Amlodipine (BioDeep_00000001425)

human metabolite blood metabolite

代谢物信息卡片

3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid

化学式: C20H25ClN2O5 (408.145191)
中文名称: 氨氯地平
谱图信息: 最多检出来源 Homo sapiens(blood) 22.22%

分子结构信息

SMILES: CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl
InChI: InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3

描述信息

Amlodipine is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. As other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence improving blood pressure; in angina it improves blood flow to the myocardium. It was developed under the direction of Dr. Simon Campbell; A long acting dihydropyridine calcium channel blocker. It is effective in the treatment of angina pectoris and hypertension; in angina it improves blood flow to the myocardium.; Amlodipine (as besylate, mesylate or maleate) is a long-acting calcium channel blocker used as an anti hypertensive and in the treatment of angina. Amlodipine is marketed as Norvasc in North America and as Istin in the United Kingdom as well as under various other names. As other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence improving blood pressure; Amlodipine (as besylate, mesylate or maleate) is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. Amlodipine is marketed as Norvasc in North America and as Istin in the United Kingdom as well as under various other names. As other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence improving blood pressure; in angina it improves blood flow to the myocardium. It was developed under the direction of Dr. Simon Campbell. [HMDB]
Amlodipine is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. As other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence improving blood pressure; in angina it improves blood flow to the myocardium. It was developed under the direction of Dr. Simon Campbell; A long acting dihydropyridine calcium channel blocker. It is effective in the treatment of angina pectoris and hypertension; in angina it improves blood flow to the myocardium. Amlodipine (as besylate, mesylate or maleate) is a long-acting calcium channel blocker used as an anti hypertensive and in the treatment of angina. Amlodipine is marketed as Norvasc in North America and as Istin in the United Kingdom as well as under various other names. As other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence improving blood pressure; Amlodipine (as besylate, mesylate or maleate) is a long-acting calcium channel blocker used as an anti-hypertensive and in the treatment of angina. Amlodipine is marketed as Norvasc in North America and as Istin in the United Kingdom as well as under various other names. As other calcium channel blockers, amlodipine acts by relaxing the smooth muscle in the arterial wall, decreasing peripheral resistance and hence improving blood pressure; in angina it improves blood flow to the myocardium. It was developed under the direction of Dr. Simon Campbell.
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

28 个代谢物同义名

3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid; 3-Ethyl-5-methyl (+-)-2-(2-aminoethoxymethyl)-4-(O-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate; 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate; Eczacibasi brand OF amlodipine besilate; Amlodipine, (+-)-isomer, maleate (1:1); Almirall brand OF amlodipine besilate; Amlodipine, (S)-isomer, maleate (1:1); Pfizer brand OF amlodipine besilate; Mack brand OF amlodipine besilate; Amlodipine maleate (1:1); Amlodipine, (+-)-isomer; Amlodipine, (R)-isomer; Amlodipine free base; Amlodipine besylate; Amlodipine besilate; Racemic amlodipine; Amlodipine maleate; (+-)-amlodipine; Amlodipinum; Amlodipino; amlodipine; Norvasc; Astudal; Amlodis; Pelmec; AMVAZ; Istin; Amlor

数据库引用编号

18 个数据库交叉引用编号

ChEBI: CHEBI:2668
KEGG: C06825
KEGGdrug: D07450
PubChem: 2162
HMDB: HMDB0005018
Metlin: METLIN955
DrugBank: DB00381
ChEMBL: CHEMBL3304444
ChEMBL: CHEMBL3211346
ChEMBL: CHEMBL1491
Wikipedia: Amlodipine
MeSH: Amlodipine
foodb: FDB023590
chemspider: 2077
CAS: 88150-42-9
PMhub: MS000000487
PubChem: 9043
NIKKAJI: J33.383B

分类词条

Dihydropyridinecarboxylic acids and derivatives

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Shiqi Wang, Jiahui Wu, Qingcheng Wang, Yunfeng Zhang, Hong Yuan, Jianding Wang, Yonghui Wu, Yaxi Xu, Na Ji, Bin Quan, Haixing Wang, Qing Shen. Evaluation of a miniature mass spectrometer based point-of-care-test method for direct analysis of amlodipine and benazepril in whole blood. Journal of pharmaceutical and biomedical analysis. 2024 Aug; 245(?):116194. doi: 10.1016/j.jpba.2024.116194. [PMID: 38704878]
Qi-Fang Huang, Di Zhang, Yihong Luo, Kun Hu, Qiong Wu, Hailong Qiu, Fei Xu, Mei-Ling Wang, Xin Chen, Yan Li, Ji-Guang Wang. Comparison of two single-pill dual combination antihypertensive therapies in Chinese patients: a randomized, controlled trial. BMC medicine. 2024 01; 22(1):28. doi: 10.1186/s12916-023-03244-4. [PMID: 38263021]
Aozi Feng, Weizhao Lin, Li Li, Mengnan Zeng, Jun Lyu. Pharmacoeconomic evaluation of stroke and myocardial infarction prevention in hypertensive patients: Markov model based on the ACCOMPLISH trial. The Journal of international medical research. 2023 Dec; 51(12):3000605231214921. doi: 10.1177/03000605231214921. [PMID: 38114070]
Wen Yuan, Hongjun Fan, Haibing Yang, Liang Tang, Zhiming Liu, Fan Ouyang, Wei Luo, Yong Yan. Effect and mechanism of HMG-CoA reductase inhibitor on the improvement of elderly essential hypertension-induced vascular endothelial function impairment based on the JAK/STAT pathway. Diagnostic pathology. 2023 Sep; 18(1):108. doi: 10.1186/s13000-023-01393-x. [PMID: 37759223]
O A Ahmed-Farid, Areeg M Abdelrazek, Hend Elwakel, Maha M Mohamed. Hordeum vulgare ethanolic extract mitigates high salt-induced cerebellum damage via attenuation of oxidative stress, neuroinflammation, and neurochemical alterations in hypertensive rats. Metabolic brain disease. 2023 Aug; ?(?):. doi: 10.1007/s11011-023-01277-5. [PMID: 37646962]
Kyeong-Eon Park, Soo Hee Lee, Sung Il Bae, Yeran Hwang, Seong-Ho Ok, Seung Hyun Ahn, Gyujin Sim, Soonghee Chung, Ju-Tae Sohn. Lipid Emulsion Inhibits Amlodipine-Induced Nitric Oxide-Mediated Vasodilation in Isolated Rat Aorta. International journal of molecular sciences. 2023 May; 24(10):. doi: 10.3390/ijms24108741. [PMID: 37240087]
Giovanna Gallo, Riccardo Sarzani, Arrigo Francesco Giuseppe Cicero, Stefano Genovese, Matteo Pirro, Luca Gallelli, Andrea Faggiano, Massimo Volpe. An Expert Opinion on the Role of the Rosuvastatin/Amlodipine Single Pill Fixed Dose Combination in Cardiovascular Prevention. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension. 2023 Apr; ?(?):. doi: 10.1007/s40292-023-00570-9. [PMID: 37020154]
Tian Xia, Lu-Lu Xu, Peng-Yue Guo, Wan-Ting Shi, Yan-Qiong Cheng, Ai-Jun Liu. Synergism of amlodipine and telmisartan or candesartan on blood pressure reduction by using SynergyFinder 3.0 and probability sum test in vivo. Pharmacology research & perspectives. 2023 04; 11(2):e01064. doi: 10.1002/prp2.1064. [PMID: 36810974]
Ju-Tae Sohn. Lipid Emulsion-Mediated Improvement of Hemodynamic Depression Caused by Amlodipine Toxicity. Pediatric emergency care. 2023 03; 39(3):205-206. doi: 10.1097/pec.0000000000002842. [PMID: 36083186]
Stephen Y Wang, Jonathan M Hanna, Prajesh Gongal, Oyere K Onuma, Michael G Nanna. Choice of antihypertensive agent in isolated systolic hypertension and isolated diastolic hypertension: A secondary analysis of the ALLHAT trial. American heart journal. 2022 Dec; 254(?):30-34. doi: 10.1016/j.ahj.2022.07.006. [PMID: 35932912]
G Christina Gutierrez, Christopher Dayton, Rebecca L Attridge, Lucas Smedley, Haritha Saikumar, Christopher Everett, Abraham Rodriguez, Shawn Varney. Angiotensin II Use in Treatment of Refractory Shock Due to Benazepril and Amlodipine Toxic Ingestion. Journal of pharmacy practice. 2022 Oct; ?(?):8971900221137389. doi: 10.1177/08971900221137389. [PMID: 36314764]
Pandeng Miao, Jie Gan, Jian Zhang, Mingxuan Ma, Xiaoqi Li, Yingxiang Du, Zijie Feng, Liu Zhang. Carboxymethyl-β-cyclodextrin and histidine-zeolitic imidazolate framework-8 used for enantioseparation of three basic drugs in open-tubular capillary electrochromatography. Chirality. 2022 09; 34(9):1209-1218. doi: 10.1002/chir.23480. [PMID: 35678370]
Xiying Zhao, Jiahao Mo, Beiping Zhang, Jian Tang. Hypertension as a rare adverse effect caused by infliximab in the treatment of Crohn's disease: a case report. Annals of palliative medicine. 2022 Sep; 11(9):3001-3004. doi: 10.21037/apm-22-807. [PMID: 36217627]
Peng Liu, Xiaowei Wu, Suyi Pan, Jiamin Dai, Zixuan Zhang, Xuetao Guo. Photochlorination-induced degradation of microplastics and interaction with Cr(VI) and amlodipine. The Science of the total environment. 2022 Aug; 835(?):155499. doi: 10.1016/j.scitotenv.2022.155499. [PMID: 35472361]
Ting Li, Yan-Ping Liu, Shu-Qin Liu, Ping Shi, Xin Jiang, Ye Tao, Xiao-Meng Gao, Ya-Ping Ma, Yu Cao. Bioequivalence evaluation and food effect assessment of Lisinopril/amlodipine tablets in healthy Chinese subjects under fasting and fed conditions. BMC pharmacology & toxicology. 2022 07; 23(1):45. doi: 10.1186/s40360-022-00590-6. [PMID: 35794660]
Sonali R Gnanenthiran, Nelson Wang, Gian Luca Di Tanna, Abdul Salam, Ruth Webster, H Asita de Silva, Rama Guggilla, Stephen Jan, Pallab K Maulik, Nitish Naik, Vanessa Selak, Simon Thom, Dorairaj Prabhakaran, Aletta E Schutte, Anushka Patel, Anthony Rodgers. Association of Low-Dose Triple Combination Therapy vs Usual Care With Time at Target Blood Pressure: A Secondary Analysis of the TRIUMPH Randomized Clinical Trial. JAMA cardiology. 2022 06; 7(6):645-650. doi: 10.1001/jamacardio.2022.0471. [PMID: 35416909]
Vineeta Gupta, Ishan Kumar, Vibhesh Raj, Priyanka Aggarwal, Vikas Agrawal. Comparison of the effects of calcium channel blockers plus iron chelation therapy versus chelation therapy only on iron overload in children and young adults with transfusion-dependent thalassemia: A randomized double-blind placebo-controlled trial. Pediatric blood & cancer. 2022 06; 69(6):e29564. doi: 10.1002/pbc.29564. [PMID: 35092347]
Bin Chen, ZhiMin Chen, DongQing Lv, Yuan Sun, HuaFang Chen. Pharmacokinetics, Bioequivalence, and Safety Studies of Amlodipine Besylate in Healthy Subjects. Clinical pharmacology in drug development. 2022 06; 11(6):717-723. doi: 10.1002/cpdd.1064. [PMID: 34981666]
Xinjing Li, Enpan Mo, Lin Chen. Pharmacokinetics and Bioequivalence Evaluation of 2 Olmesartan Medoxomil and Amlodipine Besylate Fixed-Dose Combination Tablets in Healthy Chinese Volunteers Under Fasting and Fed Conditions. Clinical pharmacology in drug development. 2022 06; 11(6):761-769. doi: 10.1002/cpdd.1086. [PMID: 35289500]
Yang Li, Danyang Zhao, Minyi Qian, Jun Liu, Chuyue Pan, Xinxin Zhang, Xubin Duan, Yufei Zhang, Wenxin Jia, Lirui Wang. Amlodipine, an anti-hypertensive drug, alleviates non-alcoholic fatty liver disease by modulating gut microbiota. British journal of pharmacology. 2022 05; 179(9):2054-2077. doi: 10.1111/bph.15768. [PMID: 34862599]
Jessica L Ward, Emilie Guillot, Oliver Domenig, Wendy A Ware, Lingnan Yuan, Jonathan P Mochel. Circulating renin-angiotensin-aldosterone system activity in cats with systemic hypertension or cardiomyopathy. Journal of veterinary internal medicine. 2022 May; 36(3):897-909. doi: 10.1111/jvim.16401. [PMID: 35285549]
Hee-Won Jang, Su-Min Park, Seo-Young Hwang, Kyuyong Kang, Mincheol Choi, Ju-Hyun An, Hyung-Kyu Chae, Ye-In Oh, Hwa-Young Youn. Unusual case of pleural effusion caused by amlodipine in a dog with systemic hypertension. Veterinary medicine and science. 2022 03; 8(2):445-449. doi: 10.1002/vms3.727. [PMID: 35132803]
Yu Wang, Zhen Hua, Wenjing Chen, Yushuo Zhu, Yunlun Li. Efficacy and safety of Tengfu Jiangya tablet combined with valsartan/amlodipine in the treatment of stage 2 hypertension: study protocol for a randomized controlled trial. Trials. 2022 Feb; 23(1):171. doi: 10.1186/s13063-022-06089-z. [PMID: 35193665]
Mohd Aftab Alam, Yousef A Bin Jardan, Mohammad Raish, Abdullah M Al-Mohizea, Abdul Ahad, Fahad I Al-Jenoobi. Herb-drug interaction: pharmacokinetics and pharmacodynamics of anti-hypertensive drug amlodipine besylate in presence of Lepidium sativum and Curcuma longa. Xenobiotica; the fate of foreign compounds in biological systems. 2022 Feb; 52(2):177-185. doi: 10.1080/00498254.2021.2023787. [PMID: 34958609]
Fumihiko Takeuchi, Yi-Qiang Liang, Masato Isono, Mia Yang Ang, Kotaro Mori, Norihiro Kato. Transcriptomic Response in the Heart and Kidney to Different Types of Antihypertensive Drug Administration. Hypertension (Dallas, Tex. : 1979). 2022 02; 79(2):413-423. doi: 10.1161/hypertensionaha.121.18026. [PMID: 34879704]
Abdul-Fatawu Osman, Rohan Madhu Prasad, Shawn Marein, Corey O'Brien. Multi-organ dysfunction as a presentation of calcium channel blocker intoxication. BMJ case reports. 2022 Jan; 15(1):. doi: 10.1136/bcr-2021-245711. [PMID: 35039350]
L Koliastasis, I Lampadakis, A Milkas, P Strempelas, V Sourides, K Kakava, P Tsioufis, S Papaioannou. Refractory Shock from Amlodipine Overdose Overcomed with Hyperinsulinemia. Cardiovascular toxicology. 2022 01; 22(1):63-66. doi: 10.1007/s12012-021-09699-2. [PMID: 34643856]
Jenna Essink, Sydney Berg, Jaka Montange, Andrew Sankey, Veronica Taylor, Jeffrey Salomon. Single-Pass Albumin Dialysis as Rescue Therapy for Pediatric Calcium Channel Blocker Overdose. Journal of investigative medicine high impact case reports. 2022 Jan; 10(?):23247096221105251. doi: 10.1177/23247096221105251. [PMID: 35856321]
Inseung Jeon, Seol Ju Moon, Sang-In Park, Yewon Choi, Jina Jung, Kyung-Sang Yu, Jae-Yong Chung. Pharmacokinetics of a Fixed-Dose Combination of Amlodipine/Losartan and Chlorthalidone Compared to Concurrent Administration of the Separate Components. Clinical pharmacology in drug development. 2022 01; 11(1):91-99. doi: 10.1002/cpdd.963. [PMID: 34159751]
Jianli Fu, Ting Wang, Botao Li, Na Zhao. The Efficacy of Rosuvastatin, Amlodipine, and Aspirin in the Treatment of Hypertension with Coronary Heart Disease and Its Effect on Platelet Aggregation. Disease markers. 2022; 2022(?):1111438. doi: 10.1155/2022/1111438. [PMID: 36284992]
Maryana I Prokosa. INDICATORS OF ENDOTHELIAL DYSFUNCTION, MARKERS OF INFLAMMATION AND LIPID METABOLISM IN PATIENTS WITH HYPERTENSION WITH THE ADMINISTRATION OF QUERCETIN. Wiadomosci lekarskie (Warsaw, Poland : 1960). 2022; 75(7):1653-1657. doi: 10.36740/wlek202207107. [PMID: 35962675]
Jung-Chi Li, Po-Chung Cheng, Chien-Nin Huang, Li-Fen Jian, Ying-Syuan Wu, Chih-Li Lin. Antihypertensive treatment improves glycemic control in patients with newly diagnosed type 2 diabetes mellitus: A prospective cohort study. Frontiers in endocrinology. 2022; 13(?):935561. doi: 10.3389/fendo.2022.935561. [PMID: 36157468]
Ahmed Mohamed Youssef, Hesham Abdallah Elghoneimy, Maged Wasfy Helmy, Ahmed Mokhtar Abdelazeem, Noha Mahmoud El-Khodary. Effect of amlodipine versus bisoprolol in hypertensive patients on maintenance hemodialysis: A randomized controlled trial. Medicine. 2021 Dec; 100(51):e28322. doi: 10.1097/md.0000000000028322. [PMID: 34941131]
Di Zhang, Qi-Fang Huang, Chang-Sheng Sheng, Yan Li, Ji-Guang Wang. Serum uric acid change in relation to antihypertensive therapy with the dihydropyridine calcium channel blockers. Blood pressure. 2021 12; 30(6):395-402. doi: 10.1080/08037051.2021.1996220. [PMID: 34714194]
Gwenolé Loas, Pascal Le Corre. Comment on 'Comparison of losartan and amlodipine effects on the outcomes of patient with COVID-19 and primary hypertension: A randomised clinical trial'. International journal of clinical practice. 2021 12; 75(12):e14957. doi: 10.1111/ijcp.14957. [PMID: 34965651]
Nisita Chaihongsa, Putcharawipa Maneesai, Weerapon Sangartit, Prapassorn Potue, Sarawoot Bunbupha, Poungrat Pakdeechote. Galangin alleviates vascular dysfunction and remodelling through modulation of the TNF-R1, p-NF-κB and VCAM-1 pathways in hypertensive rats. Life sciences. 2021 Nov; 285(?):119965. doi: 10.1016/j.lfs.2021.119965. [PMID: 34543638]
Robert Hermann, Kristina Gundlach, Dan Seiler. Mechanistic Considerations About an Unexpected Ramipril Drug-Drug Interaction in the Development of a Triple Fixed-Dose Combination Product Containing Ramipril, Amlodipine, and Atorvastatin. Clinical pharmacology in drug development. 2021 11; 10(11):1307-1315. doi: 10.1002/cpdd.930. [PMID: 33773093]
Nathan K Itoga, Daniel S Tawfik, Maria E Montez-Rath, Tara I Chang. Contributions of Systolic and Diastolic Blood Pressures to Cardiovascular Outcomes in the ALLHAT Study. Journal of the American College of Cardiology. 2021 10; 78(17):1671-1678. doi: 10.1016/j.jacc.2021.08.035. [PMID: 34674811]
Brian Pearlman, Bereket T Lodebo. Renin secreting tumour: a rare cause of secondary hypertension. Lancet (London, England). 2021 09; 398(10305):1074. doi: 10.1016/s0140-6736(21)01696-2. [PMID: 34537092]
Masayo Koide, Osama F Harraz, Fabrice Dabertrand, Thomas A Longden, Hannah R Ferris, George C Wellman, David C Hill-Eubanks, Adam S Greenstein, Mark T Nelson. Differential restoration of functional hyperemia by antihypertensive drug classes in hypertension-related cerebral small vessel disease. The Journal of clinical investigation. 2021 09; 131(18):. doi: 10.1172/jci149029. [PMID: 34351870]
Jack S Lawson, Rosanne E Jepson. Feline comorbidities: The intermingled relationship between chronic kidney disease and hypertension. Journal of feline medicine and surgery. 2021 09; 23(9):812-822. doi: 10.1177/1098612x211037872. [PMID: 34428941]
Muhammed Khaled Elfaituri, Sherief Ghozy, Amr Ebied, Mostafa Ebraheem Morra, Osama Gamal Hassan, Ahmed Alhusseiny, Alzhraa Salah Abbas, Nourin Ali Sherif, Juliano Lara Fernandes, Nguyen Tien Huy. Amlodipine as adjuvant therapy to current chelating agents for reducing iron overload in thalassaemia major: a systematic review, meta-analysis and simulation of future studies. Vox sanguinis. 2021 Sep; 116(8):887-897. doi: 10.1111/vox.13083. [PMID: 33634883]
Qian Wei, Zhang Jing, Hao Zhi-Ye. Evaluation of Danzhi Xiaoyao powder and amlodipine sustained-release tablets in follow-up treatment of the hypertensive crisis and the interleukin-6 gene expression. Cellular and molecular biology (Noisy-le-Grand, France). 2021 Aug; 67(2):166-170. doi: 10.14715/cmb/2021.67.2.26. [PMID: 34817321]
N N Pribylova, M V Yakovleva, C A Pribylov, T A Barbashina, E V Gavriljuk, G S Mal, V S Pribylov. [Vasoprotective effects hypotensive therapy in patients with coronary heart disease combined with chronic kidney disease stage 2-3 after coronary stenting]. Kardiologiia. 2021 Aug; 61(8):14-22. doi: 10.18087/cardio.2021.8.n1525. [PMID: 34549689]
Mohd Aftab Alam, Yousef A Bin Jardan, Bader Alzenaidy, Mohammad Raish, Abdullah M Al-Mohizea, Abdul Ahad, Fahad Ibrahim Al-Jenoobi. Effect of Hibiscus sabdariffa and Zingiber officinale on pharmacokinetics and pharmacodynamics of amlodipine. The Journal of pharmacy and pharmacology. 2021 Aug; 73(9):1151-1160. doi: 10.1093/jpp/rgaa062. [PMID: 34383955]
Hossein Karami, Hadiseh Khalilzadeh Arjmandi, Ebrahim Salehifar, Hadi Darvishi-Khezri, Mojdeh Dabirian, Mehrnoush Kosaryan, Aily Aliasgharian, Rosetta Akbarzadeh, Raheleh Naeimayi Aali, Amirreza Nasirzadeh. A double-blind, controlled, crossover trial of amlodipine on iron overload status in transfusion dependent β-thalassemia patients. International journal of clinical practice. 2021 Aug; 75(8):e14337. doi: 10.1111/ijcp.14337. [PMID: 33969592]
O D Ostroumova, A I Kochetkov, N A Arablincky, N A Shatalova, R R Romanovsky, A A Kirichenko. [What do we Mean by "Ideal" Blood Pressure Control?]. Kardiologiia. 2021 Jul; 61(7):68-78. doi: 10.18087/cardio.2021.7.n1662. [PMID: 34397344]
Kawin Khachornsakkul, Wijitar Dungchai. A Portable Reflective Absorbance Spectrophotometric Smartphone Device for the Rapid and Highly Accurate Determination of Amlodipine in Pharmaceutical Formulation and Human Urine Samples. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2021 Jul; 37(7):963-969. doi: 10.2116/analsci.20p349. [PMID: 33229823]
M U Maneesh, Syed Sagheer Ahmed, T Yunus Pasha, B Ramesh, Manish Majumder. A Simple Bioanalytical Method for Simultaneous Estimation of Amlodipine and Celecoxib in Rat Plasma by High Performance Liquid Chromatography. Journal of chromatographic science. 2021 Jun; 59(7):627-633. doi: 10.1093/chromsci/bmab046. [PMID: 33912904]
Masoud Nouri-Vaskeh, Niusha Kalami, Ramin Zand, Zahra Soroureddin, Mojtaba Varshochi, Khalil Ansarin, Haleh Rezaee, Ali Taghizadieh, Armin Sadeghi, Masoud Ahangari Maleki, Azam Esmailnajad, Parviz Saleh, Mehdi Haghdoost, Mehdi Maleki, Akbar Sharifi. Comparison of losartan and amlodipine effects on the outcomes of patient with COVID-19 and primary hypertension: A randomised clinical trial. International journal of clinical practice. 2021 Jun; 75(6):e14124. doi: 10.1111/ijcp.14124. [PMID: 33650197]
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