L-Threoneopterin (BioDeep_00000001315)

human metabolite PANOMIX_OTCML-2023 Endogenous

代谢物信息卡片

2-amino-6-[(1S,2S)-1,2,3-trihydroxypropyl]-4,8-dihydropteridin-4-one

化学式: C9H11N5O4 (253.08110059999998)
中文名称: 新蝶呤
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(N=C2C(=O)NC(=NC2=N1)N)C(C(CO)O)O
InChI: InChI=1S/C9H11N5O4/c10-9-13-7-5(8(18)14-9)12-3(1-11-7)6(17)4(16)2-15/h1,4,6,15-17H,2H2,(H3,10,11,13,14,18)

描述信息

L-Threoneopterin is a catabolic product of GTP. It is synthesized by macrophages upon stimulation by interferon-gamma. It is used as a marker of HIV infection. It belongs to the chemical group known as pterins. Neopterin is a pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections (From Stedman, 26th ed). Neopterin also serves as a precursor in the biosynthesis of biopterin.
Neopterin is a catabolic product of GTP. It is synthesised by macrophages upon stimulation with interferon-gamma. It is used as a marker of HIV infection. It belongs to the chemical group known as pterins.A pteridine derivative present in body fluids; elevated levels result from immune system activation, malignant disease, allograft rejection, and viral infections. (From Stedman, 26th ed) Neopterin also serves as a precursor in the biosynthesis of biopterin. [HMDB]
Neopterin (D-(+)-Neopterin), a catabolic product of guanosine triphosphate (GTM), serves as a marker of cellular immune system activation.

同义名列表

18 个代谢物同义名

2-amino-6-[(1S,2S)-1,2,3-trihydroxypropyl]-4,8-dihydropteridin-4-one; 2-Amino-6-[(1S,2S)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone; 2-amino-6-[(1S,2S)-1,2,3-trihydroxypropyl]-8H-pteridin-4-one; 2-Amino-6-(L-threo-trihydroxypropyl)-4(3H)-pteridinone; 2-Amino-6-(1,2,3-trihydroxypropyl)-4(3H)-pteridinone; L-6-(Threo-1’,2’,3’-trihydroxypropyl)pterin; L-6-(Threo-1,2,3-trihydroxypropyl)pterin; Neopterin, (erythro-L)-isomer; Neopterin, (threo-L)-isomer; D-erythro-Neopterin; L-Threo-monapterin; L-Threo-neopterin; L-Threoneopterin; L-(+)-Monapterin; D-(+)-Neopterin; L-Monapterin; Monapterin; neopterin

数据库引用编号

20 个数据库交叉引用编号

KEGG: C05926
PubChem: 135398721
PubChem: 135408877
PubChem: 440842
HMDB: HMDB0000727
Metlin: METLIN43211
DrugBank: DB15050
MeSH: Neopterin
foodb: FDB022205
chemspider: 389684
CAS: 1217632-04-6
CAS: 2009-64-5
CAS: 2277-42-1
CAS: 670-65-5
PMhub: MS000000320
PubChem: 8214
PDB-CCD: NEU
3DMET: B01915
NIKKAJI: J108.020B
medchemexpress: HY-W040055

分类词条

Biopterins and derivatives

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

37000 Pyrrhocoris apterus: 10.1016/0021-9673(95)00932-9
2062 Streptomycetaceae: 10.1128/JB.170.3.1396-1398.1988
37000 Pyrrhocoris apterus: 10.1016/0021-9673(95)00932-9
2062 Streptomycetaceae: 10.1128/JB.170.3.1396-1398.1988
9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Amir Kiani, Daniel Elieh-Ali-Komi, Fariborz Bahrehmand, Shayan Mostafaei, Asad Vaisi-Raygani, Hosein Baniamerian, Farank Aghaz, Maryam Tanhapour, Ebrahim Shakiba, Zohreh Rahimi, Tayebeh Pourmotabbed. Association of angiotensin-converting enzyme (ACE) I/D variation with biochemical parameters and oxidative stress markers in systemic lupus erythematosus patients in west of Iran. Molecular biology reports. 2023 Aug; ?(?):. doi: 10.1007/s11033-023-08685-x. [PMID: 37561325]
Clément Leveque, Simona Mrakic Sposta, Sigrid Theunissen, Peter Germonpré, Kate Lambrechts, Alessandra Vezzoli, Maristella Gussoni, Morgan Levenez, Pierre Lafère, François Guerrero, Costantino Balestra. Oxidative Stress Response Kinetics after 60 Minutes at Different Levels (10\% or 15\%) of Normobaric Hypoxia Exposure. International journal of molecular sciences. 2023 Jun; 24(12):. doi: 10.3390/ijms241210188. [PMID: 37373334]
Xiaodan Fu, Zhemin Liu, Rong Li, Junyi Yin, Han Sun, Changliang Zhu, Qing Kong, Haijin Mou, Shaoping Nie. Amelioration of hydrolyzed guar gum on high-fat diet-induced obesity: Integrated hepatic transcriptome and metabolome. Carbohydrate polymers. 2022 Dec; 297(?):120051. doi: 10.1016/j.carbpol.2022.120051. [PMID: 36184152]
Allison C Vilander, Ann Hess, Zaid Abdo, Hend Ibrahim, Lassina Doumbia, Seydou Douyon, Karim Koné, Abdoulaye Boré, Luis E Zambrana, Samuel Vilchez, Ousmane Koita, Elizabeth P Ryan. A Randomized Controlled Trial of Dietary Rice Bran Intake on Microbiota Diversity, Enteric Dysfunction, and Fecal Secretory IgA in Malian and Nicaraguan Infants. The Journal of nutrition. 2022 07; 152(7):1792-1800. doi: 10.1093/jn/nxac087. [PMID: 35441218]
Gaidaa M Dogheim, Ibtsam Khairat, Gamal A Omran, Sahar M El-Haggar, Ahmed M El Amrawy, Rehab H Werida. Clinical comparative study assessing the effect of ivabradine on neopterin and NT-Pro BNP against standard treatment in chronic heart failure patients. European journal of clinical pharmacology. 2022 Jun; 78(6):943-954. doi: 10.1007/s00228-022-03290-6. [PMID: 35238960]
Yousef Rasmi, Nadia Heidari, Kevser Kübra Kırboğa, Shima Hatamkhani, Burcu Tekin, Shahryar Alipour, Roya Naderi, Yeghaneh Farnamian, Ilknur Akca. The importance of neopterin in COVID-19: The prognostic value and relation with the disease severity. Clinical biochemistry. 2022 Jun; 104(?):1-12. doi: 10.1016/j.clinbiochem.2022.03.002. [PMID: 35307400]
Cecilia M Shikuma, Thuy Le, Thao Vu Phuong, Glen M Chew, Van Vinh Chau Nguyen, Trieu Ly Vo, Chathura Siriwardhana, Dominic Chow, Hayk Ghukasyan, Nath Limpruttidham, Thomas Premeaux, Louie Mar Gangcuangco, Robert Paul, Lishomwa C Ndhlovu. Immunologic Change over 72 Weeks Following Raltegravir- Versus Efavirenz-Based Therapy in HIV/HCV-Coinfected Individuals in Vietnam. AIDS research and human retroviruses. 2022 06; 38(6):441-450. doi: 10.1089/aid.2021.0076. [PMID: 34861767]
Arvid Edén, Anna Grahn, Daniel Bremell, Anahit Aghvanyan, Pradeepthi Bathala, Dietmar Fuchs, Johanna Gostner, Lars Hagberg, Nelly Kanberg, Sunsanee Kanjananimmanont, Magnus Lindh, Salvia Misaghian, Staffan Nilsson, Michael Schöll, George Sigal, Erika Stentoft, Marie Studahl, Aylin Yilmaz, Mingyue Wang, Martin Stengelin, Henrik Zetterberg, Magnus Gisslén. Viral Antigen and Inflammatory Biomarkers in Cerebrospinal Fluid in Patients With COVID-19 Infection and Neurologic Symptoms Compared With Control Participants Without Infection or Neurologic Symptoms. JAMA network open. 2022 05; 5(5):e2213253. doi: 10.1001/jamanetworkopen.2022.13253. [PMID: 35604688]
Koichi Azuma, Huihui Xiang, Tomoyuki Tagami, Rika Kasajima, Yumiko Kato, Sachise Karakawa, Shinya Kikuchi, Akira Imaizumi, Norikazu Matsuo, Hidenobu Ishii, Takaaki Tokito, Akihiko Kawahara, Kenta Murotani, Tetsuro Sasada, Yohei Miyagi, Tomoaki Hoshino. Clinical significance of plasma-free amino acids and tryptophan metabolites in patients with non-small cell lung cancer receiving PD-1 inhibitor: a pilot cohort study for developing a prognostic multivariate model. Journal for immunotherapy of cancer. 2022 05; 10(5):. doi: 10.1136/jitc-2021-004420. [PMID: 35569917]
Sergio M De Almeida, Indianara Rotta, Bin Tang, Anya Umlauf, Florin Vaida, Mariana Cherner, Donald Franklin, Scott Letendre, Ronald J Ellis. Higher Cerebrospinal Fluid Soluble Urokinase-type Plasminogen Activator Receptor, But Not Interferon γ-inducible Protein 10, Correlate With Higher Working Memory Deficits. Journal of acquired immune deficiency syndromes (1999). 2022 05; 90(1):106-114. doi: 10.1097/qai.0000000000002924. [PMID: 35090158]
Zemichael Gizaw, Alemayehu Worku Yalew, Bikes Destaw Bitew, Jiyoung Lee, Michael Bisesi. Fecal biomarkers of environmental enteric dysfunction and associated factors among children aged 24-59 months in east Dembiya district, northwest Ethiopia. BMC gastroenterology. 2022 Apr; 22(1):172. doi: 10.1186/s12876-022-02255-4. [PMID: 35395735]
Rowan Saloner, Natalie Savini, Scott L Letendre, David J Moore, Jessica L Montoya. Neopterin Relates to Lifetime Depression in Older Adults With HIV on Suppressive Antiretroviral Therapy. Journal of acquired immune deficiency syndromes (1999). 2022 04; 89(4):454-461. doi: 10.1097/qai.0000000000002883. [PMID: 35202052]
Meltem Yıldız Kayaoğlu, Gözde Girgin, Ismail Solmaz, Terken Baydar, Banu Anlar. Urine neopterin in childhood acute demyelinating diseases: Potential for differential diagnosis. Multiple sclerosis and related disorders. 2022 Mar; 59(?):103662. doi: 10.1016/j.msard.2022.103662. [PMID: 35149394]
Daniel R Ambruso, Natalie J Briones, Angelina F Baroffio, John R Murphy, Alexander D Tran, Katherine Gowan, Bridget Sanford, Michael Ellison, Kenneth L Jones. In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype. PloS one. 2022; 17(2):e0263370. doi: 10.1371/journal.pone.0263370. [PMID: 35113934]
Katinka Nordheim Alme, Arve Ulvik, Torunn Askim, Jörg Assmus, Tom Eirik Mollnes, Mala Naik, Halvor Næss, Ingvild Saltvedt, Per-Magne Ueland, Anne-Brita Knapskog. Neopterin and kynurenic acid as predictors of stroke recurrence and mortality: a multicentre prospective cohort study on biomarkers of inflammation measured three months after ischemic stroke. BMC neurology. 2021 Dec; 21(1):476. doi: 10.1186/s12883-021-02498-w. [PMID: 34879833]
Kazuhisa Ikemoto, Chiho Sumi-Ichinose, Yui Suganuma, Taiki Kano, Noriko Ihira, Toshiharu Nagatsu, Kazunao Kondo. Salivary neopterin and related pterins: their comparison to those in plasma and changes in individuals. Journal of biochemistry. 2021 Dec; 170(4):559-567. doi: 10.1093/jb/mvab076. [PMID: 34181024]
Songul Unuvar, Rauf Melekoglu, Nese B Turkmen, Ercan Yilmaz, Seyma Yasar, Hande Yuce. Comparison of preoperative serum neopterin, periostin, indoleamine 2,3-dioxygenase, YKL-40, and tenascin-C levels with current tumor markers for early-stage endometrial cancer. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2021 Dec; 155(3):417-424. doi: 10.1002/ijgo.13666. [PMID: 33660848]
Carolina Rosadas, Henrik Zetterberg, Amanda Heslegrave, Jana Haddow, Mina Borisova, Graham P Taylor. Neurofilament Light in CSF and Plasma Is a Marker of Neuronal Damage in HTLV-1-Associated Myelopathy and Correlates With Neuroinflammation. Neurology(R) neuroimmunology & neuroinflammation. 2021 11; 8(6):. doi: 10.1212/nxi.0000000000001090. [PMID: 34611039]
Hayder M Al-Kuraishy, Ali I Al-Gareeb, Khalid J Alzahrani, Natália Cruz-Martins, Gaber El-Saber Batiha. The potential role of neopterin in Covid-19: a new perspective. Molecular and cellular biochemistry. 2021 Nov; 476(11):4161-4166. doi: 10.1007/s11010-021-04232-z. [PMID: 34319496]
Josefina Robertson, Arvid Edén, Kristina Nyström, Lars Hagberg, Aylin Yilmaz, Johanna M Gostner, Dietmar Fuchs, Staffan Nilsson, Kaj Blennow, Henrik Zetterberg, Magnus Gisslén. Increased immune activation and signs of neuronal injury in HIV-negative people on preexposure prophylaxis. AIDS (London, England). 2021 11; 35(13):2129-2136. doi: 10.1097/qad.0000000000002980. [PMID: 34115648]
Lin-Lie Meng, Li Cao. Serum neopterin levels and their role in the prognosis of patients with ischemic stroke: A systematic review and meta-analysis. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 2021 Oct; 92(?):55-60. doi: 10.1016/j.jocn.2021.07.033. [PMID: 34509262]
Halina Baran, Markus Draxler, Carina Kronsteiner, Berthold Kepplinger. Increase of Kynurenic Acid after Encephalomyocarditis Virus Infection and Its Significances. Neuro-Signals. 2021 09; 29(1):24-34. doi: 10.33594/000000434. [PMID: 34590795]
Anita Helland, Marianne Bratlie, Ingrid V Hagen, Øivind Midttun, Harald Sveier, Gunnar Mellgren, Per Magne Ueland, Oddrun A Gudbrandsen. Effect of high intake of cod or salmon on serum total neopterin concentration: a randomised clinical trial. European journal of nutrition. 2021 Sep; 60(6):3237-3248. doi: 10.1007/s00394-021-02497-0. [PMID: 33576844]
Esther Uwimaana, Bernard S Bagaya, Barbara Castelnuovo, David P Kateete, Anguzu Godwin, Noah Kiwanuka, Christopher C Whalen, Moses L Joloba. Heme oxygenase-1 and neopterin plasma/serum levels and their role in diagnosing active and latent TB among HIV/TB co-infected patients: a cross sectional study. BMC infectious diseases. 2021 Jul; 21(1):711. doi: 10.1186/s12879-021-06370-7. [PMID: 34315412]
Sabri Ekin, Abdullah Sivrikaya, Turan Akdağ, Sema Yilmaz, Semral Gülcemal. Elevated levels of neopterin and pentraxin 3 in patients with rheumatoid arthritis. Hormone molecular biology and clinical investigation. 2021 Jul; 42(4):419-423. doi: 10.1515/hmbci-2021-0012. [PMID: 34303320]
Hekma Saad Farghaly, Kotb Abbass Metwalley, Duaa Mohamed Raafat, Ghada Mohamed Saied, Magda Farghali Gabri, Magdy Algowhary. Association between vascular endothelial dysfunction and the inflammatory marker neopterin in patients with classic congenital adrenal hyperplasia. Atherosclerosis. 2021 07; 328(?):38-43. doi: 10.1016/j.atherosclerosis.2021.05.017. [PMID: 34091068]
Katja Schmitz, Sandra Trautmann, Lisa Hahnefeld, Caroline Fischer, Yannick Schreiber, Annett Wilken-Schmitz, Robert Gurke, Robert Brunkhorst, Ernst R Werner, Katrin Watschinger, Sabine Wicker, Dominique Thomas, Gerd Geisslinger, Irmgard Tegeder. Sapropterin (BH4) Aggravates Autoimmune Encephalomyelitis in Mice. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2021 07; 18(3):1862-1879. doi: 10.1007/s13311-021-01043-4. [PMID: 33844153]
Jacob D Negrey, Verena Behringer, Kevin E Langergraber, Tobias Deschner. Urinary neopterin of wild chimpanzees indicates that cell-mediated immune activity varies by age, sex, and female reproductive status. Scientific reports. 2021 04; 11(1):9298. doi: 10.1038/s41598-021-88401-6. [PMID: 33927233]
Takuya Watanabe. Neopterin derivatives - a novel therapeutic target rather than biomarker for atherosclerosis and related diseases. VASA. Zeitschrift fur Gefasskrankheiten. 2021 Apr; 50(3):165-173. doi: 10.1024/0301-1526/a000903. [PMID: 32924886]
Nooshin Ghodsian, Anthony Yeandle, Steven P Gieseg. Foam cell formation but not oxLDL cytotoxicity is inhibited by CD36 down regulation by the macrophage antioxidant 7,8-dihydroneopterin. The international journal of biochemistry & cell biology. 2021 04; 133(?):105918. doi: 10.1016/j.biocel.2021.105918. [PMID: 33421634]
Riska Habriel Ruslie, Darmadi Darmadi, Gontar Alamsyah Siregar. Vascular Endothelial Growth Factor (VEGF) and Neopterin Levels in Children with Steroid-sensitive and Steroid-resistant Nephrotic Syndrome. Medical archives (Sarajevo, Bosnia and Herzegovina). 2021 Apr; 75(2):133-137. doi: 10.5455/medarh.2021.75.133-137. [PMID: 34219873]
Federica Klaus, Karoline Guetter, Rebecca Schlegel, Erich Seifritz, Anahita Rassi, Beat Thöny, Flurin Cathomas, Stefan Kaiser. Peripheral biopterin and neopterin in schizophrenia and depression. Psychiatry research. 2021 03; 297(?):113745. doi: 10.1016/j.psychres.2021.113745. [PMID: 33524773]
Hasan Selcuk Ozger, Murat Dizbay, Seref Kerem Corbacioglu, Pinar Aysert, Zehra Demirbas, Ozlem Guzel Tunccan, Kenan Hizel, Gulendam Bozdayi, Kayhan Caglar. The prognostic role of neopterin in COVID-19 patients. Journal of medical virology. 2021 03; 93(3):1520-1525. doi: 10.1002/jmv.26472. [PMID: 32860465]
Sheela S Sinharoy, Heather E Reese, Ira Praharaj, Howard H Chang, Thomas Clasen. Effects of a combined water and sanitation intervention on biomarkers of child environmental enteric dysfunction and associations with height-for-age z-score: A matched cohort study in rural Odisha, India. PLoS neglected tropical diseases. 2021 03; 15(3):e0009198. doi: 10.1371/journal.pntd.0009198. [PMID: 33684111]
Brian J Koos, Jeffrey A Gornbein. Early pregnancy metabolites predict gestational diabetes mellitus: implications for fetal programming. American journal of obstetrics and gynecology. 2021 02; 224(2):215.e1-215.e7. doi: 10.1016/j.ajog.2020.07.050. [PMID: 32739399]
Felix Grabherr, Maria Effenberger, Alisa Pedrini, Lisa Mayr, Julian Schwärzler, Simon Reider, Barbara Enrich, Gernot Fritsche, Sophie Wildner, Rosa Bellmann-Weiler, Günter Weiss, Sabine Scholl-Bürgi, Thomas Müller, Alexander Moschen, Timon E Adolph, Herbert Tilg. Increased Fecal Neopterin Parallels Gastrointestinal Symptoms in COVID-19. Clinical and translational gastroenterology. 2021 01; 12(1):e00293. doi: 10.14309/ctg.0000000000000293. [PMID: 33438988]
Jin Yu, Hong Zhu, Saeid Taheri, William Mondy, Stephen Perry, Mark S Kindy. Plant-Based Nutritional Supplementation Attenuates LPS-Induced Low-Grade Systemic Activation. International journal of molecular sciences. 2021 Jan; 22(2):. doi: 10.3390/ijms22020573. [PMID: 33430045]
Mao Mizuta, Masaki Shimizu, Hitoshi Irabu, Masaaki Usami, Natsumi Inoue, Yasuo Nakagishi, Taizo Wada, Akihiro Yachie. Comparison of serum cytokine profiles in macrophage activation syndrome complicating different background rheumatic diseases in children. Rheumatology (Oxford, England). 2021 01; 60(1):231-238. doi: 10.1093/rheumatology/keaa299. [PMID: 32681176]
S Mrakic-Sposta, M Gussoni, C Dellanoce, M Marzorati, M Montorsi, L Rasica, L Pratali, G D'Angelo, M Martinelli, L Bastiani, L Di Natale, A Vezzoli. Effects of acute and sub-acute hypobaric hypoxia on oxidative stress: a field study in the Alps. European journal of applied physiology. 2021 Jan; 121(1):297-306. doi: 10.1007/s00421-020-04527-x. [PMID: 33057877]
Gregory Baxter-Parker, Lloyd Roffe, Elena Moltchanova, Jay Jefferies, Siddarth Raajasekar, Gary Hooper, Steven P Gieseg. Urinary neopterin and total neopterin measurements allow monitoring of oxidative stress and inflammation levels of knee and hip arthroplasty patients. PloS one. 2021; 16(8):e0256072. doi: 10.1371/journal.pone.0256072. [PMID: 34403444]
Manon Chauvin, Martin Larsen, Bibiana Quirant, Paul Quentric, Karim Dorgham, Luca Royer, Hélène Vallet, Amelie Guihot, Béhazine Combadière, Christophe Combadière, Jaume Barallat, Julien Mayaux, Charles-Edouard Luyt, Alexis Mathian, Zahir Amoura, Jacques Boddaert, Fernando Armestar, Guy Gorochov, Eva Martinez-Caceres, Delphine Sauce. Elevated Neopterin Levels Predict Fatal Outcome in SARS-CoV-2-Infected Patients. Frontiers in cellular and infection microbiology. 2021; 11(?):709893. doi: 10.3389/fcimb.2021.709893. [PMID: 34497777]
Yan-Ping Wang, Ting Wei, Xiao Ma, Xiao-Liang Zhu, Long-Fei Ren, Lei Zhang, Fang-Hui Ding, Xun Li, Hai-Ping Wang, Zhong-Tian Bai, Ke-Xiang Zhu, Long Miao, Jun Yan, Wen-Ce Zhou, Wen-Bo Meng, Yu-Qin Liu. Effect of Helicobacter Pylori on Plasma Metabolic Phenotype in Patients With Gastric Cancer. Cancer control : journal of the Moffitt Cancer Center. 2021 Jan; 28(?):10732748211041881. doi: 10.1177/10732748211041881. [PMID: 34569311]
Flávia Dos Santos Souza, Nicole Lardini Freitas, Yago Côrtes Pinheiro Gomes, Rafael Carvalho Torres, Juliana Echevarria-Lima, Isaac Lima da Silva-Filho, Ana Claudia Celestino Bezerra Leite, Marco Antonio Sales Dantas de Lima, Marcus Tulius Teixeira da Silva, Abelardo de Queiroz Campos Araújo, Otávio Melo Espíndola. Following the Clues: Usefulness of Biomarkers of Neuroinflammation and Neurodegeneration in the Investigation of HTLV-1-Associated Myelopathy Progression. Frontiers in immunology. 2021; 12(?):737941. doi: 10.3389/fimmu.2021.737941. [PMID: 34764955]
Okan Zenger, Burcu Eren, Pırıl Arısoy, Sibel Özdaş, Gözde Baydemir Peşint. Determination of Neopterin as a Prognostic Indicator Using Neopterin-Imprinted Cryogel Membranes. Methods in molecular biology (Clifton, N.J.). 2021; 2359(?):171-181. doi: 10.1007/978-1-0716-1629-1_15. [PMID: 34410669]
Josefina Robertson, Johanna M Gostner, Staffan Nilsson, Lars-Magnus Andersson, Dietmar Fuchs, Magnus Gisslen. Serum neopterin levels in relation to mild and severe COVID-19. BMC infectious diseases. 2020 Dec; 20(1):942. doi: 10.1186/s12879-020-05671-7. [PMID: 33302893]
Wael El-Deeb, Mahmoud Fayez, Ibrahim Elsohaby, Hermine V Mkrtchyan, Abdulrahman Alhaider. Changes in blood biomarkers in Arabian horses with Clostridium difficile-induced enterocolitis. Comparative immunology, microbiology and infectious diseases. 2020 Dec; 73(?):101525. doi: 10.1016/j.cimid.2020.101525. [PMID: 32877870]
Christian Lunetta, Andrea Lizio, Francesca Gerardi, Claudia Tarlarini, Massimo Filippi, Nilo Riva, Lucio Tremolizzo, Susanna Diamanti, Cinzia Carla Dellanoce, Lorena Mosca, Valeria Ada Sansone, Jonica Campolo. Urinary neopterin, a new marker of the neuroinflammatory status in amyotrophic lateral sclerosis. Journal of neurology. 2020 Dec; 267(12):3609-3616. doi: 10.1007/s00415-020-10047-7. [PMID: 32638112]
Alireza Hejrati, Mahdi Taghadosi, Reza Alizadeh-Navaei, Shahnaz Hosseinzadeh, Davood Bashash, Mozhgan Esmaili, Parisa Zafari. Neopterin serum level does not reflect the disease activity in rheumatoid arthritis: A systematic review and meta-analysis. IUBMB life. 2020 12; 72(12):2563-2571. doi: 10.1002/iub.2398. [PMID: 33089617]
Fathia M Khattab, Mai A Samir. Assessment of neopterin level and severity in lichen planus patients treated with narrow-band ultraviolet B. Journal of cosmetic dermatology. 2020 Dec; 19(12):3389-3392. doi: 10.1111/jocd.13417. [PMID: 32530076]
Priscilla Biswas, Cinzia Dellanoce, Alessandra Vezzoli, Simona Mrakic-Sposta, Mauro Malnati, Alberto Beretta, Roberto Accinni. Antioxidant Activity with Increased Endogenous Levels of Vitamin C, E and A Following Dietary Supplementation with a Combination of Glutathione and Resveratrol Precursors. Nutrients. 2020 Oct; 12(11):. doi: 10.3390/nu12113224. [PMID: 33105552]
Sinem Gürcü, Gözde Girgin, Göknur Yorulmaz, Bilge Kılıçarslan, Belgin Efe, Terken Baydar. Neopterin and biopterin levels and tryptophan degradation in patients with diabetes. Scientific reports. 2020 10; 10(1):17025. doi: 10.1038/s41598-020-74183-w. [PMID: 33046801]
Guy-Marino Hinnouho, K Ryan Wessells, Maxwell A Barffour, Somphou Sayasone, Charles D Arnold, Sengchanh Kounnavong, Sonja Y Hess. Impact of Different Strategies for Delivering Supplemental Zinc on Selected Fecal Markers of Environmental Enteric Dysfunction among Young Laotian Children: A Randomized Controlled Trial. The American journal of tropical medicine and hygiene. 2020 10; 103(4):1416-1426. doi: 10.4269/ajtmh.20-0106. [PMID: 32618258]
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Maiko Takakura, Masaki Shimizu, Hitoshi Irabu, Naoto Sakumura, Natsumi Inoue, Mao Mizuta, Yasuo Nakagishi, Akihiro Yachie. Comparison of serum biomarkers for the diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis. Clinical immunology (Orlando, Fla.). 2019 11; 208(?):108252. doi: 10.1016/j.clim.2019.108252. [PMID: 31449879]
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Débora da Luz Scheffer, Karina Ghisoni, Aderbal Silva Aguiar, Alexandra Latini. Moderate running exercise prevents excessive immune system activation. Physiology & behavior. 2019 05; 204(?):248-255. doi: 10.1016/j.physbeh.2019.02.023. [PMID: 30794851]
Fatih Dal, Yusuf Cicek, Salih Pekmezci, Bekir Kocazeybek, Hrisi Bahar Tokman, Dildar Konukoglu, Osman Şimşek, Zeynep Taner, Serhat Sirekbasan, Server Sezgin Uludağ. Role of Alvarado score and biological indicators of C-reactive protein, procalicitonin and neopterin in diagnosis of acute appendicitis. Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES. 2019 May; 25(3):229-237. doi: 10.5505/tjtes.2018.57362. [PMID: 31135946]
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Thomas A Premeaux, Michelle L D'Antoni, Mohamed Abdel-Mohsen, Satish K Pillai, Kalpana J Kallianpur, Beau K Nakamoto, Melissa Agsalda-Garcia, Bruce Shiramizu, Cecilia M Shikuma, Magnus Gisslén, Richard W Price, Victor Valcour, Lishomwa C Ndhlovu. Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals. Journal of neurovirology. 2019 04; 25(2):150-161. doi: 10.1007/s13365-018-0696-3. [PMID: 30478799]
Tomasz W Kaminski, Krystyna Pawlak, Malgorzata Karbowska, Beata Znorko, Adrian L Mor, Michal Mysliwiec, Dariusz Pawlak. The impact of antihypertensive pharmacotherapy on interplay between protein-bound uremic toxin (indoxyl sulfate) and markers of inflammation in patients with chronic kidney disease. International urology and nephrology. 2019 Mar; 51(3):491-502. doi: 10.1007/s11255-018-02064-3. [PMID: 30617956]
Xiao Yang, Huang Huang, Qing Lu, Shao-Hong Chen, Feng Wang, Ou-Ping Huang, Bin Hu, Bi-Cheng Yang. High-throughput polymer tip-electrospray ionization mass spectrometry for enhanced detection of neopterin and biopterin in clinical urine samples. Journal of mass spectrometry : JMS. 2019 Feb; 54(2):189-194. doi: 10.1002/jms.4322. [PMID: 30597687]
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Stein-Erik Hafstad Solvang, Jan Erik Nordrehaug, Grethe S Tell, Ottar Nygård, Adrian McCann, Per Magne Ueland, Øivind Midttun, Klaus Meyer, Christian A Vedeler, Dag Aarsland, Helga Refsum, A David Smith, Lasse Melvaer Giil. The kynurenine pathway and cognitive performance in community-dwelling older adults. The Hordaland Health Study. Brain, behavior, and immunity. 2019 01; 75(?):155-162. doi: 10.1016/j.bbi.2018.10.003. [PMID: 30675874]
Marwan Al-Nimer, Rawa Ratha, Taha Mahwi. Utility of Tetrahydrobiopterin Pathway in the Assessment of Diabetic Foot Ulcer: Significant and Complex Interrelations. Journal of diabetes research. 2019; 2019(?):3426878. doi: 10.1155/2019/3426878. [PMID: 31828160]
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Therese Löhrich, Verena Behringer, Roman M Wittig, Tobias Deschner, Fabian H Leendertz. The Use of Neopterin as a Noninvasive Marker in Monitoring Diseases in Wild Chimpanzees. EcoHealth. 2018 12; 15(4):792-803. doi: 10.1007/s10393-018-1357-y. [PMID: 30117002]
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Vasilios Pergialiotis, Nikoleta Karampetsou, Panagiotis Zoumpourlis, Nikolaos Papantoniou, Nikolaos Thomakos, Georgios Daskalakis. Serum neopterin levels in women with preeclampsia: a systematic review. Hypertension in pregnancy. 2018 Nov; 37(4):220-226. doi: 10.1080/10641955.2018.1526300. [PMID: 30301383]