N-Methyltryptamine (BioDeep_00000001396)

 

Secondary id: BioDeep_00000403381

human metabolite blood metabolite BioNovoGene_Lab2019 natural product


代谢物信息卡片


[2-(1H-indol-3-yl)ethyl](methyl)amine

化学式: C11H14N2 (174.1157)
中文名称: N-甲基色胺-d3, N-甲基色胺, N(omega)-甲基色胺
谱图信息: 最多检出来源 Viridiplantae(plant) 13.12%

分子结构信息

SMILES: c1(c[nH]c2c1cccc2)CCNC
InChI: InChI=1S/C11H14N2/c1-12-7-6-9-8-13-11-5-3-2-4-10(9)11/h2-5,8,12-13H,6-7H2,1H3

描述信息

N-Methyltryptamine (NMT), or monomethyltryptamine, is a tryptamine alkaloid that has been found in the bark, shoots and leaves of numerous plants. (wikipedia). N-Methyltryptamine was detected in urine from all autistic patients with mental retardation and epilepsy and many autistic patients (32/47) with mental retardation (PubMed ID 8747157 ).
N-Methyltryptamine (NMT), or monomethyltryptamine, is a tryptamine alkaloid that has been found in the bark, shoots and leaves of numerous plants. (wikipedia)

同义名列表

23 个代谢物同义名

[2-(1H-indol-3-yl)ethyl](methyl)amine; 2-(1H-indol-3-yl)-N-Methylethanamine; N-Methyltryptamine hydrochloride; 1-Methyl-2-(3-indolyl)ethylamine; N-Methyl-1H-indole-3-ethanamine; 3-(2-(methylamino)Ethyl)indole; 3-(2-[Methylamino]ethyl)indole; 3-(2-Methylaminoethyl)indole; N-ω-Methyltryptamine; N-Methyltryptamine oxalate; N(Omega)-methyltryptamine; N-Methylindoleethylamine; N-Omega-methyltryptamine; N-Monomethyltryptamine; N10-Methyltryptamine; Nω-methyltryptamine; DL-Methyltryptamine; N-Methyltryptamine; Methyltryptamine; Dipterine; N-Methyltryptamine; N-Methyltryptamine; H-Cys(1)-Pro-Gly-Glu-Gly-Glu-Gln-Cys(2)-Asp-Val-Glu-Phe-Asn-Pro-Cys(3)-Cys(1)-Pro-Pro-Leu-Thr-Cys(2)-Ile-Pro-Gly-Asp-Pro-Tyr-Gly-Ile-Cys(3)-Tyr-Ile-Ile-OH



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

6 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(5)

PharmGKB(0)

64 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 GTPBP4, HTR4, INMT, OSCP1, PIK3R6
Peripheral membrane protein 3 ACHE, GBA1, PIK3R6
Endosome membrane 1 HTR4
Nucleus 2 ACHE, GTPBP4
cytosol 4 GSR, GTPBP4, INMT, PIK3R6
dendrite 3 HTR2A, HTR4, MAOB
trans-Golgi network 1 GBA1
nucleoplasm 1 GTPBP4
Cell membrane 4 ACHE, HTR2A, HTR4, PIK3R6
Cytoplasmic side 1 MAOB
Cell projection, axon 1 HTR2A
Multi-pass membrane protein 3 HTR2A, HTR4, MPC1L
Synapse 2 ACHE, HTR4
cell surface 1 ACHE
dendritic shaft 1 HTR2A
glutamatergic synapse 2 HTR2A, HTR4
Golgi apparatus 2 ACHE, GBA1
lysosomal membrane 1 GBA1
mitochondrial inner membrane 1 MPC1L
neuromuscular junction 1 ACHE
neuronal cell body 2 HTR2A, MAOB
postsynapse 1 HTR4
presynaptic membrane 1 HTR2A
Lysosome 1 GBA1
Presynapse 1 HTR2A
endosome 1 HTR4
plasma membrane 6 ACHE, BCHE, HTR2A, HTR4, OSCP1, PIK3R6
Membrane 4 ACHE, GTPBP4, HTR4, PIK3R6
axon 1 HTR2A
caveola 1 HTR2A
extracellular exosome 2 GBA1, GSR
Lysosome membrane 1 GBA1
Lumenal side 1 GBA1
endoplasmic reticulum 1 GBA1
extracellular space 2 ACHE, BCHE
lysosomal lumen 1 GBA1
perinuclear region of cytoplasm 2 ACHE, GTPBP4
mitochondrion 2 GSR, MAOB
Secreted 2 ACHE, BCHE
extracellular region 2 ACHE, BCHE
Mitochondrion outer membrane 1 MAOB
mitochondrial outer membrane 1 MAOB
mitochondrial matrix 1 GSR
Extracellular side 1 ACHE
nuclear membrane 1 GTPBP4
external side of plasma membrane 1 GSR
cytoplasmic vesicle 1 HTR2A
nucleolus 1 GTPBP4
postsynaptic membrane 1 HTR2A
Mitochondrion inner membrane 1 MPC1L
basement membrane 1 ACHE
Nucleus, nucleolus 1 GTPBP4
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
Membrane, caveola 1 HTR2A
cell body fiber 1 HTR2A
Cell projection, dendrite 1 HTR2A
side of membrane 1 ACHE
basal plasma membrane 1 OSCP1
endoplasmic reticulum lumen 1 BCHE
phosphatidylinositol 3-kinase complex 1 PIK3R6
phosphatidylinositol 3-kinase complex, class IA 1 PIK3R6
mitochondrial envelope 1 MAOB
Single-pass type IV membrane protein 1 MAOB
nuclear envelope lumen 1 BCHE
neurofilament 1 HTR2A
synaptic cleft 1 ACHE
[Isoform H]: Cell membrane 1 ACHE
G protein-coupled serotonin receptor complex 1 HTR2A
phosphatidylinositol 3-kinase complex, class IB 1 PIK3R6


文献列表

  • Luiz C Klein-Júnior, Sylvian Cretton, Pierre-Marie Allard, Grégory Genta-Jouve, Carolina S Passos, Juliana Salton, Pablo Bertelli, Marion Pupier, Damien Jeannerat, Yvan Vander Heyden, André L Gasper, Jean-Luc Wolfender, Philippe Christen, Amélia T Henriques. Targeted Isolation of Monoterpene Indole Alkaloids from Palicourea sessilis. Journal of natural products. 2017 11; 80(11):3032-3037. doi: 10.1021/acs.jnatprod.7b00681. [PMID: 29120642]
  • Dale Gardner, Franklin Riet-Correa, Danilo Lemos, Kevin Welch, James Pfister, Kip Panter. Teratogenic effects of Mimosa tenuiflora in a rat model and possible role of N-methyl- and N,N-dimethyltryptamine. Journal of agricultural and food chemistry. 2014 Jul; 62(30):7398-401. doi: 10.1021/jf5005176. [PMID: 24689494]
  • Luigi Servillo, Alfonso Giovane, Maria Luisa Balestrieri, Domenico Cautela, Domenico Castaldo. N-methylated tryptamine derivatives in citrus genus plants: identification of N,N,N-trimethyltryptamine in bergamot. Journal of agricultural and food chemistry. 2012 Sep; 60(37):9512-8. doi: 10.1021/jf302767e. [PMID: 22957740]
  • M Soledade C Pedras, Pearson W K Ahiahonu, Mohammad Hossain. Detoxification of the cruciferous phytoalexin brassinin in Sclerotinia sclerotiorum requires an inducible glucosyltransferase. Phytochemistry. 2004 Oct; 65(19):2685-94. doi: 10.1016/j.phytochem.2004.08.033. [PMID: 15464156]
  • T Forsström, J Tuominen, J Karkkäinen. Determination of potentially hallucinogenic N-dimethylated indoleamines in human urine by HPLC/ESI-MS-MS. Scandinavian journal of clinical and laboratory investigation. 2001; 61(7):547-56. doi: 10.1080/003655101753218319. [PMID: 11763413]
  • R W Walker, L R Mandel, L Delisi, R J Wyatt, W J Vandenheuvel. Capillary column gas-liquid chromatography selected ion monitoring assay for [13C, 15N]N-methyltryptamine in human urine: failure to detect conversion of [13C,15N]tryptamine in schizophrenia patients. Journal of chromatography. 1984 Apr; 289(?):223-9. doi: 10.1016/s0021-9673(00)95090-8. [PMID: 6736154]
  • R G TABORSKY, W M MCISAAC. THE RELATIONSHIP BETWEEN THE METABOLIC FATE AND PHARMACOLOGICAL ACTION OF 5-METHOXY-N-METHYLTRYPTAMINE. Biochemical pharmacology. 1964 Mar; 13(?):531-4. doi: 10.1016/0006-2952(64)90174-1. [PMID: 14157616]