Amitriptyline (BioDeep_00000001424)

 

Secondary id: BioDeep_00000397488

human metabolite blood metabolite


代谢物信息卡片


dimethyl(3-{tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}propyl)amine

化学式: C20H23N (277.1830398)
中文名称: 阿米替林
谱图信息: 最多检出来源 Homo sapiens(blood) 50%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Amitriptyline. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/amitriptyline (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000001424). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: CN(C)CCC=C1C2=CC=CC=C2CCC2=CC=CC=C12
InChI: InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3

描述信息

Amitriptyline hydrochloride is a dibenzocycloheptene-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, amitriptyline does not affect mood or arousal, but may cause sedation. In depressed individuals, amitriptyline exerts a positive effect on mood. TCAs are potent inhibitors of serotonin and norepinephrine reuptake. Tertiary amine TCAs, such as amitriptyline, are more potent inhibitors of serotonin reuptake than secondary amine TCAs, such as nortriptyline. TCAs also down-regulate cerebral cortical β-adrenergic receptors and sensitize post-synaptic serotonergic receptors with chronic use. The antidepressant effects of TCAs are thought to be due to an overall increase in serotonergic neurotransmission. TCAs also block histamine-H1 receptors, α1-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred vision, dry mouth, constipation, urinary retention), respectively. See toxicity section below for a complete listing of side effects. Amitriptyline may be used to treat depression, chronic pain (unlabeled use), irritable bowel syndrome (unlabeled use), diabetic neuropathy (unlabeled use), post-traumatic stress disorder (unlabeled use), and for migraine prophylaxis (unlabeled use).
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D018759 - Adrenergic Uptake Inhibitors
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent > C94727 - Tricyclic Antidepressant
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D049990 - Membrane Transport Modulators

同义名列表

80 个代谢物同义名

dimethyl(3-{tricyclo[9.4.0.0³,⁸]pentadeca-1(15),3,5,7,11,13-hexaen-2-ylidene}propyl)amine; 3-(10,11-Dihydro-5H-dibenzo[a,D]cyclohepten-5-ylidene)-N,N-dimethylpropan-1-amine; 3-(10,11-Dihydro-5H-dibenzo(a,D)cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine; 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,D)heptalene-Delta(5),gamma-propylamine; 10,11-Dihydro-5-(gamma-dimethylaminopropylidene)-5H-dibenzo(a,D)cycloheptene; 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,D)cycloheptatriene; 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,D)heptalene-delta(5),g-propylamine; 5-(3-Dimethylaminopropylidene)-10,11-dihydro-5H-dibenzo(a,D)cycloheptene; 10,11-Dihydro-5-(g-dimethylaminopropylidene)-5H-dibenzo(a,D)cycloheptene; 10,11-Dihydro-5-(γ-dimethylaminopropylidene)-5H-dibenzo(a,D)cycloheptene; 5-(gamma-Dimethylaminopropylidene)-5H-dibenzo[a,D][1,4]cycloheptadiene; 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,D)heptalene-δ(5),γ-propylamine; 10,11-Dihydro-N,N-dimethyl-5H-dibenzo(a,D)heptalene-δ(5),g-propylamine; 5-(Γ-dimethylaminopropylidene)-5H-dibenzo[a,D][1,4]cycloheptadiene; 5-(g-Dimethylaminopropylidene)-5H-dibenzo[a,D][1,4]cycloheptadiene; Merck sharp and dohme brand OF amitriptyline hydrochloride; Rhône-poulenc rorer brand OF amitriptyline hydrochloride; Rhône poulenc rorer brand OF amitriptyline hydrochloride; Cahill may roberts brand OF amitriptyline hydrochloride; Merck sharp and dohme brand OF amitriptyline embonate; Cahill may roberts brand OF amitriptyline embonate; Neuro hexal brand OF amitriptyline hydrochloride; Parke davis brand OF amitriptyline hydrochloride; Neuraxpharm brand OF amitriptyline hydrochloride; Psicofarma brand OF amitriptyline hydrochloride; Alphapharm brand OF amitriptyline hydrochloride; Goldshield brand OF amitriptyline hydrochloride; Betapharm brand OF amitriptyline hydrochloride; Lundbeck brand OF amitriptyline hydrochloride; Rodleben brand OF amitriptyline hydrochloride; Desitin brand OF amitriptyline hydrochloride; Douglas brand OF amitriptyline hydrochloride; Krewel brand OF amitriptyline hydrochloride; Protea brand OF amitriptyline hydrochloride; Zeneca brand OF amitriptyline hydrochloride; Apotex brand OF amitriptyline hydrochloride; Bayer brand OF amitriptyline hydrochloride; Hexal brand OF amitriptyline hydrochloride; Roche brand OF amitriptyline hydrochloride; Amrad brand OF amitriptyline hydrochloride; Merck brand OF amitriptyline hydrochloride; DDSA brand OF amitriptyline hydrochloride; APS brand OF amitriptyline hydrochloride; Amitriptyline Hydrochloride; Amitriptylin neuraxpharm; Amitriptylin-neuraxpharm; Amitriptylinneuraxpharm; Desitin, amitriptylin; Amitriptylin desitin; beta, Amitriptylin; Apo amitriptyline; RPH, Amitriptylin; Apo-amitriptyline; Amitriptylin beta; Amitriptylin RPH; ApoAmitriptyline; Amitriprolidine; amitriptyline; Amitryptiline; Amytriptiline; Amitryptyline; Amitriptylin; Novoprotect; Amineurin; Tryptizol; Triptafen; Tryptanol; Anapsique; Syneudon; Tryptine; Lentizol; Amitrip; Damilen; Domical; Amitrol; Saroten; Laroxyl; Sarotex; Elavil; Endep



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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  • Chi-Jung Tsai, Chuang-Hsin Chiu, Yu-Yeh Kuo, Wen-Sheng Huang, Tsung-Hsun Yu, Leo Garcia Flores, Skye Hsin-Hsien Yeh, Kuo-Hsing Ma. Amitriptyline Accelerates SERT Binding Recovery in a Rat 3,4-Methylenedioxymethamphetamine (MDMA) Model: In Vivo 4-[18F]-ADAM PET Imaging. International journal of molecular sciences. 2022 Jun; 23(13):. doi: 10.3390/ijms23137035. [PMID: 35806049]
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  • Trang Thi Doan Luong, Rashad Tuffaha, Mirjam Schuchardt, Barbara Moser, Nadeshda Schelski, Beate Boehme, Can Gollmann-Tepeköylü, Clara Schramm, Johannes Holfeld, Burkert Pieske, Erich Gulbins, Markus Tölle, Markus van der Giet, Florian Lang, Kai-Uwe Eckardt, Jakob Voelkl, Ioana Alesutan. Acid sphingomyelinase promotes SGK1-dependent vascular calcification. Clinical science (London, England : 1979). 2021 02; 135(3):515-534. doi: 10.1042/cs20201122. [PMID: 33479769]
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  • Mahin Hashemi Hedeshi, Omid Rezvani, Habib Bagheri. Silane-based modified papers and their extractive phase roles in a microfluidic platform. Analytica chimica acta. 2020 Sep; 1128(?):31-41. doi: 10.1016/j.aca.2020.05.069. [PMID: 32825910]
  • Judy Caron, Randall Kaye, Thomas Wessel, Amy Halseth, Gary Kay. An assessment of the centrally acting muscle relaxant tolperisone on driving ability and cognitive effects compared to placebo and cyclobenzaprine. Journal of clinical pharmacy and therapeutics. 2020 Aug; 45(4):774-782. doi: 10.1111/jcpt.13165. [PMID: 32390248]
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