benfluorex (BioDeep_00000271393)

   


代谢物信息卡片


benfluorex

化学式: C19H20F3NO2 (351.14460560000003)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CC1=CC(=CC=C1)C(F)(F)F)NCCOC(=O)C2=CC=CC=C2
InChI: InChI=1S/C19H20F3NO2/c1-14(12-15-6-5-9-17(13-15)19(20,21)22)23-10-11-25-18(24)16-7-3-2-4-8-16/h2-9,13-14,23H,10-12H2,1H3

描述信息

A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D019440 - Anti-Obesity Agents > D001067 - Appetite Depressants
C78272 - Agent Affecting Nervous System > C29728 - Anorexiant
D009676 - Noxae > D000963 - Antimetabolites

同义名列表

1 个代谢物同义名

benfluorex



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Mario Thevis, Gerd Sigmund, Vassilios Gougoulidis, Simon Beuck, Nils Schlörer, Andreas Thomas, Dorota Kwiatkowska, Andrzej Pokrywka, Wilhelm Schänzer. Screening for benfluorex and its major urinary metabolites in routine doping controls. Analytical and bioanalytical chemistry. 2011 Aug; 401(2):543-51. doi: 10.1007/s00216-010-4455-4. [PMID: 21116611]
  • Kejia Cai, Shelton D Caruthers, Wenjing Huang, Todd A Williams, Huiying Zhang, Samuel A Wickline, Gregory M Lanza, Patrick M Winter. MR molecular imaging of aortic angiogenesis. JACC. Cardiovascular imaging. 2010 Aug; 3(8):824-32. doi: 10.1016/j.jcmg.2010.03.012. [PMID: 20705262]
  • P Moulin, M André, H Alawi, L C Dos Santos, A K Khalid, D Koev, R Moore, V Serban, B Picandet, M Francillard. Efficacy of benfluorex in combination with sulfonylurea in type 2 diabetic patients: an 18 to 34-week, open-label, extension period. Diabetes & metabolism. 2009 Feb; 35(1):64-70. doi: 10.1016/j.diabet.2008.10.002. [PMID: 19150252]
  • I Poizot-Martin, M P Drogoul-Vey, D Di Stefano, E Jouve, G Fabre, A Saout, J A Gastaut. A randomized, double-blind, placebo-controlled study of benfluorex in HIV-infected patients with insulin resistance or impaired glucose tolerance. HIV clinical trials. 2009 Jan; 10(1):33-40. doi: 10.1310/hct1001-033. [PMID: 19362994]
  • Philippe Moulin, Marie Andre, Hasan Alawi, Lelita C dos Santos, Abdul K Khalid, Dragomir Koev, Ray Moore, Viorel Serban, Brigitte Picandet, Marie Francillard. Efficacy of benfluorex in combination with sulfonylurea in type 2 diabetic patients: an 18-week, randomized, double-blind study. Diabetes care. 2006 Mar; 29(3):515-20. doi: 10.2337/diacare.29.03.06.dc05-1439. [PMID: 16505498]
  • ". Hidden amphetamines: from smoking cessation to diabetes. Prescrire international. 2004 Feb; 13(69):18-20. doi: ". [PMID: 15055218]
  • S Del Prato, D W Erkelens, M Leutenegger. Six-month efficacy of benfluorex vs. placebo or metformin in diet-failed type 2 diabetic patients. Acta diabetologica. 2003 Mar; 40(1):20-7. doi: 10.1007/s005920300004. [PMID: 12682825]
  • J M Brogard, N Neyrolles, E Andres, J F Blicklé. [Current status of the treatment of type 2 diabetes mellitus. The revival of insulin-resistance drugs]. La Revue de medecine interne. 1999 Aug; 20 Suppl 3(?):371s-378s. doi: 10.1016/s0248-8663(99)80510-4. [PMID: 10480188]
  • G Marquié, T El Madani, M L Solera, M T Pieraggi, P Hadjiisky, D Ravel, L Seguin, N Bennani. Metabolic and anti-atherogenic effects of long-term benfluorex in dyslipidemic insulin-resistant sand rats (Psammomys obesus). Life sciences. 1998; 63(1):65-76. doi: 10.1016/s0024-3205(98)00237-9. [PMID: 9667766]
  • M Fields, C G Lewis. Benfluorex, a hypotriglyceridemic drug, reduces lipid peroxidation and alleviates adverse metabolic complications of copper deficiency. Nutrition (Burbank, Los Angeles County, Calif.). 1997 Oct; 13(10):895-9. doi: 10.1016/s0899-9007(97)00266-9. [PMID: 9357027]
  • J C Russell, S E Graham, P J Dolphin, R M Amy, G O Wood, D N Brindley. Antiatherogenic effects of long-term benfluorex treatment in male insulin resistant JCR:LA-cp rats. Atherosclerosis. 1997 Jul; 132(2):187-97. doi: 10.1016/s0021-9150(97)00092-0. [PMID: 9242964]
  • A E Pontiroli, M Pacchioni, P M Piatti, C Cassisa, R Camisasca, G Pozza. Benfluorex in obese noninsulin dependent diabetes mellitus patients poorly controlled by insulin: a double blind study versus placebo. The Journal of clinical endocrinology and metabolism. 1996 Oct; 81(10):3727-32. doi: 10.1210/jcem.81.10.8855830. [PMID: 8855830]
  • N Stucci, P de Gregoris, R Lavielle, F Tomasi. Therapeutic benefit of benfluorex in type II diabetic patients treated with sulfonylureas. Journal of diabetes and its complications. 1996 Sep; 10(5):267-73. doi: 10.1016/1056-8727(96)00042-6. [PMID: 8887015]
  • D Ravel, N Laudignon. Research prospects with benfluorex. Journal of diabetes and its complications. 1996 Sep; 10(5):246-54. doi: 10.1016/1056-8727(96)00045-1. [PMID: 8887012]
  • J C Russell, S E Graham, P J Dolphin, D N Brindley. Effects of benfluorex on serum triacylglycerols and insulin sensitivity in the corpulent rat. Canadian journal of physiology and pharmacology. 1996 Aug; 74(8):879-86. doi: 10.1139/cjpp-74-8-879. [PMID: 8960376]
  • T Orsière, M Chauvet, M Dell'Amico, H Lafont, M Bourdeaux. In vitro influence of benfluorex and its main metabolites on rat liver microsomal membrane properties. Chemico-biological interactions. 1995 Aug; 97(3):297-306. doi: 10.1016/0009-2797(95)03624-u. [PMID: 7671345]
  • J E Nestler, N A Beer, D J Jakubowicz, C Colombo, R M Beer. Effects of insulin reduction with benfluorex on serum dehydroepiandrosterone (DHEA), DHEA sulfate, and blood pressure in hypertensive middle-aged and elderly men. The Journal of clinical endocrinology and metabolism. 1995 Feb; 80(2):700-6. doi: 10.1210/jcem.80.2.7852539. [PMID: 7852539]
  • A Riccio, S Vigili de Kreutzenberg, M Dorella, V Da Tos, L De Biasi, M C Marescotti, A Tiengo, S Del Prato. Mechanism(s) of the blood glucose lowering action of benfluorex. Diabetes/metabolism reviews. 1993 Nov; 9 Suppl 1(?):19S-27S. doi: 10.1002/dmr.5610090505. [PMID: 8299485]
  • R Bianchi, V Bongers, B Bravenboer, D W Erkelens. Benfluorex decreases insulin resistance and improves lipid profiles in obese type 2 diabetic patients. Diabetes/metabolism reviews. 1993 Nov; 9 Suppl 1(?):29S-34S. doi: 10.1002/dmr.5610090506. [PMID: 8299486]
  • B Portha, P Serradas, D Bailbé, O Blondel, F Picarel. Effect of benfluorex on insulin secretion and insulin action in streptozotocin-diabetic rats. Diabetes/metabolism reviews. 1993 Nov; 9 Suppl 1(?):57S-63S. doi: 10.1002/dmr.5610090510. [PMID: 8299491]
  • J C Sodoyez, F Sodoyez-Goffaux. Effect of chronic benfluorex treatment on interaction of insulin 123I with liver receptors in fa/fa Zucker rats. Diabetes/metabolism reviews. 1993 Nov; 9 Suppl 1(?):73S-79S. doi: 10.1002/dmr.5610090512. [PMID: 8299493]
  • R Bianchi, V Bongers, B Bravenboer, D W Erkelens. Effects of benfluorex on insulin resistance and lipid metabolism in obese type II diabetic patients. Diabetes care. 1993 Apr; 16(4):557-9. doi: 10.2337/diacare.16.4.557. [PMID: 8462377]
  • P Serradas, O Blondel, D Bailbe, B Portha. Benfluorex normalizes hyperglycemia and reverses hepatic insulin resistance in STZ-induced diabetic rats. Diabetes. 1993 Apr; 42(4):564-70. doi: 10.2337/diab.42.4.564. [PMID: 8454107]
  • L H Storlien, N D Oakes, D A Pan, M Kusunoki, A B Jenkins. Syndromes of insulin resistance in the rat. Inducement by diet and amelioration with benfluorex. Diabetes. 1993 Mar; 42(3):457-62. doi: 10.2337/diab.42.3.457. [PMID: 8432416]
  • S Vigili de Kreutzenberg, A Riccio, M Dorella, V Da Tos, S Del Prato. [Mechanisms of hypoglycemic action of benfluorex]. Presse medicale (Paris, France : 1983). 1992 Sep; 21(28):1340-3. doi: NULL. [PMID: 1438104]
  • J M Brun. [Antidiabetic efficacy of benfluorex. Clinical data]. Presse medicale (Paris, France : 1983). 1992 Sep; 21(28):1344-52. doi: NULL. [PMID: 1438105]
  • J C Sodoyez, F Sodoyez-Goffaux. [Effects of chronic administration of benfluorex on the pharmacokinetics of iodine 123 labelled insulin in Zucker obese rats (fa/fa)]. Presse medicale (Paris, France : 1983). 1992 Sep; 21(28):1336-9. doi: NULL. [PMID: 1438103]
  • C J Bailey, T Page, C Day, C C Thornburn. Acute effect of benfluorex on glucose metabolism. Biochemical pharmacology. 1992 Jul; 44(2):379-82. doi: 10.1016/0006-2952(92)90023-c. [PMID: 1642649]
  • D N Brindley, P Hales, A I al-Sieni, J C Russell. Decreased serum lipids, serum insulin and triacylglycerol synthesis in adipose tissue of JCR:LA-corpulent rats treated with benfluorex. Biochimica et biophysica acta. 1991 Aug; 1085(1):119-25. doi: 10.1016/0005-2760(91)90239-e. [PMID: 1892872]
  • A Franceschini, J M Duthel, J J Vallon. [Specific detection of urinary sympathomimetic amines for control of anti-doping by gas chromatography-mass spectroscopy]. Journal of chromatography. 1991 Mar; 541(1-2):109-20. doi: 10.1016/s0021-9673(01)95988-6. [PMID: 2037649]
  • P Cavallo-Perin, P Estivi, L Boine, R Galletti, G Pacini, C Cobelli, G Pagano. Benfluorex and blood glucose control in non insulin-dependent diabetic patients. Journal of endocrinological investigation. 1991 Feb; 14(2):109-13. doi: 10.1007/bf03350279. [PMID: 2061566]
  • J C Mazière, C Mazière, M Auclair, L Mora, O Arnaud. The liver metabolite S-422 of the hypolipidaemic drug benfluorex decreases cholesterol esterification in fibroblasts and monocyte-like cells. European journal of clinical pharmacology. 1991; 41(4):339-44. doi: 10.1007/bf00314964. [PMID: 1666560]
  • D N Brindley, H Akester, G P Derrick, C D Irvine, R D Patmore, H Spencer, A Yule-Smith, C Finnerty, J Saxton, I A Macdonald. Effects of chronic administration of benfluorex to rats on the metabolism of corticosterone, glucose, triacylglycerols, glycerol and fatty acid. Biochemical pharmacology. 1988 Feb; 37(4):695-705. doi: 10.1016/0006-2952(88)90144-x. [PMID: 3342101]
  • D Sommariva, F Blasi, R Cosentini, M Berruto. Effects of benfluorex on sterol biosynthesis in incubated human blood mononuclear cells. Drugs under experimental and clinical research. 1986; 12(11):923-7. doi: ". [PMID: 3816510]
  • B Graisely, M Cloarec. [Cross-over study of benfluorex and a hypolipemic agent in diet-resistant types IV and II b hyperlipemia (author's transl)]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris. 1980 Jun; 56(25-28):1221-5. doi: ". [PMID: 6256875]
  • M Glikmanas. [Efficacy of benfluorex in the treatment of multiple metabolic overloads: preliminary results concerning 1609 cases]. Journees annuelles de diabetologie de l'Hotel-Dieu. 1980 May; ?(?):297-303. doi: ". [PMID: 7401426]