Isoorientin (BioDeep_00000180167)

   

human metabolite blood metabolite natural product


代谢物信息卡片


2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-4H-chromen-4-one

化学式: C21H20O11 (448.1006)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=C(C=C1C2=CC(=O)C3=C(O2)C=C(C(=C3O)C4C(C(C(C(O4)CO)O)O)O)O)O)O
InChI: InChI=1S/C21H20O11/c22-6-14-17(27)19(29)20(30)21(32-14)16-11(26)5-13-15(18(16)28)10(25)4-12(31-13)7-1-2-8(23)9(24)3-7/h1-5,14,17,19-24,26-30H,6H2

描述信息

同义名列表

7 个代谢物同义名

2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-4H-chromen-4-one; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one; luteolin-6-C-glucoside; 6-Glc-luteolin; iso-orientin; Homoorientin; Isoorientin



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

771 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Zhongbao Zhang, Xiaoqin Tan, Xiaorong Sun, Jianhua Wei, Qing X Li, Zhongyi Wu. Isoorientin Affects Markers of Alzheimer's Disease via Effects on the Oral and Gut Microbiota in APP/PS1 Mice. The Journal of nutrition. 2022 01; 152(1):140-152. doi: 10.1093/jn/nxab328. [PMID: 34636875]
  • Wenliang Wang, Denghui Gao, Qiancheng Zheng, Xi Zhao, Risong Na, Xinsheng Wan, Qing X Li. Interactions of isoorientin and its Semi-synthetic analogs with human serum albumin. Bioorganic chemistry. 2021 11; 116(?):105319. doi: 10.1016/j.bioorg.2021.105319. [PMID: 34488124]
  • Ícaro Putinhon Caruso, Wagner Vilegas, Leandro Cristante de Oliveira, Marinônio Lopes Cornélio. Fluorescence spectroscopic and dynamics simulation studies on isoorientin binding with human serum albumin. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2020 Mar; 228(?):117738. doi: 10.1016/j.saa.2019.117738. [PMID: 31718973]
  • Li Yuan, Xueyi Li, Shenyuan He, Chunxia Gao, Chengtao Wang, Yuyu Shao. Effects of Natural Flavonoid Isoorientin on Growth Performance and Gut Microbiota of Mice. Journal of agricultural and food chemistry. 2018 Sep; 66(37):9777-9784. doi: 10.1021/acs.jafc.8b03568. [PMID: 30160114]
  • Min-Ji Kim, Seung-Hwan Kwon, Choon-Gon Jang, Han-Joo Maeng. Determination of isoorientin levels in rat plasma after oral administration of Vaccinum bracteatum Thunb. methanol extract by high-performance liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC. 2018 Jun; 32(6):e4188. doi: 10.1002/bmc.4188. [PMID: 29334125]
  • Li Yuan, Xiao Han, Wenfeng Li, Daoyuan Ren, Xingbin Yang. Isoorientin Prevents Hyperlipidemia and Liver Injury by Regulating Lipid Metabolism, Antioxidant Capability, and Inflammatory Cytokine Release in High-Fructose-Fed Mice. Journal of agricultural and food chemistry. 2016 Apr; 64(13):2682-9. doi: 10.1021/acs.jafc.6b00290. [PMID: 26961674]
  • Peiying Shi, Xinhua Lin, Hong Yao. Metabolism and plasma pharmacokinetics of isoorientin, a natural active ingredient, in Sprague-Dawley male rats after oral and intravenous administration. Xenobiotica; the fate of foreign compounds in biological systems. 2015; 45(11):999-1008. doi: 10.3109/00498254.2015.1028513. [PMID: 26084374]
  • Vishal R Mali, V Mohan, Subhash L Bodhankar. Antihypertensive and cardioprotective effects of the Lagenaria siceraria fruit in NG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats. Pharmaceutical biology. 2012 Nov; 50(11):1428-35. doi: 10.3109/13880209.2012.684064. [PMID: 22994444]
  • Yong Huang, Feng He, Lin Zheng, Zhirong Zhang, Yanyu Lan, Yonglin Wang. [Simultaneous determination of isoorientin, scutellarin and cynaroside in rat plasma and pharmacokinetics by UPLC-MS/MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Feb; 37(4):529-32. doi: . [PMID: 22667158]
  • Yong Huang, Zhirong Zhang, Lin Zheng, Feng He, Hui Cheng, Yonglin Wang. [Simultaneous determination of protocatechuic acid, isoorientin and scutellarin in rat tissues after a single intravenous administration of compound hongcao for injection by UPLC-MS/MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Nov; 36(22):3189-93. doi: . [PMID: 22375405]
  • Didem Deliorman Orhan, Mustafa Aslan, Göknur Aktay, Ender Ergun, Erdem Yesilada, Fatma Ergun. Evaluation of hepatoprotective effect of Gentiana olivieri herbs on subacute administration and isolation of active principle. Life sciences. 2003 Apr; 72(20):2273-83. doi: 10.1016/s0024-3205(03)00117-6. [PMID: 12628447]
  • M Hattori, Y Z Shu, A I el-Sedawy, T Namba, K Kobashi, T Tomimori. Metabolism of homoorientin by human intestinal bacteria. Journal of natural products. 1988 Sep; 51(5):874-8. doi: 10.1021/np50059a010. [PMID: 3204379]