Exact Mass: 351.1153752
Exact Mass Matches: 351.1153752
Found 488 metabolites which its exact mass value is equals to given mass value 351.1153752,
within given mass tolerance error 0.05 dalton. Try search metabolite list with more accurate mass tolerance error
0.01 dalton.
Lomefloxacin
Lomefloxacin is only found in individuals that have used or taken this drug. It is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.Lomefloxacin is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited. J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AE - Fluoroquinolones D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic D004791 - Enzyme Inhibitors
trans-zeatin riboside
C15H21N5O5 (351.15426160000004)
Trans-zeatin riboside, also known as (E)-N-(4-hydroxy-3-methyl-2-butenyl)adenosine or 9-beta-D-ribofuranosyl-trans-zeatin, is a member of the class of compounds known as purine nucleosides. Purine nucleosides are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety. Trans-zeatin riboside is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Trans-zeatin riboside can be found in a number of food items such as winter squash, plains prickly pear, dill, and common buckwheat, which makes trans-zeatin riboside a potential biomarker for the consumption of these food products. D006133 - Growth Substances > D010937 - Plant Growth Regulators > D003583 - Cytokinins Acquisition and generation of the data is financially supported in part by CREST/JST. trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits. trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits. trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits.
Tos-phe-CH2CL
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors D009676 - Noxae > D000477 - Alkylating Agents > D000590 - Amino Acid Chloromethyl Ketones D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
O-beta-D-Xyloxylzeatin
C15H21N5O5 (351.15426160000004)
N-Acetyl-4-O-acetylneuraminic acid
N-Acetyl-4-O-acetylneuraminic acid is a component of glycoprotein- and glycolipid-bound sialic acids present in the human erythrocyte membrane (RBC). (PMID: 12527384) [HMDB] N-Acetyl-4-O-acetylneuraminic acid is a component of glycoprotein- and glycolipid-bound sialic acids present in the human erythrocyte membrane (RBC). (PMID: 12527384).
N-Acetyl-7-O-acetylneuraminic acid
N-Acetyl-7-O-acetylneuraminic acid is a component of glycoprotein- and glycolipid-bound sialic acids present in the human erythrocyte membrane (RBC). (PMID: 12527384). N-Acetyl-7-O-acetylneuraminic acid has been detected in basaliomas and normal human skin. (PMID: 11180001). Determination of N-Acetyl-7-O-acetylneuraminic acid in human serum has been obtained by fluorometric high-performance liquid chromatography. (PMID: 2757191). N-Acetyl-7-O-acetylneuraminic acid is a component of glycoprotein- and glycolipid-bound sialic acids present in the human erythrocyte membrane (RBC). (PMID: 12527384)
N-Acetyl-9-O-acetylneuraminic acid
N-Acetyl-9-O-acetylneuraminic acid (alternatively 9-O-acetyl-N-acetylneuraminic acid) is an O acetylated sialic acid identified in human colon by using high-pressure liquid chromatography and gas-liquid chromatography/mass spectrometry (PMID 3623000). It also has been suggested that 9-O-acetyl-N-acetylneuraminic acid is an essential component of the cell surface receptor of influenza C virus (PMID 3700379). 9-O-acetyl-N-acetylneuraminic acid is an O acetylated sialic acid identified in human colon by using high-pressure liquid chromatography and gas-liquid chromatography/mass spectrometry. (PMID 3623000) It also has been suggested that 9-O-acetyl-N-acetylneuraminic acid is an essential component of the cell surface receptor of influenza C virus. (PMID 3700379) [HMDB]
Aniflorine
Tazarotene
C21H21NO2S (351.12929260000004)
Tazarotene is only found in individuals that have used or taken this drug. It is a prescription topical retinoid sold as a cream or gel. This medication is approved for treatment of psoriasis, acne, and sun damaged skin (photodamage). [Wikipedia]Although the exact mechanism of tazarotene action is not known, studies have shown that the active form of the drug (tazarotenic acid) binds to all three members of the retinoic acid receptor (RAR) family: RARa, RARb, and RARg, but shows relative selectivity for RARb, and RARg and may modify gene expression. It also has affinity for RXR receptors. C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C804 - Retinoic Acid Agent D - Dermatologicals > D05 - Antipsoriatics > D05A - Antipsoriatics for topical use C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent D003879 - Dermatologic Agents > D007641 - Keratolytic Agents D009676 - Noxae > D013723 - Teratogens Same as: D01132
Zindoxifene
C21H21NO4 (351.14705060000006)
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1821 - Selective Estrogen Receptor Modulator C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist C1892 - Chemopreventive Agent
S-(2-Hydroxyethyl)glutathione
S-(2-Hydroxyethyl)glutathione is also known as S-(2-Hydroxyethyl)GSH. S-(2-Hydroxyethyl)glutathione is considered to be slightly soluble (in water) and acidic
oxycodone hydrochloride
C18H22ClNO4 (351.1237282000001)
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist D002491 - Central Nervous System Agents > D000700 - Analgesics
Oxoglaucine
Oxoglaucine is an isoquinoline alkaloid. Oxoglaucine is a natural product found in Sarcocapnos baetica, Sarcocapnos saetabensis, and other organisms with data available. Oxoglaucine is found in beverages. Oxoglaucine is an alkaloid from Annona purpurea (soncoya
ribosylzeatin
C15H21N5O5 (351.15426160000004)
9-ribosyl-trans-zeatin is a 9-ribosylzeatin having trans-zeatin as the nucleobase. It has a role as a plant metabolite and a cytokinin. It is a nucleoside analogue and a 9-ribosylzeatin. It is functionally related to an adenosine. Zeatin riboside is a natural product found in Rhodococcus fascians, Pseudomonas syringae, and other organisms with data available. D006133 - Growth Substances > D010937 - Plant Growth Regulators > D003583 - Cytokinins A 9-ribosylzeatin having trans-zeatin as the nucleobase. trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits. trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits. trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits.
Adinazolam
Adinazolam is only found in individuals that have used or taken this drug. It is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative, and antidepressant properties. Adinazolam was developed by Dr. Jackson B. Hester, who was seeking to enhance the antidepressant properties of alprazolam, which he also developed.Adinazolam binds to peripheral-type benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways. D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
9-(beta-D-Ribofuranosyl)zeatin
C15H21N5O5 (351.15426160000004)
9-(beta-D-Ribofuranosyl)-(Z)-Zeatin is found in alfalfa. Zeatin is a plant hormone derived from the purine adenine. It is a member of the plant growth hormone family known as cytokinins. Zeatin was first discovered in immature corn kernels from the genus Zea. Zeatin and derivatives were discovered to be the primary active ingredient in coconut milk, which has long been known to actively induce plant growth. As in the case of kinetin, zeatin has also been reported to have several in vitro anti-aging effects on human skin fibroblasts.(Wikipedia). Isolated from many plants. (E)-Ribosylzeatin is found in many foods, some of which are cauliflower, chicory, chayote, and wild carrot. trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits. trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits. trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits.
Phenylalanyltryptophan
Phenylalanyltryptophan is a dipeptide composed of phenylalanine and tryptophan. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. H-Phe-Trp-OH (Phenylalanyltryptophan) is an endogenous metabolite[1]. H-Phe-Trp-OH (Phenylalanyltryptophan) is an endogenous metabolite[1].
Tryptophyl-Phenylalanine
Tryptophyl-Phenylalanine is a dipeptide composed of tryptophan and phenylalanine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.
Indole-3-acetic-acid-O-glucuronide
Indole-3-acetic-acid-O-glucuronide is a conjugate of Indole-3-acetic-acid and glucuronide. A glucuronide, also known as glucuronoside, is any substance produced by linking glucuronic acid to another substance via a glycosidic bond. The glucuronides belong to the glycosides. (Wikipedia)
N-acetyl-O-acetylneuraminate
This compound belongs to the family of Neuraminic Acid Derivatives. These are compounds containingor dervivated from a neuraminic acid moeity (5-amino-3,5-dideoxy-D-glycero-D-galacto-non-2-ulosonic acid), which is a 9-carbon monosaccharide.
(2R,3S,5R)-2-[6-[[(1S,2S)-2-Hydroxycyclopentyl]amino]-9-purinyl]-5-(hydroxymethyl)oxolane-3,4-diol
C15H21N5O5 (351.15426160000004)
2-(3,4,5-Trimethoxybenzoyl)-4,4-diethyl-3,5-isoxazolidinedione
C17H21NO7 (351.13179560000003)
N-(3-Chloro-2-oxo-1-(phenylmethyl)propyl)-4-methylbenzenesulfonamide
benfluorex
C19H20F3NO2 (351.14460560000003)
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents D019440 - Anti-Obesity Agents > D001067 - Appetite Depressants C78272 - Agent Affecting Nervous System > C29728 - Anorexiant D009676 - Noxae > D000963 - Antimetabolites
Estradiol sulfamate
C18H25NO4S (351.15042100000005)
Epicillin
6-(4-Azanyl-4-Methyl-Piperidin-1-Yl)-3-[2,3-Bis(Chloranyl)phenyl]pyrazin-2-Amine
C16H19Cl2N5 (351.10174340000003)
cis-zeatin riboside
C15H21N5O5 (351.15426160000004)
Cis-zeatin riboside is a member of the class of compounds known as purine nucleosides. Purine nucleosides are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety. Cis-zeatin riboside is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Cis-zeatin riboside can be found in a number of food items such as american pokeweed, sesbania flower, moth bean, and common chokecherry, which makes cis-zeatin riboside a potential biomarker for the consumption of these food products.
4A04YKB3FT
Oxyberberine is a natural product found in Thalictrum podocarpum, Thalictrum acutifolium, and other organisms with data available. 8-Oxoepiberberine is an alkaloid metabolite in the plasma after oral administration of Zuojin formula, a traditional chinese medicine used to treat gastrointestinal disease[1]. Oxyberberine (Oxyberberin) is a natural alkaloid isolated from many plants[1]. Oxyberberine (Oxyberberin) is a natural alkaloid isolated from many plants[1].
Oxyepiberberine
8-Oxoepiberberine is an alkaloid metabolite in the plasma after oral administration of Zuojin formula, a traditional chinese medicine used to treat gastrointestinal disease[1].
9-Ribosyl-cis-zeatin
C15H21N5O5 (351.15426160000004)
Bianfugenine
Bianfugenine is an isoquinoline alkaloid that is dibenzo[de,h]quinolin-7-one carrying four methoxy substituents at positions 4, 5, 6 and 9. It has a role as a plant metabolite, a platelet aggregation inhibitor and an antineoplastic agent. It is an isoquinoline alkaloid, a polyether, an aromatic ether, a cyclic ketone, an aromatic ketone and an organic heterotetracyclic compound. Bianfugenine is a natural product found in Sinomenium acutum and Menispermum dauricum with data available. An isoquinoline alkaloid that is dibenzo[de,h]quinolin-7-one carrying four methoxy substituents at positions 4, 5, 6 and 9.
benfluorex
C19H20F3NO2 (351.14460560000003)
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents D019440 - Anti-Obesity Agents > D001067 - Appetite Depressants C78272 - Agent Affecting Nervous System > C29728 - Anorexiant D009676 - Noxae > D000963 - Antimetabolites
(-)-phyllosteminine|Phyllosteminine
C21H21NO4 (351.14705060000006)
Lindechunine A
An isoquinoline alkaloid that is 4,5,6,6a-tetradehydronoraporphin-7-one substituted by a methylenedioxy group across positions 1 and 2, methoxy groups at positions 3 and 11 and a hydroxy group at position 10. Isolated from the roots of Lindera chunii, it exhibits anti-HIV activity.
3-methylcarboxymethyl-indole-1-N-beta-D-glucopyranoside
C17H21NO7 (351.13179560000003)
(+)-(6aR,7R)-N-butyrylnorushinsunine
C21H21NO4 (351.14705060000006)
Sialsaeure; beta-D-(-)-6O-N-Diacetyl-neussaminosaeure; 6-Acetoxy-5-acetamido-3.5-di-desoxy-D-glycero-beta-D-ido-nonulo-pyranoson-(1)-saeure
O-Demethylbuchenavianine
C21H21NO4 (351.14705060000006)
A piperidine alkaloid that consists of 5,7-dihydroxyflavone attached to a 1-methylpiperindin-2-yl moiety at position 8. It is a flavonoid alkaloid isolated from Buchenavia capitata, and has been shown to exhibit anti-HIV activity.
methyl 1-(1-b-Glucopyranosyl)-1H-indole-3-acetate
C17H21NO7 (351.13179560000003)
RCS-4 N-(5-carboxypentyl) metabolite
C21H21NO4 (351.14705060000006)
(E)-1-(L-cysteinylglycin-S-yl)-N-hydroxy-omega-(methylsulfanyl)heptan-1-imine
9-Ribosyl-trans-zeatin
C15H21N5O5 (351.15426160000004)
CONFIDENCE standard compound; ML_ID 23
Cis-Zeatin-riboside-[d5]
C15H21N5O5 (351.15426160000004)
Acquisition and generation of the data is financially supported by the Max-Planck-Society
Cis-Zeatin-riboside
C15H21N5O5 (351.15426160000004)
Acquisition and generation of the data is financially supported by the Max-Planck-Society
trans-Zeatin-riboside
C15H21N5O5 (351.15426160000004)
Acquisition and generation of the data is financially supported by the Max-Planck-Society
Trans-Zeatin-riboside-[d5]
C15H21N5O5 (351.15426160000004)
Acquisition and generation of the data is financially supported by the Max-Planck-Society
Trans-zeatin riboside
C15H21N5O5 (351.15426160000004)
trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits. trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits. trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits.
Oxoglaucine
Alkaloid from Annona purpurea (soncoya). Oxoglaucine is found in cherimoya, beverages, and fruits. relative retention time with respect to 9-anthracene Carboxylic Acid is 1.251 relative retention time with respect to 9-anthracene Carboxylic Acid is 1.249
9-ribosylzeatin
C15H21N5O5 (351.15426160000004)
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.545 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.538 relative retention time with respect to 9-anthracene Carboxylic Acid is 0.540
Tazarotene
C21H21NO2S (351.12929260000004)
C274 - Antineoplastic Agent > C2122 - Cell Differentiating Agent > C1934 - Differentiation Inducer C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C804 - Retinoic Acid Agent D - Dermatologicals > D05 - Antipsoriatics > D05A - Antipsoriatics for topical use C308 - Immunotherapeutic Agent > C129820 - Antineoplastic Immunomodulating Agent D003879 - Dermatologic Agents > D007641 - Keratolytic Agents D009676 - Noxae > D013723 - Teratogens Same as: D01132
N-Acetyldemethylphosphinothricin tripeptide
C12H22N3O7P (351.11953120000004)
Adinazolamum
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BA - Benzodiazepine derivatives C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C1012 - Benzodiazepine C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
Phe-TRP
A dipeptide formed from L-phenylalanine and L-tryptophan residues.
TRP-Phe
A dipeptide formed from L-tryptophan and L-phenylalanine residues.
ribosylzeatin
C15H21N5O5 (351.15426160000004)
trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits. trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits. trans-Zeatinriboside is a type of cytokinin precursor, acts as a major long-distance signalling form in xylem vessels, regulates leaf size and meristem activity-related traits.
TERT-BUTYL 6-CHLORO-4-OXOSPIRO[CHROMAN-2,4-PIPERIDINE]-1-CARBOXYLATE
C18H22ClNO4 (351.1237282000001)
alizapride hydrochloride
C16H22ClN5O2 (351.14619419999997)
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents D005765 - Gastrointestinal Agents > D000932 - Antiemetics D002491 - Central Nervous System Agents Alizapride is a potent antiemetic, acting as a dopamine receptor antagonist. Alizapride also used in human digestive disorders[1][3].
thiazolidine-2,4-dicarboxylic, acid compound with L-arginine (1:1)
C11H21N5O6S (351.12124860000006)
A - Alimentary tract and metabolism > A05 - Bile and liver therapy > A05B - Liver therapy, lipotropics > A05BA - Liver therapy
moquizone
C78276 - Agent Affecting Digestive System or Metabolism > C66913 - Cholagogues or Choleretic Agents
4-CYANO-3-FLUOROPHENYL 4-(TRANS-4-ETHYLCYCLOHEXYL)-BENZOATE
(2S,6S)-2,6-DI-TERT-BUTYL-1,2,3,5,6,7-HEXAHYDROIMIDAZO[1,2-A]IMIDAZOL-4-IUM IODIDE
C13H26IN3 (351.11713860000003)
2-(1,3-benzodioxol-5-yl)-6-(4-methoxyphenyl)imidazo[2,1-b][1,3,4]thiadiazole
C18H13N3O3S (351.0677588000001)
(Rac)-Rotigotine hydrochloride
C19H26ClNOS (351.14235360000004)
(Rac)-Rotigotine hydrochloride is a racemate of Rotigotine. Rotigotine is a full agonist of?dopamine receptor, a partial agonist of the?5-HT1A receptor, and an antagonist of the?α2B-adrenergic receptor, with?Kis of 0.71?nM, 4-15?nM, and 83?nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
4-Acetyl-1-(4-Chloro-2-Fluorophenyl)-5-Cyclohexyl-1,5-Dihydro-3-Hydroxy-2H-Pyrrol-2-One
C18H19ClFNO3 (351.10374260000003)
5,6,7,8-Tetrahydro-6-[propyl[2-(3-thienyl)ethyl]amino]-1-naphthalenol hydrochloride
C19H26ClNOS (351.14235360000004)
(-)-(1R,3S)-N-Fmoc-3-Aminocyclopentanecarboxylic acid
C21H21NO4 (351.14705060000006)
(R)-N-Fmoc-2-(2-propylenyl)alanine
C21H21NO4 (351.14705060000006)
4-(2-carboxy-6-nitro-phenyl)-piperazine-1-carboxylic acid tertier-butyl ester
N-[(2-Methyl-1H-benzimidazol-1-yl)acetyl]-L-phenylalanine
3-(4-METHOXYPHENYL)-5-ISOXAZOLYL]METHANAMINE
C21H21NO4 (351.14705060000006)
2-CHLORO-5-METHYL-1,4-BENZOQUINONE
C21H21NO4 (351.14705060000006)
(+)-(1S,3R)-N-Fmoc-3-Aminocyclopentanecarboxylic acid
C21H21NO4 (351.14705060000006)
BOC-THIONOALA-1-(6-NITRO)BENZOTRIAZOLIDE
C14H17N5O4S (351.10012020000005)
2,2-[3-methyl-4-(5-nitrothiazol-2-ylazo)phenylimino]bisethanol
C14H17N5O4S (351.10012020000005)
2H-Pyrrol-2-one, 4-acetyl-1-(4-chloro-2-fluorophenyl)-5-cyclohexyl-1,5-dihydro-3-hydroxy-, (5S)
C18H19ClFNO3 (351.10374260000003)
2-[[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]METHYL]PHTHALIMIDE
C21H21NO4 (351.14705060000006)
Benzyl (4-chloro-3-cyano-7-quinolinyl)methylcarbamate
C19H14ClN3O2 (351.07744940000003)
tert-Butyl 6-(benzyloxy)-3-formyl-1H-indole-1-carboxylate
C21H21NO4 (351.14705060000006)
Ethyl 5-hydroxy-8-isopentyl-2-(methylthio)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxylate
ETHYL 8-ALLYL-5-HYDROXY-7-OXO-2-PHENYL-7,8-DIHYDROPYRIDO[2,3-D]PYRIMIDINE-6-CARBOXYLATE
rotigotine hydrochloride
C19H26ClNOS (351.14235360000004)
Rotigotine Hydrochloride (N-0923 Hydrochloride) is a full agonist of dopamine receptor, a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor, with Ki of 0.71?nM, 4-15?nM, and 83?nM for the dopamine D3 receptor and D2, D5, D4 receptors, and dopamine D1 receptor.
epicillin
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01C - Beta-lactam antibacterials, penicillins > J01CA - Penicillins with extended spectrum A penicillin in which the substituent at position 6 of the penam ring is a (2R)-2-amino-2-(cyclohexa-1,4-dien-1-yl)acetamido group. D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D010406 - Penicillins D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
Analgin
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents D002491 - Central Nervous System Agents > D000700 - Analgesics D000893 - Anti-Inflammatory Agents D018501 - Antirheumatic Agents D058633 - Antipyretics
Ethyl 4-(4-chloro-3-(trifluoromethyl)phenyl)-4-hydroxypiperidine-1-carboxylate
(1R,2R)-2-((((9H-FLUOREN-9-YL)METHOXY)CARBONYL)AMINO)CYCLOPENTANECARBOXYLIC ACID
C21H21NO4 (351.14705060000006)
Thiazolidine, 2-(4-methylphenyl)-3-[(2-oxo-2H-1-benzopyran-3-yl)carbonyl]- (9CI)
Ethyl4-(4-chloro-a,a,a-trifluoro-m-tolylo)-4-hxdroxy-1-piperidinecarbxylate
N-[4-(4-Fluorophenyl)-5-formyl-6-(1-methylethyl)-2-pyrimidinyl]-N-methyl-methanesulfonamide
C16H18FN3O3S (351.1052850000001)
ethyl 2-piperazine-4-(3-chloro)phenyl thiazole-5-carboxylate
C16H18ClN3O2S (351.08081980000003)
Adipiplon
C18H18FN7 (351.16076400000003)
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
4-(5-(4-(Pentyloxy)phenyl)isoxazol-3-yl)benzoic acid
C21H21NO4 (351.14705060000006)
4-[Bis(4-fluorophenyl)(hydroxy)methyl]-3-(hydroxymethyl)benzonitrile
C21H15F2NO2 (351.10707940000003)
SHP099
C16H19Cl2N5 (351.10174340000003)
1-(3-AZIDO-2,3-DIDEOXY-5-O-PIVALOYL-BETA-D-ERYTHRO-PENTOFURANOSYL)-THYMINE
C15H21N5O5 (351.15426160000004)
N-Fmoc-1-amino-1-cyclopentanecarboxylic acid
C21H21NO4 (351.14705060000006)
(3R,4S)-REL-1-BENZYL-4-(4-CHLOROPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID HYDROCHLORIDE
Dextromethorphan Hydrobromide
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist D019141 - Respiratory System Agents > D000996 - Antitussive Agents D002491 - Central Nervous System Agents
Phenol,4-[(7-chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-
C19H14ClN3O2 (351.07744940000003)
Estradiol 3-sulfamate
C18H25NO4S (351.15042100000005)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
2-(3,4,5-Trimethoxybenzoyl)-4,4-diethyl-3,5-isoxazolidinedione
C17H21NO7 (351.13179560000003)
N-((1S,trans)-2-Hydroxycyclopentyl)adenosine
C15H21N5O5 (351.15426160000004)
D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058913 - Purinergic Agonists D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents D009676 - Noxae > D000963 - Antimetabolites GR79236 is a highly potent, selective and orally active adenosine A1 receptor agonist with a Kis of 3.1 nM and 1300 nM for A1 and A2 receptors, respectively. GR79236 has anti-nociceptive and anti-inflammatory actions[1][2]. GR79236 is a highly potent, selective and orally active adenosine A1 receptor agonist with a Kis of 3.1 nM and 1300 nM for A1 and A2 receptors, respectively. GR79236 has anti-nociceptive and anti-inflammatory actions[1][2].
3-(difluoromethyl)-N-(7-fluoro-1,1,3-trimethyl-2,3-dihydro-1H-inden-4-yl)-1-methyl-1H-pyrazole-4-carboxamide
C18H20F3N3O (351.15583860000004)
Carbol-Fuchsin
C21H22ClN3 (351.15021620000005)
D004396 - Coloring Agents > D012394 - Rosaniline Dyes
4-acetamido-N-(2-amino-5-thiophen-2-ylphenyl)benzamide
4-hydroxy-1-methyl-N-[(3-methylphenyl)-oxomethyl]-2-oxo-3-quinolinecarbohydrazide
8-(Mesitylthio)-9-(pent-4-yn-1-yl)-9H-purin-6-amine
C19H21N5S (351.15175860000005)
2-[(4-Amino-7-tert-butyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl)thio]acetic acid
3-(4-Nitro-benzyloxy)-7,8,9,10-tetrahydro-benzo[c]chromen-6-one
3-amino-N-(2-chlorophenyl)-4-(pyrrolidin-1-yl)benzene-1-sulfonamide
C16H18ClN3O2S (351.08081980000003)
Benzenesulfonic acid, 5-[(4-amino-5-methoxy-2-methylphenyl)azo]-2-methoxy-
C15H17N3O5S (351.08888720000004)
(1S,2S,3R,4S,5R,6S)-4-(hydroxymethyl)-6-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}cyclohexane-1,2,3,5-tetrol
N-(4-acetylphenyl)-5-[(phenylthio)methyl]-2-furancarboxamide
1,2,3,4-Tetrahydroacridine-9-carboxylic acid (2-oxo-2-thiophen-2-ylethyl) ester
5-[2-[(4-chlorophenyl)thio]-1-oxoethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
1-(2-Methylpropyl)-1H-imidazo(4,5-c)(1,5)naphthyridin-4-amine monoethanesulfonate
C15H21N5O3S (351.1365036000001)
4-(2-(2-Chlorophenyl)ethyl)amino-8-methoxy-3,10-dimethyl-2,9-dioxatricyclo(4,3,1,0(3,7))decane
C19H26ClNO3 (351.16011160000005)
2-[(7-Hydroxy-naphthalen-1-YL)-oxalyl-amino]-benzoic acid
1-(O-Carboxy-phenylamino)-1-deoxy-D-ribulose-5-phosphate
(2S)-4-Methyl-2-(3-phenylthioureido)-N-((3S)-tetrahydro-2-hydroxy-3-furanyl)pentanamide
6-Chloro-4-(cyclohexylsulfinyl)-3-propylquinolin-2(1H)-one
C18H22ClNO2S (351.10597020000006)
2-[(2,3,4-Trihydroxy-5-phosphonooxypentyl)amino]benzoic acid
(2S,5R)-5-acetamido-6-[(1S)-3-acetyloxy-1,2-dihydroxypropyl]-2,4-dihydroxyoxane-2-carboxylic acid
2-[[(2R)-2-amino-3-[(E)-N-hydroxy-C-(6-methylsulfanylhexyl)carbonimidoyl]sulfanylpropanoyl]amino]acetic acid
6-{[2-Carboxy-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]sulfanyl}-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium
2-[[(4-Methyl-1-piperazinyl)-sulfanylidenemethyl]amino]benzene-1,4-dicarboxylic acid dimethyl ester
(2R,3S,5R)-2-[6-[[(1S,2S)-2-Hydroxycyclopentyl]amino]-9-purinyl]-5-(hydroxymethyl)oxolane-3,4-diol
C15H21N5O5 (351.15426160000004)
D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058913 - Purinergic Agonists D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents D009676 - Noxae > D000963 - Antimetabolites
8,10-Dimethyl-4-(2-methylphenyl)-1,3-dihydropyrido[2,3]thieno[2,4-d][1,4]diazepine-2,5-dione
N-(2-aminophenyl)-1-butyl-4-hydroxy-2-oxo-3-quinolinecarboxamide
2-[2-butyl-5-chloro-3-[(2-nitrophenyl)methyl]imidazol-4-yl]acetic Acid
C16H18ClN3O4 (351.09857780000004)
[3-(2-Furanyl)-5-(thiophen-2-ylmethylamino)-1,2,4-triazol-1-yl]-(3-pyridinyl)methanone
C17H13N5O2S (351.07899180000004)
N-(4-ethoxyphenyl)-2-[4-[2-(methylthio)ethyl]-2,5-dioxo-1-imidazolidinyl]acetamide
(4R,5S,6S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
17beta-Hydroxyestra-1(10),2,4-trien-3-yl sulfate
C18H23O5S- (351.12661280000003)
N-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]-2-(2,3,5-trimethylphenoxy)acetamide
2-Phenoxybenzoic acid [2-(2-furanylmethylamino)-2-oxoethyl] ester
N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(3-methyl-4-oxo-1-phthalazinyl)acetamide
4-[(1-methyl-2-oxo-4-quinolinyl)oxy]-N-(4-methyl-2-pyridinyl)butanamide
N-(3,4-dimethylphenyl)-2-[[1-(phenylmethyl)-2-imidazolyl]thio]acetamide
C20H21N3OS (351.14052560000005)
N-[5-(4-tert-butylphenyl)-1,3,4-thiadiazol-2-yl]-4-methylbenzamide
C20H21N3OS (351.14052560000005)
3-(1-piperidinylsulfonyl)-N-(2-thiazolyl)benzamide
C15H17N3O3S2 (351.07112920000003)
4-nitro-N-[(1E)-1-(2-oxo-2H-chromen-3-yl)ethylidene]benzohydrazide
C18H13N3O5 (351.08551680000005)
6-(1,3-benzodioxol-5-ylmethylamino)-3-(2-methylphenyl)-1H-pyrimidine-2,4-dione
[1-(4,5-Diphenyl-2-thienyl)ethylideneamino]thiourea
2-hydroxy-N-[[5-(3-nitrophenyl)furan-2-yl]methylideneamino]benzamide
C18H13N3O5 (351.08551680000005)
(3aR,6aR)-5-(3-methoxyphenyl)-3-(pyrazine-2-carbonyl)-3a,6a-dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione
C17H13N5O4 (351.09674980000005)
6-(4-bromo-3,5-dimethyl-1-pyrazolyl)-N-cyclohexyl-1,2,4,5-tetrazin-3-amine
(E)-N-cyclohexyl-3-(4-nitrophenyl)-N-pyridin-2-ylprop-2-enamide
(6Z)-5-imino-6-(1H-indol-3-ylmethylene)-2-isobutyl-5,6-dihydro-7H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-one
1-(2-fluorophenyl)-3-(N-(phenylmethyl)anilino)thiourea
N-[3-[[(4-nitrophenyl)-oxomethyl]amino]phenyl]-2-furancarboxamide
C18H13N3O5 (351.08551680000005)
(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-(4-methyl-2-oxochromen-7-yl)oxyoxane-2-carboxylate
N-[2-(cyclohexen-1-yl)ethyl]-2-(4-oxochromeno[4,3-c]pyrazol-1-yl)acetamide
4-Methyl-3-[[1-oxo-2-(4-oxo-3-quinazolinyl)ethyl]amino]benzoic acid methyl ester
2-[[[(4-Methoxyphenyl)-oxomethyl]amino]methyl]-5-phenyl-3-furancarboxylic acid
2-(1,3-dioxo-2-isoindolyl)-N-(4-methyl-1,3-benzothiazol-2-yl)acetamide
C18H13N3O3S (351.0677588000001)
1-[4-[3-[5-(2-furanyl)-1H-pyrazol-3-yl]-5-sulfanylidene-1H-1,2,4-triazol-4-yl]phenyl]ethanone
C17H13N5O2S (351.07899180000004)
7-amino-1,3-dimethyl-2,2,4-trioxo-6-spiro[1H-indole-3,5-pyrano[2,3-d]pyrimidine]carbonitrile
C17H13N5O4 (351.09674980000005)
4-[5-(4-methoxyphenyl)-3-isoxazolyl]-N-(2-pyridinylmethyl)butanamide
1-[[[2-(Difluoromethoxy)phenyl]-oxomethyl]amino]-3-(3-methylphenyl)thiourea
2-[(3-cyano-5,7-dimethyl-2-quinolinyl)thio]-N-(2-furanylmethyl)acetamide
N-[(2-methoxyphenyl)methyl]-2-methyl-3-prop-2-enoxy-6-indazolecarboxamide
4-Hydroxy-3-methoxybenzaldehyde [5-(4-methoxyphenyl)-1,2,4-triazin-3-yl]hydrazone
1-butyl-4-hydroxy-N-(3-methyl-2-pyridinyl)-2-oxo-3-quinolinecarboxamide
[(3Z)-2-oxo-3-(1,3,3-trimethylindol-2-ylidene)propyl] 4-hydroxybenzoate
C21H21NO4 (351.14705060000006)
Phe-Ala-Asp
A tripeptide composed of L-phenylalanine, L-alanine, and L-aspartic acid joined by peptide linkages.
beta-D-tyvelosyl-(1->3)-N-acetyl-beta-D-galactosamine
Methyl 4-(5-{[(2-hydroxy-2-phenylethyl)amino]methyl}furan-2-yl)benzoate
C21H21NO4 (351.14705060000006)
3-[4-(3,4-dihydro-2H-1,5-benzodioxepin-7-ylsulfonyl)-1-piperazinyl]propanenitrile
N-[(2R)-4-chloro-3-oxo-1-phenylbutan-2-yl]-4-methylbenzenesulfonamide
2-[(2S,3R,6S)-3-[[(3-fluoroanilino)-oxomethyl]amino]-2-(hydroxymethyl)-3,6-dihydro-2H-pyran-6-yl]-N,N-dimethylacetamide
C17H22FN3O4 (351.15942640000003)
2-[(2S,3S,6R)-3-[[(3-fluoroanilino)-oxomethyl]amino]-2-(hydroxymethyl)-3,6-dihydro-2H-pyran-6-yl]-N,N-dimethylacetamide
C17H22FN3O4 (351.15942640000003)
1-[(2S,3S)-2-(hydroxymethyl)-6-[oxo(2-pyridinyl)methyl]-3-phenyl-1,6-diazaspiro[3.3]heptan-1-yl]ethanone
1-[(2S,3R)-2-(hydroxymethyl)-6-[oxo(2-pyridinyl)methyl]-3-phenyl-1,6-diazaspiro[3.3]heptan-1-yl]ethanone
2-[(2S,3R,6R)-3-[[(3-fluoroanilino)-oxomethyl]amino]-2-(hydroxymethyl)-3,6-dihydro-2H-pyran-6-yl]-N,N-dimethylacetamide
C17H22FN3O4 (351.15942640000003)
2-[(2R,3S,6S)-3-[[(3-fluoroanilino)-oxomethyl]amino]-2-(hydroxymethyl)-3,6-dihydro-2H-pyran-6-yl]-N,N-dimethylacetamide
C17H22FN3O4 (351.15942640000003)
2-[(2R,3S,6R)-3-[[(3-fluoroanilino)-oxomethyl]amino]-2-(hydroxymethyl)-3,6-dihydro-2H-pyran-6-yl]-N,N-dimethylacetamide
C17H22FN3O4 (351.15942640000003)
2-[(2R,3R,6S)-3-[[(3-fluoroanilino)-oxomethyl]amino]-2-(hydroxymethyl)-3,6-dihydro-2H-pyran-6-yl]-N,N-dimethylacetamide
C17H22FN3O4 (351.15942640000003)
2-[(2S,3S,6S)-3-[[(3-fluoroanilino)-oxomethyl]amino]-2-(hydroxymethyl)-3,6-dihydro-2H-pyran-6-yl]-N,N-dimethylacetamide
C17H22FN3O4 (351.15942640000003)
2-[(2R,3R,6R)-3-[[(3-fluoroanilino)-oxomethyl]amino]-2-(hydroxymethyl)-3,6-dihydro-2H-pyran-6-yl]-N,N-dimethylacetamide
C17H22FN3O4 (351.15942640000003)
1-[(2R,3R)-2-(hydroxymethyl)-6-[oxo(2-pyridinyl)methyl]-3-phenyl-1,6-diazaspiro[3.3]heptan-1-yl]ethanone
1-Hydroxy-5-methoxy-3-methyl-6-[[7-(3-methyl-1,3-butadienyl)-1H-indole-3-yl]methyl]pyrazine-2(1H)-one
4,6-diphenyl-N-[(E)-pyridin-3-ylmethylideneamino]pyrimidin-2-amine
Methyl 2,2-dimethyl-5-(naphthalen-1-yliminomethyl)-4,6-dioxocyclohexane-1-carboxylate
C21H21NO4 (351.14705060000006)
(2R,4S,5R,6R)-5-acetamido-6-[(1R,2R)-1-acetyloxy-2,3-dihydroxypropyl]-2,4-dihydroxyoxane-2-carboxylic acid
2-(2,2-Dimethyl-4,6-dioxo-6-phenylhexyl)benzothiazole
C21H21NO2S (351.12929260000004)
1-Benzyl-3,4-bis(methoxycarbonyl)-2-phenyl-3-pyrroline
C21H21NO4 (351.14705060000006)
1-Methyl-2,5-diphenyl-2,5-dihydro-1H-pyrrole-3,4-dicarboxylic acid dimethyl ester
C21H21NO4 (351.14705060000006)
lomefloxacin
A fluoroquinolone antibiotic, used (generally as the hydrochloride salt) to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery. J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AE - Fluoroquinolones D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic D004791 - Enzyme Inhibitors
Tosylphenylalanyl chloromethyl ketone
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015842 - Serine Proteinase Inhibitors D009676 - Noxae > D000477 - Alkylating Agents > D000590 - Amino Acid Chloromethyl Ketones D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
beta-D-Tyvp-(1->3)-beta-D-GalpNAc
An amino disaccharide consisting of N-acetyl-beta-D-galactosamine having a beta-D-tyvelosyl residue attached at the 3-position.
2-(4-bromophenyl)propanoic acid (8-methyl-8-azabicyclo[3.2.1]octan-3-yl) ester
17beta-estradiol 3-sulfate(1-)
C18H23O5S (351.12661280000003)
A steroid sulfate oxoanion obtained by deprotonation of the sulfo group of 17beta-estradiol 3-sulfate; major species at pH 7.3.
IMT1
C21H21NO4 (351.14705060000006)
IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases[1].
NAB-14
NAB-14 is a potent, selective, orally active and non-competitive GluN2C/2D antagonists with an IC50 of 580 nM for GluN1/GluN2D. NAB-14 shows >800-fold selective for recombinant GluN2C and GluN2D over GluN2A and GluN2B. NAB-14 can cross the blood-brain-barrier[1].
VU 0238429
VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM.
1-hydroxy-5-methoxy-3-methyl-6-{[7-(3-methylbuta-1,3-dien-1-yl)-1h-indol-3-yl]methyl}pyrazin-2-one
16-methoxy-6,11,11-trimethyl-5,8,13-triazatetracyclo[10.7.0.0³,⁸.0¹⁴,¹⁹]nonadeca-1(12),2,9,14,16,18-hexaene-4,7-dione
(5r)-6-methyl-2',6',7,8-tetrahydro-2h-spiro[[1,3]dioxolo[4,5-g]isoquinoline-5,7'-indeno[4,5-d][1,3]dioxol]-8'-one
(3r,4s,5s,10s)-4-hydroxy-9-thia-11,15,20-triazaheptacyclo[12.6.1.1³,¹⁰.0²,¹².0³,⁸.0⁵,²⁰.0¹⁷,²¹]docosa-1,7,11,14(21),16-pentaene-6,13-dione
C18H13N3O3S (351.0677588000001)
4,15,16-trimethoxy-10-methyl-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(16),2(7),4,8,11,13(17),14-heptaene-3,6-dione
(2-{14-methoxy-3,5,16-trioxapentacyclo[9.6.2.0²,⁶.0⁸,¹⁸.0¹⁵,¹⁹]nonadeca-1,6,8(18),9,11(19),12,14-heptaen-12-yl}ethyl)dimethylamine
C21H21NO4 (351.14705060000006)
14,15,16-trimethoxy-8,8-dimethyl-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(16),2,4,6,9(17),10,12,14-octaen-5-ol
C21H21NO4 (351.14705060000006)
(2r,3r,4s,5s)-2-(6-{[(2z)-4-hydroxy-3-methylbut-2-en-1-yl]amino}purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
C15H21N5O5 (351.15426160000004)
3-methanesulfonyl-n-methyl-n-(2-{4-[(3-methylbut-2-en-1-yl)oxy]phenyl}ethyl)prop-2-enamide
C18H25NO4S (351.15042100000005)
1-[(12r,13r)-13-hydroxy-3,5-dioxa-11-azapentacyclo[10.7.1.0²,⁶.0⁸,²⁰.0¹⁴,¹⁹]icosa-1(20),2(6),7,14,16,18-hexaen-11-yl]butan-1-one
C21H21NO4 (351.14705060000006)
(1s,4r)-1-benzyl-1,3,10-trihydroxy-4-methyl-4h-pyrazino[2,1-b]quinazolin-6-one
2-{6-[(4-hydroxy-3-methylbut-2-en-1-yl)amino]purin-9-yl}-5-(hydroxymethyl)oxolane-3,4-diol
C15H21N5O5 (351.15426160000004)
3,4,11-trimethoxy-13-methyl-7,8-dihydro-6-azatetraphen-10-one
C21H21NO4 (351.14705060000006)
(2s)-2-{[(2s)-2-amino-1-hydroxy-3-(1h-indol-3-yl)propylidene]amino}-3-phenylpropanoic acid
13-methyl-5,7,17,19,25-pentaoxa-13-azaheptacyclo[12.10.1.0¹,¹².0²,¹⁰.0⁴,⁸.0¹⁵,²³.0¹⁶,²⁰]pentacosa-2,4(8),9,15,20,22-hexaene
(4s,7r)-4-benzyl-4,6-dihydroxy-7-methyl-15-oxa-2,5,8-triazatricyclo[8.5.0.0³,⁸]pentadeca-1(10),2,5,11,13-pentaen-9-one
methyl 2-{1-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]indol-3-yl}acetate
C17H21NO7 (351.13179560000003)
3-[2-(2,3-dihydroxyindol-3-yl)ethyl]-1-methylquinazoline-2,4-dione
methyl 2-{1-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]indol-3-yl}acetate
C17H21NO7 (351.13179560000003)
4-benzyl-4,6-dihydroxy-7-methyl-15-oxa-2,5,8-triazatricyclo[8.5.0.0³,⁸]pentadeca-1(10),2,5,11,13-pentaen-9-one
4-(4-hydroxy-3-methoxyphenyl)-7-methoxy-3h-benzo[f]isoindole-1,6-diol
16-hydroxy-7,17-dimethoxy-3,5-dioxa-11-azapentacyclo[10.7.1.0²,⁶.0⁸,²⁰.0¹⁴,¹⁹]icosa-1(20),2(6),7,9,11,14(19),15,17-octaen-13-one
5-hydroxy-9-thia-11,15,20-triazaheptacyclo[12.6.1.1³,¹⁰.0²,¹².0³,⁸.0⁵,²⁰.0¹⁷,²¹]docosa-1,7,11,14(21),16-pentaene-6,13-dione
C18H13N3O3S (351.0677588000001)
1-chloro-n-[(6e)-2-chloro-9-(3,3-dimethyloxiran-2-yl)-7-methyl-3-methylidenenon-6-en-1-yl]methanecarbonimidoyl chloride
{1-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]indol-3-yl}methyl acetate
C17H21NO7 (351.13179560000003)
methyl 3-[(dimethylcarbamoyl)methyl]-2-(4-methylphenyl)imidazo[1,2-a]pyridine-6-carboxylate
17-hydroxy-7,16-dimethoxy-3,5-dioxa-11-azapentacyclo[10.7.1.0²,⁶.0⁸,²⁰.0¹⁴,¹⁹]icosa-1,6,8,10,12(20),14(19),15,17-octaen-13-one
16,17-dimethoxy-5,7-dioxa-12-azapentacyclo[11.8.0.0²,¹⁰.0⁴,⁸.0¹⁵,²⁰]henicosa-1(13),2,4(8),9,14,16,18,20-octaen-14-ol
(2s,3z)-2-{[(2s)-2-amino-5-carbamimidamido-1-hydroxypentylidene]amino}-5-phosphonopent-3-enoic acid
C11H22N5O6P (351.13076420000004)
14,15,16-trimethoxy-10-methyl-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(17),2(7),3,5,8,13,15-heptaene-11,12-dione
1-chloro-n-[(2s,6e)-2-chloro-9-[(2s)-3,3-dimethyloxiran-2-yl]-7-methyl-3-methylidenenon-6-en-1-yl]methanecarbonimidoyl chloride
5-chloro-7-hydroxy-2-(2-hydroxyethyl)-7-methyl-3-(3-methylpent-1-en-1-yl)isoquinoline-6,8-dione
C18H22ClNO4 (351.1237282000001)
(1s,12r,14s)-13-methyl-5,7,17,19,25-pentaoxa-13-azaheptacyclo[12.10.1.0¹,¹².0²,¹⁰.0⁴,⁸.0¹⁵,²³.0¹⁶,²⁰]pentacosa-2,4(8),9,15,20,22-hexaene
(2s,3r)-3-chloro-2-(3,4-dimethylpent-3-en-1-yl)-2-(methoxymethyl)-3,4-dihydro-1h-quinoline-6-carboxylic acid
C19H26ClNO3 (351.16011160000005)
(3e)-2-[(2-amino-5-carbamimidamido-1-hydroxypentylidene)amino]-5-phosphonopent-3-enoic acid
C11H22N5O6P (351.13076420000004)
(1r,14s,19s,21s)-20-oxa-15-thia-4,9,13-triazaheptacyclo[12.7.1.1³,⁷.0¹,¹⁶.0²,¹².0¹⁹,²¹.0¹⁰,²³]tricosa-2(12),3,7,10(23),16-pentaene-11,18-dione
C18H13N3O3S (351.0677588000001)
12,14,15,16-tetramethoxy-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(16),2,4,6,9(17),10,12,14-octaen-8-one
(7s)-5-chloro-7-hydroxy-2-(2-hydroxyethyl)-7-methyl-3-[(1e,3s)-3-methylpent-1-en-1-yl]isoquinoline-6,8-dione
C18H22ClNO4 (351.1237282000001)
1-benzyl-1,3,10-trihydroxy-4-methyl-4h-pyrazino[2,1-b]quinazolin-6-one
(5ar)-2-ethanimidoyl-1-hydroxy-5,5-dimethyl-10-(methylamino)-5ah,6h-naphtho[2,3-a]pyrrolizine-3,11-dione
4,5,15,16-tetramethoxy-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(16),2(7),3,5,9(17),10,12,14-octaen-8-one
(5s)-6-methyl-2',6',7,8-tetrahydro-2h-spiro[[1,3]dioxolo[4,5-g]isoquinoline-5,7'-indeno[4,5-d][1,3]dioxol]-8'-one
7'-methoxy-2'-methyl-6-methylidene-2,3',4',8-tetrahydrospiro[indeno[4,5-d][1,3]dioxole-7,1'-isoquinolin]-6'-ol
C21H21NO4 (351.14705060000006)
1-chloro-n-[2-chloro-9-(3,3-dimethyloxiran-2-yl)-7-methyl-3-methylidenenon-6-en-1-yl]methanecarbonimidoyl chloride
5,7-dihydroxy-6-(1-methylpiperidin-2-yl)-2-phenylchromen-4-one
C21H21NO4 (351.14705060000006)
7-(2h-1,3-benzodioxol-5-yl)-6-(4-hydroxyphenyl)-1,2,3,5,8,8a-hexahydroindolizin-8-ol
C21H21NO4 (351.14705060000006)
7-hydroxy-5-methoxy-2-phenyl-8-(piperidin-2-yl)chromen-4-one
C21H21NO4 (351.14705060000006)
(1r,13s)-12-methyl-6,8,18,20-tetraoxa-12-azahexacyclo[11.11.0.0²,¹⁰.0⁵,⁹.0¹⁵,²³.0¹⁷,²¹]tetracosa-2(10),3,5(9),15,17(21),22-hexaen-24-one
2-ethanimidoyl-1-hydroxy-5,5-dimethyl-10-(methylamino)-5ah,6h-naphtho[2,3-a]pyrrolizine-3,11-dione
4,5,15,16-tetramethoxy-10-methyl-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(17),2(7),3,5,8,11,13,15-octaene
C21H21NO4 (351.14705060000006)
(1r,4r)-1-benzyl-1,3,10-trihydroxy-4-methyl-4h-pyrazino[2,1-b]quinazolin-6-one
5,14,15,16-tetramethoxy-10-azatetracyclo[7.7.1.0²,⁸.0¹³,¹⁷]heptadeca-1(16),2,4,7,9(17),10,12,14-octaen-6-one
5,10,11,12-tetramethoxy-16-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(17),2,4,6,9,11,13,15-octaen-8-one
20-oxa-15-thia-4,9,13-triazaheptacyclo[12.7.1.1³,⁷.0¹,¹⁶.0²,¹².0¹⁹,²¹.0¹⁰,²³]tricosa-2(12),3,7,10(23),16-pentaene-11,18-dione
C18H13N3O3S (351.0677588000001)
(2r,3r)-3-chloro-2-(3,4-dimethylpent-3-en-1-yl)-2-(methoxymethyl)-3,4-dihydro-1h-quinoline-6-carboxylic acid
C19H26ClNO3 (351.16011160000005)
6-methyl-2',6',7,8-tetrahydro-2h-spiro[[1,3]dioxolo[4,5-g]isoquinoline-5,7'-indeno[4,5-d][1,3]dioxol]-8'-one
15,16-dimethoxy-21-methyl-4,6-dioxa-21-azapentacyclo[10.9.0.0²,¹⁰.0³,⁷.0¹³,¹⁸]henicosa-1(12),2(10),3(7),8,13(18),14,16-heptaene
C21H21NO4 (351.14705060000006)
3-chloro-2-(3,4-dimethylpent-3-en-1-yl)-2-(methoxymethyl)-3,4-dihydro-1h-quinoline-6-carboxylic acid
C19H26ClNO3 (351.16011160000005)
(2z,6r,9z)-4-hydroxy-16-methoxy-6,11,11-trimethyl-5,8,13-triazatetracyclo[10.7.0.0³,⁸.0¹⁴,¹⁹]nonadeca-1(12),2,4,9,14,16,18-heptaen-7-one
(8r,8as)-7-(2h-1,3-benzodioxol-5-yl)-6-(4-hydroxyphenyl)-1,2,3,5,8,8a-hexahydroindolizin-8-ol
C21H21NO4 (351.14705060000006)
(2s,3r,4s,5r)-2-(6-{[(2z)-4-hydroxy-3-methylbut-2-en-1-yl]amino}purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
C15H21N5O5 (351.15426160000004)
4,5,15,16-tetramethoxy-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(17),2(7),3,5,8,10,13,15-octaen-12-one
18,19-dimethoxy-5,7-dioxa-13-azapentacyclo[10.7.1.0²,¹⁰.0⁴,⁸.0¹⁶,²⁰]icosa-1(20),2(10),3,8,11,16,18-heptaene-11-carbaldehyde
(2e)-3-methanesulfonyl-n-methyl-n-(2-{4-[(3-methylbut-2-en-1-yl)oxy]phenyl}ethyl)prop-2-enamide
C18H25NO4S (351.15042100000005)
3-{2-[(3r)-2,3-dihydroxyindol-3-yl]ethyl}-1-methylquinazoline-2,4-dione
3,4,10,11-tetramethoxy-5h-6-azatetraphene
C21H21NO4 (351.14705060000006)