Chlorothiazide (BioDeep_00000002343)

 

Secondary id: BioDeep_00001867782

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulphonic acid amide

化学式: C7H6ClN3O4S2 (294.9488)
中文名称: 氯噻嗪
谱图信息: 最多检出来源 Homo sapiens(urine) 34.24%

分子结构信息

SMILES: C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)N=CN2
InChI: InChI=1S/C7H6ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-3H,(H,10,11)(H2,9,12,13)

描述信息

Chlorothiazide is only found in individuals that have used or taken this drug. It is a thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812)As a diuretic, chlorothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like chlorothiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of chlorothiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle.
C - Cardiovascular system > C03 - Diuretics > C03A - Low-ceiling diuretics, thiazides > C03AA - Thiazides, plain
D045283 - Natriuretic Agents > D004232 - Diuretics > D049993 - Sodium Chloride Symporter Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C448 - Diuretic > C49185 - Thiazide Diuretic
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3256
D049990 - Membrane Transport Modulators

同义名列表

16 个代谢物同义名

6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulphonic acid amide; 6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonic acid amide; 6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulphonate amide; 6-Chloro-1,1-dioxo-1,2-dihydro-1lambda*6*-benzo[1,2,4]thiadiazine-7-sulfonate amide; 6-chloro-1,1-dioxo-4H-1λ⁶,2,4-benzothiadiazine-7-sulfonamide; 6-Chloro-7-sulphamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; 6-Chloro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide; Chlorothiazidum; chlorothiazide; Chlorothiazid; Chlorthiazide; Clorotiazida; Chlortiazid; Microzide; Diuril; Chlorothiazide



数据库引用编号

37 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ACE, ALB, BGLAP, CALCA, EGFR, NR3C2, WNK1, WNK4
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 2 EGFR, NR3C2
Nucleus 4 ALB, EGFR, NR3C2, WNK1
cytosol 6 ALB, AVP, NR3C2, SLC12A3, WNK1, WNK4
dendrite 2 AVP, BGLAP
centrosome 1 ALB
nucleoplasm 2 NR3C2, SCNN1G
Cell membrane 7 ACE, ADRB3, AGTR1, AGTR2, EGFR, SLC12A1, SLC12A3
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 8 ADRB3, AGTR1, AGTR2, CACNA1I, SCNN1G, SLC12A1, SLC12A3, SLC22A6
cell junction 1 EGFR
cell surface 1 EGFR
glutamatergic synapse 1 EGFR
Golgi apparatus 1 ALB
Golgi membrane 2 EGFR, INS
neuronal cell body 1 CALCA
Lysosome 1 ACE
endosome 2 ACE, EGFR
plasma membrane 11 ACE, ADRB3, AGTR1, AGTR2, CACNA1I, EGFR, REN, SCNN1G, SLC12A1, SLC12A3, SLC22A6
terminal bouton 1 CALCA
Membrane 10 ACE, AGTR1, CACNA1I, EGFR, REN, SLC12A1, SLC12A3, SLC22A6, WNK1, WNK4
apical plasma membrane 4 EGFR, SCNN1G, SLC12A1, SLC12A3
basolateral plasma membrane 2 EGFR, SLC22A6
caveola 1 SLC22A6
extracellular exosome 6 ACE, ALB, SCNN1G, SLC12A1, SLC12A3, SLC22A6
endoplasmic reticulum 1 ALB
extracellular space 9 ACE, ALB, AVP, BGLAP, CALCA, EGFR, INS, PTH, REN
perinuclear region of cytoplasm 1 EGFR
Cell junction, tight junction 1 WNK4
bicellular tight junction 1 WNK4
protein-containing complex 5 ALB, EGFR, SLC22A6, WNK1, WNK4
Single-pass type I membrane protein 2 ACE, EGFR
Secreted 7 ACE, ALB, AVP, BGLAP, CALCA, INS, REN
extracellular region 8 ACE, ALB, AVP, BGLAP, CALCA, INS, PTH, REN
hippocampal mossy fiber to CA3 synapse 1 CALCA
anchoring junction 1 ALB
nuclear membrane 1 EGFR
external side of plasma membrane 2 ACE, SCNN1G
perikaryon 1 BGLAP
apical part of cell 1 REN
vesicle 1 BGLAP
Apical cell membrane 3 SCNN1G, SLC12A1, SLC12A3
Membrane raft 1 EGFR
Cytoplasm, cytoskeleton, spindle 1 WNK1
focal adhesion 1 EGFR
intracellular vesicle 1 EGFR
secretory granule 1 AVP
receptor complex 3 ADRB3, EGFR, NR3C2
ciliary basal body 1 ALB
chromatin 1 NR3C2
mitotic spindle 1 WNK1
centriole 1 ALB
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 1 ALB
sperm midpiece 1 ACE
Basolateral cell membrane 1 SLC22A6
endosome lumen 1 INS
sodium channel complex 1 SCNN1G
cell body 1 WNK4
basal plasma membrane 3 ACE, EGFR, SLC22A6
synaptic membrane 1 EGFR
secretory granule lumen 1 INS
Golgi lumen 2 BGLAP, INS
endoplasmic reticulum lumen 3 ALB, BGLAP, INS
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 2 AVP, CALCA
clathrin-coated endocytic vesicle membrane 2 AVP, EGFR
Basal cell membrane 1 SLC22A6
intracellular non-membrane-bounded organelle 1 WNK1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
ciliary transition fiber 1 ALB


文献列表

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