Captopril (BioDeep_00000001304)

 

Secondary id: BioDeep_00000398788

human metabolite blood metabolite


代谢物信息卡片


(2S)-1-[(2S)-2-Methyl-3-sulphanylpropanoyl]pyrrolidine-2-carboxylic acid

化学式: C9H15NO3S (217.07726)
中文名称: 卡托普利
谱图信息: 最多检出来源 Homo sapiens(blood) 20%

分子结构信息

SMILES: CC(CS)C(=O)N1CCCC1C(=O)O
InChI: InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1

描述信息

Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
C - Cardiovascular system > C09 - Agents acting on the renin-angiotensin system > C09A - Ace inhibitors, plain > C09AA - Ace inhibitors, plain
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D000806 - Angiotensin-Converting Enzyme Inhibitors
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor > C783 - Protease Inhibitor > C247 - ACE Inhibitor
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

26 个代谢物同义名

(2S)-1-[(2S)-2-Methyl-3-sulphanylpropanoyl]pyrrolidine-2-carboxylic acid; (2S)-1-[(2S)-2-Methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid; (2S)-1-[(2S)-2-Methyl-3-sulphanylpropanoyl]pyrrolidine-2-carboxylate; (2S)-1-[(2S)-2-Methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylate; (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline; D-2-Methyl-3-mercaptopropanoyl-L-proline; D-3-Mercapto-2-methylpropanoyl-L-proline; Captopril Impurity F; Captoprilum; L-Captopril; Captolane; Tensoprel; Captopryl; Captopril; Garranil; Hypertil; Acepress; Captoril; Tenosbon; Tensobon; Capoten; Dilabar; Apopril; Lopirin; Cesplon; CP



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Fernando García-Valdespino, Gustavo Axel Elizalde-Velázquez, Selene Elizabeth Herrera-Vázquez, Leobardo Manuel Gómez-Oliván. Captopril's influence on Danio rerio embryonic development: Unveiling significant toxic outcomes at environmentally relevant concentrations. The Science of the total environment. 2024 Jul; 933(?):173179. doi: 10.1016/j.scitotenv.2024.173179. [PMID: 38750761]
  • Brian M Egan, Franziska Pohl, Xavier Anderson, Shoshana C Williams, Imienreluefe Gregory Adodo, Patrick Hunt, Zuoxu Wang, Chen-Hao Chiu, Andrea Scharf, Matthew Mosley, Sandeep Kumar, Daniel L Schneider, Hideji Fujiwara, Fong-Fu Hsu, Kerry Kornfeld. The ACE-inhibitor drug captopril inhibits ACN-1 to control dauer formation and aging. Development (Cambridge, England). 2024 Jan; ?(?):. doi: 10.1242/dev.202146. [PMID: 38284547]
  • Kyeong-Jung Kim, Min-Jin Hwang, Wang-Geun Shim, Young-Nam Youn, Soon-Do Yoon. Sustained drug release behavior of captopril-incorporated chitosan/carboxymethyl cellulose biomaterials for antihypertensive therapy. International journal of biological macromolecules. 2024 Jan; 255(?):128087. doi: 10.1016/j.ijbiomac.2023.128087. [PMID: 37979743]
  • Shadi A D Mohammed, Hanxing Liu, Salem Baldi, Yu Wang, Pingping Chen, Fang Lu, Shumin Liu. Antihypertensive, antioxidant, and renal protective impact of integrated GJD with captopril in spontaneously hypertensive rats. Scientific reports. 2023 Jul; 13(1):10944. doi: 10.1038/s41598-023-38020-0. [PMID: 37414816]
  • Jing Li, Guanying Hu, Wenxiu Liu, Xiaoyu Cao, Guanru Chen, Fu Peng, Xie Xiaofang, Cheng Peng. Patchouli alcohol against renal fibrosis of spontaneously hypertensive rats via Ras/Raf-1/ERK1/2 signalling pathway. The Journal of pharmacy and pharmacology. 2023 May; ?(?):. doi: 10.1093/jpp/rgad032. [PMID: 37177974]
  • João Pedro Tôrres Guimarães, Kalhara R Menikdiwela, Theresa Ramalho, Luiz A D Queiroz, Nishan S Kalupahana, Sonia Jancar, Latha Ramalingam, Joilson O Martins, Naima Moustaid-Moussa. Effects of captopril on glucose metabolism and autophagy in liver and muscle from mice with type 1 diabetes and diet-induced obesity. Biochimica et biophysica acta. Molecular basis of disease. 2022 10; 1868(10):166477. doi: 10.1016/j.bbadis.2022.166477. [PMID: 35780942]
  • Massimo Volpe, Valeria Pegoraro, Ilaria Peduto, Franca Heiman, Suada Meto. Extemporaneous combination therapy with nebivolol/zofenopril in hypertensive patients: usage in Italy. Current medical research and opinion. 2022 10; 38(10):1673-1681. doi: 10.1080/03007995.2022.2096352. [PMID: 35787718]
  • Armenia Armenia, Fatma Sri Wahyuni, Almahdy Almahdy, Rahmad Abdillah, Popy Genca Aquista, Diana Puspita Putri, Murhamah Zikra. Blood pressure and blood sugar-lowering effects of purified gambir on diabetic hypertensive Wistar Kyoto rats. Journal of complementary & integrative medicine. 2022 Sep; 19(3):627-636. doi: 10.1515/jcim-2022-0054. [PMID: 35446514]
  • Lixia Han, Ting Liu, Di Cui, Jiaqi Yi, Wei Jiang, Xiaoshuang Li, Na Niu, Ligang Chen. Quantitative detection of captopril in urine by smartphone-assisted ratiometric fluorescence sensing platform. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Jun; 280(?):121562. doi: 10.1016/j.saa.2022.121562. [PMID: 35780761]
  • Xuemei Dong, Minhui Wang, Yecang Tang. Green synthesis of fluorescent carbon nanospheres from chrysanthemum as a multifunctional sensor for permanganate, Hg(II), and captopril. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Apr; 271(?):120886. doi: 10.1016/j.saa.2022.120886. [PMID: 35063823]
  • Carolina B A Restini, Arthur F E Garcia, Henrique M Natalin, Mariane F A Carmo, Vinicius F Nowicki, Elen Rizzi, Leandra N Z Ramalho. Resveratrol Supplants Captopril's Protective Effect on Cardiac Remodeling in a Hypertension Model Elicited by Renal Artery Stenosis. The Yale journal of biology and medicine. 2022 03; 95(1):57-69. doi: . [PMID: 35370490]
  • Su-Han Zhou, Qian Huang, Ying Zhou, Xiao-Xia Cai, Yu Cui, Qin Zhou, Jie Guo, Shan Jiang, Nan Xu, Jiang-Hua Chen, Ling-Li Li, En-Yin Lai, Liang Zhao. Captopril related kidney damage: renal afferent arteriolar responses to angiotensin II and inflammatory signaling. Sheng li xue bao : [Acta physiologica Sinica]. 2022 Feb; 74(1):125-133. doi: . [PMID: 35199133]
  • Rachel P L van Swelm, Sanne Beurskens, Henry Dijkman, Erwin T G Wiegerinck, Rian Roelofs, Frank Thévenod, Johan van der Vlag, Jack F M Wetzels, Dorine W Swinkels, Bart Smeets. Kidney tubule iron loading in experimental focal segmental glomerulosclerosis. Scientific reports. 2022 01; 12(1):1199. doi: 10.1038/s41598-022-05261-4. [PMID: 35075227]
  • Anna Górska, Beata Paczosa-Bator, Marek Szlósarczyk, Robert Piech. Highly sensitive voltammetric determination of captopril on renewable amalgam film electrode. Talanta. 2022 Jan; 237(?):122937. doi: 10.1016/j.talanta.2021.122937. [PMID: 34736668]
  • Shadi A D Mohammed, Hanxing Liu, Salem Baldi, Pingping Chen, Fang Lu, Shumin Liu. GJD Modulates Cardiac/Vascular Inflammation and Decreases Blood Pressure in Hypertensive Rats. Mediators of inflammation. 2022; 2022(?):7345116. doi: 10.1155/2022/7345116. [PMID: 36164390]
  • Liuting Zhou, Zhenyan Ye, E Zhang, Li Chen, Yitong Hou, JuChun Lin, Fenglan Huang, Zhixiang Yuan. Co-Delivery of Dexamethasone and Captopril by α8 Integrin Antibodies Modified Liposome-PLGA Nanoparticle Hybrids for Targeted Anti-Inflammatory/Anti-Fibrosis Therapy of Glomerulonephritis. International journal of nanomedicine. 2022; 17(?):1531-1547. doi: 10.2147/ijn.s347164. [PMID: 35388271]
  • Y Luo, W W He, Q F Cheng, S M Yang, Z P Du, M Mei, Z X Xu, J B Hu, K R Wang, Y F He, Q F Li, Y Song. [Re-evaluation of the diagnostic value and optimal cutoff point of captopril challenge test in diagnosis of primary aldosteronism]. Zhonghua nei ke za zhi. 2022 Jan; 61(1):60-65. doi: 10.3760/cma.j.cn112138-20210331-00254. [PMID: 34979771]
  • Na Zhang, Yanan Huo, Chen Yao, Jie Sun, Yafeng Zhang. The Effect of the Angiotensin-Converting Enzyme Inhibitor on Bone Health in Castrated Hypertensive Rats Is Mediated via the Kinin-Kallikrein System. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2022; 2022(?):9067167. doi: 10.1155/2022/9067167. [PMID: 35814865]
  • B Dong, X W Ma, X H Guo, Y Gao, J Q Zhang. [Clinical value of captopril test in noninvasive diagnosis of aldosterone-producing adenoma]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences. 2021 Dec; 53(6):1128-1132. doi: . [PMID: 34916693]
  • Valentina Anuta, Constantin Mircioiu, Victor Voicu, Ion Mircioiu, Roxana Sandulovici. Square root law model for the delivery and intestinal absorption of drugs: a case of hydrophilic captopril. Drug delivery. 2021 Dec; 28(1):1685-1694. doi: 10.1080/10717544.2021.1960929. [PMID: 34355621]
  • Ting Wang, Kaiju Xu, Liyun Zhao, Rongsheng Tong, Liang Xiong, Jianyou Shi. Recent research and development of NDM-1 inhibitors. European journal of medicinal chemistry. 2021 Nov; 223(?):113667. doi: 10.1016/j.ejmech.2021.113667. [PMID: 34225181]
  • Flávio de Castro Magalhães, Tiago Fernandes, Vinícius Bassaneze, Katt Coelho Mattos, Isolmar Schettert, Fabio Luiz Navarro Marques, José Eduardo Krieger, Roberto Nava, Valério Garrone Barauna, Edilamar Menezes de Oliveira. High-volume endurance exercise training stimulates hematopoiesis by increasing ACE NH2-terminal activity. Clinical science (London, England : 1979). 2021 10; 135(20):2377-2391. doi: 10.1042/cs20210739. [PMID: 34608942]
  • Maral Aminpour, Williams Ernesto Miranda Delgado, Soren Wacker, Sergey Noskov, Michael Houghton, D Lorne J Tyrrell, Jack A Tuszynski. Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19. BMC pharmacology & toxicology. 2021 10; 22(1):61. doi: 10.1186/s40360-021-00519-5. [PMID: 34674775]
  • Karl H Pang, Christopher R Chapple, Robin Chatters, Alison P Downey, Christopher K Harding, Daniel Hind, Nick Watkin, Nadir I Osman. A Systematic Review and Meta-analysis of Adjuncts to Minimally Invasive Treatment of Urethral Stricture in Men. European urology. 2021 10; 80(4):467-479. doi: 10.1016/j.eururo.2021.06.022. [PMID: 34275660]
  • Mohamed Amar, Simon W Lam, Kathleen Faulkenberg, Antonio Perez, W H Wilson Tang, J Bradley Williams. Captopril Versus Hydralazine-Isosorbide Dinitrate Vasodilator Protocols in Patients With Acute Decompensated Heart Failure Transitioning From Sodium Nitroprusside. Journal of cardiac failure. 2021 10; 27(10):1053-1060. doi: 10.1016/j.cardfail.2021.05.007. [PMID: 34051349]
  • Wen-Cong Gao, Xin Ma, Peng Wang, Xiao-Yan He, Yong-Tang Zheng, Feng-Liang Liu, Chang-Bo Zheng. Captopril alleviates lung inflammation in SARS-CoV-2-infected hypertensive mice. Zoological research. 2021 Sep; 42(5):633-636. doi: 10.24272/j.issn.2095-8137.2021.206. [PMID: 34423606]
  • Arti Nile, Shivraj Hariram Nile, Carlos L Cespedes-Acuña, Jae-Wook Oh. Spiraeoside extracted from red onion skin ameliorates apoptosis and exerts potent antitumor, antioxidant and enzyme inhibitory effects. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Aug; 154(?):112327. doi: 10.1016/j.fct.2021.112327. [PMID: 34116102]
  • Alshimaa Badreldeen, Osama El Razaky, Adel Erfan, Amal El-Bendary, Doaa El Amrousy. Comparative study of the efficacy of captopril, simvastatin, and L-carnitine as cardioprotective drugs in children with type 1 diabetes mellitus: a randomised controlled trial. Cardiology in the young. 2021 Aug; 31(8):1315-1322. doi: 10.1017/s1047951121000226. [PMID: 33536102]
  • Huimin Guo, Yuqiong Hao, Xin Fan, Aurore Richel, Nadia Everaert, Xiushi Yang, Guixing Ren. Administration with Quinoa Protein Reduces the Blood Pressure in Spontaneously Hypertensive Rats and Modifies the Fecal Microbiota. Nutrients. 2021 Jul; 13(7):. doi: 10.3390/nu13072446. [PMID: 34371955]
  • Dominique M Bovée, Liwei Ren, Estrellita Uijl, Marian C Clahsen-van Groningen, Richard van Veghel, Ingrid M Garrelds, Oliver Domenig, Marko Poglitsch, Ivan Zlatev, Jae B Kim, Stephen Huang, Lauren Melton, Xifeng Lu, Ewout J Hoorn, Don Foster, A H Jan Danser. Renoprotective Effects of Small Interfering RNA Targeting Liver Angiotensinogen in Experimental Chronic Kidney Disease. Hypertension (Dallas, Tex. : 1979). 2021 05; 77(5):1600-1612. doi: 10.1161/hypertensionaha.120.16876. [PMID: 33719507]
  • Seyedeh Mahsa Poormoosavi, Mohammad Amin Behmanesh, Hamed Abeyat, Ehsan Sangtarash. Evaluation of the Effect of Captopril and Losartan on Tacrolimus-induced Nephrotoxicity in Rats. Drug research. 2021 May; 71(5):243-249. doi: 10.1055/a-1369-8651. [PMID: 33711846]
  • Yucheng Wang, Yunliang Li, Siyu Ruan, Feng Lu, Wanmin Tian, Haile Ma. Antihypertensive effect of rapeseed peptides and their potential in improving the effectiveness of captopril. Journal of the science of food and agriculture. 2021 May; 101(7):3049-3055. doi: 10.1002/jsfa.10939. [PMID: 33179311]
  • Fedor Simko, Tomas Baka. Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers: potential allies in the COVID-19 pandemic instead of a threat?. Clinical science (London, England : 1979). 2021 04; 135(8):1009-1014. doi: 10.1042/cs20210182. [PMID: 33881142]
  • Muhammad F Rasool, Shazia Ali, Sundus Khalid, Ramsha Khalid, Abdul Majeed, Imran Imran, Hamid Saeed, Muhammad Usman, Mohsin Ali, Amer S Alali, Abdullah F AlAsmari, Nemat Ali, Ali Mohammed Asiri, Fawaz Alasmari, Faleh Alqahtani. Development and evaluation of physiologically based pharmacokinetic drug-disease models for predicting captopril pharmacokinetics in chronic diseases. Scientific reports. 2021 04; 11(1):8589. doi: 10.1038/s41598-021-88154-2. [PMID: 33883647]
  • Bin Liu, Jinbo Hu, Ying Song, Wenwen He, Qingfeng Cheng, Zhihong Wang, Zhengping Feng, Zhipeng Du, Zhixin Xu, Jun Yang, Qifu Li, Shumin Yang. Seated Saline Suppression Test Is Comparable With Captopril Challenge Test for the Diagnosis of Primary Aldosteronism: A Prospective Study. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2021 Apr; 27(4):326-333. doi: 10.1016/j.eprac.2020.10.016. [PMID: 33779561]
  • Shihan Chen, Hui Liu, Panyu Luo, Yerong Yu. Computed tomography combined with confirmatory tests for the diagnosis of aldosterone-producing adenoma. Endocrine journal. 2021 Mar; 68(3):299-306. doi: 10.1507/endocrj.ej20-0395. [PMID: 33100281]
  • Min Lin, Hai-Yan Dong, Huan-Zhang Xie, Yu-Mei Li, Lee Jia. Why do we lack a specific magic anti-COVID-19 drug? Analyses and solutions. Drug discovery today. 2021 03; 26(3):631-636. doi: 10.1016/j.drudis.2020.12.010. [PMID: 33385574]
  • Maria A Pedrosa, Rita Valenzuela, Pablo Garrido-Gil, Carmen M Labandeira, Gemma Navarro, Rafael Franco, Jose L Labandeira-Garcia, Ana I Rodriguez-Perez. Experimental data using candesartan and captopril indicate no double-edged sword effect in COVID-19. Clinical science (London, England : 1979). 2021 02; 135(3):465-481. doi: 10.1042/cs20201511. [PMID: 33479758]
  • Norio Wada, Arina Miyoshi, Hiroaki Usubuchi, Satoshi Terae, Yui Shibayama, Bunya Takahashi, Shuhei Baba, Hajime Sugawara, Shinji Obara. Prediction of unilateral hyperaldosteronism on adrenal vein sampling using captopril challenge test in patients with primary aldosteronism. Endocrine journal. 2021 Jan; 68(1):45-51. doi: 10.1507/endocrj.ej20-0329. [PMID: 32848105]
  • Sayed M M Mizar, Magy R Kozman, Ali A Abo-Saif, Basim A S Messiha. Combination of Captopril with Gliclazide Decreases Vascular and Renal Complications and Improves Glycemic Control in Rats with Streptozotocin- Induced Diabetes Mellitus. Endocrine, metabolic & immune disorders drug targets. 2021; 21(6):1096-1106. doi: 10.2174/1871530320666200821160436. [PMID: 32955003]
  • Kacper Maksymilian Mil, Małgorzata Ewa Gryciuk, Cezary Pawlukianiec, Małgorzata Żendzian-Piotrowska, Jerzy Robert Ładny, Anna Zalewska, Mateusz Maciejczyk. Pleiotropic Properties of Valsartan: Do They Result from the Antiglycooxidant Activity? Literature Review and In Vitro Study. Oxidative medicine and cellular longevity. 2021; 2021(?):5575545. doi: 10.1155/2021/5575545. [PMID: 33763167]
  • Shi-Han Chen, Pan-Yu Luo, Ye-Rong Yu. [The Diagnostic Value of Captopril Challenge Test for Primary Aldosteronism]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2021 Jan; 52(1):134-141. doi: 10.12182/20201260301. [PMID: 33474903]
  • Qiao Xiang, Tao Chen, Kai Yu, Yuanmei Li, Qianrui Li, Haoming Tian, Yan Ren. The Value of Different Single or Combined Indexes of the Captopril Challenge Test in the Diagnosis of Primary Aldosteronism. Frontiers in endocrinology. 2021; 12(?):689618. doi: 10.3389/fendo.2021.689618. [PMID: 34220715]
  • W Bradley Rittase, Elizabeth A McCart, Jeannie M Muir, Roxane M Bouten, John E Slaven, Ognoon Mungunsukh, Michelle A Bylicky, W Louis Wilkins, Sang-Ho Lee, Kristbjorn O Gudmundsson, Tiziana Di Pucchio, Cara H Olsen, Yang Du, Regina M Day. Effects of captopril against radiation injuries in the Göttingen minipig model of hematopoietic-acute radiation syndrome. PloS one. 2021; 16(8):e0256208. doi: 10.1371/journal.pone.0256208. [PMID: 34449797]
  • Janiana Raíza Jentsch Matias de Oliveira, Mayara Alves Amorim, Eunice André. The role of TRPA1 and TRPV4 channels in bronchoconstriction and plasma extravasation in airways of rats treated with captopril. Pulmonary pharmacology & therapeutics. 2020 12; 65(?):102004. doi: 10.1016/j.pupt.2021.102004. [PMID: 33610768]
  • Xuemei Liu, Deliang Liu, Youyou Shuai, Huilin Li, Hengxia Zhao, Xin Qu, Shufang Chu, Xuewen Zhang. Effects of HuoxueJiangtang decoction alone or in combination with metformin on renal function and renal cortical mRNA expression in diabetic nephropathy rats. Pharmaceutical biology. 2020 Dec; 58(1):1123-1130. doi: 10.1080/13880209.2020.1844242. [PMID: 33191822]
  • Nabil Elkafrawy, Khaled Younes, Ahmed Naguib, Hytham Badr, Shimaa Kamal Zewain, Mai Kamel, Gehan Fawzy Abdel Raoof, Ahmed M El-Desoky, Shanaz Mohamed. Antihypertensive efficacy and safety of a standardized herbal medicinal product of Hibiscus sabdariffa and Olea europaea extracts (NW Roselle): A phase-II, randomized, double-blind, captopril-controlled clinical trial. Phytotherapy research : PTR. 2020 Dec; 34(12):3379-3387. doi: 10.1002/ptr.6792. [PMID: 32725873]
  • S K Kanthlal, Jipnomon Joseph, Bindhu Paul, Vijayakumar M, Uma Devi P. Antioxidant and vasorelaxant effects of aqueous extract of large cardamom in L-NAME induced hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993). 2020 Oct; 42(7):581-589. doi: 10.1080/10641963.2020.1739699. [PMID: 32202168]
  • S R Gilyarevsky, N G Bendeliani, M V Golshmid, G Yu Zaharova, I M Kuzmina, Irina Ivanovna Sinitcina. [Evidence-Based Information Which Could Influence Arterial Hypertension Treatment Approach after Publication of SPRINT Trial Results]. Kardiologiia. 2020 Sep; 60(8):130-140. doi: 10.18087/cardio.2020.8.n1177. [PMID: 33164724]
  • Naohisa Tamura, Kanako Yamada, Hiroshi Hatakeyama, Mizuki Torii-Hanakita, Chika Kyo, Rieko Kosugi, Takako Yonemoto, Tatsuo Ogawa, Masato Kotani, Takeshi Usui, Tatsuhide Inoue. Parameters of captopril challenge test can predict results of other confirmatory tests for primary aldosteronism and propose the next test to be done. Endocrine journal. 2020 Jul; 67(7):741-750. doi: 10.1507/endocrj.ej19-0498. [PMID: 32249243]
  • Aduragbenro D A Adedapo, Abayomi M Ajayi, Nancy Losie Ekwunife, Olufunke O Falayi, Ademola Oyagbemi, Temidayo Olutayo Omobowale, Adeolu A Adedapo. Antihypertensive effect of Phragmanthera incana (Schum) Balle on NG-nitro-L-Arginine methyl ester (L-NAME) induced hypertensive rats. Journal of ethnopharmacology. 2020 Jul; 257(?):112888. doi: 10.1016/j.jep.2020.112888. [PMID: 32311480]
  • Hamid Azizi-Malekabadi, Farimah Beheshti, Azam Abareshi, Fatemeh Norouzi, Majid Khazaei, Mohammad Soukhtanloo, Mahmoud Hosseini. Angiotensin-Converting Enzyme Inhibitor Captopril: Does it Improve Renal Function in Lipopolysaccharide-induced Inflammation Model in Rats. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2020 Jul; 31(4):727-738. doi: 10.4103/1319-2442.292306. [PMID: 32801233]
  • Chandra Shekhar Biyani, Victor Palit, Sunil Daga. The Use of Captopril-Angiotensin Converting Enzyme (ACE) Inhibitor for Cystinuria During COVID-19 Pandemic. Urology. 2020 07; 141(?):182-183. doi: 10.1016/j.urology.2020.04.057. [PMID: 32333991]
  • Yuan-Mei Li, Yan Ren, Tao Chen, Hao-Ming Tian. [Update and Research Progress in the Diagnosis of Primary Aldosteronism]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2020 May; 51(3):267-277. doi: 10.12182/20200560201. [PMID: 32543129]
  • Yun Qiu, Fen Zheng, Chao Ye, Ai-Dong Chen, Jue-Jin Wang, Qi Chen, Yue-Hua Li, Yu-Ming Kang, Guo-Qing Zhu. Angiotensin Type 1 Receptors and Superoxide Anion Production in Hypothalamic Paraventricular Nucleus Contribute to Capsaicin-Induced Excitatory Renal Reflex and Sympathetic Activation. Neuroscience bulletin. 2020 May; 36(5):463-474. doi: 10.1007/s12264-019-00460-y. [PMID: 31989424]
  • Shuli Man, Li Yang, Hao Xiang, Guanyu Lu, Yijia Wang, Changxiao Liu, Wenyuan Gao. Antihypertensive and renal protective effect of Shunaoxin pill combined with captopril on spontaneous hypertension rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 May; 125(?):109977. doi: 10.1016/j.biopha.2020.109977. [PMID: 32032892]
  • Ali Raza, Uzma Hayat, Hua-Jie Wang, Jin-Ye Wang. Preparation and evaluation of captopril loaded gastro-retentive zein based porous floating tablets. International journal of pharmaceutics. 2020 Apr; 579(?):119185. doi: 10.1016/j.ijpharm.2020.119185. [PMID: 32112929]
  • Satoshi Kidoguchi, Naoki Sugano, Ruri Kawauchi, Daisuke Nakashima, Naomi Hayashi-Ishikawa, Goro Tokudome, Takashi Yokoo. Evaluation of various confirmatory tests for the diagnosis of aldosterone-producing adenoma. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2020 Apr; 21(2):1470320320919610. doi: 10.1177/1470320320919610. [PMID: 32370649]
  • Juan María Alcaide-Hidalgo, María Margalef, Francisca I Bravo, Begoña Muguerza, Eduardo López-Huertas. Virgin olive oil (unfiltered) extract contains peptides and possesses ACE inhibitory and antihypertensive activity. Clinical nutrition (Edinburgh, Scotland). 2020 04; 39(4):1242-1249. doi: 10.1016/j.clnu.2019.05.016. [PMID: 31178246]
  • Chuan Lin, Jun Yang, Peter J Fuller, Huan Jing, Ying Song, Wenwen He, Zhipeng Du, Ting Luo, Qingfeng Cheng, Shumin Yang, Hongman Wang, Qifu Li, Jinbo Hu. A combination of captopril challenge test after saline infusion test improves diagnostic accuracy for primary aldosteronism. Clinical endocrinology. 2020 02; 92(2):131-137. doi: 10.1111/cen.14134. [PMID: 31774187]
  • Nursela Hijriani, Lilik Yusetyani, Didik Hasmono. The effect of curcuma (Curcuma xanthorrizha roxb.) extract as an adjuvant of captopril therapy on cardiac histopathology of male mice (Mus musculus) with hypertension. Journal of basic and clinical physiology and pharmacology. 2020 Jan; 30(6):. doi: 10.1515/jbcpp-2019-0280. [PMID: 31926086]
  • Qiong Wu, Ruiying Wang, Yang Shi, Wenchao Li, Meng Li, Peng Chen, Bowen Pan, Qing Wang, Caifeng Li, Jianbing Wang, Guibo Sun, Xiaobo Sun, Hongzheng Fu. Synthesis and biological evaluation of panaxatriol derivatives against myocardial ischemia/reperfusion injury in the rat. European journal of medicinal chemistry. 2020 Jan; 185(?):111729. doi: 10.1016/j.ejmech.2019.111729. [PMID: 31655431]
  • Cassandra Nocito, Cody Lubinsky, Michelle Hand, Sabeeya Khan, Tulsi Patel, Alecia Seliga, Malika Winfield, Viviana Zuluaga-Ramirez, Nicole Fernandes, Xiangdang Shi, Ellen M Unterwald, Yuri Persidsky, Uma Sriram. Centrally Acting Angiotensin-Converting Enzyme Inhibitor Suppresses Type I Interferon Responses and Decreases Inflammation in the Periphery and the CNS in Lupus-Prone Mice. Frontiers in immunology. 2020; 11(?):573677. doi: 10.3389/fimmu.2020.573677. [PMID: 33042154]
  • Hamidreza Ardalani, Parisa Jandaghi, Aramsadat Meraji, Maryam Hassanpour Moghadam. The Effect of Cynara scolymus on Blood Pressure and BMI in Hypertensive Patients: A Randomized, Double-Blind, Placebo-Controlled, Clinical Trial. Complementary medicine research. 2020; 27(1):40-46. doi: 10.1159/000502280. [PMID: 31484191]
  • Fatma Mostafa, Eman M Mantawy, Samar S Azab, Ebtehal El-Demerdash. The angiotensin converting enzyme inhibitor captopril attenuates testosterone-induced benign prostatic hyperplasia in rats; a mechanistic approach. European journal of pharmacology. 2019 Dec; 865(?):172729. doi: 10.1016/j.ejphar.2019.172729. [PMID: 31605676]
  • Gregory H Tesch, Nick Pullen, Michael I Jesson, Franklin J Schlerman, David J Nikolic-Paterson. Combined inhibition of CCR2 and ACE provides added protection against progression of diabetic nephropathy in Nos3-deficient mice. American journal of physiology. Renal physiology. 2019 12; 317(6):F1439-F1449. doi: 10.1152/ajprenal.00340.2019. [PMID: 31566438]
  • Ana B Segarra, Isabel Prieto-Gomez, Inmaculada Banegas, Magdalena Martínez-Cañamero, Juan de Dios Luna, Marc de Gasparo, Manuel Ramírez-Sánchez. Functional and neurometabolic asymmetry in SHR and WKY rats following vasoactive treatments. Scientific reports. 2019 11; 9(1):16098. doi: 10.1038/s41598-019-52658-9. [PMID: 31695104]
  • Mohamed Abouelkheir, Tarek H El-Metwally. Dipeptidyl peptidase-4 inhibitors can inhibit angiotensin converting enzyme. European journal of pharmacology. 2019 Nov; 862(?):172638. doi: 10.1016/j.ejphar.2019.172638. [PMID: 31491403]
  • Imen Gorsane, Tasnime Ben Ayed, Raja Aoudia, Hayet Kaaroud, Fethi Ben Hamida, Amel Harzallah, Taieb Ben Abdallah. Simultaneous acute pancreatitis and angioedema associated with angiotensin-converting enzyme inhibitor. Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia. 2019 Nov; 30(6):1479-1484. doi: 10.4103/1319-2442.275498. [PMID: 31929301]
  • Che-Hsiung Wu, Vincent Wu, Ya-Wen Yang, Yen-Hung Lin, Shao-Yu Yang, Po-Chih Lin, Chin-Chen Chang, Yao-Chou Tsai, Shuo-Meng Wang. Plasma Aldosterone After Seated Saline Infusion Test Outperforms Captopril Test at Predicting Clinical Outcomes After Adrenalectomy for Primary Aldosteronism. American journal of hypertension. 2019 10; 32(11):1066-1074. doi: 10.1093/ajh/hpz098. [PMID: 31216359]
  • Bonan Zhang, Hong Xu, Yi Zhang, Xue Yi, Guizhen Zhang, Xin Zhang, Dingjie Xu, Xuemin Gao, Shifeng Li, Ying Zhu, Hui Zhang, Zhongqiu Wei, Shumin Li, Lijuan Zhang, Ruimin Wang, Fang Yang. Targeting the RAS axis alleviates silicotic fibrosis and Ang II-induced myofibroblast differentiation via inhibition of the hedgehog signaling pathway. Toxicology letters. 2019 Oct; 313(?):30-41. doi: 10.1016/j.toxlet.2019.05.023. [PMID: 31181250]
  • Zahra Ebadi, Nariman Moradi, Toktam Kazemi Fard, Tourandokht Balochnejadmojarrad, Elham Chamani, Reza Fadaei, Soudabeh Fallah. Captopril and Spironolactone Can Attenuate Diabetic Nephropathy in Wistar Rats by Targeting microRNA-192 and microRNA-29a/b/c. DNA and cell biology. 2019 Oct; 38(10):1134-1142. doi: 10.1089/dna.2019.4732. [PMID: 31433203]
  • Xiaohua Jiang, Dongmiao Qin, Guichun Mo, Jinsu Feng, Xiangfei Zheng, Biyang Deng. Facile Preparation of Boron and Nitrogen Codoped Green Emission Carbon Quantum Dots for Detection of Permanganate and Captopril. Analytical chemistry. 2019 09; 91(17):11455-11460. doi: 10.1021/acs.analchem.9b02938. [PMID: 31397151]
  • Livia Lenzini, Selene Prisco, Paul Emmanuel Vanderriele, Silvia Lerco, Francesca Torresan, Giuseppe Maiolino, Teresa Maria Seccia, Maurizio Iacobone, Gian Paolo Rossi. PTH Modulation by Aldosterone and Angiotensin II is Blunted in Hyperaldosteronism and Rescued by Adrenalectomy. The Journal of clinical endocrinology and metabolism. 2019 09; 104(9):3726-3734. doi: 10.1210/jc.2019-00143. [PMID: 30865228]
  • Yu-Ying Su, Huan-Min Li, Zhen-Xing Yan, Ming-Chun Li, Ji-Peng Wei, Wen-Xia Zheng, Si-Qin Liu, Yi-Ting Deng, Hui-Fang Xie, Chun-Guang Li. Renin-angiotensin system activation and imbalance of matrix metalloproteinase-9/tissue inhibitor of matrix metalloproteinase-1 in cold-induced stroke. Life sciences. 2019 Aug; 231(?):116563. doi: 10.1016/j.lfs.2019.116563. [PMID: 31200003]
  • Yao-Ling Wang, Sha Liu, Zhu-Jun Yu, Yuan Lei, Meng-Yi Huang, Yu-Hang Yan, Qiang Ma, Yang Zheng, Hui Deng, Ying Sun, Chengyong Wu, Yamei Yu, Qiang Chen, Zhenling Wang, Yong Wu, Guo-Bo Li. Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-β-lactamases. Journal of medicinal chemistry. 2019 08; 62(15):7160-7184. doi: 10.1021/acs.jmedchem.9b00735. [PMID: 31269398]
  • Jean-Yu Hwang, Wei-Chih Kan, Yao-Bin Liu, Lea-Yea Chuang, Jinn-Yuh Guh, Yu-Lin Yang, Jau-Shyang Huang. Angiotensin-converting enzyme inhibitors attenuated advanced glycation end products-induced renal tubular hypertrophy via enhancing nitric oxide signaling. Journal of cellular physiology. 2019 08; 234(10):17473-17481. doi: 10.1002/jcp.28369. [PMID: 30825199]
  • Daniela Carmen Ababei, Veronica Bild, Alin Ciobică, Radu Marian Lefter, Răzvan Nicolae Rusu, Walther Bild. A Comparative Study on the Memory-Enhancing Actions of Oral Renin-Angiotensin System Altering Drugs in Scopolamine-Treated Mice. American journal of Alzheimer's disease and other dementias. 2019 08; 34(5):329-336. doi: 10.1177/1533317519847042. [PMID: 31106575]
  • Satoshi Kidoguchi, Naoki Sugano, Naomi Hayashi-Ishikawa, Norihiko Morisawa, Goro Tokudome, Takashi Yokoo. The characteristics of captopril challenge test-positive patients using various criteria. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2019 Jul; 20(3):1470320319870891. doi: 10.1177/1470320319870891. [PMID: 31434530]
  • Ke-Ying Zhu, Yan Zhang, Wen-Jing Zhang, Hong-Yun Li, Wen-Huan Feng, Da-Long Zhu, Ping Li. The captopril challenge test for diagnosing primary Aldosteronism in a Chinese population. BMC endocrine disorders. 2019 Jun; 19(1):65. doi: 10.1186/s12902-019-0390-3. [PMID: 31234846]
  • Priscilla D S Ventura, Carolina P F Carvalho, Nilana M T Barros, Leonardo Martins-Silva, Edilson O Dantas, Carolina Martinez, Pollyana M S Melo, João B Pesquero, Adriana K Carmona, Marcia R Nagaoka, Marcos L Gazarini. Malaria infection promotes a selective expression of kinin receptors in murine liver. Malaria journal. 2019 Jun; 18(1):213. doi: 10.1186/s12936-019-2846-3. [PMID: 31234939]
  • Norasikin Ab Azis, Renu Agarwal, Nafeeza Mohd Ismail, Nor Hadiani Ismail, Mohd Saleh Ahmad Kamal, Zurain Radjeni, Harbindar Jeet Singh. Blood pressure lowering effect of Ficus deltoidea var kunstleri in spontaneously hypertensive rats: possible involvement of renin-angiotensin-aldosterone system, endothelial function and anti-oxidant system. Molecular biology reports. 2019 Jun; 46(3):2841-2849. doi: 10.1007/s11033-019-04730-w. [PMID: 30977084]
  • Erlend Skaga, Ida Ø Skaga, Zanina Grieg, Cecilie J Sandberg, Iver A Langmoen, Einar O Vik-Mo. The efficacy of a coordinated pharmacological blockade in glioblastoma stem cells with nine repurposed drugs using the CUSP9 strategy. Journal of cancer research and clinical oncology. 2019 Jun; 145(6):1495-1507. doi: 10.1007/s00432-019-02920-4. [PMID: 31028540]
  • Toshihiro Kita, Eiji Furukoji, Tatefumi Sakae, Kazuo Kitamura. Efficient screening of patients with aldosterone-producing adenoma using the ACTH stimulation test. Hypertension research : official journal of the Japanese Society of Hypertension. 2019 06; 42(6):801-806. doi: 10.1038/s41440-018-0191-5. [PMID: 30622316]
  • Liping Sun, Beiyi Wu, Mingyan Yan, Hu Hou, Yongliang Zhuang. Antihypertensive Effect in Vivo of QAGLSPVR and Its Transepithelial Transport Through the Caco-2 Cell Monolayer. Marine drugs. 2019 May; 17(5):. doi: 10.3390/md17050288. [PMID: 31086041]
  • Jinlong Zhang, Qiuping Zhang, Yanni Wang, Jili Li, Zhongjie Bai, Quanyi Zhao, Zhen Wang, Dian He, Jingke Zhang, Yonglin Chen. Toxicities and beneficial protection of H2S donors based on nonsteroidal anti-inflammatory drugs. MedChemComm. 2019 May; 10(5):742-756. doi: 10.1039/c8md00611c. [PMID: 31191865]
  • Abdel Rahman El-Naggar, Dalia Zaafar, Mohammed Elyamany, Soha Hassanin, Atef Bassyouni, Hekma Abdel-Latif. The Role of Vildagliptin in Treating Hypertension Through Modulating Serum VEGF in Diabetic Hypertensive Patients. Journal of cardiovascular pharmacology and therapeutics. 2019 05; 24(3):254-261. doi: 10.1177/1074248418817345. [PMID: 30630371]
  • Ramu Periyasamy, Subhankar Das, Kailash N Pandey. Genetic disruption of guanylyl cyclase/natriuretic peptide receptor-A upregulates renal (pro) renin receptor expression in Npr1 null mutant mice. Peptides. 2019 04; 114(?):17-28. doi: 10.1016/j.peptides.2019.03.001. [PMID: 30965084]
  • Hong-Li Xiao, Lian-Xing Zhao, Jun Yang, Nan Tong, Le An, Qi-Tong Liu, Miao-Rong Xie, Chun-Sheng Li. Imbalance of angiotensin-converting enzymes affects myocardial apoptosis during cardiac arrest induced by acute pulmonary embolism in a porcine model. International journal of molecular medicine. 2019 Apr; 43(4):1575-1584. doi: 10.3892/ijmm.2019.4109. [PMID: 30816437]
  • Maryam Paseban, Reza Mohebbati, Saeed Niazmand, Thozhukat Sathyapalan, Amirhossein Sahebkar. Comparison of the Neuroprotective Effects of Aspirin, Atorvastatin, Captopril and Metformin in Diabetes Mellitus. Biomolecules. 2019 03; 9(4):. doi: 10.3390/biom9040118. [PMID: 30934759]
  • Sarawoot Bunbupha, Poungrat Pakdeechote, Putcharawipa Maneesai, Parichat Prachaney, Pattanapong Boonprom. Carthamus Tinctorius L. extract attenuates cardiac remodeling in L-NAME-induced hypertensive rats by inhibiting the NADPH oxidase-mediated TGF-β1 and MMP-9 pathway. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2019 Mar; 222(?):120-128. doi: 10.1016/j.aanat.2018.12.006. [PMID: 30590121]
  • Mehdi Shahbakhsh, Meissam Noroozifar. 2D-Single-crystal hexagonal gold nanosheets for ultra-trace voltammetric determination of captopril. Mikrochimica acta. 2019 02; 186(3):195. doi: 10.1007/s00604-019-3260-9. [PMID: 30783850]
  • Elizabeth A McCart, Young H Lee, Jyoti Jha, Ognoon Mungunsukh, W Bradley Rittase, Thomas A Summers, Jeannie Muir, Regina M Day. Delayed Captopril Administration Mitigates Hematopoietic Injury in a Murine Model of Total Body Irradiation. Scientific reports. 2019 02; 9(1):2198. doi: 10.1038/s41598-019-38651-2. [PMID: 30778109]
  • Stefano Omboni, Claudio Borghi. Efficacy of Zofenopril Alone or in Combination with Hydrochlorothiazide in Patients with Kidney Dysfunction. Current clinical pharmacology. 2019; 14(1):5-15. doi: 10.2174/1574884713666181025145404. [PMID: 30360726]
  • Tippaporn Bualeong, James Michael Wyss, Sanya Roysommuti. Inhibition of Renin-Angiotensin System from Conception to Young Mature Life Induces Salt-Sensitive Hypertension via Angiotensin II-Induced Sympathetic Overactivity in Adult Male Rats. Advances in experimental medicine and biology. 2019; 1155(?):45-59. doi: 10.1007/978-981-13-8023-5_5. [PMID: 31468385]
  • Akira Maeda, Naoshi Fukushima, Naoshi Horiba, Hiroko Segawa, Ken-Ichi Miyamoto. The Role of Extracellular Phosphate Levels on Kidney Disease Progression in a Podocyte Injury Mouse Model. Nephron. 2019; 142(2):135-146. doi: 10.1159/000497118. [PMID: 30731452]
  • Yong-Fu Lei, Min Li. [The correlation between the carotid artery plaque and the change of aldosterone level related indexes during captopril challenge test]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. 2019 Jan; 35(1):85-89. doi: 10.12047/j.cjap.5694.2019.020. [PMID: 31245959]
  • Yusheng Lu, Shu Lian, Yuying Ye, Ting Yu, Haiyan Liang, Yunlong Cheng, Jingjing Xie, Yewei Zhu, Xiaodong Xie, Suhong Yu, Yu Gao, Lee Jia. S-Nitrosocaptopril prevents cancer metastasis in vivo by creating the hostile bloodstream microenvironment against circulating tumor cells. Pharmacological research. 2019 01; 139(?):535-549. doi: 10.1016/j.phrs.2018.10.020. [PMID: 30366102]
  • Huma Khan, Varun Jaiswal, Saurabh Kulshreshtha, Azhar Khan. Potential Angiotensin Converting Enzyme Inhibitors from Moringa oleifera. Recent patents on biotechnology. 2019; 13(3):239-248. doi: 10.2174/1872208313666190211114229. [PMID: 30747089]