(4R,5S,6S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (BioDeep_00001035386)
代谢物信息卡片
(4R,5S,6S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
化学式: C15H19N4O4S+ (351.1126954)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C2C(C(=O)N2C(=C1SC3CN4C=NC=[N+]4C3)C(=O)O)C(C)O
InChI: InChI=1S/C15H18N4O4S/c1-7-11-10(8(2)20)14(21)19(11)12(15(22)23)13(7)24-9-3-17-5-16-6-18(17)4-9/h5-11,20H,3-4H2,1-2H3/p+1/t7-,8-,10-,11-/m1/s1
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Koichi Yamada, Yoshihiro Yamamoto, Katsunori Yanagihara, Nobuko Araki, Yosuke Harada, Yoshitomo Morinaga, Koichi Izumikawa, Hiroshi Kakeya, Hiroo Hasegawa, Shigeru Kohno, Shimeru Kamihira. In vivo efficacy and pharmacokinetics of biapenem in a murine model of ventilator-associated pneumonia with Pseudomonas aeruginosa.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2012 Aug; 18(4):472-8. doi:
10.1007/s10156-011-0359-2. [PMID: 22215228] - Qin Yu, Mao-Zhi Liang, Jin Xiang, Yong-Ping Qin, Feng Nan. [Determination of biapenem in human plasma by high performance liquid chromatography].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2011 Jul; 42(4):564-6. doi:
NULL. [PMID: 21866650] - Libo Zhao, Yi Liu, Zhibin Kou, Aidijie Bayasi, Huan Cai, Chunyan Zhang, Qian Wang, Yuzhen Li, Yi Fang. Improved RP-HPLC method to determine biapenem in human plasma/urine and its application to a pharmacokinetic study.
Arzneimittel-Forschung.
2011; 61(3):197-204. doi:
10.1055/s-0031-1296189. [PMID: 21528646] - Maria Saroglou, Stavros Tryfon, Georgios Ismailos, Ioannis Liapakis, Manolis Tzatzarakis, Aristidis Tsatsakis, Apostolos Papalois, Demosthenes Bouros. Pharmacokinetics of Linezolid and Ertapenem in experimental parapneumonic pleural effusion.
Journal of inflammation (London, England).
2010 May; 7(?):22. doi:
10.1186/1476-9255-7-22. [PMID: 20482752] - Keiko Kameda, Mizuka Miki, Kazuro Ikawa, Norifumi Morikawa, Masao Kobayashi. [Dosing regimen rationalization of biapenem in pediatric patients: use of Monte Carlo simulation].
The Japanese journal of antibiotics.
2009 Feb; 62(1):1-8. doi:
NULL. [PMID: 19378765] - Yutaka Nakamura, Keiko Nakahira, Takaharu Mizutani. Decreased valproate level caused by VPA-glucuronidase inhibition by carbapenem antibiotics.
Drug metabolism letters.
2008 Dec; 2(4):280-5. doi:
10.2174/187231208786734049. [PMID: 19356106] - Hidemichi Suyama, Kazuro Ikawa, Norifumi Morikawa, Kayo Ikeda, Yoshihiro Fujiue, Shingo Morikawa, Kotaro Kaneko, Masao Kuwabara, Takao Yamanoue. Pharmacokinetics and pharmacodynamics of biapenem in critically ill patients under continuous venovenous hemodiafiltration.
The Japanese journal of antibiotics.
2008 Oct; 61(5):303-13. doi:
. [PMID: 19260350] - Kazuro Ikawa, Norifumi Morikawa, Kayo Ikeda, Hiroki Ohge, Taijiro Sueda. Pharmacodynamic evaluation of biapenem in peritoneal fluid using population pharmacokinetic modelling and Monte Carlo simulation.
International journal of antimicrobial agents.
2008 Oct; 32(4):339-43. doi:
10.1016/j.ijantimicag.2008.03.011. [PMID: 18602798] - K Ikawa, N Morikawa, K Ikeda, M Miki, S Nishimura, M Kobayashi. Population pharmacokinetics and pharmacodynamics of biapenem in paediatric patients.
Journal of clinical pharmacy and therapeutics.
2008 Apr; 33(2):203-10. doi:
10.1111/j.1365-2710.2008.00908.x. [PMID: 18315787] - Noriko Tsuchimochi, Takahiro Takuma, Nobuyuki Shimono, Yoji Nagasaki, Yujiro Uchida, Mine Harada. Antimicrobial susceptibility and molecular epidemiological analysis of clinical strains of Pseudomonas aeruginosa.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2008 Apr; 14(2):99-104. doi:
10.1007/s10156-007-0578-8. [PMID: 18622671] - Yuko Muto, Yukio Mikami, Shiro Sakakibara, Atsuyuki Shimizu, Masashi Niida, Hiroshi Kataoka, Fumi Ito, Katsuyoshi Suzuki, Koji Kijima, Kazunori Maebashi, Toshihiko Takata, Muneo Hikida, Kazunori Takeda, Michiaki Unno. Pharmacokinetic and pharmacodynamic properties of biapenem, a carbapenem antibiotic, in rat experimental model of severe acute pancreatitis.
Pancreas.
2008 Mar; 36(2):125-32. doi:
10.1097/mpa.0b013e3181568ed7. [PMID: 18376302] - Kazuro Ikawa, Norifumi Morikawa, Kayo Ikeda, Hidemichi Suyama. Pharmacokinetic modeling and dosage adaptation of biapenem in Japanese patients during continuous venovenous hemodiafiltration.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2008 Feb; 14(1):35-9. doi:
10.1007/s10156-007-0572-1. [PMID: 18297447] - Masafumi Seki, Naofumi Suyama, Kohji Hashiguchi, Atsuko Hara, Kosuke Kosai, Shintaro Kurihara, Shigeki Nakamura, Kazuko Yamamoto, Yoshifumi Imamura, Koichi Izumikawa, Hiroshi Kakaya, Katsunori Yanagihara, Yoshihiro Yamamoto, Hiroshi Mukae, Takayoshi Tashiro, Shigeru Kohno. A patient with fulminant influenza-related bacterial pneumonia due to Streptococcus pneumoniae followed by Mycobacterium tuberculosis infection.
Internal medicine (Tokyo, Japan).
2008; 47(23):2043-7. doi:
10.2169/internalmedicine.47.1473. [PMID: 19043258] - Kazuro Ikawa, Norifumi Morikawa, Kayo Ikeda, Hiroki Ohge, Taijiro Sueda, Hidemichi Suyama, Masao Doi, Masao Kuwabara. Pharmacokinetic-pharmacodynamic target attainment analysis of biapenem in adult patients: a dosing strategy.
Chemotherapy.
2008; 54(5):386-94. doi:
10.1159/000152459. [PMID: 18769027] - Kayo Ikeda, Kazuro Ikawa, Aki Ikeda, Yoshimi Nishikawa, Norifumi Morikawa. A simple and rapid determination of biapenem in plasma by high-performance liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Nov; 844(1):148-52. doi:
10.1016/j.jchromb.2006.06.023. [PMID: 16875889] - Yaeko Watanabe, Yoshihiro Fujiue, Sintarou Yano, Satomi Shimizu, Kunio Muroki, Masao Doi, Masao Kuwabara. [Antimicrobial susceptibility of Pseudomonas aeruginosa isolated from urine at one hospital to mainly carbapenem and fluoroquinolone drugs].
The Japanese journal of antibiotics.
2006 Apr; 59(2):65-71. doi:
. [PMID: 16805317] - Toshiaki Niwa, Atsushi Nakamura, Takashi Kato, Takeo Kutsuna, Ken Katou, Hiroki Morita, Yasuhiro Kojima, Makoto Itoh. Pharmacokinetic study of pleural fluid penetration of carbapenem antibiotic agents in chemical pleurisy.
Respiratory medicine.
2006 Feb; 100(2):324-31. doi:
10.1016/j.rmed.2005.05.009. [PMID: 16493791] - Akiyoshi Tsuji, Intetsu Kobayashi, Toyoko Oguri, Matsuhisa Inoue, Eiko Yabuuchi, Sachiko Goto. An epidemiological study of the susceptibility and frequency of multiple-drug-resistant strains of Pseudomonas aeruginosa isolated at medical institutes nationwide in Japan.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2005 Apr; 11(2):64-70. doi:
10.1007/s10156-005-0377-z. [PMID: 15856373] - Toshihiko Takata, Kazumasa Aizawa, Atsuyuki Shimizu, Shiro Sakakibara, Hiroomi Watabe, Kyoichi Totsuka. Optimization of dose and dose regimen of biapenem based on pharmacokinetic and pharmacodynamic analysis.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2004 Apr; 10(2):76-85. doi:
10.1007/s10156-003-0292-0. [PMID: 15160299] - Akiko Aoki, Takako Sato, Toshihisa Igarashi. [Clinical evaluation on biapenem for respiratory infections in elderly patients: safety for renal function].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.
2003 Jul; 40(4):402-3. doi:
10.3143/geriatrics.40.402. [PMID: 12934573]