Gabexate (BioDeep_00000179290)
human metabolite blood metabolite
代谢物信息卡片
ethyl 4-[(6-carbamimidamidohexanoyl)oxy]benzoate
化学式: C16H23N3O4 (321.16884780000004)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 97.14%
分子结构信息
SMILES: CCOC(=O)C1=CC=C(C=C1)OC(=O)CCCCCN=C(N)N
InChI: InChI=1S/C16H23N3O4/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18/h7-10H,2-6,11H2,1H3,(H4,17,18,19)
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent
D006401 - Hematologic Agents > D000925 - Anticoagulants
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor
同义名列表
15 个代谢物同义名
ethyl 4-[(6-carbamimidamidohexanoyl)oxy]benzoate; Gabexate monomethanesulfonate, 14C labeled CPD; Gabexate monomethanesulfonate, 14C-labeled CPD; Monomethanesulfonate, gabexate; Gabexate monomethanesulfonate; Methanesulfonate, gabexate; GABEXic acid mesilic acid; Gabexate methanesulfonate; Mesylate, gabexate; Mesilate, gabexate; GABEXATE MESILATE; Gabexate mesylate; Gabexic acid; gabexate; Foy
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:93036
- PubChem: 3447
- HMDB: HMDB0252569
- DrugBank: DB12831
- ChEMBL: CHEMBL87563
- Wikipedia: Gabexate
- MeSH: Gabexate
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
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European journal of pharmacology.
2021 Jan; 890(?):173720. doi:
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Pulmonary pharmacology & therapeutics.
2015 Aug; 33(?):66-74. doi:
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Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2015 Mar; 26(2):175-84. doi:
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Nephron.
2015; 129(3):223-32. doi:
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2014 Apr; 126(8):545-56. doi:
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Pancreas.
2014 Jan; 43(1):53-63. doi:
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2013 Dec; 87(23):12552-61. doi:
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American journal of physiology. Renal physiology.
2013 Jul; 305(2):F173-81. doi:
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Renal failure.
2013; 35(5):721-4. doi:
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American journal of physiology. Renal physiology.
2012 Oct; 303(7):F939-43. doi:
10.1152/ajprenal.00705.2011. [PMID: 22832922] - Kenichiro Kitamura, Kimio Tomita. Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension.
Clinical and experimental nephrology.
2012 Feb; 16(1):44-8. doi:
10.1007/s10157-011-0506-1. [PMID: 22038264] - Yuko Harada, Hisanao Akiyama, Tatsuji Yoshimoto, Yasuko Urao, Munekazu Ryuzaki, Michiko Handa. Thyroid storm with multiple organ failure, disseminated intravascular coagulation, and stroke with a normal serum FT3 level.
Internal medicine (Tokyo, Japan).
2012; 51(17):2379-83. doi:
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Transplantation proceedings.
2011 Nov; 43(9):3176-8. doi:
10.1016/j.transproceed.2011.10.035. [PMID: 22099749] - Seigo Hidaka, Hideo Iwasaka, Satoshi Hagiwara, Takayuki Noguchi. Gabexate mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury.
The Journal of surgical research.
2011 Jan; 165(1):142-50. doi:
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Transplantation proceedings.
2010 Jul; 42(6):2102-3. doi:
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Journal of gastroenterology and hepatology.
2010 Jul; 25(7):1321-8. doi:
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2010 Apr; 36(4):793-800. doi:
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2009 Jan; 27(1):181-9. doi:
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Journal of gastroenterology and hepatology.
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Digestive diseases and sciences.
2005 May; 50(5):868-73. doi:
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Journal of gastroenterology.
2005 Mar; 40(3):260-5. doi:
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Surgery.
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Pancreas.
2005 Jan; 30(1):54-61. doi:
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Nihon rinsho. Japanese journal of clinical medicine.
2004 Nov; 62(11):2049-56. doi:
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The journal of medical investigation : JMI.
2004 Aug; 51(3-4):186-93. doi:
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Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2004 Aug; 2(8):713-8. doi:
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Clinical cancer research : an official journal of the American Association for Cancer Research.
2004 Jul; 10(13):4517-26. doi:
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Nihon rinsho. Japanese journal of clinical medicine.
2004 May; 62 Suppl 5(?):46-9. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2004 May; 286(5):G784-90. doi:
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Medical science monitor : international medical journal of experimental and clinical research.
2004 Mar; 10(3):PI40-3. doi:
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The American journal of gastroenterology.
2003 Oct; 98(10):2182-6. doi:
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Internal medicine (Tokyo, Japan).
2003 Sep; 42(9):850-5. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2003 Aug; 285(2):G255-65. doi:
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Hepato-gastroenterology.
2003 May; 50(51):851-5. doi:
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Hepato-gastroenterology.
2003 Mar; 50(50):553-8. doi:
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Journal of perinatal medicine.
2003; 31(4):345-9. doi:
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European radiology.
2002 Dec; 12 Suppl 3(?):S189-91. doi:
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Gastrointestinal endoscopy.
2002 Oct; 56(4):488-95. doi:
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Journal of the American College of Surgeons.
2002 Jul; 195(1):41-50. doi:
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Japanese journal of pharmacology.
2002 Jul; 89(3):290-5. doi:
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Current gastroenterology reports.
2002 Apr; 4(2):112-9. doi:
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Shock (Augusta, Ga.).
2002 Mar; 17(3):205-9. doi:
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Anti-cancer drugs.
2001 Sep; 12(8):677-80. doi:
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Gastroenterology.
2001 Jun; 120(7):1784-800. doi:
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2001; 16(2):147-55. doi:
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Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
2001 Jan; 33(1):49-57. doi:
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Hinyokika kiyo. Acta urologica Japonica.
2000 May; 46(5):335-8. doi:
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Critical care medicine.
2000 May; 28(5):1419-22. doi:
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Critical care medicine.
1999 Sep; 27(9):1958-64. doi:
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The Journal of pharmacy and pharmacology.
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Regulatory peptides.
1999 Jun; 82(1-3):19-33. doi:
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Anaesthesia and intensive care.
1999 Jun; 27(3):287-8. doi:
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Rinsho shinkeigaku = Clinical neurology.
1999 Jun; 39(6):653-7. doi:
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1999 Jan; 13(1):56-8. doi:
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1999 Jan; 177(1):78-82. doi:
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1998 Nov; 87(11):1335-40. doi:
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1998 Aug; 17(2):153-7. doi:
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1998 Aug; 115(2):388-96. doi:
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Biological & pharmaceutical bulletin.
1998 Mar; 21(3):227-30. doi:
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The American journal of physiology.
1998 02; 274(2):G406-12. doi:
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Arzneimittel-Forschung.
1998 Jan; 48(1):65-9. doi:
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Internal medicine (Tokyo, Japan).
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