Pyrrolidine-2-carboxamide (BioDeep_00000180344)

   

human metabolite blood metabolite


代谢物信息卡片


Pyrrolidine-2-carboximidate

化学式: C5H10N2O (114.0793)
中文名称: DL-脯氨酰胺, 吡咯烷-2-甲酰胺
谱图信息: 最多检出来源 Homo sapiens(blood) 12.93%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Pyrrolidine-2-carboxamide. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/pyrrolidine-2-carboxamide (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000180344). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1CC(NC1)C(=O)N
InChI: InChI=1S/C5H10N2O/c6-5(8)4-2-1-3-7-4/h4,7H,1-3H2,(H2,6,8)



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 2 BCL2, CCND1
Endoplasmic reticulum membrane 1 BCL2
Nucleus 2 BCL2, CCND1
cytosol 3 AVP, BCL2, CCND1
dendrite 3 AVP, OPRM1, PNOC
centrosome 1 CCND1
nucleoplasm 1 CCND1
Cell membrane 6 AVPR1A, AVPR1B, OPRD1, OPRL1, OPRM1, TNF
Cell projection, axon 1 OPRM1
Multi-pass membrane protein 6 AVPR1A, AVPR1B, KCNA3, OPRD1, OPRL1, OPRM1
Synapse 2 OPRM1, PNOC
cell surface 1 TNF
glutamatergic synapse 1 KCNA3
Golgi apparatus 2 AVPR1B, OPRM1
Golgi membrane 1 INS
neuronal cell body 2 PNOC, TNF
presynaptic membrane 2 KCNA3, OPRD1
endosome 3 AVPR1A, AVPR1B, OPRM1
plasma membrane 9 AVPR1A, AVPR1B, KCNA3, KNG1, OPRD1, OPRL1, OPRM1, PNOC, TNF
synaptic vesicle membrane 1 OPRD1
Membrane 4 BCL2, KCNA3, OPRD1, OPRM1
axon 2 KCNA3, OPRM1
extracellular exosome 1 KNG1
endoplasmic reticulum 2 BCL2, OPRM1
extracellular space 5 AVP, CXCL8, INS, KNG1, TNF
perinuclear region of cytoplasm 1 KCNA3
bicellular tight junction 1 CCND1
mitochondrion 1 BCL2
protein-containing complex 1 BCL2
Secreted 4 AVP, CXCL8, INS, PNOC
extracellular region 6 AVP, CXCL8, INS, KNG1, PNOC, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 1 TNF
perikaryon 1 OPRM1
cytoplasmic vesicle 1 OPRL1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 1 KCNA3
Membrane raft 2 KCNA3, TNF
pore complex 1 BCL2
collagen-containing extracellular matrix 1 KNG1
secretory granule 1 AVP
neuron projection 3 OPRD1, OPRL1, OPRM1
phagocytic cup 1 TNF
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
[Isoform 2]: Cell membrane 1 KCNA3
endosome lumen 1 INS
Cell projection, dendrite 1 OPRM1
myelin sheath 1 BCL2
synaptic membrane 1 PNOC
voltage-gated potassium channel complex 1 KCNA3
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, KNG1
transcription repressor complex 1 CCND1
platelet alpha granule lumen 1 KNG1
axon terminus 2 OPRD1, PNOC
endocytic vesicle 1 AVPR1A
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 2 AVP, OPRD1
calyx of Held 1 KCNA3
clathrin-coated endocytic vesicle membrane 1 AVP
[Isoform 1]: Cell membrane 1 KCNA3
dendrite membrane 1 OPRD1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
cyclin D1-CDK6 complex 1 CCND1
[Isoform 12]: Cytoplasm 1 OPRM1
spine apparatus 1 OPRD1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Jonas Schilz, Charlotte Clement, Franziska Greiner, Arne Skerra. Direct Affinity Purification of Long-Acting PASylated Proteins with Therapeutic Potential Using L-Prolinamide for Mild Elution. Angewandte Chemie (International ed. in English). 2022 06; 61(25):e202200079. doi: 10.1002/anie.202200079. [PMID: 35325504]
  • Il Hak Bae, Hee Sun Kim, Youngsu You, Chieyeon Chough, Weonu Choe, Min Kyung Seon, Seung Gi Lee, Gyochang Keum, Sung Key Jang, B Moon Kim. Novel benzidine and diaminofluorene prolinamide derivatives as potent hepatitis C virus NS5A inhibitors. European journal of medicinal chemistry. 2015 Aug; 101(?):163-78. doi: 10.1016/j.ejmech.2015.06.033. [PMID: 26134551]
  • Takashi Kondo, Takahiro Nekado, Isamu Sugimoto, Kenya Ochi, Shigeyuki Takai, Atsushi Kinoshita, Akira Hatayama, Susumu Yamamoto, Kazuhito Kawabata, Hisao Nakai, Masaaki Toda. Discovery of long-acting N-(cyanomethyl)-N-alkyl-L-prolinamide inhibitors of dipeptidyl peptidase IV. Bioorganic & medicinal chemistry. 2008 Jan; 16(1):190-208. doi: 10.1016/j.bmc.2007.10.005. [PMID: 17962025]