Oxoglaucine (BioDeep_00000017262)

   

human metabolite Endogenous


代谢物信息卡片


N-[3-Ethyl-3-methyl-7-(2-methylpropyl)-5,8-dioxo-2-oxa-6,9-diazabicyclo[10.2.2]hexadeca-10,12,14,15-tetraen-4-yl]-1-methyl-2-pyrrolidinecarboxamide, 9ci

化学式: C20H17NO5 (351.1106672)
中文名称: 氧海罂粟碱
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 6.06%

分子结构信息

SMILES: c1(c(cc2c(c1)c1c3c(C2=O)nccc3cc(c1OC)OC)OC)OC
InChI: InChI=1S/C20H17NO5/c1-23-13-8-11-12(9-14(13)24-2)19(22)18-16-10(5-6-21-18)7-15(25-3)20(26-4)17(11)16/h5-9H,1-4H3

描述信息

Oxoglaucine is an isoquinoline alkaloid.
Oxoglaucine is a natural product found in Sarcocapnos baetica, Sarcocapnos saetabensis, and other organisms with data available.
Oxoglaucine is found in beverages. Oxoglaucine is an alkaloid from Annona purpurea (soncoya

同义名列表

18 个代谢物同义名

N-[3-Ethyl-3-methyl-7-(2-methylpropyl)-5,8-dioxo-2-oxa-6,9-diazabicyclo[10.2.2]hexadeca-10,12,14,15-tetraen-4-yl]-1-methyl-2-pyrrolidinecarboxamide, 9ci; 4,5,15,16-tetramethoxy-10-azatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadeca-1(16),2,4,6,9(17),10,12,14-octaen-8-one; 4,5,15,16-tetramethoxy-10-azatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(16),2(7),3,5,9,11,13(17),14-octaen-8-one; 4,5,15,16-tetramethoxy-10-azatetracyclo[7.7.1.02,7.013,17]heptadeca-1(17),2,4,6,9,11,13,15-octaen-8-one; Noraporphin-7-one, 4,5,6,6a-tetradehydro-1,2,9,10-tetramethoxy-; Noraporphin-7-one,5,6,6a-tetradehydro-1,2,9,10-tetramethoxy-; 1,2,9,10-Tetramethoxy-7H-dibenzo[de,g]quinolin-7-one, 9CI; 1,2,9,10-Tetramethoxy-7H-dibenzo[de,g]quinolin-7-one #; 7H-Dibenzo[de,g]quinolin-7-one, 1,2,9,10-tetramethoxy-; 7H-Dibenzo(de,g)quinolin-7-one, 1,2,9,10-tetramethoxy-; 1,2,9,10-Tetramethoxy-7H-dibenzo[de,g]quinolin-7-one; 1,2,9,10-Tetramethoxy-7H-Dibenzo(de,g)quinolin-7-one; 7H-Dibenzo[de, 1,2,9,10-tetramethoxy-; ATHEROLINE, O-METHYL; tetramethoxy[?]one; O-Methylatheroline; Liriodendron base; Oxoglaucine



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • InWha Park, Hee Sun Byun, Gang Min Hur, MinKyun Na. Tulipiferamide A, an Alkamide from Liriodendron tulipifera, Exhibits an Anti-Inflammatory Effect via Targeting IKKβ Phosphorylation. Journal of natural products. 2021 05; 84(5):1598-1606. doi: 10.1021/acs.jnatprod.1c00146. [PMID: 33939429]
  • Jian-Hua Wei, Zhen-Feng Chen, Jiao-Lan Qin, Yan-Cheng Liu, Zhu-Quan Li, Taj-Malook Khan, Meng Wang, Yan-Hua Jiang, Wen-Ying Shen, Hong Liang. Water-soluble oxoglaucine-Y(III), Dy(III) complexes: in vitro and in vivo anticancer activities by triggering DNA damage, leading to S phase arrest and apoptosis. Dalton transactions (Cambridge, England : 2003). 2015 Jul; 44(25):11408-19. doi: 10.1039/c5dt00926j. [PMID: 26017376]
  • Minetaro Arita, Stefan Philipov, Angel S Galabov. Phosphatidylinositol 4-kinase III beta is the target of oxoglaucine and pachypodol (Ro 09-0179) for their anti-poliovirus activities, and is located at upstream of the target step of brefeldin A. Microbiology and immunology. 2015 Jun; 59(6):338-47. doi: 10.1111/1348-0421.12261. [PMID: 25891300]
  • Zhen-Feng Chen, Yan-Fang Shi, Yan-Cheng Liu, Xue Hong, Bo Geng, Yan Peng, Hong Liang. TCM active ingredient oxoglaucine metal complexes: crystal structure, cytotoxicity, and interaction with DNA. Inorganic chemistry. 2012 Feb; 51(4):1998-2009. doi: 10.1021/ic200443p. [PMID: 22309171]
  • Ziming Lu, Wuxing Sun, Xuhong Duan, Zhiyun Yang, Yadong Liu, Pengfei Tu. [Chemical constituents from Corydalis yanhusuo]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Jan; 37(2):235-7. doi: . [PMID: 22737858]
  • Mimi Remichkova, Petya Dimitrova, Stefan Philipov, Nina Ivanovska. Toll-like receptor-mediated anti-inflammatory action of glaucine and oxoglaucine. Fitoterapia. 2009 Oct; 80(7):411-4. doi: 10.1016/j.fitote.2009.05.016. [PMID: 19481591]
  • Cristina Flors, Chantal Prat, Rafael Suau, Francisco Nájera, Santi Nonell. Photochemistry of phytoalexins containing phenalenone-like chromophores: photophysics and singlet oxygen photosensitizing properties of the plant oxoaporphine alkaloid oxoglaucine. Photochemistry and photobiology. 2005 Jan; 81(1):120-4. doi: 10.1562/2004-07-23-ra-243. [PMID: 15493958]
  • N Ivanovska, M Hristova. Treatment with oxoglaucine can enhance host resistance to Candida albicans infection of mice with adjuvant arthritis. Diagnostic microbiology and infectious disease. 2000 Sep; 38(1):17-20. doi: 10.1016/s0732-8893(00)00167-x. [PMID: 11025179]
  • N Ivanovska, M Hristova, S Philipov. Immunosuppression and recovery of drug-impaired host resistance against Candida albicans infection by oxoglaucine. Pharmacological research. 2000 Jan; 41(1):101-7. doi: NULL. [PMID: 10600277]
  • G G Harrigan, A A Gunatilaka, D G Kingston, G W Chan, R K Johnson. Isolation of bioactive and other oxoaporphine alkaloids from two annonaceous plants, Xylopia aethiopica and Miliusa cf. banacea. Journal of natural products. 1994 Jan; 57(1):68-73. doi: 10.1021/np50103a009. [PMID: 8158166]