Neuromedin K (BioDeep_00000011002)
代谢物信息卡片
Neurokinin B trifluoroacetate salt
化学式: C55H79N13O14S2 (1209.5311)
中文名称: 神经激肽B
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CC(=O)O)NC(=O)C(CC3=CN=CN3)NC(=O)C(CCSC)NC(=O)C(CC(=O)O)N
InChI: InChI=1S/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)/t35-,36-,37-,38-,39-,40-,41-,42-,46-/m0/s1
描述信息
D018377 - Neurotransmitter Agents > D015320 - Tachykinins
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:80312
- KEGG: C16098
- PubChem: 5311312
- Metlin: METLIN71130
- ChEMBL: CHEMBL437797
- MeSH: Neurokinin B
- CAS: 86933-75-7
- PMhub: MS000024935
- PubChem: 47205408
- NIKKAJI: J260.381K
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ge Xu, Xuedan Zhao, Zhihao Li, Junwei Hu, Xu Li, Juanjuan Li, Yuelai Chen. Effects of electroacupuncture on the kisspeptin-gonadotropin-releasing hormone (GnRH) /luteinizing hormone (LH) neural circuit abnormalities and androgen receptor expression of kisspeptin/neurokinin B/dynorphin neurons in PCOS rats.
Journal of ovarian research.
2023 Jan; 16(1):15. doi:
10.1186/s13048-022-01078-x. [PMID: 36650561] - Anna Szeliga, Agnieszka Podfigurna, Gregory Bala, Blazej Meczekalski. The influence of estro-progestin therapy on neurohormonal activity in functional hypothalamic amenorrhea.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2022 Nov; 38(11):997-1002. doi:
10.1080/09513590.2022.2128103. [PMID: 36170883] - Kristie Conde, Danielle Kulyk, Allison Vanschaik, Sierra Daisey, Catherine Rojas, Kimberly Wiersielis, Ali Yasrebi, Thomas J Degroat, Yuxiang Sun, Troy A Roepke. Deletion of Growth Hormone Secretagogue Receptor in Kisspeptin Neurons in Female Mice Blocks Diet-Induced Obesity.
Biomolecules.
2022 Sep; 12(10):. doi:
10.3390/biom12101370. [PMID: 36291579] - KaLynn Harlow, Max J Griesgraber, Andrew D Seman, Sydney L Shuping, Jeffrey R Sommer, Emily H Griffith, Stanley M Hileman, Casey C Nestor. The impact of undernutrition on KNDy (kisspeptin/neurokinin B/dynorphin) neurons in female lambs.
Journal of neuroendocrinology.
2022 06; 34(6):e13135. doi:
10.1111/jne.13135. [PMID: 35579068] - Ismail Guzelkas, Zerrin Orbak, Hakan Doneray, Nurinnisa Ozturk, Nevin Sagsoz. Serum kisspeptin, leptin, neuropeptide Y, and neurokinin B levels in adolescents with polycystic ovary syndrome.
Journal of pediatric endocrinology & metabolism : JPEM.
2022 Apr; 35(4):481-487. doi:
10.1515/jpem-2021-0487. [PMID: 35170267] - Anna Szeliga, Ewa Rudnicka, Marzena Maciejewska-Jeske, Marek Kucharski, Anna Kostrzak, Marta Hajbos, Olga Niwczyk, Roman Smolarczyk, Blazej Meczekalski. Neuroendocrine Determinants of Polycystic Ovary Syndrome.
International journal of environmental research and public health.
2022 03; 19(5):. doi:
10.3390/ijerph19053089. [PMID: 35270780] - Hiroyuki Enomoto, Kinuyo Iwata, Keisuke Matsumoto, Mai Otsuka, Akio Morita, Hitoshi Ozawa. Hypothalamic KNDy neuron expression in streptozotocin-induced diabetic female rats.
The Journal of endocrinology.
2022 02; 253(1):39-51. doi:
10.1530/joe-21-0169. [PMID: 35084363] - Hyun-Joo Park, Mi-Kyoung Kim, Yeon Kim, Hyung Joon Kim, Soo-Kyung Bae, Moon-Kyoung Bae. Neuromedin B modulates phosphate-induced vascular calcification.
BMB reports.
2021 Nov; 54(11):569-574. doi:
NULL. [PMID: 34674793] - Zhi Wang, Li Yang, Hui Dong, Haoxu Dong, Ling Cheng, Ping Yi, Dongmei Huang. Effect of electroacupuncture on the kisspeptin system in a pubertal rat model of polycystic ovary syndrome.
Acupuncture in medicine : journal of the British Medical Acupuncture Society.
2021 Oct; 39(5):491-500. doi:
10.1177/0964528420971299. [PMID: 33406849] - Shiori Minabe, Kinuyo Iwata, Hitomi Tsuchida, Hiroko Tsukamura, Hitoshi Ozawa. Effect of diet-induced obesity on kisspeptin-neurokinin B-dynorphin A neurons in the arcuate nucleus and luteinizing hormone secretion in sex hormone-primed male and female rats.
Peptides.
2021 08; 142(?):170546. doi:
10.1016/j.peptides.2021.170546. [PMID: 33794282] - Yujuan Chen, Yanlu Gao, Wenwen Lu, Wei Gao. Influence of acupuncture on the expression of VIP, SP, NKA and NKB, cAMP/cGMP and HE content and treatment of bronchial asthma in rats.
Cellular and molecular biology (Noisy-le-Grand, France).
2020 Jul; 66(5):29-35. doi:
. [PMID: 33040809] - Rebecka Amodei, Kyle Gribbin, Wen He, Isa Lindgren, Keely R Corder, Sonnet S Jonker, Charles T Estill, Lique M Coolen, Michael N Lehman, William Whitler, Fred Stormshak, Charles E Roselli. Role for Kisspeptin and Neurokinin B in Regulation of Luteinizing Hormone and Testosterone Secretion in the Fetal Sheep.
Endocrinology.
2020 04; 161(4):. doi:
10.1210/endocr/bqaa013. [PMID: 32005991] - Guihong Yang, Huipeng Huang, Mengyao Tang, Zifeng Cai, Cuiqin Huang, Baomin Qi, Ji-Long Chen. Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo.
Veterinary research.
2019 Oct; 50(1):80. doi:
10.1186/s13567-019-0695-2. [PMID: 31601264] - Shiori Minabe, Marimo Sato, Naoko Inoue, Youki Watanabe, Fumie Magata, Fuko Matsuda, Yoshihisa Uenoyama, Hitoshi Ozawa, Hiroko Tsukamura. Neonatal Estrogen Causes Irreversible Male Infertility via Specific Suppressive Action on Hypothalamic Kiss1 Neurons.
Endocrinology.
2019 05; 160(5):1223-1233. doi:
10.1210/en.2018-00732. [PMID: 30920587] - Tony M Plant. The neurobiological mechanism underlying hypothalamic GnRH pulse generation: the role of kisspeptin neurons in the arcuate nucleus.
F1000Research.
2019; 8(?):. doi:
10.12688/f1000research.18356.2. [PMID: 31297186] - Abdolkarim Hosseini, Homayoun Khazali. Central Orexin A Affects Reproductive Axis by Modulation of Hypothalamic Kisspeptin/Neurokinin B/Dynorphin Secreting Neurons in the Male Wistar Rats.
Neuromolecular medicine.
2018 12; 20(4):525-536. doi:
10.1007/s12017-018-8506-x. [PMID: 30218420] - Jennifer F Thorson, Ligia D Prezotto, Hillary Adams, Sandra L Petersen, Jeffrey A Clapper, Elane C Wright, William T Oliver, Bradley A Freking, Andrew P Foote, Elaine D Berry, Danny J Nonneman, Clay A Lents. Energy balance affects pulsatile secretion of luteinizing hormone from the adenohypophesis and expression of neurokinin B in the hypothalamus of ovariectomized gilts.
Biology of reproduction.
2018 08; 99(2):433-445. doi:
10.1093/biolre/ioy069. [PMID: 30101293] - Min Jae Kang, Yeon Joung Oh, Young Suk Shim, Joon Woo Baek, Seung Yang, Il Tae Hwang. The usefulness of circulating levels of leptin, kisspeptin, and neurokinin B in obese girls with precocious puberty.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2018 Jul; 34(7):627-630. doi:
10.1080/09513590.2017.1423467. [PMID: 29303010] - Henna Salman, Mohsin Shah, Asif Ali, Asma Aziz, Salvatore Giovanni Vitale. Assessment of Relationship of Serum Neurokinin-B Level in the Pathophysiology of Pre-eclampsia: A Case-Control Study.
Advances in therapy.
2018 07; 35(7):1114-1121. doi:
10.1007/s12325-018-0723-z. [PMID: 29923045] - Takeshi Iwasa, Toshiya Matsuzaki, Kiyohito Yano, Rie Yanagihara, Yiliyasi Mayila, Minoru Irahara. The effects of chronic testosterone administration on hypothalamic gonadotropin-releasing hormone regulatory factors (Kiss1, NKB, pDyn and RFRP) and their receptors in female rats.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2018 May; 34(5):437-441. doi:
10.1080/09513590.2017.1409709. [PMID: 29187003] - Toshiya Matsuzaki, Altankhuu Tungalagsuvd, Munkhsaikhan Munkhzaya, Takeshi Iwasa, Kiyohito Yano, Yiliyasi Mayila, Takako Tokui, Rie Yanagihara, Sumika Matsui, Takeshi Kato, Akira Kuwahara, Minoru Irahara. Neurokinin B receptor agonist and Dynorphin receptor antagonist stimulated luteinizing hormone secretion in fasted male rodents.
Endocrine journal.
2018 Apr; 65(4):485-492. doi:
10.1507/endocrj.ej17-0136. [PMID: 29479004] - Ahmad Samir Gul, Kevin K Tran, Christopher E Jones. Neurokinin B and serum albumin limit copper binding to mammalian gonadotropin releasing hormone.
Biochemical and biophysical research communications.
2018 02; 497(1):1-6. doi:
10.1016/j.bbrc.2017.12.165. [PMID: 29427668] - Kimihiko Nakao, Kinuyo Iwata, Toshiyuki Takeshita, Hitoshi Ozawa. Expression of hypothalamic kisspeptin, neurokinin B, and dynorphin A neurons attenuates in female Zucker fatty rats.
Neuroscience letters.
2018 02; 665(?):135-139. doi:
10.1016/j.neulet.2017.12.002. [PMID: 29203206] - Mesut Parlak, Doğa Türkkahraman, Hamit Yaşar Ellidağ, Gamze Çelmeli, Ayşe Eda Parlak, Necat Yılmaz. Basal Serum Neurokinin B Levels in Differentiating Idiopathic Central Precocious Puberty from Premature Thelarche.
Journal of clinical research in pediatric endocrinology.
2017 Jun; 9(2):101-105. doi:
10.4274/jcrpe.3817. [PMID: 28008860] - Karolina Skorupskaite, Jyothis T George, Johannes D Veldhuis, Robert P Millar, Richard A Anderson. Interactions Between Neurokinin B and Kisspeptin in Mediating Estrogen Feedback in Healthy Women.
The Journal of clinical endocrinology and metabolism.
2016 12; 101(12):4628-4636. doi:
10.1210/jc.2016-2132. [PMID: 27636018] - G S M Paula, L L Souza, N O S Bressane, R Maravalhas, M Wilieman, T Bento-Bernardes, K R Silva, L S Mendonca, K J Oliveira, C C Pazos-Moura. Mice with Deletion of Neuromedin B Receptor Exhibit Decreased Oral Glucose-Stimulated Insulin Release.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2016 Dec; 48(12):854-861. doi:
10.1055/s-0042-115643. [PMID: 27756093] - Shakunthala Narayanaswamy, Julia K Prague, Channa N Jayasena, Deborah A Papadopoulou, Maria Mizamtsidi, Amar J Shah, Paul Bassett, Alexander N Comninos, Ali Abbara, Stephen R Bloom, Johannes D Veldhuis, Waljit S Dhillo. Investigating the KNDy Hypothesis in Humans by Coadministration of Kisspeptin, Neurokinin B, and Naltrexone in Men.
The Journal of clinical endocrinology and metabolism.
2016 09; 101(9):3429-36. doi:
10.1210/jc.2016-1911. [PMID: 27379743] - Melinda A Mittelman-Smith, Sally J Krajewski-Hall, Nathaniel T McMullen, Naomi E Rance. Ablation of KNDy Neurons Results in Hypogonadotropic Hypogonadism and Amplifies the Steroid-Induced LH Surge in Female Rats.
Endocrinology.
2016 05; 157(5):2015-27. doi:
10.1210/en.2015-1740. [PMID: 26937713] - Clare L Whitehead, Helen McNamara, Susan P Walker, Maria Alexiadis, Peter J Fuller, Daniel K Vickers, Natalie J Hannan, Roxanne Hastie, Laura Tuohey, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong. Identifying late-onset fetal growth restriction by measuring circulating placental RNA in the maternal blood at 28 weeks' gestation.
American journal of obstetrics and gynecology.
2016 Apr; 214(4):521.e1-521.e8. doi:
10.1016/j.ajog.2016.01.191. [PMID: 26880734] - H Q Zhao, G Yao, S Yannaing, S ThanThan, H Kuwayama. Insulinotropic action of bombesin-like peptides mediated by gastrin-releasing peptide receptors in steers.
Journal of animal science.
2016 Jan; 94(1):58-64. doi:
10.2527/jas.2015-9495. [PMID: 26812312] - Alejandro Lomniczi, Hollis Wright, Juan Manuel Castellano, Valerie Matagne, Carlos A Toro, Suresh Ramaswamy, Tony M Plant, Sergio R Ojeda. Epigenetic regulation of puberty via Zinc finger protein-mediated transcriptional repression.
Nature communications.
2015 Dec; 6(?):10195. doi:
10.1038/ncomms10195. [PMID: 26671628] - Dursun Çayan Akkoyun, Aydın Akyüz, Şeref Alpsoy, Ahmet Gürel, Niyazi Güler, Hasan Değirmenci, Ümit Gürkan. Plasma urotensin II and neurokinin B levels in acute myocardial infarction and stable coronary artery disease.
Anatolian journal of cardiology.
2015 Aug; 15(8):628-33. doi:
10.5152/akd.2014.5596. [PMID: 25550175] - Xue-Lian Zhou, Jun-Fen Fu, Ju-Hua Jin, Guan-Ping Dong, You-Jun Jiang, Ke Huang, Xue-Feng Chen, Wei Wu. [Effects of obesity on peak level of luteinizing hormone in gonadotropin-releasing hormone agonist test and obesity-related hormones in girls with central precocious puberty].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2015 Aug; 17(8):763-8. doi:
NULL. [PMID: 26287335] - Dursun C Akkoyun, Aydin Akyuz, Seref Alpsoy, Murat Aydin, Kubilay Erselcan. Serum neurokinin B levels in newly diagnosed nondipper hypertensive patients.
Blood pressure monitoring.
2015 Jun; 20(3):144-9. doi:
10.1097/mbp.0000000000000108. [PMID: 25647283] - Hamid R Hoveyda, Graeme L Fraser, Marie-Odile Roy, Guillaume Dutheuil, Frédéric Batt, Mohamed El Bousmaqui, Julien Korac, François Lenoir, Alexey Lapin, Sophie Noël, Sébastien Blanc. Discovery and optimization of novel antagonists to the human neurokinin-3 receptor for the treatment of sex-hormone disorders (Part I).
Journal of medicinal chemistry.
2015 Apr; 58(7):3060-82. doi:
10.1021/jm5017413. [PMID: 25738882] - Ayhan Abacı, Gönül Çatlı, Ahmet Anık, Tuncay Küme, Özlem Gürsoy Çalan, Bumin Nuri Dündar, Ece Böber. Significance of serum neurokinin B and kisspeptin levels in the differential diagnosis of premature thelarche and idiopathic central precocious puberty.
Peptides.
2015 Feb; 64(?):29-33. doi:
10.1016/j.peptides.2014.12.011. [PMID: 25572302] - Nicholas F Parchim, Wei Wang, Takayuki Iriyama, Olaide A Ashimi, Athar H Siddiqui, Sean Blackwell, Baha Sibai, Rodney E Kellems, Yang Xia. Neurokinin 3 receptor and phosphocholine transferase: missing factors for pathogenesis of C-reactive protein in preeclampsia.
Hypertension (Dallas, Tex. : 1979).
2015 Feb; 65(2):430-9. doi:
10.1161/hypertensionaha.114.04439. [PMID: 25452470] - Wen Hua, Lei Luo, Yuan Tian, Min Song, Yajie Liu, Pei Cui, Shuang Song, Shudong Jiang, Fubao Li, Fugui Fang. Analysis of the serum concentrations of kisspeptin and neurokinin B in the geese during reproductive cycle and their localisation in the ovary.
Animal reproduction science.
2014 Dec; 151(1-2):78-84. doi:
10.1016/j.anireprosci.2014.09.014. [PMID: 25282553] - Jakob Biran, Matan Golan, Naama Mizrahi, Satoshi Ogawa, Ishwar S Parhar, Berta Levavi-Sivan. Direct regulation of gonadotropin release by neurokinin B in tilapia (Oreochromis niloticus).
Endocrinology.
2014 Dec; 155(12):4831-42. doi:
10.1210/en.2013-2114. [PMID: 25211586] - Zhu Jia, Li Feixia. Effects of Qufeng Xuanfei decoction in animal model of post-infectious cough.
Cell biochemistry and biophysics.
2014 Nov; 70(2):881-5. doi:
10.1007/s12013-014-9994-4. [PMID: 24807845] - Ryosuke Misu, Shinya Oishi, Ai Yamada, Takashi Yamamura, Fuko Matsuda, Koki Yamamoto, Taro Noguchi, Hiroaki Ohno, Hiroaki Okamura, Satoshi Ohkura, Nobutaka Fujii. Development of novel neurokinin 3 receptor (NK3R) selective agonists with resistance to proteolytic degradation.
Journal of medicinal chemistry.
2014 Oct; 57(20):8646-51. doi:
10.1021/jm500771w. [PMID: 25247671] - Christine A Glidewell-Kenney, Crystal Trang, Paul P Shao, Navarre Gutierrez-Reed, Adaku M Uzo-Okereke, Djurdjica Coss, Pamela L Mellon. Neurokinin B induces c-fos transcription via protein kinase C and activation of serum response factor and Elk-1 in immortalized GnRH neurons.
Endocrinology.
2014 Oct; 155(10):3909-19. doi:
10.1210/en.2014-1263. [PMID: 25057795] - Hiraku Kameda, Hideaki Miyoshi, Chikara Shimizu, So Nagai, Akinobu Nakamura, Takuma Kondo, Dai Chida, Tatsuya Atsumi. Expression and regulation of neuromedin B in pituitary corticotrophs of male melanocortin 2 receptor-deficient mice.
Endocrinology.
2014 Jul; 155(7):2492-9. doi:
10.1210/en.2013-2077. [PMID: 24742195] - Xiaonan Yan, Chun Yuan, Nannan Zhao, Yugui Cui, Jiayin Liu. Prenatal androgen excess enhances stimulation of the GNRH pulse in pubertal female rats.
The Journal of endocrinology.
2014 Jul; 222(1):73-85. doi:
10.1530/joe-14-0021. [PMID: 24829217] - Sekoni D Noel, Ana Paula Abreu, Shuyun Xu, Titilayo Muyide, Elena Gianetti, Cintia Tusset, Jessica Carroll, Ana Claudia Latronico, Stephanie B Seminara, Rona S Carroll, Ursula B Kaiser. TACR3 mutations disrupt NK3R function through distinct mechanisms in GnRH-deficient patients.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2014 Apr; 28(4):1924-37. doi:
10.1096/fj.13-240630. [PMID: 24376026] - C K Boughton, S A Patel, E L Thompson, M Patterson, A E Curtis, A Amin, K Chen, M A Ghatei, S R Bloom, K G Murphy. Neuromedin B stimulates the hypothalamic-pituitary-gonadal axis in male rats.
Regulatory peptides.
2013 Nov; 187(?):6-11. doi:
10.1016/j.regpep.2013.10.002. [PMID: 24120470] - Debora Russino, Elle McDonald, Leila Hejazi, Graeme R Hanson, Christopher E Jones. The tachykinin peptide neurokinin B binds copper forming an unusual [CuII(NKB)2] complex and inhibits copper uptake into 1321N1 astrocytoma cells.
ACS chemical neuroscience.
2013 Oct; 4(10):1371-81. doi:
10.1021/cn4000988. [PMID: 23875773] - Nicole Wege, Alexandra Schutkowski, Bettina König, Corinna Brandsch, Matthias Weiwad, Gabriele I Stangl. PPARα modulates the TSH β-subunit mRNA expression in thyrotrope TαT1 cells and in a mouse model.
Molecular nutrition & food research.
2013 Mar; 57(3):376-89. doi:
10.1002/mnfr.201200409. [PMID: 23255496] - F Ruiz-Pino, V M Navarro, A H Bentsen, D Garcia-Galiano, M A Sanchez-Garrido, P Ciofi, R A Steiner, J D Mikkelsen, L Pinilla, M Tena-Sempere. Neurokinin B and the control of the gonadotropic axis in the rat: developmental changes, sexual dimorphism, and regulation by gonadal steroids.
Endocrinology.
2012 Oct; 153(10):4818-29. doi:
10.1210/en.2012-1287. [PMID: 22822161] - Melinda A Mittelman-Smith, Hemalini Williams, Sally J Krajewski-Hall, Josephine Lai, Philippe Ciofi, Nathaniel T McMullen, Naomi E Rance. Arcuate kisspeptin/neurokinin B/dynorphin (KNDy) neurons mediate the estrogen suppression of gonadotropin secretion and body weight.
Endocrinology.
2012 Jun; 153(6):2800-12. doi:
10.1210/en.2012-1045. [PMID: 22508514] - Matthew C Poling, Alexander S Kauffman. Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling.
Endocrinology.
2012 Feb; 153(2):782-93. doi:
10.1210/en.2011-1838. [PMID: 22202164] - Masakuni Ishikawa, Tetsuya Imamura, Osamu Ishizuka, Yoshiki Kurizaki, Wataru Noguchi, Lei Zhang, Osamu Nishizawa. A galenical of traditional Chinese herbal mixture (THC-002) reduces expression of tachykinin peptides within urethras of spontaneously hypertensive rats.
Neurourology and urodynamics.
2012 Jan; 31(1):201-6. doi:
10.1002/nau.21179. [PMID: 21780176] - A Kemal Topaloglu, Robert K Semple. Neurokinin B signalling in the human reproductive axis.
Molecular and cellular endocrinology.
2011 Oct; 346(1-2):57-64. doi:
10.1016/j.mce.2011.07.014. [PMID: 21807065] - Ken-Ichi Noritake, Junko Suzuki, Toshiki Matsuoka, Toshihiko Makino, Hitoshi Ohnishi, Kazuhiro Shimomura, Yoshihisa Uenoyama, Hiroko Tsukamura, Kei-Ichiro Maeda, Atsushi Sanbuissho. Testicular toxicity induced by a triple neurokinin receptor antagonist in male dogs.
Reproductive toxicology (Elmsford, N.Y.).
2011 May; 31(4):440-6. doi:
10.1016/j.reprotox.2010.12.007. [PMID: 21185367] - Suresh Ramaswamy, Stephanie B Seminara, Tony M Plant. Evidence from the agonadal juvenile male rhesus monkey (Macaca mulatta) for the view that the action of neurokinin B to trigger gonadotropin-releasing hormone release is upstream from the kisspeptin receptor.
Neuroendocrinology.
2011; 94(3):237-45. doi:
10.1159/000329045. [PMID: 21832818] - Suresh Ramaswamy, Stephanie B Seminara, Barkat Ali, Philippe Ciofi, Nisar A Amin, Tony M Plant. Neurokinin B stimulates GnRH release in the male monkey (Macaca mulatta) and is colocalized with kisspeptin in the arcuate nucleus.
Endocrinology.
2010 Sep; 151(9):4494-503. doi:
10.1210/en.2010-0223. [PMID: 20573725] - Yanyan Liu, Yufeng Li, Xiaoyan Xu, Xi Chen, Hanping Chen. Neurokinin B and urotensin II levels in pre-eclampsia.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2010 Aug; 23(8):869-73. doi:
10.3109/14767050903358355. [PMID: 20017703] - Tetsuya Tachibana, Kiyoko Matsuda, Sakirul Islam Khan, Hiroshi Ueda, Mark A Cline. Feeding and drinking response following central administrations of bombesin-like peptides in chicks.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2010 Aug; 156(4):394-9. doi:
10.1016/j.cbpa.2010.03.008. [PMID: 20233609] - Tetsuya Tachibana, Md Sakirul Islam Khan, Kiyoko Matsuda, Hiroshi Ueda, Mark A Cline. Central administration of substance P inhibits feeding behavior in chicks.
Hormones and behavior.
2010 Feb; 57(2):203-8. doi:
10.1016/j.yhbeh.2009.11.001. [PMID: 19909753] - Naomi E Rance. Menopause and the human hypothalamus: evidence for the role of kisspeptin/neurokinin B neurons in the regulation of estrogen negative feedback.
Peptides.
2009 Jan; 30(1):111-22. doi:
10.1016/j.peptides.2008.05.016. [PMID: 18614256] - Tetsuya Imamura, Osamu Ishizuka, Chen Zhong, Teruyuki Ogawa, Tsuyoshi Nakayama, Yoshiki Kurizaki, Tomoaki Tanabe, Osamu Nishizawa, Karl-Erik Andersson. An extract (THC-002) of Ba-Wei-Die-Huang-Wan inhibits expression of tachykinins, and P2X3 and TRPV1 receptors, and inhibits ATP-induced detrusor overactivity in spontaneously hypertensive rats.
Neurourology and urodynamics.
2009; 28(6):529-34. doi:
10.1002/nau.20702. [PMID: 19283865] - Zhi-Min Li, Yun Zhao, Qian Chen, Li Zou, Ze-Hua Wang. [Relationship between neurokinin B and endothelin-1 and hypertensive disorders complicating pregnancy].
Zhonghua fu chan ke za zhi.
2008 Aug; 43(8):584-8. doi:
. [PMID: 19087492] - Verena Geissbuehler, Renate Hillermann, Janusz Czarniecki, Stefan G Gebhardt, Susanne Forst, Jakob Eberhard, René Moser. Third trimester plasma neurokinin B levels in women with and without preeclampsia.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2008 Feb; 21(2):95-100. doi:
10.1080/14767050701836784. [PMID: 18240076] - Tetsuya Imamura, Osamu Ishizuka, Naoki Aizawa, Chen Zhong, Teruyuki Ogawa, Tsuyoshi Nakayama, Tomoaki Tanabe, Osamu Nishizawa. Gosha-jinki-gan reduces transmitter proteins and sensory receptors associated with C fiber activation induced by acetic acid in rat urinary bladder.
Neurourology and urodynamics.
2008; 27(8):832-7. doi:
10.1002/nau.20559. [PMID: 18551569] - Jing Yang, Vivek Dhawan, Donald W Morrish, Susan Kaufman. Bimodal effects of chronically administered neurokinin B (NKB) on in vivo and in vitro cardiovascular responses in female rats.
Regulatory peptides.
2007 Oct; 143(1-3):136-42. doi:
10.1016/j.regpep.2007.05.003. [PMID: 17573134] - Verena Geissbuehler, Rene Moser, Kathrin Zimmermann, Renate Hillermann, Janusz Czarniecki, Stefan G Gebhardt, Jakob Eberhard. Altered plasma neurokinin B levels in patients with pre-eclampsia.
Archives of gynecology and obstetrics.
2007 Aug; 276(2):151-7. doi:
10.1007/s00404-006-0316-y. [PMID: 17318561] - Priyanka Prakash, Ramasubbu Sankararamakrishnan. Molecular dynamics simulations of C-terminal decapeptide of gastrin-releasing peptide in DMPC bilayers: structure, stability and orientation of the peptide hormone within the bilayers.
Protein and peptide letters.
2007; 14(6):590-6. doi:
10.2174/092986607780989868. [PMID: 17627601] - Subbaya Subramanian, Robert B West, Robert J Marinelli, Torsten O Nielsen, Brian P Rubin, John R Goldblum, Rajiv M Patel, Shirley Zhu, Kelli Montgomery, Tony L Ng, Christopher L Corless, Michael C Heinrich, Matt van de Rijn. The gene expression profile of extraskeletal myxoid chondrosarcoma.
The Journal of pathology.
2005 Aug; 206(4):433-44. doi:
10.1002/path.1792. [PMID: 15920699] - Takahiro Shimizu, Shoshiro Okada, Naoko Yamaguchi, Junichi Arai, Hiroshi Wakiguchi, Kunihiko Yokotani. Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.
European journal of pharmacology.
2005 May; 514(2-3):151-8. doi:
10.1016/j.ejphar.2005.03.033. [PMID: 15910801] - Yi-Ruu Lin, Pei-Chi Kao, Ming-Huan Chan. Involvement of Ca2+ signaling in tachykinin-mediated contractile responses in swine trachea.
Journal of biomedical science.
2005; 12(3):547-58. doi:
10.1007/s11373-005-6796-0. [PMID: 15971006] - Luigi Bouchard, Vicky Drapeau, Véronique Provencher, Simone Lemieux, Yvon Chagnon, Treva Rice, D C Rao, Marie-Claude Vohl, Angelo Tremblay, Claude Bouchard, Louis Pérusse. Neuromedin beta: a strong candidate gene linking eating behaviors and susceptibility to obesity.
The American journal of clinical nutrition.
2004 Dec; 80(6):1478-86. doi:
10.1093/ajcn/80.6.1478. [PMID: 15585758] - Rosario D'Anna, Giovanni Baviera, Francesco Corrado, Alessandra Crisafulli, Riccardo Ientile, Michele Buemi, Francesco Squadrito. Neurokinin B and nitric oxide plasma levels in pre-eclampsia and isolated intrauterine growth restriction.
BJOG : an international journal of obstetrics and gynaecology.
2004 Oct; 111(10):1046-50. doi:
10.1111/j.1471-0528.2004.00257.x. [PMID: 15383105] - Anil K Mantha, Indu R Chandrashekar, Najma Z Baquer, Sudha M Cowsik. Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles.
Journal of biomolecular structure & dynamics.
2004 Oct; 22(2):137-48. doi:
10.1080/07391102.2004.10506990. [PMID: 15317475] - Júlia M M Santos, Maria Aparecida K F Tatsuo, Regina Maria M Turchetti-Maia, Marcela C G Lisboa, Janetti N de Francischi. Leukocyte recruitment to peritoneal cavity of rats following formalin injection: role of tachykinin receptors.
Journal of pharmacological sciences.
2004 Apr; 94(4):384-92. doi:
10.1254/jphs.94.384. [PMID: 15107578] - T Sandoval-Guzmán, S T Stalcup, S J Krajewski, M L Voytko, N E Rance. Effects of ovariectomy on the neuroendocrine axes regulating reproduction and energy balance in young cynomolgus macaques.
Journal of neuroendocrinology.
2004 Feb; 16(2):146-53. doi:
10.1111/j.0953-8194.2004.01143.x. [PMID: 14764001] - May Lee Tjoa, Marie Lomecky, Frans Martens, Inge J van Wijk, John M G van Vugt, Marinus A Blankenstein, Cees B M Oudejans. Neurokinin B levels in maternal circulation during early pregnancy.
Clinical chemistry and laboratory medicine.
2004; 42(6):611-3. doi:
10.1515/cclm.2004.105. [PMID: 15259376] - Dietmar Schlembach, Fortunato Scalera, Tina Fischer, Stephen G Marx, Ernst Beinder, Robert E Garfield. Neurokinin B peptide serum levels are higher in normotensive pregnant women than in preeclamptic pregnant women.
American journal of obstetrics and gynecology.
2003 Nov; 189(5):1418-22. doi:
10.1067/s0002-9378(03)00775-0. [PMID: 14634580] - Fabien Schmidlin, Dirk Roosterman, Nigel W Bunnett. The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins.
American journal of physiology. Cell physiology.
2003 Oct; 285(4):C945-58. doi:
10.1152/ajpcell.00541.2002. [PMID: 12958028] - Tânia Maria Ortiga-Carvalho, Karen de Jesus Oliveira, Marcelo Marcos Morales, Viviane Pinto Martins, Carmen Cabanelas Pazos-Moura. Thyrotropin secretagogues reduce rat pituitary neuromedin B, a local thyrotropin release inhibitor.
Experimental biology and medicine (Maywood, N.J.).
2003 Oct; 228(9):1083-8. doi:
10.1177/153537020322800916. [PMID: 14530520] - Rie Sakamoto, Hisao Osada, Yoshinori Iitsuka, Kentarou Masuda, Kenshi Kaku, Katsuyoshi Seki, Souei Sekiya. Profile of neurokinin B concentrations in maternal and cord blood in normal pregnancy.
Clinical endocrinology.
2003 May; 58(5):597-600. doi:
10.1046/j.1365-2265.2003.01758.x. [PMID: 12699441] - Rachel Moraes Moreira, Flavio Henrique Curty, Patricia Cristina Lisboa, Daniele Amaral, Tania Maria Ortiga-Carvalho, Carmen C Pazos-Moura. Estrogen modulates neuromedin B effects on thyrotropin and prolactin release in vitro.
Life sciences.
2003 Jan; 72(8):917-23. doi:
10.1016/s0024-3205(02)02351-2. [PMID: 12493572] - Andrew D Grant, Roksana Akhtar, Norma P Gerard, Susan D Brain. Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms.
The Journal of physiology.
2002 Sep; 543(Pt 3):1007-14. doi:
10.1113/jphysiol.2002.018846. [PMID: 12231654] - Nigel M Page, C Fred Kemp, David J Butlin, Philip J Lowry. Placental peptides as markers of gestational disease.
Reproduction (Cambridge, England).
2002 Apr; 123(4):487-95. doi:
10.1530/rep.0.1230487. [PMID: 11914111] - P G Du, S Kato, Y H Li, T Maeda, T Yamane, S Yamamoto, M Fujiwara, Y Yamamoto, K Nishi, I Ohkubo. Rat tripeptidyl peptidase I: molecular cloning, functional expression, tissue localization and enzymatic characterization.
Biological chemistry.
2001 Dec; 382(12):1715-25. doi:
10.1515/bc.2001.207. [PMID: 11843185] - G Cassano, N Resta, G Gasparre, C Lippe, G Guanti. The proliferative response of HT-29 human colon adenocarcinoma cells to bombesin-like peptides.
Cancer letters.
2001 Oct; 172(2):151-7. doi:
10.1016/s0304-3835(01)00642-5. [PMID: 11566490] - H M Sarau, J A Feild, R S Ames, J J Foley, P Nuthulaganti, D B Schmidt, P T Buckley, N A Elshourbagy, M E Brawner, M A Luttmann, G A Giardina, D W Hay. Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor.
European journal of pharmacology.
2001 Feb; 413(2-3):143-50. doi:
10.1016/s0014-2999(01)00732-4. [PMID: 11226387] - M M Campos, J B Calixto. Neurokinin mediation of edema and inflammation.
Neuropeptides.
2000 Oct; 34(5):314-22. doi:
10.1054/npep.2000.0823. [PMID: 11049735] - F H Curty, P C Lisbôa, T M Ortiga-Carvalho, C C Pazos-Moura. The somatostatin analogue octreotide modulates Iodothyronine deiodinase activity and pituitary neuromedin B.
Thyroid : official journal of the American Thyroid Association.
2000 Aug; 10(8):647-52. doi:
10.1089/10507250050137716. [PMID: 11014308] - N M Page, R J Woods, S M Gardiner, K Lomthaisong, R T Gladwell, D J Butlin, I T Manyonda, P J Lowry. Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia.
Nature.
2000 Jun; 405(6788):797-800. doi:
10.1038/35015579. [PMID: 10866201] - J M Siegfried, N Krishnamachary, A Gaither Davis, C Gubish, J D Hunt, S P Shriver. Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer.
Pulmonary pharmacology & therapeutics.
1999; 12(5):291-302. doi:
10.1006/pupt.1999.0210. [PMID: 10545285] - F Y Chang, S D Lee, G H Yeh, P S Wang. Rat gastrointestinal motor responses mediated via activation of neurokinin receptors.
Journal of gastroenterology and hepatology.
1999 Jan; 14(1):39-45. doi:
10.1046/j.1440-1746.1999.01808.x. [PMID: 10029276] - H H Chen, H P Kuo. Effect of sensory neuropeptides on mucus secretion from cultured goblet cells.
Changgeng yi xue za zhi.
1998 Sep; 21(3):283-90. doi:
NULL. [PMID: 9849009] - W Hou, T Tsuda, R T Jensen. Neuromedin B activates phospholipase D through both PKC-dependent and PKC-independent mechanisms.
Biochimica et biophysica acta.
1998 Apr; 1391(3):337-50. doi:
10.1016/s0005-2760(98)00014-9. [PMID: 9555086] - E Polverini, R Casadio, P Neyroz, L Masotti. Conformational changes of neuromedin B and delta sleep-inducing peptide induced by their interaction with lipid membranes as revealed by spectroscopic techniques and molecular dynamics simulation.
Archives of biochemistry and biophysics.
1998 Jan; 349(2):225-35. doi:
10.1006/abbi.1997.0395. [PMID: 9448709] - T Tsuda, T Kusui, R T Jensen. Neuromedin B receptor activation causes tyrosine phosphorylation of p125FAK by a phospholipase C independent mechanism which requires p21rho and integrity of the actin cytoskeleton.
Biochemistry.
1997 Dec; 36(51):16328-37. doi:
10.1021/bi971448o. [PMID: 9405068] - H A Ferris, R E Carroll, M M Rasenick, R V Benya. Constitutive activation of the gastrin-releasing peptide receptor expressed by the nonmalignant human colon epithelial cell line NCM460.
The Journal of clinical investigation.
1997 Nov; 100(10):2530-7. doi:
10.1172/jci119795. [PMID: 9366567] - H M Sarau, D E Griswold, W Potts, J J Foley, D B Schmidt, E F Webb, L D Martin, M E Brawner, N A Elshourbagy, A D Medhurst, G A Giardina, D W Hay. Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonist.
The Journal of pharmacology and experimental therapeutics.
1997 Jun; 281(3):1303-11. doi:
NULL. [PMID: 9190866] - Y D Yuan, R Couture. Renal effects of intracerebroventricularly injected tachykinins in the conscious saline-loaded rat: receptor characterization.
British journal of pharmacology.
1997 Mar; 120(5):785-96. doi:
10.1038/sj.bjp.0700972. [PMID: 9138683] - G L Wenk, W Zajaczkowski, W Danysz. Neuroprotection of acetylcholinergic basal forebrain neurons by memantine and neurokinin B.
Behavioural brain research.
1997 Feb; 83(1-2):129-33. doi:
10.1016/s0166-4328(97)86056-1. [PMID: 9062671]
