AP3A-lyophilized (BioDeep_00000175548)

   

human metabolite blood metabolite


代谢物信息卡片


bis[({[5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy]phosphinic acid

化学式: C20H27N10O16P3 (756.0819)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)OCC4C(C(C(O4)N5C=NC6=C(N=CN=C65)N)O)O)O)O)N
InChI: InChI=1S/C20H27N10O16P3/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(43-19)1-41-47(35,36)45-49(39,40)46-48(37,38)42-2-8-12(32)14(34)20(44-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H2,21,23,25)(H2,22,24,26)



数据库引用编号

4 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 FHIT, HINT1, ITPR3, KARS1, MYLK, NIT1, NT5C2, SHMT2
Peripheral membrane protein 1 KARS1
Endoplasmic reticulum membrane 1 ITPR3
Nucleus 6 FHIT, HINT1, KARS1, NIT1, SHMT2, TRIM33
cytosol 5 FHIT, HINT1, KARS1, MYLK, NT5C2
dendrite 1 P2RY1
nucleoplasm 4 HINT1, ITPR3, KARS1, TRIM33
Cell membrane 3 KARS1, P2RX1, P2RY1
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Multi-pass membrane protein 4 ITPR3, KCNA3, P2RX1, P2RY1
Synapse 1 MYLK
cell surface 3 ENPP1, P2RY1, TNR
glutamatergic synapse 4 KCNA3, P2RX1, P2RY1, TNR
Golgi membrane 1 INS
lysosomal membrane 1 ENPP1
mitochondrial inner membrane 1 SHMT2
neuronal cell body 1 ITPR3
postsynapse 1 P2RX1
presynaptic membrane 1 KCNA3
Cytoplasm, cytosol 1 NT5C2
plasma membrane 11 ENPP1, F2, FHIT, GCG, HINT1, ITPR3, KARS1, KCNA3, MYLK, P2RX1, P2RY1
Membrane 4 ENPP1, ITPR3, KCNA3, P2RX1
apical plasma membrane 1 P2RY1
axon 1 KCNA3
basolateral plasma membrane 2 ENPP1, P2RY1
brush border 1 ITPR3
extracellular exosome 3 F2, HINT1, SHMT2
endoplasmic reticulum 1 ITPR3
extracellular space 8 ENPP1, F2, GCG, IFNA1, INS, KARS1, MTHFD2, TNR
perinuclear region of cytoplasm 1 KCNA3
Schaffer collateral - CA1 synapse 1 TNR
mitochondrion 5 FHIT, KARS1, MTHFD2, NIT1, SHMT2
protein-containing complex 1 P2RX1
postsynaptic density 1 P2RY1
Secreted 6 ENPP1, F2, GCG, IFNA1, INS, KARS1
extracellular region 4 F2, GCG, INS, TNR
mitochondrial matrix 4 KARS1, MTHFD2, NUDT2, SHMT2
external side of plasma membrane 1 P2RX1
Secreted, extracellular space, extracellular matrix 1 TNR
actin cytoskeleton 1 MYLK
microtubule cytoskeleton 1 SHMT2
nucleolus 1 ITPR3
apical part of cell 1 ITPR3
postsynaptic membrane 3 KCNA3, P2RX1, P2RY1
presynaptic active zone membrane 2 P2RX1, P2RY1
Cell projection, lamellipodium 1 MYLK
Mitochondrion inner membrane 1 SHMT2
Membrane raft 3 KCNA3, P2RX1, TNR
mitochondrial nucleoid 1 SHMT2
sarcoplasmic reticulum 1 ITPR3
collagen-containing extracellular matrix 2 F2, TNR
nuclear outer membrane 1 ITPR3
receptor complex 1 ITPR3
cilium 1 P2RY1
chromatin 1 TRIM33
cytoskeleton 1 HINT1
[Isoform 2]: Mitochondrion 1 NIT1
blood microparticle 1 F2
Basolateral cell membrane 1 ENPP1
[Isoform 2]: Cell membrane 1 KCNA3
fibrillar center 1 FHIT
endosome lumen 1 INS
specific granule membrane 1 P2RX1
cell body 1 P2RY1
stress fiber 1 MYLK
[Isoform 1]: Cytoplasm 1 NIT1
voltage-gated potassium channel complex 1 KCNA3
secretory granule lumen 2 GCG, INS
secretory granule membrane 2 ITPR3, P2RX1
Golgi lumen 2 F2, INS
endoplasmic reticulum lumen 3 F2, GCG, INS
histone deacetylase complex 1 HINT1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
perineuronal net 1 TNR
calyx of Held 1 KCNA3
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
platelet dense tubular network membrane 1 ITPR3
[Isoform 1]: Cell membrane 1 KCNA3
aminoacyl-tRNA synthetase multienzyme complex 1 KARS1
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
[Glucagon-like peptide 1]: Secreted 1 GCG
transport vesicle membrane 1 ITPR3
[Isoform Mitochondrial]: Mitochondrion 1 KARS1
[Isoform Cytoplasmic]: Cytoplasm, cytosol 1 KARS1
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
tenascin complex 1 TNR
[Ectonucleotide pyrophosphatase/phosphodiesterase family member 1]: Cell membrane 1 ENPP1
[Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form]: Secreted 1 ENPP1
Mitochondrion matrix, mitochondrion nucleoid 1 SHMT2
BRISC complex 1 SHMT2


文献列表

  • Anita Śliwińska, Marcin R Naliwajski, Agnieszka Pietrosiuk, Katarzyna Sykłowska-Baranek. In Vitro Response of Polyscias filicifolia (Araliaceae) Shoots to Elicitation with Alarmone-Diadenosine Triphosphate, Methyl Jasmonate, and Salicylic Acid. Cells. 2021 02; 10(2):. doi: 10.3390/cells10020419. [PMID: 33671225]
  • Małgorzata Pietrowska-Borek, Łukasz Czekała, Sarai Belchí-Navarro, María Angeles Pedreño, Andrzej Guranowski. Diadenosine triphosphate is a novel factor which in combination with cyclodextrins synergistically enhances the biosynthesis of trans-resveratrol in Vitis vinifera cv. Monastrell suspension cultured cells. Plant physiology and biochemistry : PPB. 2014 Nov; 84(?):271-276. doi: 10.1016/j.plaphy.2014.09.019. [PMID: 25310254]
  • Anna Schulz, Vera Jankowski, Walter Zidek, Joachim Jankowski. Highly sensitive, selective and rapid LC-MS method for simultaneous quantification of diadenosine polyphosphates in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Jun; 961(?):91-6. doi: 10.1016/j.jchromb.2014.05.018. [PMID: 24869945]
  • David G Watson, Francesca Tonelli, Manal Alossaimi, Leon Williamson, Edmond Chan, Irina Gorshkova, Evgeny Berdyshev, Robert Bittman, Nigel J Pyne, Susan Pyne. The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells. Cellular signalling. 2013 Apr; 25(4):1011-7. doi: 10.1016/j.cellsig.2013.01.002. [PMID: 23314175]
  • Ronald A Albright, William C Chang, Donna Robert, Deborah L Ornstein, Wenxiang Cao, Lynn Liu, Meredith E Redick, J Isaac Young, Enrique M De La Cruz, Demetrios T Braddock. NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Blood. 2012 Nov; 120(22):4432-40. doi: 10.1182/blood-2012-04-425215. [PMID: 22995898]
  • Joachim Jankowski, Vera Jankowski, Udo Laufer, Markus van der Giet, Lars Henning, Martin Tepel, Walter Zidek, Hartmut Schlüter. Identification and quantification of diadenosine polyphosphate concentrations in human plasma. Arteriosclerosis, thrombosis, and vascular biology. 2003 Jul; 23(7):1231-8. doi: 10.1161/01.atv.0000075913.00428.fd. [PMID: 12738682]
  • Michael Kron, Michael Petridis, Youli Milev, Joseph Leykam, Michael Härtlein. Expression, localization and alternative function of cytoplasmic asparaginyl-tRNA synthetase in Brugia malayi. Molecular and biochemical parasitology. 2003 Jun; 129(1):33-9. doi: 10.1016/s0166-6851(03)00080-x. [PMID: 12798504]
  • A Minelli, L Liguori, I Bellezza, T Renieri, C Castellini. Effects of diadenosine polyphosphates and seminal fluid vesicles on rabbit sperm cells. Reproduction (Cambridge, England). 2003 Jun; 125(6):827-35. doi: 10.1530/rep.0.1250827. [PMID: 12773105]
  • G Gabriëls, K Endlich, K H Rahn, E Schlatter, M Steinhausen. In vivo effects of diadenosine polyphosphates on rat renal microcirculation. Kidney international. 2000 Jun; 57(6):2476-84. doi: 10.1046/j.1523-1755.2000.00106.x. [PMID: 10844616]
  • A Minelli, M Moroni, I Mezzasoma. Human seminal plasma soluble 5'-nucleotidase: regulatory aspects of the dephosphorylation of nucleoside 5'-monophosphates. Biochemical and molecular medicine. 1997 Jun; 61(1):95-101. doi: 10.1006/bmme.1997.2589. [PMID: 9232203]
  • J Mateo, P Rotllan, E Marti, I Gomez De Aranda, C Solsona, M T Miras-Portugal. Diadenosine polyphosphate hydrolase from presynaptic plasma membranes of Torpedo electric organ. The Biochemical journal. 1997 May; 323 ( Pt 3)(?):677-84. doi: 10.1042/bj3230677. [PMID: 9169600]
  • A Ogilvie, R Bläsius, E Schulze-Lohoff, R B Sterzel. Adenine dinucleotides: a novel class of signalling molecules. Journal of autonomic pharmacology. 1996 Dec; 16(6):325-8. doi: 10.1111/j.1474-8673.1996.tb00045.x. [PMID: 9131408]
  • H Hohage, C Reinhardt, U Borucki, G Enck, H Schlüter, E Schlatter, W Zidek. Effects of diadenosine polyphosphates on renal function and blood pressure in anesthetized Wistar rats. Journal of the American Society of Nephrology : JASN. 1996 Aug; 7(8):1216-22. doi: 10.1681/asn.v781216. [PMID: 8866415]
  • E Schlatter, I Ankorina, S Haxelmans, R Kleta. Effects of diadenosine polyphosphates, ATP and angiotensin II on cytosolic Ca2+ activity and contraction of rat mesangial cells. Pflugers Archiv : European journal of physiology. 1995 Sep; 430(5):721-8. doi: 10.1007/bf00386167. [PMID: 7478924]
  • E Busshardt, W Gerok, D Häussinger. Regulation of hepatic parenchymal and non-parenchymal cell function by the diadenine nucleotides Ap3A and Ap4A. Biochimica et biophysica acta. 1989 Feb; 1010(2):151-9. doi: 10.1016/0167-4889(89)90155-9. [PMID: 2563228]
  • J Lüthje, A Ogilvie. Catabolism of Ap4A and Ap3A in whole blood. The dinucleotides are long-lived signal molecules in the blood ending up as intracellular ATP in the erythrocytes. European journal of biochemistry. 1988 Apr; 173(1):241-5. doi: 10.1111/j.1432-1033.1988.tb13990.x. [PMID: 3356191]
  • J Lüthje, A Ogilvie. Catabolism of Ap4A and Ap3A in human serum. Identification of isoenzymes and their partial characterization. European journal of biochemistry. 1987 Dec; 169(2):385-8. doi: 10.1111/j.1432-1033.1987.tb13624.x. [PMID: 2826143]
  • J Lüthje, D Miller, A Ogilvie. Unproportionally high concentrations of diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) in heavy platelets. Consequences for in vitro studies with human platelets. Blut. 1987 Apr; 54(4):193-200. doi: 10.1007/bf00594193. [PMID: 3030468]
  • J Lüthje, J Baringer, A Ogilvie. Effects of diadenosine triphosphate (Ap3A) and diadenosine tetraphosphate (Ap4A) on platelet aggregation in unfractionated human blood. Blut. 1985 Dec; 51(6):405-13. doi: 10.1007/bf00320727. [PMID: 3852686]
  • J Lüthje, J Baringer, A Ogilvie. Highly efficient induction of human platelet aggregation in heparinized platelet-rich plasma by diadenosine triphosphate (Ap3A). Thrombosis and haemostasis. 1985 Aug; 54(2):469-71. doi: . [PMID: 4082083]
  • J Lüthje, A Ogilvie. Catabolism of Ap3A and Ap4A in human plasma. Purification and characterization of a glycoprotein complex with 5'-nucleotide phosphodiesterase activity. European journal of biochemistry. 1985 May; 149(1):119-27. doi: 10.1111/j.1432-1033.1985.tb08901.x. [PMID: 2986968]
  • J Lüthje, A Ogilvie. Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. Biochemical and biophysical research communications. 1984 Feb; 118(3):704-9. doi: 10.1016/0006-291x(84)91451-7. [PMID: 6704102]