with intravenous chlorothiazide to promote diuresis in cardiac intensive care infants.
Cardiology in the young.
2017 Aug; 27(6):1104-1109. doi:
10.1017/s1047951116002122. [PMID: 27834164] - Christopher J Michaud, Kendall C Mintus. Intravenous Chlorothiazide Versus Enteral Metolazone to Augment Loop Diuretic Therapy in the Intensive Care Unit.
The Annals of pharmacotherapy.
2017 Apr; 51(4):286-292. doi:
10.1177/1060028016683971. [PMID: 28228057] - Viljami Jokinen, Tuomas Lilius, Jouko Laitila, Mikko Niemi, Oleg Kambur, Eija Kalso, Pekka Rauhala. Do Diuretics have Antinociceptive Actions: Studies of Spironolactone, Eplerenone, Furosemide and Chlorothiazide, Individually and with Oxycodone and Morphine.
Basic & clinical pharmacology & toxicology.
2017 Jan; 120(1):38-45. doi:
10.1111/bcpt.12634. [PMID: 27312359] - Maria Cardinale, Jerry Altshuler, Jeffrey M Testani. Efficacy of Intravenous Chlorothiazide for Refractory Acute Decompensated Heart Failure Unresponsive to Adjunct Metolazone.
Pharmacotherapy.
2016 08; 36(8):843-51. doi:
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Pharmacotherapy.
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American journal of physiology. Renal physiology.
2016 Feb; 310(3):F230-6. doi:
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EMBO molecular medicine.
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Kidney international.
2013 Sep; 84(3):501-8. doi:
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Journal of pharmaceutical sciences.
2013 May; 102(5):1683-7. doi:
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The Journal of clinical investigation.
2013 Feb; 123(2):657-65. doi:
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2012; 27(3):349-53. doi:
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Bioorganic & medicinal chemistry.
2010 Nov; 18(21):7486-96. doi:
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2010 Jun; 81(4-5):1264-72. doi:
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Electrolyte & blood pressure : E & BP.
2010 Jun; 8(1):51-7. doi:
10.5049/ebp.2010.8.1.51. [PMID: 21468197] - Fumie Satoh, Tomokazu Okado, Mari Iwamoto, Wataru Akita, Mai Wakabayashi, Akihito Ohta, Eisei Sohara, Yumi Noda, Tatemitsu Rai, Shinichi Uchida, Sei Sasaki. Calcium-alkali syndrome-like symptoms manifested by daily alphacalcidol and thiazide.
Internal medicine (Tokyo, Japan).
2010; 49(9):837-40. doi:
10.2169/internalmedicine.49.2601. [PMID: 20453404] - K Deventer, O J Pozo, P Van Eenoo, F T Delbeke. Detection of urinary markers for thiazide diuretics after oral administration of hydrochlorothiazide and altizide-relevance to doping control analysis.
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AAPS PharmSciTech.
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2007 Oct; 18(10):2724-31. doi:
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2006 Dec; 1135(2):219-29. doi:
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2003 Nov; 33(4):673-85. doi:
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The Journal of dermatology.
2003 Nov; 30(11):801-4. doi:
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2002 Dec; 36(12):1870-4. doi:
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