Gabexate (BioDeep_00000179290)
human metabolite blood metabolite
代谢物信息卡片
ethyl 4-[(6-carbamimidamidohexanoyl)oxy]benzoate
化学式: C16H23N3O4 (321.1688)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 66.35%
分子结构信息
SMILES: CCOC(=O)C1=CC=C(C=C1)OC(=O)CCCCCN=C(N)N
InChI: InChI=1S/C16H23N3O4/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18/h7-10H,2-6,11H2,1H3,(H4,17,18,19)
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent
D006401 - Hematologic Agents > D000925 - Anticoagulants
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor
同义名列表
15 个代谢物同义名
ethyl 4-[(6-carbamimidamidohexanoyl)oxy]benzoate; Gabexate monomethanesulfonate, 14C labeled CPD; Gabexate monomethanesulfonate, 14C-labeled CPD; Monomethanesulfonate, gabexate; Gabexate monomethanesulfonate; Methanesulfonate, gabexate; GABEXic acid mesilic acid; Gabexate methanesulfonate; Mesylate, gabexate; Mesilate, gabexate; GABEXATE MESILATE; Gabexate mesylate; Gabexic acid; gabexate; Foy
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:93036
- PubChem: 3447
- HMDB: HMDB0252569
- DrugBank: DB12831
- ChEMBL: CHEMBL87563
- Wikipedia: Gabexate
- MeSH: Gabexate
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Himanshu G Toor, Devjani I Banerjee, Soumya Lipsa Rath, Siddhi A Darji. Computational drug re-purposing targeting the spike glycoprotein of SARS-CoV-2 as an effective strategy to neutralize COVID-19.
European journal of pharmacology.
2021 Jan; 890(?):173720. doi:
10.1016/j.ejphar.2020.173720. [PMID: 33160938] - Yoshiharu Uno. Camostat mesilate therapy for COVID-19.
Internal and emergency medicine.
2020 Nov; 15(8):1577-1578. doi:
10.1007/s11739-020-02345-9. [PMID: 32347443] - Safaa M Kishk, Rania M Kishk, Asmaa S A Yassen, Mohamed S Nafie, Nader A Nemr, Gamal ElMasry, Salim Al-Rejaie, Claire Simons. Molecular Insights into Human Transmembrane Protease Serine-2 (TMPS2) Inhibitors against SARS-CoV2: Homology Modelling, Molecular Dynamics, and Docking Studies.
Molecules (Basel, Switzerland).
2020 Oct; 25(21):. doi:
10.3390/molecules25215007. [PMID: 33137894] - Veronica Mollica, Alessandro Rizzo, Francesco Massari. The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer.
Future oncology (London, England).
2020 Sep; 16(27):2029-2033. doi:
10.2217/fon-2020-0571. [PMID: 32658591] - Richard A Giovane, Shadi Rezai, Ellen Cleland, Cassandra E Henderson. Current pharmacological modalities for management of novel coronavirus disease 2019 (COVID-19) and the rationale for their utilization: A review.
Reviews in medical virology.
2020 09; 30(5):e2136. doi:
10.1002/rmv.2136. [PMID: 32644275] - George Mihai Nitulescu, Horia Paunescu, Sterghios A Moschos, Dimitrios Petrakis, Georgiana Nitulescu, George Nicolae Daniel Ion, Demetrios A Spandidos, Taxiarchis Konstantinos Nikolouzakis, Nikolaos Drakoulis, Aristidis Tsatsakis. Comprehensive analysis of drugs to treat SARS‑CoV‑2 infection: Mechanistic insights into current COVID‑19 therapies (Review).
International journal of molecular medicine.
2020 Aug; 46(2):467-488. doi:
10.3892/ijmm.2020.4608. [PMID: 32468014] - Hong Zhou, Yan Fang, Tao Xu, Wei-Jian Ni, Ai-Zong Shen, Xiao-Ming Meng. Potential therapeutic targets and promising drugs for combating SARS-CoV-2.
British journal of pharmacology.
2020 07; 177(14):3147-3161. doi:
10.1111/bph.15092. [PMID: 32368792] - Mizuki Yamamoto, Maki Kiso, Yuko Sakai-Tagawa, Kiyoko Iwatsuki-Horimoto, Masaki Imai, Makoto Takeda, Noriko Kinoshita, Norio Ohmagari, Jin Gohda, Kentaro Semba, Zene Matsuda, Yasushi Kawaguchi, Yoshihiro Kawaoka, Jun-Ichiro Inoue. The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner.
Viruses.
2020 06; 12(6):. doi:
10.3390/v12060629. [PMID: 32532094] - Konrad H Stopsack, Lorelei A Mucci, Emmanuel S Antonarakis, Peter S Nelson, Philip W Kantoff. TMPRSS2 and COVID-19: Serendipity or Opportunity for Intervention?.
Cancer discovery.
2020 06; 10(6):779-782. doi:
10.1158/2159-8290.cd-20-0451. [PMID: 32276929] - Noor Rahman, Zarrin Basharat, Muhammad Yousuf, Giuseppe Castaldo, Luca Rastrelli, Haroon Khan. Virtual Screening of Natural Products against Type II Transmembrane Serine Protease (TMPRSS2), the Priming Agent of Coronavirus 2 (SARS-CoV-2).
Molecules (Basel, Switzerland).
2020 May; 25(10):. doi:
10.3390/molecules25102271. [PMID: 32408547] - Mutsuo Yamaya, Hidekazu Nishimura, Xue Deng, Akiko Kikuchi, Ryoichi Nagatomi. Protease Inhibitors: Candidate Drugs to Inhibit Severe Acute Respiratory Syndrome Coronavirus 2 Replication.
The Tohoku journal of experimental medicine.
2020 05; 251(1):27-30. doi:
10.1620/tjem.251.27. [PMID: 32448818] - Sarah E Henrickson. Learning from our immunological history: What can SARS-CoV teach us about SARS-CoV-2?.
Science immunology.
2020 04; 5(46):. doi:
10.1126/sciimmunol.abb8618. [PMID: 32245885] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Kamal Albarazanji, Matthew Jennis, Cassandre R Cavanaugh, Wensheng Lang, Bhanu Singh, James C Lanter, James M Lenhard, Pamela J Hornby. Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice.
American journal of physiology. Gastrointestinal and liver physiology.
2019 05; 316(5):G653-G667. doi:
10.1152/ajpgi.00404.2018. [PMID: 30920846] - Hanjing Gao, Qing Song, Faqin Lv, Shan Wang, Yiru Wang, Xiaoyan Li, Yukun Luo, Xingguo Mei, Jie Tang. Protection Provided by a Gabexate Mesylate Thermo-Sensitive In Situ Gel for Rats with Grade III Pancreatic Trauma.
Gut and liver.
2017 Jan; 11(1):156-163. doi:
10.5009/gnl15281. [PMID: 27646597] - Naoki Kuroshima, Takayuki Tanaka, Tamotsu Kuroki, Amane Kitasato, Tomohiko Adachi, Shinichiro Ono, Hajime Matsushima, Takanori Hirayama, Akihiko Soyama, Masaaki Hidaka, Mitsuhisa Takatsuki, Susumu Eguchi. Triple-drug therapy to prevent pancreatic fistula after pancreatectomy in a rat model.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].
2016 Sep; 16(5):917-21. doi:
10.1016/j.pan.2016.06.011. [PMID: 27396917] - Yuki Narita, Miki Ueda, Kohei Uchimura, Yutaka Kakizoe, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Terumasa Nakagawa, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Daisuke Kadowaki, Sumio Hirata, Masashi Mukoyama, Kenichiro Kitamura. Combination therapy with renin-angiotensin-aldosterone system inhibitor telmisartan and serine protease inhibitor camostat mesilate provides further renoprotection in a rat chronic kidney disease model.
Journal of pharmacological sciences.
2016 Feb; 130(2):110-6. doi:
10.1016/j.jphs.2016.01.003. [PMID: 26887332] - Rafaela Gladysz, Yves Adriaenssens, Hans De Winter, Jurgen Joossens, Anne-Marie Lambeir, Koen Augustyns, Pieter Van der Veken. Discovery and SAR of Novel and Selective Inhibitors of Urokinase Plasminogen Activator (uPA) with an Imidazo[1,2-a]pyridine Scaffold.
Journal of medicinal chemistry.
2015 Dec; 58(23):9238-57. doi:
10.1021/acs.jmedchem.5b01171. [PMID: 26575094] - Mutsuo Yamaya, Yoshitaka Shimotai, Yukimasa Hatachi, Nadine Lusamba Kalonji, Yukiko Tando, Yasuo Kitajima, Kaori Matsuo, Hiroshi Kubo, Ryoichi Nagatomi, Seiji Hongo, Morio Homma, Hidekazu Nishimura. The serine protease inhibitor camostat inhibits influenza virus replication and cytokine production in primary cultures of human tracheal epithelial cells.
Pulmonary pharmacology & therapeutics.
2015 Aug; 33(?):66-74. doi:
10.1016/j.pupt.2015.07.001. [PMID: 26166259] - Hsin-Jung Tsai, Chen Ding, Cheng-Ming Tsao, Mei-Hui Liao, Shuk-Man Ka, Wen-Jinn Liaw, Chin-Chen Wu. Effects of gabexate mesilate on coagulopathy and organ dysfunction in rats with endotoxemia: a potential use of thrombelastography in endotoxin-induced sepsis.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.
2015 Mar; 26(2):175-84. doi:
10.1097/mbc.0000000000000214. [PMID: 25396762] - Miki Ueda, Kohei Uchimura, Yuki Narita, Yoshikazu Miyasato, Teruhiko Mizumoto, Jun Morinaga, Manabu Hayata, Yutaka Kakizoe, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Daisuke Kadowaki, Yoshiki Sakai, Masashi Mukoyama, Kenichiro Kitamura. The serine protease inhibitor camostat mesilate attenuates the progression of chronic kidney disease through its antioxidant effects.
Nephron.
2015; 129(3):223-32. doi:
10.1159/000375308. [PMID: 25766432] - Juhui Zhao, Zongyan Wang, Baicang Zou, Yahua Song, Lei Dong. [Camostat mesilate, a protease inhibitor, inhibits visceral sensitivity and spinal c-fos expression in rats with acute restraint stress].
Nan fang yi ke da xue xue bao = Journal of Southern Medical University.
2014 Oct; 34(10):1546-50. doi:
NULL. [PMID: 25345960] - Fiorentina Roviezzo, Antonella De Angelis, Luana De Gruttola, Antonio Bertolino, Nikol Sullo, Vincenzo Brancaleone, Mariarosaria Bucci, Raffaele De Palma, Konrad Urbanek, Bruno D'Agostino, Angela Ianaro, Raffaella Sorrentino, Giuseppe Cirino. Involvement of proteinase activated receptor-2 in the vascular response to sphingosine 1-phosphate.
Clinical science (London, England : 1979).
2014 Apr; 126(8):545-56. doi:
10.1042/cs20130272. [PMID: 24131465] - L-B Xie, D-Y Zeng, X-D Wang, T Lin, Y-P Li, Y-P Lu. Preconditioning with gabexate is superior to inosine for ameliorating acute renal ischemia-reperfusion injury in rats.
Transplantation proceedings.
2014 Jan; 46(1):40-5. doi:
10.1016/j.transproceed.2013.10.037. [PMID: 24507023] - Giovanni Brandi, Simona Tavolari, Tiziana Guarnieri, Mariacristina Di Marco, Paola Paterini, Marina Macchini, Stefania Di Girolamo, Alessio Papi, Francesco De Rosa, Guido Biasco. Antiprotease strategy in pancreatic cancer treatment: emergence from a preclinical study.
Pancreas.
2014 Jan; 43(1):53-63. doi:
10.1097/mpa.0b013e3182a6486e. [PMID: 24201777] - Hideo Wada, Takeshi Matsumoto, Yoshiki Yamashita. [Recent therapeutic strategy for disseminated intravascular coagulation].
[Rinsho ketsueki] The Japanese journal of clinical hematology.
2014 Jan; 55(1):75-82. doi:
NULL. [PMID: 24492040] - Kazuya Shirato, Miyuki Kawase, Shutoku Matsuyama. Middle East respiratory syndrome coronavirus infection mediated by the transmembrane serine protease TMPRSS2.
Journal of virology.
2013 Dec; 87(23):12552-61. doi:
10.1128/jvi.01890-13. [PMID: 24027332] - Jun Morinaga, Yutaka Kakizoe, Taku Miyoshi, Tomoaki Onoue, Miki Ueda, Teruhiko Mizumoto, Rika Yamazoe, Kohei Uchimura, Manabu Hayata, Naoki Shiraishi, Masataka Adachi, Yoshiki Sakai, Kimio Tomita, Kenichiro Kitamura. The antifibrotic effect of a serine protease inhibitor in the kidney.
American journal of physiology. Renal physiology.
2013 Jul; 305(2):F173-81. doi:
10.1152/ajprenal.00586.2012. [PMID: 23698112] - Antonietta Gigante, Maria Ludovica Gasperini, Biagio Barbano, Marta Liberatori, Liborio Sardo, Tamara Jovanovic, Konstantinos Giannakakis, Rosario Cianci, Antonio Amoroso. Gabexate mesylate as treatment in the course of ANCA-negative microscopic polyangiitis.
Renal failure.
2013; 35(5):721-4. doi:
10.3109/0886022x.2013.780620. [PMID: 23560992] - Manabu Hayata, Yutaka Kakizoe, Kohei Uchimura, Jun Morinaga, Rika Yamazoe, Teruhiko Mizumoto, Tomoaki Onoue, Miki Ueda, Naoki Shiraishi, Masataka Adachi, Taku Miyoshi, Yoshiki Sakai, Kimio Tomita, Kenichiro Kitamura. Effect of a serine protease inhibitor on the progression of chronic renal failure.
American journal of physiology. Renal physiology.
2012 Oct; 303(8):F1126-35. doi:
10.1152/ajprenal.00706.2011. [PMID: 22832926] - Kohei Uchimura, Yutaka Kakizoe, Tomoaki Onoue, Manabu Hayata, Jun Morinaga, Rika Yamazoe, Miki Ueda, Teruhiko Mizumoto, Masataka Adachi, Taku Miyoshi, Naoki Shiraishi, Yoshiki Sakai, Kimio Tomita, Kenichiro Kitamura. In vivo contribution of serine proteases to the proteolytic activation of γENaC in aldosterone-infused rats.
American journal of physiology. Renal physiology.
2012 Oct; 303(7):F939-43. doi:
10.1152/ajprenal.00705.2011. [PMID: 22832922] - Kenichiro Kitamura, Kimio Tomita. Proteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension.
Clinical and experimental nephrology.
2012 Feb; 16(1):44-8. doi:
10.1007/s10157-011-0506-1. [PMID: 22038264] - Yuko Harada, Hisanao Akiyama, Tatsuji Yoshimoto, Yasuko Urao, Munekazu Ryuzaki, Michiko Handa. Thyroid storm with multiple organ failure, disseminated intravascular coagulation, and stroke with a normal serum FT3 level.
Internal medicine (Tokyo, Japan).
2012; 51(17):2379-83. doi:
10.2169/internalmedicine.51.7974. [PMID: 22975553] - K Tokodai, M Goto, A Inagaki, T Imura, S Satomi. Effect of synthetic protease inhibitor gabexate mesilate on attenuation of coagulant activity and cytokine release in a rat model of islet transplantation.
Transplantation proceedings.
2011 Nov; 43(9):3176-8. doi:
10.1016/j.transproceed.2011.10.035. [PMID: 22099749] - Seigo Hidaka, Hideo Iwasaka, Satoshi Hagiwara, Takayuki Noguchi. Gabexate mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury.
The Journal of surgical research.
2011 Jan; 165(1):142-50. doi:
10.1016/j.jss.2009.05.039. [PMID: 19766246] - K Tokodai, M Goto, A Inagaki, W Nakanishi, N Okada, H Okada, S Satomi. C5a-inhibitory peptide combined with gabexate mesilate prevents the instant blood-mediated inflammatory reaction in a rat model of islet transplantation.
Transplantation proceedings.
2010 Jul; 42(6):2102-3. doi:
10.1016/j.transproceed.2010.05.100. [PMID: 20692418] - Chia-Yang Hsu, Fa-Yauh Lee, Teh-Ia Huo, Cho-Yu Chan, Hui-Chun Huang, Han-Chih Lin, Ching-Chih Chang, Tzu-Hua Teng, Sun-Sang Wang, Shou-Dong Lee. Lack of therapeutic effects of gabexate mesilate on the hepatic encephalopathy in rats with acute and chronic hepatic failure.
Journal of gastroenterology and hepatology.
2010 Jul; 25(7):1321-8. doi:
10.1111/j.1440-1746.2010.06235.x. [PMID: 20594263] - Shin-ichi Nakanuma, Hidehiro Tajima, Kouichi Okamoto, Hironori Hayashi, Hisatoshi Nakagawara, Ichiro Onishi, Hiroyuki Takamura, Hirohisa Kitagawa, Sachio Fushida, Takashi Tani, Takashi Fujimura, Masato Kayahara, Tetsuo Ohta, Tomohiko Wakayama, Shoichi Iseki, Shin-ichi Harada. Tumor-derived trypsin enhances proliferation of intrahepatic cholangiocarcinoma cells by activating protease-activated receptor-2.
International journal of oncology.
2010 Apr; 36(4):793-800. doi:
10.3892/ijo_00000555. [PMID: 20198321] - Tomoki Doi, Kiyoyasu Kurahashi, Takahisa Goto. [Case of hyperkalemia possibly caused by gabexate mesilate].
Masui. The Japanese journal of anesthesiology.
2010 Feb; 59(2):249-51. doi:
NULL. [PMID: 20169971] - Helga Engi, Nóra Gyémánt, Motohiro Ohkoshi, Leonard Amaral, Joseph Molnár. Modelling of tumour--host coexistence In vitro in the presence of serine protease inhibitors.
In vivo (Athens, Greece).
2009 Sep; 23(5):711-5. doi:
NULL. [PMID: 19779105] - Ai Maekawa, Yutaka Kakizoe, Taku Miyoshi, Naoki Wakida, Takehiro Ko, Naoki Shiraishi, Masataka Adachi, Kimio Tomita, Kenichiro Kitamura. Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension.
Journal of hypertension.
2009 Jan; 27(1):181-9. doi:
10.1097/hjh.0b013e328317a762. [PMID: 19145783] - Yoshifumi Ino, Yoshiyuki Arita, Tetsuro Akashi, Toshinari Kimura, Hisato Igarashi, Takamasa Oono, Masayuki Furukawa, Ken Kawabe, Keiichiro Ogoshi, Jiro Ouchi, Toshihiko Miyahara, Ryoichi Takayanagi, Tetsuhide Ito. Continuous regional arterial infusion therapy with gabexate mesilate for severe acute pancreatitis.
World journal of gastroenterology.
2008 Nov; 14(41):6382-7. doi:
10.3748/wjg.14.6382. [PMID: 19009656] - Yun Ju Jo, Ho Soon Choi, Dae Won Jun, Oh Young Lee, Joo Seop Kang, Il Gyu Park, Kyung Hwan Jung, Joon Soo Hahm. The effects of a new human leukocyte elastase inhibitor (recombinant guamerin) on cerulein-induced pancreatitis in rats.
International immunopharmacology.
2008 Jul; 8(7):959-66. doi:
10.1016/j.intimp.2008.02.014. [PMID: 18486906] - Yang-Il Kim, Shogo Fujita, Yoon-Jin Hwang, Jae-Min Chun, Kyung-Eun Song, Byung-Yeol Chun. Successful intermittent application of the Pringle maneuver for 30 minutes during human hepatectomy: a clinical randomized study with use of a protease inhibitor.
Hepato-gastroenterology.
2007 Oct; 54(79):2055-60. doi:
NULL. [PMID: 18251159] - Yohei Yamada, Ken Hoshino, Yasuhide Morikawa, Jun Okamura, Ryo Hotta, Koji Komori, Shioko Nakao, Hideaki Obara, Shigeyuki Kawachi, Yasushi Fuchimoto, Minoru Tanabe, Motohide Shimazu, Masaki Kitajima. Successful liver transplantation across the ABO incompatibility barrier in 6 cases of biliary atresia.
Journal of pediatric surgery.
2006 Dec; 41(12):1976-9. doi:
10.1016/j.jpedsurg.2006.08.021. [PMID: 17161185] - Shi-Bing Su, Yi-Qun Li, Hong-Yi Shen, Yoshiharu Motoo, Motoo Yoshiharu. [Effects of Chinese herbal medicines on spontaneous chronic pancreatitis in rats and the pathological relationships between formulas and syndromes].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2006 Jul; 4(4):358-62. doi:
10.3736/jcim20060408. [PMID: 16834971] - Ayten Gezici, Hayrettin Ozturk, Huseyin Buyukbayram, Hulya Ozturk, Hanifi Okur. Effects of gabexate mesilate on ischemia-reperfusion-induced testicular injury in rats.
Pediatric surgery international.
2006 May; 22(5):435-41. doi:
10.1007/s00383-006-1667-y. [PMID: 16557390] - Nobuo Ashizawa, Tomoyuki Hashimoto, Tatsuya Miyake, Toshihiro Shizuku, Tomonori Imaoka, Yoshikazu Kinoshita. Efficacy of camostat mesilate compared with famotidine for treatment of functional dyspepsia: is camostat mesilate effective?.
Journal of gastroenterology and hepatology.
2006 Apr; 21(4):767-71. doi:
10.1111/j.1440-1746.2005.04041.x. [PMID: 16677167] - Chun-Chia Chen, Sun-Sang Wang, Shyh-Haw Tsay, Fa-Yauh Lee, Rei-Hwa Lu, Full-Young Chang, Shou-Dong Lee. Effects of gabexate mesilate on serum inflammatory cytokines in rats with acute necrotizing pancreatitis.
Cytokine.
2006 Jan; 33(2):95-9. doi:
10.1016/j.cyto.2005.12.004. [PMID: 16473521] - Yang-Il Kim, Han-Jun Chung, Kyung-Eun Song, Yoon-Jin Hwang, Jong-Won Lee, Yu-Jin Lee, Byung-Yeol Chun. Evaluation of a protease inhibitor in the prevention of ischemia and reperfusion injury in hepatectomy under intermittent Pringle maneuver.
American journal of surgery.
2006 Jan; 191(1):72-6. doi:
10.1016/j.amjsurg.2005.04.018. [PMID: 16399110] - Jiahui Yin, Yasuhiro Noda, Norio Hazemoto, Toshihisa Yotsuyanagi. Distribution of protease inhibitors in lipid emulsions: gabexate mesilate and camostat mesilate.
Chemical & pharmaceutical bulletin.
2005 Aug; 53(8):893-8. doi:
10.1248/cpb.53.893. [PMID: 16079515] - Roberto Caronna, Loretta Diana, Italo Nofroni, Simone Sibio, Stefania Catinelli, Paolo Sammartino, Piero Chirletti. Effects of gabexate mesilate (FOY) on amylase and phospholipase A2 in human serum and pancreatic juice.
Digestive diseases and sciences.
2005 May; 50(5):868-73. doi:
10.1007/s10620-005-2655-0. [PMID: 15906759] - Dongmei Jia, Masashi Taguchi, Makoto Otsuki. Synthetic protease inhibitor camostat prevents and reverses dyslipidemia, insulin secretory defects, and histological abnormalities of the pancreas in genetically obese and diabetic rats.
Metabolism: clinical and experimental.
2005 May; 54(5):619-27. doi:
10.1016/j.metabol.2004.12.005. [PMID: 15877292] - Ken-ichiro Mikami, Takashi Goto, Kouichi Miura, Shigetoshi Ohshima, Kazuo Yoneyama, Jiun-Guey Lin, Daisuke Watanabe, Daisuke Segawa, Ei Kataoka, Tomomi Shibuya, Sumio Watanabe. Gabexate mesilate, a synthetic protease inhibitor, attenuates carbon tetrachloride-induced liver injury in rats.
Journal of gastroenterology.
2005 Mar; 40(3):260-5. doi:
10.1007/s00535-004-1534-3. [PMID: 15830285] - Shigetaka Inoue, Atsushi Sugitani, Hirofumi Yamamoto, Hidehisa Kitada, Kentaro Motoyama, Yasuhiro Okabe, Morihito Ohta, Jun-ichi Yoshida, Ken-ichi Nishiyama, Masao Tanaka. Effect of synthetic protease inhibitor gabexate mesilate on the attenuation of ischemia/reperfusion injury in canine kidney autotransplantation.
Surgery.
2005 Feb; 137(2):216-24. doi:
10.1016/j.surg.2004.07.014. [PMID: 15674204] - Dongmei Jia, Masashi Taguchi, Makoto Otsuki. Preventive and therapeutic effects of the protease inhibitor camostat on pancreatic fibrosis and atrophy in CCK-1 receptor-deficient rats.
Pancreas.
2005 Jan; 30(1):54-61. doi:
NULL. [PMID: 15632700] - Koichi Hirata. [Essential therapeutic strategies for acute pancreatitis--guidelines for initial treatment and their significance].
Nihon rinsho. Japanese journal of clinical medicine.
2004 Nov; 62(11):2049-56. doi:
NULL. [PMID: 15552888] - Hirohiko Satoh, Masamitsu Harada, Seiki Tashiro, Tsutomu Shiroya, Haruo Imawaka, Koji Machii. The effect of continuous arterial infusion of gabexate mesilate (FOY-007) on experimental acute pancreatitis.
The journal of medical investigation : JMI.
2004 Aug; 51(3-4):186-93. doi:
10.2152/jmi.51.186. [PMID: 15460905] - Angelo Andriulli, Luigi Solmi, Silvano Loperfido, Pietro Leo, Virginia Festa, Angelo Belmonte, Fulvio Spirito, Michele Silla, Giovambattista Forte, Vittorio Terruzzi, Giorgio Marenco, Enrico Ciliberto, Antonio Sabatino, Fabio Monica, Maria Rita Magnolia, Francesco Perri. Prophylaxis of ERCP-related pancreatitis: a randomized, controlled trial of somatostatin and gabexate mesylate.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.
2004 Aug; 2(8):713-8. doi:
10.1016/s1542-3565(04)00295-2. [PMID: 15290665] - Wan-Hee Yoon, Yeon-Joo Jung, Tae-Dong Kim, Ge Li, Byoung-Jeon Park, Ji-Yeon Kim, Young-Chul Lee, Jin-Man Kim, Jong-Il Park, Hae-Duck Park, Zae-Sung No, Kyu Lim, Byung-Doo Hwang, Young S Kim. Gabexate mesilate inhibits colon cancer growth, invasion, and metastasis by reducing matrix metalloproteinases and angiogenesis.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2004 Jul; 10(13):4517-26. doi:
10.1158/1078-0432.ccr-04-0084. [PMID: 15240544] - Kazo Kaizu, Kohei Uriu, Masanori Ikeda. [Changes in coagulation, fibrinolysis and platelet functions during extracorporeal circulation].
Nihon rinsho. Japanese journal of clinical medicine.
2004 May; 62 Suppl 5(?):46-9. doi:
NULL. [PMID: 15197886] - Mitsuo Tashiro, Linda C Samuelson, Rodger A Liddle, John A Williams. Calcineurin mediates pancreatic growth in protease inhibitor-treated mice.
American journal of physiology. Gastrointestinal and liver physiology.
2004 May; 286(5):G784-90. doi:
10.1152/ajpgi.00446.2003. [PMID: 14684381] - Marco Ranucci. Gabexate mesilate and heparin responsiveness in coronary patients.
Medical science monitor : international medical journal of experimental and clinical research.
2004 Mar; 10(3):PI40-3. doi:
NULL. [PMID: 14976449] - Enzo Masci, Giorgio Cavallini, Alberto Mariani, Luca Frulloni, Pier Alberto Testoni, Simona Curioni, Alberto Tittobello, Generoso Uomo, Guido Costamagna, Sandro Zambelli, Gianpiero Macarri, Paolo Innocenti, Carola Dragonetti. Comparison of two dosing regimens of gabexate in the prophylaxis of post-ERCP pancreatitis.
The American journal of gastroenterology.
2003 Oct; 98(10):2182-6. doi:
10.1111/j.1572-0241.2003.07698.x. [PMID: 14572565] - Takatoshi Saito, Masahito Tsuchiya, Chihiro Shikata, Hiroshi Yamaguchi, Shu-ichi Miyata, Sei-ichiro Matsuo, Sho Ishizawa, Kunihiko Yoshimura. Microscopic polyangiitis associated with marked systemic bleeding tendency caused by disseminated intravascular coagulation.
Internal medicine (Tokyo, Japan).
2003 Sep; 42(9):850-5. doi:
10.2169/internalmedicine.42.850. [PMID: 14518675] - Joseph R Reeve, Gary M Green, Peter Chew, Viktor E Eysselein, David A Keire. CCK-58 is the only detectable endocrine form of cholecystokinin in rat.
American journal of physiology. Gastrointestinal and liver physiology.
2003 Aug; 285(2):G255-65. doi:
10.1152/ajpgi.00523.2002. [PMID: 12686511] - Raffaele Pezzilli, Armando Gabbrielli, Antonio Maria Morselli Labate, Pasquale D'Alessio, Bahjat Barakat, Guido Costamagna, Francesco Dibenedetti, Margherita Massa, Giovanni Merlini, Gianvico Melzi d'Eril. Does gabexate mesilate affect serum concentrations of acute phase proteins after endoscopic retrograde cholangiopancreatography examination?.
Hepato-gastroenterology.
2003 May; 50(51):851-5. doi:
NULL. [PMID: 12828103] - De-Fa Chiu, Jih-Chang Chen, Han-Ming Chen, Chip-Jin Ng, Ming-Hwang Shyr, Miin-Fu Chen. Results of treating severe acute pancreatitis with gabexate is associated with neutrophil apoptosis activity.
Hepato-gastroenterology.
2003 Mar; 50(50):553-8. doi:
. [PMID: 12749271] - Tatsuya Fukami, Hideto Chaen, Hiroshi Imura, Kenji Sudou, Fuyuki Eguchi. Acute pancreatitis occurring in the early postpartum period: a case report.
Journal of perinatal medicine.
2003; 31(4):345-9. doi:
10.1515/jpm.2003.051. [PMID: 12951894] - Yukihiro Hama, Yoshie Iwasaki, Tatsumi Kaji, Kazuo Hatsuse, Shoichi Kusano. Coil compaction after embolization of the superior mesenteric artery pseudoaneurysm.
European radiology.
2002 Dec; 12 Suppl 3(?):S189-91. doi:
10.1007/s00330-002-1465-4. [PMID: 12522638] - Angelo Andriulli, Rocco Clemente, Luigi Solmi, Vittorio Terruzzi, Renzo Suriani, Angelo Sigillito, Gioacchino Leandro, Pietro Leo, Giovanni De Maio, Francesco Perri. Gabexate or somatostatin administration before ERCP in patients at high risk for post-ERCP pancreatitis: a multicenter, placebo-controlled, randomized clinical trial.
Gastrointestinal endoscopy.
2002 Oct; 56(4):488-95. doi:
10.1067/mge.2002.128130. [PMID: 12297762] - Yang-Il Kim, Yoon-Jin Hwang, Kyung-Eun Song, Young-Kook Yun, Jong-Won Lee, Byung-Yeol Chun. Hepatocyte protection by a protease inhibitor against ischemia/reperfusion injury of human liver.
Journal of the American College of Surgeons.
2002 Jul; 195(1):41-50. doi:
10.1016/s1072-7515(01)01118-8. [PMID: 12113544] - Norikazu Sato, Shinji Suzuki, Setsuko Kanai, Minoru Ohta, Atsuo Jimi, Tetsuo Noda, Souichi Takiguchi, Akihiro Funakoshi, Kyoko Miyasaka. Different effects of oral administration of synthetic trypsin inhibitor on the pancreas between cholecystokinin-A receptor gene knockout mice and wild type mice.
Japanese journal of pharmacology.
2002 Jul; 89(3):290-5. doi:
10.1254/jjp.89.290. [PMID: 12184735] - John Baillie. Predicting and preventing post-ERCP pancreatitis.
Current gastroenterology reports.
2002 Apr; 4(2):112-9. doi:
10.1007/s11894-002-0047-6. [PMID: 11900675] - Hiroshi Mitsuoka, Erik B Kistler, Geert W Schmid-Schönbein. Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock.
Shock (Augusta, Ga.).
2002 Mar; 17(3):205-9. doi:
10.1097/00024382-200203000-00008. [PMID: 11900339] - N Tomita, H Kanamori, H Fujita, A Maruta, A Naitoh, S Nakamura, Y Ota, N Nozue, M Kihara, Y Ishigatsubo. Granulomatous tubulointerstitial nephritis induced by all-trans retinoic acid.
Anti-cancer drugs.
2001 Sep; 12(8):677-80. doi:
10.1097/00001813-200109000-00005. [PMID: 11604554] - M Okuno, K Akita, H Moriwaki, N Kawada, K Ikeda, K Kaneda, Y Suzuki, S Kojima. Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta.
Gastroenterology.
2001 Jun; 120(7):1784-800. doi:
10.1053/gast.2001.24832. [PMID: 11375959] - R Federico, L Leone, M Botta, C Binda, R Angelini, G Venturini, P Ascenzi. Inhibition of pig liver and Zea mays L. polyamine oxidase: a comparative study.
Journal of enzyme inhibition.
2001; 16(2):147-55. doi:
10.1080/14756360109162364. [PMID: 11342283] - R Pezzilli, M Miglioli. Multicentre comparative study of two schedules of gabexate mesilate in the treatment of acute pancreatitis. Italian Acute Pancreatitis Study Group.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
2001 Jan; 33(1):49-57. doi:
10.1016/s1590-8658(01)80135-3. [PMID: 11303975] - T Kondo, H Okuda, M Suzuki, T Okumura, H Toma. [A case of emphysematous pyelonephritis improved with conservative therapy--indication for conservative therapy].
Hinyokika kiyo. Acta urologica Japonica.
2000 May; 46(5):335-8. doi:
NULL. [PMID: 10876758] - T Nishiyama, T Matsukawa, K Hanaoka. Is protease inhibitor a choice for the treatment of pre- or mild disseminated intravascular coagulation?.
Critical care medicine.
2000 May; 28(5):1419-22. doi:
10.1097/00003246-200005000-00027. [PMID: 10834689] - S E Jung, I J Yun, Y K Youn, J E Lee, J Ha, D Y Noh, S J Kim, S K Oh, K J Choe. Effect of protease inhibitor on ischemia-reperfusion injury to rat liver.
World journal of surgery.
1999 Oct; 23(10):1027-31. doi:
10.1007/s002689900618. [PMID: 10512942] - N Harada, K Okajima, S Kushimoto. Gabexate mesilate, a synthetic protease inhibitor, reduces ischemia/reperfusion injury of rat liver by inhibiting leukocyte activation.
Critical care medicine.
1999 Sep; 27(9):1958-64. doi:
10.1097/00003246-199909000-00040. [PMID: 10507625] - C Yuasa, K Irimura, M Oda, K Fukui, T Oka. Oral administration of sepimostat mesilate prevents acute alcohol pancreatic injury in rats.
The Journal of pharmacy and pharmacology.
1999 Jul; 51(7):867-71. doi:
10.1211/0022357991773087. [PMID: 10467964] - T Brzozowski, P C Konturek, S J Konturek, R Pajdo, D Drozdowicz, S Kwiecień, E G Hahn. Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves.
Regulatory peptides.
1999 Jun; 82(1-3):19-33. doi:
10.1016/s0167-0115(99)00029-4. [PMID: 10458643] - K Terasako. Disseminated intravascular coagulation in a patient undergoing removal of humeral head for pain relief.
Anaesthesia and intensive care.
1999 Jun; 27(3):287-8. doi:
10.1177/0310057x9902700311. [PMID: 10389563] - M Osoegawa, S Motomura, H Yamanaka, K Tamura, T Miyoshi. [A successfully treated parkinsonian patient with neuroleptic malignant syndrome complicated by status epilepticus and disseminated intravascular coagulation].
Rinsho shinkeigaku = Clinical neurology.
1999 Jun; 39(6):653-7. doi:
NULL. [PMID: 10502992] - Y Ikeda, H Ito, K Hashimoto. Effect of camostat mesilate on urinary protein excretion in three patients with advanced diabetic nephropathy.
Journal of diabetes and its complications.
1999 Jan; 13(1):56-8. doi:
10.1016/s1056-8727(98)00016-6. [PMID: 10232711] - S Ono, S Aosasa, H Mochizuki. Effects of a protease inhibitor on reduction of surgical stress in esophagectomy.
American journal of surgery.
1999 Jan; 177(1):78-82. doi:
10.1016/s0002-9610(98)00300-6. [PMID: 10037314] - R Cortesi, P Ascenzi, M Colasanti, T Persichini, G Venturini, M Bolognesi, A Pesce, C Nastruzzi, E Menegatti. Cross-enzyme inhibition by gabexate mesylate: formulation and reactivity study.
Journal of pharmaceutical sciences.
1998 Nov; 87(11):1335-40. doi:
10.1021/js980079u. [PMID: 9811486] - L Ercolini, R Angelini, R Federico, G Rea, G Venturini, P Ascenzi. Competitive inhibition of Lens culinaris L. copper amine oxidase by amiloride, p-aminobenzamidine, clonidine, 4',6-diamidino-2-phenylindole and gabexate mesylate: a comparative study.
Journal of enzyme inhibition.
1998 Sep; 13(6):465-71. doi:
10.3109/14756369809020550. [PMID: 9825309] - K B Hahm, J H Kim, B M You, Y S Kim, S W Cho, H Yim, B O Ahn, W B Kim. Induction of apoptosis with an extract of Artemisia asiatica attenuates the severity of cerulein-induced pancreatitis in rats.
Pancreas.
1998 Aug; 17(2):153-7. doi:
10.1097/00006676-199808000-00007. [PMID: 9700946] - H Friess, J Kleeff, R Isenmann, P Malfertheiner, M W Büchler. Adaptation of the human pancreas to inhibition of luminal proteolytic activity.
Gastroenterology.
1998 Aug; 115(2):388-96. doi:
10.1016/s0016-5085(98)70205-7. [PMID: 9679044] - H Tagami, S Abe, Y Yoshida, I Tanaka, C Kamei. Effect of methylcarbonylmethyl 2(S)-[4-(4-guanidino-benzoyloxy)phenyl] propionate methanesulfonate (TT-S24) on experimental pancreatitis in rats.
Biological & pharmaceutical bulletin.
1998 Mar; 21(3):227-30. doi:
10.1248/bpb.21.227. [PMID: 9556150] - M Yamamoto, H Shirohara, M Otsuki. CCK-, secretin-, and cholinergic-independent pancreatic fluid hypersecretion in protease inhibitor-treated rats.
The American journal of physiology.
1998 02; 274(2):G406-12. doi:
10.1152/ajpgi.1998.274.2.g406. [PMID: 9486196] - K Kimura, K Tominaga, M Fujii, T Saito, H Kasai. Effects of loxiglumide on experimental acute pancreatitis in comparison with gabexate mesilate.
Arzneimittel-Forschung.
1998 Jan; 48(1):65-9. doi:
NULL. [PMID: 9522035] - R Federico, R Angelini, L Ercolini, G Venturini, A Mattevi, P Ascenzi. Competitive inhibition of swine kidney copper amine oxidase by drugs: amiloride, clonidine, and gabexate mesylate.
Biochemical and biophysical research communications.
1997 Nov; 240(1):150-2. doi:
10.1006/bbrc.1997.7630. [PMID: 9367901] - K Yoshioka, H Nagata, Y Nakamura, Y Kasamatsu, S Yokoo, T Yoshida, M Kondo. Pyogenic clavicular osteomyelitis associated with disseminated intravascular coagulation and acute renal failure in a patient with non-insulin-dependent diabetes mellitus.
Internal medicine (Tokyo, Japan).
1997 Nov; 36(11):810-4. doi:
10.2169/internalmedicine.36.810. [PMID: 9392355]
