Medroxyprogesterone (BioDeep_00000001664)

human metabolite

代谢物信息卡片

(1S,2R,8S,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one

化学式: C22H32O3 (344.2351)
中文名称: 甲孕酮, 甲羟孕酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)C1(O)CCC2C3CC(C)C4=CC(=O)CCC4(C)C3CCC21C
InChI: InChI=1S/C22H32O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h12-13,16-18,25H,5-11H2,1-4H3/t13-,16+,17-,18-,20+,21-,22-/m0/s1

描述信息

Medroxyprogesterone, or MP is a progestin (synthetic progestogen). MP is not used medically, as it is over two orders of magnitude less potent than medroxyprogesterone acetate (MPA); a derivative of MP (PMID: 16784762). MP may be formed via the metabolism of MPA. Medroxyprogesterone acetate is used to treat conditions such as absent or irregular menstrual periods, or abnormal uterine bleeding. Synthetic progestogens are widely used to simulate the effects of progesterone; a natural female sex hormone. Progesterone is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss (PMID: 20104424). In addition to progestagenic activity, MP is also a weak antiandrogen in vitro (PMID: 29990947). Medroxyprogesterone is only found in individuals that have used or taken MPA.
A synthetic progesterone (steroid hormone) involved in the female menstrual cycle, pregnancy (supports gestation) and embryogenesis of humans and other species. Progesterone belongs to a class of hormones called progestagens, and is the major naturally occurring human progestagen. -- Wikipedia
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03A - Hormonal contraceptives for systemic use > G03AC - Progestogens
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03D - Progestogens > G03DA - Pregnen (4) derivatives
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02A - Hormones and related agents > L02AB - Progestogens
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents

同义名列表

39 个代谢物同义名

(1S,2R,8S,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one; (6alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione; 17-Hydroxy-6alpha-methyl-pregn-4-ene-3,20-dione; 6alpha-Methyl-4-pregnen-17alpha-ol-3,20-dione; 17 alpha-Hydroxy-6 alpha-methylprogesterone; 17-Hydroxy-6α-methyl-pregn-4-ene-3,20-dione; 17-Hydroxy-6a-methyl-pregn-4-ene-3,20-dione; 17 alpha Hydroxy 6 alpha methylprogesterone; 17alpha-Hydroxy-6alpha-methylprogesterone; 6alpha-Methyl-17alpha-hydroxyprogesterone; 6a-Methyl-4-pregnen-17a-ol-3,20-dione; 6Α-methyl-4-pregnen-17α-ol-3,20-dione; 17-Hydroxy-6alpha-methylprogesterone; Strakan brand OF medroxyprogesterone; 6Α-methyl-17α-hydroxyprogesterone; 17a-Hydroxy-6a-methylprogesterone; Medroxyprogesterone strakan brand; 6a-Methyl-17a-hydroxyprogesterone; 17Α-hydroxy-6α-methylprogesterone; 17-Hydroxy-6α-methylprogesterone; 17-Hydroxy-6a-methylprogesterone; Medroxyprogesterone acetate; Methylhydroxyprogesterone; Medroxyprogesterone-d3; Depo-subq provera 104; Medrossiprogesterone; Medroxyprogesteronum; Medroxiprogesteronum; medroxyprogesterone; Medroxiprogesterona; Farlutal inyectable; Medroxyprogesteron; Depo-provera; Adgyn medro; Farlutal; Provera; Cycrin; Medroxyprogesterone; Medroxyprogesterone

数据库引用编号

20 个数据库交叉引用编号

ChEBI: CHEBI:6715
KEGG: C07119
KEGG: C75441
KEGGdrug: D08166
PubChem: 541103
PubChem: 10631
HMDB: HMDB0001939
Metlin: METLIN1094
ChEMBL: CHEMBL1390
Wikipedia: Medroxyprogesterone
MeSH: Medroxyprogesterone
foodb: FDB022754
chemspider: 10185
CAS: 520-85-4
PMhub: MS000000942
PubChem: 9330
LipidMAPS: LMST02030176
NIKKAJI: J6.606K
RefMet: Medroxyprogesterone
KNApSAcK: 6715

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	8	ACE, ALB, AR, BCL2, ESR1, PGR, PRL, TBX20
Peripheral membrane protein	1	ESR1
Endoplasmic reticulum membrane	2	BCL2, HSP90B1
Nucleus	8	ALB, AR, BCL2, ESR1, HSP90B1, PGR, PRL, TBX20
cytosol	6	ALB, AR, BCL2, ESR1, HSP90B1, PGR
centrosome	1	ALB
nucleoplasm	4	AR, ESR1, PGR, PRL
RNA polymerase II transcription regulator complex	1	PRL
Cell membrane	3	ACE, ESR1, TNF
Cytoplasmic side	1	ESR1
cell surface	1	TNF
Golgi apparatus	2	ALB, ESR1
Golgi membrane	1	INS
neuronal cell body	1	TNF
smooth endoplasmic reticulum	1	HSP90B1
Lysosome	1	ACE
endosome	1	ACE
plasma membrane	6	ACE, AR, ESR1, IFNLR1, PGR, TNF
Membrane	6	ACE, AR, BCL2, ESR1, HSP90B1, IFNLR1
extracellular exosome	4	ACE, ALB, HSP90B1, SHBG
endoplasmic reticulum	3	ALB, BCL2, HSP90B1
extracellular space	11	ACE, ALB, CRP, GNRH1, IGF1, IL2, IL6, INS, LPA, PRL, TNF
perinuclear region of cytoplasm	1	HSP90B1
mitochondrion	1	BCL2
protein-containing complex	5	ALB, AR, BCL2, ESR1, HSP90B1
Single-pass type I membrane protein	2	ACE, IFNLR1
Secreted	9	ACE, ALB, CRP, IGF1, IL2, IL6, INS, PRL, SHBG
extracellular region	14	ACE, ALB, CRP, GNRH1, HSP90B1, IGF1, IL2, IL6, INS, LPA, PLA2G7, PRL, SHBG, TNF
Mitochondrion outer membrane	1	BCL2
Single-pass membrane protein	1	BCL2
mitochondrial outer membrane	2	BCL2, PGR
anchoring junction	1	ALB
transcription regulator complex	1	ESR1
Nucleus membrane	1	BCL2
Bcl-2 family protein complex	1	BCL2
nuclear membrane	1	BCL2
external side of plasma membrane	2	ACE, TNF
high-density lipoprotein particle	1	PLA2G7
low-density lipoprotein particle	1	PLA2G7
midbody	1	HSP90B1
recycling endosome	1	TNF
Single-pass type II membrane protein	1	TNF
Membrane raft	1	TNF
pore complex	1	BCL2
focal adhesion	1	HSP90B1
collagen-containing extracellular matrix	1	HSP90B1
nuclear speck	1	AR
ciliary basal body	1	ALB
chromatin	5	AR, ESR1, PGR, PRL, TBX20
phagocytic cup	1	TNF
centriole	1	ALB
Secreted, extracellular space	1	PLA2G7
brush border membrane	1	ACE
spindle pole	1	ALB
blood microparticle	1	ALB
sperm midpiece	1	ACE
endosome lumen	2	INS, PRL
Melanosome	1	HSP90B1
euchromatin	1	ESR1
myelin sheath	1	BCL2
sperm plasma membrane	1	HSP90B1
basal plasma membrane	1	ACE
exocytic vesicle	1	IGF1
secretory granule lumen	1	INS
Golgi lumen	1	INS
endoplasmic reticulum lumen	4	ALB, HSP90B1, IL6, INS
platelet alpha granule lumen	2	ALB, IGF1
transport vesicle	1	INS
Endoplasmic reticulum-Golgi intermediate compartment membrane	1	INS
Sarcoplasmic reticulum lumen	1	HSP90B1
[Isoform 1]: Nucleus	1	ESR1
endocytic vesicle lumen	1	HSP90B1
[Tumor necrosis factor, soluble form]: Secreted	1	TNF
alphav-beta3 integrin-IGF-1-IGF1R complex	1	IGF1
insulin-like growth factor binding protein complex	1	IGF1
insulin-like growth factor ternary complex	1	IGF1
interleukin-6 receptor complex	1	IL6
[Isoform 4]: Mitochondrion outer membrane	1	PGR
endoplasmic reticulum chaperone complex	1	HSP90B1
plasma lipoprotein particle	1	LPA
BAD-BCL-2 complex	1	BCL2
[Angiotensin-converting enzyme, soluble form]: Secreted	1	ACE
[Isoform Testis-specific]: Cell membrane	1	ACE
ciliary transition fiber	1	ALB
interleukin-28 receptor complex	1	IFNLR1
[C-domain 2]: Secreted	1	TNF
[Tumor necrosis factor, membrane form]: Membrane	1	TNF
[C-domain 1]: Secreted	1	TNF

文献列表

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