4-Methylumbelliferone sulfate (BioDeep_00000001714)

   

human metabolite blood metabolite


代谢物信息卡片


(4-Methyl-2-oxidanylidene-chromen-7-yl) hydrogen sulphuric acid

化学式: C10H8O6S (256.0041588)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 10.11%

分子结构信息

SMILES: CC1=CC(=O)OC2=C1C=CC(=C2)OS(=O)(=O)O
InChI: InChI=1S/C10H8O6S/c1-6-4-10(11)15-9-5-7(2-3-8(6)9)16-17(12,13)14/h2-5H,1H3,(H,12,13,14)

描述信息

CONFIDENCE standard compound; INTERNAL_ID 8324

同义名列表

31 个代谢物同义名

(4-Methyl-2-oxidanylidene-chromen-7-yl) hydrogen sulphuric acid; (4-Methyl-2-oxidanylidene-chromen-7-yl) hydrogen sulfuric acid; 4-Methyl-2-oxo-2H-1-benzopyran-7-yl hydrogen sulphuric acid; 4-Methyl-2-oxo-2H-1-benzopyran-7-yl hydrogen sulfuric acid; (4-Methyl-2-oxidanylidene-chromen-7-yl) hydrogen sulphate; (4-Methyl-2-oxidanylidene-chromen-7-yl) hydrogen sulfate; 4-Methyl-2-oxo-2H-1-benzopyran-7-yl hydrogen sulphate; 4-Methyl-2-oxo-2H-1-benzopyran-7-yl hydrogen sulfate; (4-methyl-2-oxo-2H-chromen-7-yl)oxidanesulfonic acid; (4-Methyl-2-oxochromen-7-yl) hydrogen sulphuric acid; (4-Methyl-2-oxochromen-7-yl) hydrogen sulfuric acid; (4-Methyl-2-oxochromen-7-yl) hydrogen sulphate; (4-Methyl-2-oxochromen-7-yl) hydrogen sulfate; 4-Methylumbelliferyl sulfate, potassium salt; 4-Methyl-7-(sulphooxy)-2H-1-benzopyran-2-one; 4-Methyl-7-(sulfooxy)-2H-1-benzopyran-2-one; 4-Methylumbelliferone sulphuric acid; 4-Methylumbelliferone sulfuric acid; 4-Methylumbelliferyl sulphuric acid; 4-Methylumbelliferyl sulfuric acid; 4-Methylumbelliferone sulphate; 4-Methylumbelliferone sulfate; 4-Methylumbelliferyl sulphate; 4-Methylumbelliferyl sulfate; Hymecromone 7-sulphuric acid; 7-Sulphooxy-4-methylcoumarin; Hymecromone 7-sulfuric acid; 7-Sulfooxy-4-methylcoumarin; Hymecromone 7-sulphate; Hymecromone 7-sulfate; Hymecromone sulfate



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Claire Grignon, Antoine Dupuis, Marion Albouy-Llaty, Maxime Condylis, Laurence Barrier, Pascal Carato, Bertrand Brunet, Virginie Migeot, Nicolas Venisse. Validation of a probe for assessing deconjugation of glucuronide and sulfate phase II metabolites assayed through LC-MS/MS in biological matrices. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Sep; 1061-1062(?):72-78. doi: 10.1016/j.jchromb.2017.07.013. [PMID: 28710970]
  • Gabriella Cotugno, Patrizia Annunziata, Maria Vittoria Barone, Marianthi Karali, Sandro Banfi, Alberto Auricchio. Impact of age at administration, lysosomal storage, and transgene regulatory elements on AAV2/8-mediated rat liver transduction. PloS one. 2012; 7(3):e33286. doi: 10.1371/journal.pone.0033286. [PMID: 22428010]
  • Marc-André Frese, Stefanie Schulz, Thomas Dierks. Arylsulfatase G, a novel lysosomal sulfatase. The Journal of biological chemistry. 2008 Apr; 283(17):11388-95. doi: 10.1074/jbc.m709917200. [PMID: 18283100]
  • Hirokazu Yokoyama, Naohiko Anzai, Marija Ljubojevic, Naoko Ohtsu, Takeshi Sakata, Hiroki Miyazaki, Hiroshi Nonoguchi, Rafiqul Islam, Maristella Onozato, Akihiro Tojo, Kimio Tomita, Yoshikatsu Kanai, Takashi Igarashi, Ivan Sabolic, Hitoshi Endou. Functional and immunochemical characterization of a novel organic anion transporter Oat8 (Slc22a9) in rat renal collecting duct. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2008; 21(4):269-78. doi: 10.1159/000129385. [PMID: 18441515]
  • Xiaoyun Ye, Amber M Bishop, John A Reidy, Larry L Needham, Antonia M Calafat. Parabens as urinary biomarkers of exposure in humans. Environmental health perspectives. 2006 Dec; 114(12):1843-6. doi: 10.1289/ehp.9413. [PMID: 17185273]
  • Caroline J Dean, Michelle R Bockmann, John J Hopwood, Doug A Brooks, Peter J Meikle. Detection of mucopolysaccharidosis type II by measurement of iduronate-2-sulfatase in dried blood spots and plasma samples. Clinical chemistry. 2006 Apr; 52(4):643-9. doi: 10.1373/clinchem.2005.061838. [PMID: 16497940]
  • Naohiko Anzai, Promsuk Jutabha, Atsushi Enomoto, Hirokazu Yokoyama, Hiroshi Nonoguchi, Taku Hirata, Katsuko Shiraya, Xin He, Seok Ho Cha, Michio Takeda, Hiroki Miyazaki, Takeshi Sakata, Kimio Tomita, Takashi Igarashi, Yoshikatsu Kanai, Hitoshi Endou. Functional characterization of rat organic anion transporter 5 (Slc22a19) at the apical membrane of renal proximal tubules. The Journal of pharmacology and experimental therapeutics. 2005 Nov; 315(2):534-44. doi: 10.1124/jpet.105.088583. [PMID: 16079298]
  • Naomi Mizuno, Michiko Suzuki, Hiroyuki Kusuhara, Hiroshi Suzuki, Kenji Takeuchi, Takuro Niwa, Johan W Jonker, Yuichi Sugiyama. Impaired renal excretion of 6-hydroxy-5,7-dimethyl-2-methylamino-4-(3-pyridylmethyl) benzothiazole (E3040) sulfate in breast cancer resistance protein (BCRP1/ABCG2) knockout mice. Drug metabolism and disposition: the biological fate of chemicals. 2004 Sep; 32(9):898-901. doi: . [PMID: 15319327]
  • Paraskevi Tsoutsikos, John O Miners, Alan Stapleton, Anthony Thomas, Benedetta C Sallustio, Kathleen M Knights. Evidence that unsaturated fatty acids are potent inhibitors of renal UDP-glucuronosyltransferases (UGT): kinetic studies using human kidney cortical microsomes and recombinant UGT1A9 and UGT2B7. Biochemical pharmacology. 2004 Jan; 67(1):191-9. doi: 10.1016/j.bcp.2003.08.025. [PMID: 14667942]
  • Barbara Wolff, Andreas Billich, Waltraud Brunowsky, Gerda Herzig, Ivan Lindley, Peter Nussbaumer, Edith Pursch, Christa Rabeck, Gottfried Winkler. Microtiter plate cellular assay for human steroid sulfatase with fluorescence readout. Analytical biochemistry. 2003 Jul; 318(2):276-84. doi: 10.1016/s0003-2697(03)00256-2. [PMID: 12814632]
  • S H Cha, T Sekine, H Kusuhara, E Yu, J Y Kim, D K Kim, Y Sugiyama, Y Kanai, H Endou. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. The Journal of biological chemistry. 2000 Feb; 275(6):4507-12. doi: 10.1074/jbc.275.6.4507. [PMID: 10660625]
  • M Chiba, A J Schwab, C A Goresky, K S Pang. Carrier-mediated entry of 4-methylumbelliferyl sulfate: characterization by the multiple-indicator dilution technique in perfused rat liver. Hepatology (Baltimore, Md.). 1998 Jan; 27(1):134-46. doi: 10.1002/hep.510270122. [PMID: 9425929]
  • M Chiba, K S Pang. Effect of protein binding on 4-methylumbelliferyl sulfate desulfation kinetics in perfused rat liver. The Journal of pharmacology and experimental therapeutics. 1993 Aug; 266(2):492-9. doi: . [PMID: 8355186]
  • L A Casciola-Rosen, A L Hubbard. Hydrolases in intracellular compartments of rat liver cells. Evidence for selective activation and/or delivery. The Journal of biological chemistry. 1991 Mar; 266(7):4341-7. doi: . [PMID: 1671861]
  • C L Zimmerman, S Ratna, E Leboeuf, K S Pang. High-performance liquid chromatographic method for the direct determination of 4-methylumbelliferone and its glucuronide and sulfate conjugates. Application to studies in the single-pass in situ perfused rat intestine-liver preparation. Journal of chromatography. 1991 Jan; 563(1):83-94. doi: 10.1016/0378-4347(91)80279-l. [PMID: 2061397]
  • P M Edelbroek, G M van Kempen, T J Hessing, F A de Wolff. Analysis of phenprocoumon and its hydroxylated and conjugated metabolites in human urine by high-performance liquid chromatography after solid-phase extraction. Journal of chromatography. 1990 Sep; 530(2):347-58. doi: 10.1016/s0378-4347(00)82337-3. [PMID: 2079509]
  • J Kawano, E Aikawa. Ultrastructural localization of arylsulfatase C activity in rat kidney. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1987 May; 35(5):523-30. doi: 10.1177/35.5.3470383. [PMID: 3470383]
  • K Morita, Y Sugiyama, M Hanano. Pharmacokinetic study of 4-methylumbelliferone in rats: influence of dose on its first-pass hepatic elimination. Journal of pharmacobio-dynamics. 1986 Feb; 9(2):117-24. doi: 10.1248/bpb1978.9.117. [PMID: 3712212]
  • G J Mulder, S Brouwer, J G Weitering, E Scholtens, K S Pang. Glucuronidation and sulfation in the rat in vivo. The role of the liver and the intestine in the in vivo clearance of 4-methylumbelliferone. Biochemical pharmacology. 1985 Apr; 34(8):1325-9. doi: 10.1016/0006-2952(85)90513-1. [PMID: 3994749]
  • U Femfert, H D Kuntz, B May. Rapid high-performance liquid chromatographic method for the measurement of hymecromon and its conjugates in blood plasma or serum at concentrations attained during therapy. Journal of chromatography. 1983 Dec; 278(2):452-7. doi: 10.1016/s0378-4347(00)84808-2. [PMID: 6668328]
  • B M Keinanen, K Nelson, W L Daniel, J M Roque. Genetic analysis of murine arylsulfatase C and steroid sulfatase. Genetics. 1983 Sep; 105(1):191-206. doi: 10.1093/genetics/105.1.191. [PMID: 6225698]