D-Kynurenine (BioDeep_00000014859)

 

Secondary id: BioDeep_00000398725

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


(2R)-6-methoxy-2-phenyl-2,3-dihydrochromen-4-one

化学式: C10H12N2O3 (208.0847882)
中文名称: DL-犬尿氨酸, 犬尿素
谱图信息: 最多检出来源 Homo sapiens(blood) 1.84%

分子结构信息

SMILES: C1=CC=C(C(=C1)C(=O)CC(C(=O)O)N)N
InChI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)

描述信息

Kynurenine, also known as 3-anthraniloylalanine, is a member of the class of compounds known as alkyl-phenylketones. Alkyl-phenylketones are aromatic compounds containing a ketone substituted by one alkyl group, and a phenyl group. Kynurenine is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Kynurenine can be found in a number of food items such as yellow zucchini, carrot, spinach, and broccoli, which makes kynurenine a potential biomarker for the consumption of these food products. Kynurenine is synthesized by the enzyme tryptophan dioxygenase, which is made primarily but not exclusively in the liver, and indoleamine 2,3-dioxygenase, which is made in many tissues in response to immune activation. Kynurenine and its further breakdown products carry out diverse biological functions, including dilating blood vessels during inflammation and regulating the immune response. Some cancers increase kynurenine production, which increases tumor growth .
2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid is an endogenous metabolite.

同义名列表

6 个代谢物同义名

(2R)-6-methoxy-2-phenyl-2,3-dihydrochromen-4-one; 2-amino-4-(2-aminophenyl)-4-oxobutanoic acid; 3-Anthraniloylalanine; (+-)-kynurenine; D-kynurenine; Kynurenine



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(4)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Shanchun Ge, Lei Wang, Chang Jin, Haifeng Xie, Guoping Zheng, Zhengguo Cui, Chaofeng Zhang. Unveiling the neuroprotection effects of Volvalerenic acid A: Mitochondrial fusion induction via IDO1-mediated Stat3-Opa1 signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jul; 129(?):155555. doi: 10.1016/j.phymed.2024.155555. [PMID: 38579641]
  • Er Jin, Zhidong Yin, Xiuxiu Zheng, Chenhong Yan, Kai Xu, Fouejio Yemele Eunice, Yue Gao. Potential of Targeting TDO2 as the Lung Adenocarcinoma Treatment. Journal of proteome research. 2024 Apr; 23(4):1341-1350. doi: 10.1021/acs.jproteome.3c00746. [PMID: 38421152]
  • Aurélie Hanin, Céline Chollet, Sophie Demeret, Lucas Di Meglio, Florence Castelli, Vincent Navarro. Metabolomic changes in adults with status epilepticus: A human case-control study. Epilepsia. 2024 Apr; 65(4):929-943. doi: 10.1111/epi.17899. [PMID: 38339978]
  • Fan Ye, Meng-Chen Dong, Chen-Xi Xu, Ning Jiang, Qi Chang, Xin-Min Liu, Rui-Le Pan. Effects of different chronic restraint stress periods on anxiety- and depression-like behaviors and tryptophan-kynurenine metabolism along the brain-gut axis in C57BL/6N mice. European journal of pharmacology. 2024 Feb; 965(?):176301. doi: 10.1016/j.ejphar.2023.176301. [PMID: 38145646]
  • Yolanda Pérez-Pérez, María Teresa Solís, Alfonso Albacete, Pilar S Testillano. Opposite Auxin Dynamics Determine the Gametophytic and Embryogenic Fates of the Microspore. International journal of molecular sciences. 2023 Jul; 24(13):. doi: 10.3390/ijms241311177. [PMID: 37446349]
  • Hans-Christian Heitkamp. [Paracrine and endocrine functions of muscles]. MMW Fortschritte der Medizin. 2023 07; 165(Suppl 4):13-19. doi: 10.1007/s15006-023-2493-z. [PMID: 37415033]
  • Spencer R Rosario, Bowen Dong, Yali Zhang, Hua-Hsin Hsiao, Emily Isenhart, Jianmin Wang, Erin M Siegel, Arta M Monjazeb, Dwight H Owen, Prasenjit Dey, Fred K Tabung, Daniel J Spakowicz, William J Murphy, Stephen Edge, Sai Yendamuri, Sami Ibrahimi, Jill M Kolesar, Patsy H McDonald, Deepak Vadehra, Michelle Churchman, Song Liu, Pawel Kalinski, Sarbajit Mukherjee. Metabolic Dysregulation Explains the Diverse Impacts of Obesity in Males and Females with Gastrointestinal Cancers. International journal of molecular sciences. 2023 Jun; 24(13):. doi: 10.3390/ijms241310847. [PMID: 37446025]
  • Erika Dorochow, Nico Kraus, Nicolas Chenaux-Repond, Sandra Pierre, Anja Kolbinger, Gerd Geisslinger, Cristina Ortiz, Christoph Welsch, Jonel Trebicka, Robert Gurke, Lisa Hahnefeld, Sabine Klein, Klaus Scholich. Differential Lipidomics, Metabolomics and Immunological Analysis of Alcoholic and Non-Alcoholic Steatohepatitis in Mice. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms241210351. [PMID: 37373497]
  • Handong Xu, Can Hu, Yi Wang, Yunfu Shi, Li Yuan, Jingli Xu, Yanqiang Zhang, Jiahui Chen, Qin Wei, Jiangjiang Qin, Zhiyuan Xu, Xiangdong Cheng. Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism. Oncogene. 2023 May; ?(?):. doi: 10.1038/s41388-023-02708-4. [PMID: 37138031]
  • Mykola Zdioruk, Jorge-Luis Jimenez-Macias, Michal Oskar Nowicki, Katherine E Manz, Kurt D Pennell, Marilin S Koch, Tomer Finkelberg, Bin Wu, Paul Boucher, Yuji Takeda, Weiyi Li, Raziye Piranlioglu, Alexander L Ling, E Antonio Chiocca, Sean E Lawler. PPRX-1701, a nanoparticle formulation of 6'-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models. Cell reports. Medicine. 2023 Apr; ?(?):101019. doi: 10.1016/j.xcrm.2023.101019. [PMID: 37060903]
  • Xin Liu, Liwen Wang, Tsokyi Choera, Xin Fang, Gang Wang, Wenhua Chen, Yin-Won Lee, Sherif Ramzy Mohamed, Dawood H Dawood, Jianrong Shi, Jianhong Xu, Nancy P Keller. Paralogous FgIDO genes with differential roles in tryptophan catabolism, fungal development and virulence in Fusarium graminearum. Microbiological research. 2023 Apr; 272(?):127382. doi: 10.1016/j.micres.2023.127382. [PMID: 37030080]
  • Ping Lin, Dan Li, Yun Shi, Qingtian Li, Xiaokui Guo, Ke Dong, Qing Chen, Xiaoyan Lou, Zhenhua Li, Ping Li, Weifeng Jin, Shuzi Chen, Yang Sun, Jing Sun, Xunjia Cheng. Dysbiosis of the Gut Microbiota and Kynurenine (Kyn) Pathway Activity as Potential Biomarkers in Patients with Major Depressive Disorder. Nutrients. 2023 Apr; 15(7):. doi: 10.3390/nu15071752. [PMID: 37049591]
  • Lu Yan, Chu-Han Liu, Li Xu, Yi-Yun Qian, Ping-Ping Song, Min Wei, Bao-Lin Liu. Alpha-Asarone modulates kynurenine disposal in muscle and mediates resilience to stress-induced depression via PGC-1α induction. CNS neuroscience & therapeutics. 2023 Mar; 29(3):941-956. doi: 10.1111/cns.14030. [PMID: 36575869]
  • Arya Afrooghe, Mohammadreza Babaei, Maryam Shayan, Elham Ahmadi, Razieh Mohammad Jafari, Ahmad-Reza Dehpour. Therapeutic potential of bromhexine for acute itch in mice: Involvement of TMPRSS2 and kynurenine pathway. International immunopharmacology. 2023 Feb; 117(?):109919. doi: 10.1016/j.intimp.2023.109919. [PMID: 36842232]
  • Savera Aggarwal, Vipin Yadav, Rakhi Maiwall, Archana Rastogi, Viniyendra Pamecha, Onkar Bedi, Jaswinder Singh Maras, Nirupma Trehanpati, Gayatri Ramakrishna. Metabolomic analysis shows dysregulation in amino acid and NAD+ metabolism in palmitate treated hepatocytes and plasma of non-alcoholic fatty liver disease spectrum. Biochemical and biophysical research communications. 2023 Feb; 643(?):129-138. doi: 10.1016/j.bbrc.2022.12.078. [PMID: 36603530]
  • Chen-Chen Li, Fan Ye, Chen-Xi Xu, Ning Jiang, Qi Chang, Xin-Min Liu, Rui-Le Pan. Tryptophan-kynurenine metabolic characterization in the gut and brain of depressive-like rats induced by chronic restraint stress. Journal of affective disorders. 2023 Feb; 328(?):273-286. doi: 10.1016/j.jad.2023.02.008. [PMID: 36746244]
  • Hélène Ruffieux, Aimee L Hanson, Samantha Lodge, Nathan G Lawler, Luke Whiley, Nicola Gray, Tui H Nolan, Laura Bergamaschi, Federica Mescia, Lorinda Turner, Aloka de Sa, Victoria S Pelly, Prasanti Kotagiri, Nathalie Kingston, John R Bradley, Elaine Holmes, Julien Wist, Jeremy K Nicholson, Paul A Lyons, Kenneth G C Smith, Sylvia Richardson, Glenn R Bantug, Christoph Hess. A patient-centric modeling framework captures recovery from SARS-CoV-2 infection. Nature immunology. 2023 02; 24(2):349-358. doi: 10.1038/s41590-022-01380-2. [PMID: 36717723]
  • Zhenzhen Duan, Lei Shi, Zhen Ning Tony He, Chunxiang Kuang, Tianxiong Han, Qing Yang. The Protective Effect of IDO1 Inhibition in Aβ-Treated Neurons and APP/PS1 Mice. American journal of Alzheimer's disease and other dementias. 2023 Jan; 38(?):15333175231214861. doi: 10.1177/15333175231214861. [PMID: 37944012]
  • Rouhollah Haghshenas, Younes Aftabi, Saied Doaei, Maryam Gholamalizadeh. Synergistic effect of endurance training and nettle leaf extract on the IDO1-KYN-AHR pathway homeostasis and inhibiting of liver toxicity in rats with STZ-induced diabetes. Frontiers in endocrinology. 2023; 14(?):1071424. doi: 10.3389/fendo.2023.1071424. [PMID: 37305057]
  • Ewa Rodziewicz-Flis, Ulana Juhas, Jakub Antoni Kortas, Joanna Jaworska, Ilona Bidzan-Bluma, Anna Babińska, Katarzyna Micielska, Małgorzata Żychowska, Giovanni Lombardi, Jędrzej Antosiewicz, Ewa Ziemann. Nordic Walking training in BungyPump form improves cognitive functions and physical performance and induces changes in amino acids and kynurenine profiles in older adults. Frontiers in endocrinology. 2023; 14(?):1151184. doi: 10.3389/fendo.2023.1151184. [PMID: 37766686]
  • Cristina Razquin, Miguel Ruiz-Canela, Estefania Toledo, Clary B Clish, Marta Guasch-Ferré, Jesús F García-Gavilán, Clemens Wittenbecher, Angel Alonso-Gómez, Montse Fitó, Liming Liang, Dolores Corella, Enrique Gómez-Gracia, Ramon Estruch, Miquel Fiol, Jose M Santos-Lozano, Luis Serra-Majem, Emilio Ros, Fernando Aros, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González. Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial. International journal of molecular sciences. 2022 Dec; 24(1):. doi: 10.3390/ijms24010270. [PMID: 36613713]
  • Bowen Xu, Peng Zhang, Xiaolong Tang, Shiguan Wang, Jing Shen, Yuanwen Zheng, Chao Gao, Ping Mi, Cuijuan Zhang, Hui Qu, Shiyang Li, Detian Yuan. Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia-Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 12; 9(35):e2204697. doi: 10.1002/advs.202204697. [PMID: 36310151]
  • Jinxue Wei, Zijian Zhang, Yue Du, Xiao Yang, Liansheng Zhao, Peiyan Ni, Rongjun Ni, Meng Gong, Xiaohong Ma. A combination of neuroimaging and plasma metabolomic analysis suggests inflammation is associated with white matter structural connectivity in major depressive disorder. Journal of affective disorders. 2022 12; 318(?):7-15. doi: 10.1016/j.jad.2022.08.108. [PMID: 36057287]
  • Yanmei Chen, Jiahui Zhang, Yueying Yang, Ke Xiang, Hua Li, Dejuan Sun, Lixia Chen. Kynurenine-3-monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression. Journal of cellular physiology. 2022 12; 237(12):4339-4355. doi: 10.1002/jcp.30876. [PMID: 36088660]
  • Max Schuller, Monika Oberhuber, Barbara Prietl, Elmar Zügner, Eva-Maria Prugger, Christoph Magnes, Alexander H Kirsch, Sabine Schmaldienst, Thomas Pieber, Marianne Brodmann, Alexander R Rosenkranz, Philipp Eller, Kathrin Eller. Alterations in the Kynurenine-Tryptophan Pathway and Lipid Dysregulation Are Preserved Features of COVID-19 in Hemodialysis. International journal of molecular sciences. 2022 Nov; 23(22):. doi: 10.3390/ijms232214089. [PMID: 36430566]
  • Yun Seok Kim, Bongsub Ko, Da Jung Kim, Jihoon Tak, Chang Yeob Han, Joo-Youn Cho, Won Kim, Sang Geon Kim. Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D. Nature communications. 2022 10; 13(1):6080. doi: 10.1038/s41467-022-33749-0. [PMID: 36241614]
  • Mohammed Ghiboub, Susanne Penny, Charlotte M Verburgt, Rotem Sigall Boneh, Eytan Wine, Alejandro Cohen, Katherine A Dunn, Devanand M Pinto, Marc A Benninga, Wouter J de Jonge, Arie Levine, Johan E Van Limbergen. Metabolome Changes With Diet-Induced Remission in Pediatric Crohn's Disease. Gastroenterology. 2022 10; 163(4):922-936.e15. doi: 10.1053/j.gastro.2022.05.050. [PMID: 35679949]
  • Cong Lu, Zhen Wei, Yongquan Wang, Shuying Li, Litao Tong, Xinmin Liu, Bei Fan, Fengzhong Wang. Soy isoflavones alleviate lipopolysaccharide-induced depressive-like behavior by suppressing neuroinflammation, mediating tryptophan metabolism and promoting synaptic plasticity. Food & function. 2022 Sep; 13(18):9513-9522. doi: 10.1039/d2fo01437h. [PMID: 35993820]
  • Xiaoli Gong, Rui Chang, Ju Zou, Sijie Tan, Zeyi Huang. The role and mechanism of tryptophan - kynurenine metabolic pathway in depression. Reviews in the neurosciences. 2022 Sep; ?(?):. doi: 10.1515/revneuro-2022-0047. [PMID: 36054612]
  • Petra Majerova, Dominika Olesova, Greta Golisova, Martina Buralova, Alena Michalicova, Jozef Vegh, Juraj Piestansky, Mangesh Bhide, Jozef Hanes, Andrej Kovac. Analog of kynurenic acid decreases tau pathology by modulating astrogliosis in rat model for tauopathy. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Aug; 152(?):113257. doi: 10.1016/j.biopha.2022.113257. [PMID: 35714514]
  • Melike Kucukkarapinar, Aysegul Yay-Pence, Yesim Yildiz, Merve Buyukkoruk, Gizem Yaz-Aydin, Tuba S Deveci-Bulut, Ozlem Gulbahar, Esin Senol, Selcuk Candansayar. Psychological outcomes of COVID-19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress. Journal of neural transmission (Vienna, Austria : 1996). 2022 08; 129(8):1077-1089. doi: 10.1007/s00702-022-02525-1. [PMID: 35796878]
  • Ahmed Farouk, Rasha A Hamed, Saeid Elsawy, Nashwa F Abd El Hafez, Farag M Moftah, Muammar A Y Nassar, Fify Alfy Gabra, Tahia H Saleem. Measuring the Systemic Inflammatory Response to On- and Off-Pump Coronary Artery Bypass Graft (CABG) Surgeries Using the Tryptophan/Kynurenine Pathway. Journal of investigative surgery : the official journal of the Academy of Surgical Research. 2022 Aug; 35(8):1621-1625. doi: 10.1080/08941939.2022.2084188. [PMID: 35694760]
  • Oskar Olsson, Sten Skogmar, Fregenet Tesfaye, Daba Mulleta, Marianne Jansson, Per Björkman. Kynurenine/tryptophan ratio for detection of active tuberculosis in adults with HIV prior to antiretroviral therapy. AIDS (London, England). 2022 07; 36(9):1245-1253. doi: 10.1097/qad.0000000000003235. [PMID: 35703207]
  • Leticia Gil de Biedma-Elduayen, Pablo Giménez-Gómez, Nuria Morales-Puerto, Rebeca Vidal, Carlos Núñez-de la Calle, María Dolores Gutiérrez-López, Esther O'Shea, María Isabel Colado. Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61-8048 after chronic intermittent ethanol in mice. British journal of pharmacology. 2022 07; 179(14):3711-3726. doi: 10.1111/bph.15825. [PMID: 35189673]
  • Bartosz Osuch, Karolina Kołosowska, Natalia Chmielewska, Danuta Turzyńska, Alicja Sobolewska, Janusz Szyndler, Piotr Maciejak. Increased Hippocampal Afterdischarge Threshold in Ketogenic Diet is Accompanied by Enhanced Kynurenine Pathway Activity. Neurochemical research. 2022 Jul; 47(7):2109-2122. doi: 10.1007/s11064-022-03605-0. [PMID: 35522366]
  • Teng Huang, Jia Song, Jia Gao, Jia Cheng, Hao Xie, Lu Zhang, Yu-Han Wang, Zhichao Gao, Yi Wang, Xiaohui Wang, Jinhan He, Shiwei Liu, Qilin Yu, Shu Zhang, Fei Xiong, Qing Zhou, Cong-Yi Wang. Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling. Nature communications. 2022 06; 13(1):3489. doi: 10.1038/s41467-022-31126-5. [PMID: 35715443]
  • Joseph P Dewulf, Manon Martin, Sandrine Marie, Fabie Oguz, Leila Belkhir, Julien De Greef, Jean Cyr Yombi, Xavier Wittebole, Pierre-François Laterre, Michel Jadoul, Laurent Gatto, Guido T Bommer, Johann Morelle. Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19. Scientific reports. 2022 Jun; 12(1):9959. doi: 10.1038/s41598-022-14292-w. [PMID: 35705608]
  • Liu Ouyang, Changjiang Yu, Zhiyong Xie, Xiaoyan Su, Zengmei Xu, Ping Song, Jian Li, Hui Huang, Ye Ding, Ming-Hui Zou. Indoleamine 2,3-Dioxygenase 1 Deletion-Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification. Circulation. 2022 06; 145(24):1784-1798. doi: 10.1161/circulationaha.121.057868. [PMID: 35582948]
  • Mi Mi Ko, Jeeyoun Jung, Jung-Eun Lee, Seon Mi Shin, Hyun-Kyung Sung, Ho-Yeon Go, Soobin Jang. Metabolomic analysis of Gyejibongnyeong-Hwan for shoulder pain: A randomized, wait-list controlled pilot trial. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jun; 104(?):154248. doi: 10.1016/j.phymed.2022.154248. [PMID: 35716471]
  • M Gelpi, B Vestad, S C Raju, S Hyll Hansen, J Høgh, Ø Midttun, P M Ueland, T Ueland, T Benfield, Klaus F Kofoed, J R Hov, M Trøseid, S Dam Nielsen. Association of the Kynurenine Pathway of Tryptophan Metabolism With Human Immunodeficiency Virus-Related Gut Microbiota Alterations and Visceral Adipose Tissue Accumulation. The Journal of infectious diseases. 2022 06; 225(11):1948-1954. doi: 10.1093/infdis/jiac018. [PMID: 35089326]
  • Huan Wang, Jian Li, Zheng Wang, Yanfeng Tian, Chunlei Li, Feng Jin, Jia Li, Lanfeng Wang. Perivascular brown adipocytes-derived kynurenic acid relaxes blood vessel via endothelium PI3K-Akt-eNOS pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Jun; 150(?):113040. doi: 10.1016/j.biopha.2022.113040. [PMID: 35658210]
  • Duygu Eryavuz Onmaz, Dilek Tezcan, Sedat Abusoglu, Abdullah Sivrikaya, Menekse Kuzu, Fatma Humeyra Yerlikaya, Sema Yilmaz, Ali Unlu. Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease. Amino acids. 2022 Jun; 54(6):877-887. doi: 10.1007/s00726-022-03170-4. [PMID: 35604497]
  • Patrick M Honore, Sebastien Redant, Pharan Djimafo, Thierry Preseau, Bogdan Vasile Cismas, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Rachid Attou, Andrea Gallerani, David De Bels. Letter to the Editor: 'Activation of the kynurenine pathway predicts mortality and neurological outcome in cardiac arrest patients: A validation study'. Journal of critical care. 2022 06; 69(?):154005. doi: 10.1016/j.jcrc.2022.154005. [PMID: 35176637]
  • Qibin Qi, Jun Li, Bing Yu, Jee-Young Moon, Jin C Chai, Jordi Merino, Jie Hu, Miguel Ruiz-Canela, Casey Rebholz, Zheng Wang, Mykhaylo Usyk, Guo-Chong Chen, Bianca C Porneala, Wenshuang Wang, Ngoc Quynh Nguyen, Elena V Feofanova, Megan L Grove, Thomas J Wang, Robert E Gerszten, Josée Dupuis, Jordi Salas-Salvadó, Wei Bao, David L Perkins, Martha L Daviglus, Bharat Thyagarajan, Jianwen Cai, Tao Wang, JoAnn E Manson, Miguel A Martínez-González, Elizabeth Selvin, Kathryn M Rexrode, Clary B Clish, Frank B Hu, James B Meigs, Rob Knight, Robert D Burk, Eric Boerwinkle, Robert C Kaplan. Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies. Gut. 2022 06; 71(6):1095-1105. doi: 10.1136/gutjnl-2021-324053. [PMID: 34127525]
  • Karen Mei-Ling Tan, Mya-Thway Tint, Narasimhan Kothandaraman, Fabian Yap, Keith M Godfrey, Yung Seng Lee, Kok Hian Tan, Peter D Gluckman, Yap-Seng Chong, Mary F F Chong, Johan G Eriksson, David Cameron-Smith. Association of plasma kynurenine pathway metabolite concentrations with metabolic health risk in prepubertal Asian children. International journal of obesity (2005). 2022 06; 46(6):1128-1137. doi: 10.1038/s41366-022-01085-4. [PMID: 35173282]
  • Maiqueli Eduarda Dama Mingoti, Amanda Gollo Bertollo, Júlia Leão Batista Simões, Gabriel Rossi Francisco, Margarete Dulce Bagatini, Zuleide Maria Ignácio. COVID-19, Oxidative Stress, and Neuroinflammation in the Depression Route. Journal of molecular neuroscience : MN. 2022 Jun; 72(6):1166-1181. doi: 10.1007/s12031-022-02004-y. [PMID: 35322375]
  • Maria Giovanna Scarale, Mario Mastroianno, Cornelia Prehn, Massimiliano Copetti, Lucia Salvemini, Jerzy Adamski, Salvatore De Cosmo, Vincenzo Trischitta, Claudia Menzaghi. Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes. Diabetes. 2022 06; 71(6):1363-1370. doi: 10.2337/db22-0095. [PMID: 35358315]
  • Anna Krupa, Mikolaj M Krupa, Krystyna Pawlak. Indoleamine 2,3 Dioxygenase 1-The Potential Link between the Innate Immunity and the Ischemia-Reperfusion-Induced Acute Kidney Injury?. International journal of molecular sciences. 2022 May; 23(11):. doi: 10.3390/ijms23116176. [PMID: 35682852]
  • Tarek Bekfani, Mohamed Bekhite, Sophie Neugebauer, Steffen Derlien, Ali Hamadanchi, Jenny Nisser, Marion S Hilse, Daniela Haase, Tom Kretzschmar, Mei-Fang Wu, Michael Lichtenauer, Michael Kiehntopf, Stephan von Haehling, Peter Schlattmann, Gabriele Lehmann, Marcus Franz, Sven Möbius-Winkler, Christian Schulze. Metabolomic Profiling in Patients with Heart Failure and Exercise Intolerance: Kynurenine as a Potential Biomarker. Cells. 2022 05; 11(10):. doi: 10.3390/cells11101674. [PMID: 35626711]
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