Sulfaquinoxaline (BioDeep_00000017932)

   

human metabolite


代谢物信息卡片


4-amino-N-(quinoxalin-2-yl)benzene-1-sulfonamide

化学式: C14H12N4O2S (300.0680932)
中文名称: 磺胺喹噁啉, 磺胺喹恶啉
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)N=CC(=N2)NS(=O)(=O)C3=CC=C(C=C3)N
InChI: InChI=1S/C14H12N4O2S/c15-10-5-7-11(8-6-10)21(19,20)18-14-9-16-12-3-1-2-4-13(12)17-14/h1-9H,15H2,(H,17,18)

描述信息

Sulfaquinoxaline is an antimicrobial and a coccidiostat for veterinary use. It is a potential food contaminant in animal products arising from its veterinary use.
Antimicrobial, coccidiostat for vet. use. Potential food contaminant in animal products arising from its veterinary use.
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides

同义名列表

46 个代谢物同义名

4-amino-N-(quinoxalin-2-yl)benzene-1-sulfonamide; 4-amino-N-2-Quinoxalinylbenzenesulfonamide, 9ci; 4-amino-N-(2-Quinoxalinyl)benzenesulfonamide; 4-amino-N-2-Quinoxalinyl-benzenesulfonamide; 2-(P-Aminobenzene)sulfonamidoquinoxaline; 2-P-Aminobenzenesulphonamidoquinoxaline; Sulfanilamide, N1-2-quinoxalinyl- (8ci); 2-P-Aminobenzenesulfonamidoquinoxaline; Sulquin 6-50 concentrate (veterinary); N1-2-Quinoxalinyl, sulfanilamide; N1-(2-Quinoxalinyl)sulfanilamide; N1-2-Quinoxalinyl-sulfanilamide; N-(2-Quinoxalinyl)sulfanilamide; 2-(P-Sulfanilamido)quinoxaline; N-(2-quinoxalyl)sulfanilamide; N-(2-Quinoxalinyl)sulfanilide; 2-Sulfanilamidobenzopyrazine; N-2-quinoxalylsulfanilamide; 2-Sulfanilamidoquinoxaline; Sulfaquinoxaline, ban, inn; S. q. "40 per cent"; Sulphaquinoxaline; Sulfabenzpyrazine; Sulfaquinoxalinum; S. q. 40 per cent; sulfaquinoxaline; Sulfaquinoxalina; Sulfaquinoxalin; Sulfachinoxalin; Compound 3-120; Quinoxipra C; Ursokoxaline; Kokozigal S; Sulfa-Q 20; Sulfaline; Aviochina; Kokozigal; Italquina; Avicocid; Sulfacox; Nococcin; Sulquin; Sulfa-Q; Embazin; Anti-K; SQX



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ruyi Xu, Chen Yang, Lin Huang, Wenchao Lv, Weijuan Yang, Yongning Wu, FengFu Fu. Broad-Specificity Aptamer of Sulfonamides: Isolation and Its Application in Simultaneous Detection of Multiple Sulfonamides in Fish Sample. Journal of agricultural and food chemistry. 2022 Sep; 70(37):11804-11812. doi: 10.1021/acs.jafc.2c03423. [PMID: 36070569]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Vanessa Ribeiro Urbano, Milena Guedes Maniero, José Roberto Guimarães, Luis J Del Valle, Montserrat Pérez-Moya. Sulfaquinoxaline Oxidation and Toxicity Reduction by Photo-Fenton Process. International journal of environmental research and public health. 2021 01; 18(3):. doi: 10.3390/ijerph18031005. [PMID: 33498745]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Ahmad Soleymanpour, Seyyed Ahmad Rezvani. Development of a novel carbon paste sensor for determination of micromolar amounts of sulfaquinoxaline in pharmaceutical and biological samples. Materials science & engineering. C, Materials for biological applications. 2016 Jan; 58(?):504-9. doi: 10.1016/j.msec.2015.08.034. [PMID: 26478338]
  • Chun Liu, Sheng-Jie Wang, Qian Zhang, Yi-Xiang Shao. Influence of three coccidiostats on the pharmacokinetics of florfenicol in rabbits. Experimental animals. 2015; 64(1):73-9. doi: 10.1538/expanim.14-0064. [PMID: 25319758]
  • Robert Sheridan, Jennifer Mirabile, Kristen Hafler. Determination of six illegal antibiotics in chicken jerky dog treats. Journal of agricultural and food chemistry. 2014 Apr; 62(17):3690-6. doi: 10.1021/jf405458m. [PMID: 24437928]
  • P Hekman, G J Schefferlie. Kinetic modelling and residue depletion of drugs in eggs. British poultry science. 2011 Jun; 52(3):376-80. doi: 10.1080/00071668.2011.577055. [PMID: 21732884]
  • William C Campbell. History of the discovery of sulfaquinoxaline as a coccidiostat. The Journal of parasitology. 2008 Aug; 94(4):934-45. doi: 10.1645/ge-1413.1. [PMID: 18837573]
  • I García, M C Ortiz, L Sarabia, J M Aldama. Validation of an analytical method to determine sulfamides in kidney by HPLC-DAD and PARAFAC2 with first-order derivative chromatograms. Analytica chimica acta. 2007 Mar; 587(2):222-34. doi: 10.1016/j.aca.2007.01.054. [PMID: 17386777]
  • Titus A M Msagati, Mathew Muzi Nindi. Multiresidue determination of sulfonamides in a variety of biological matrices by supported liquid membrane with high pressure liquid chromatography-electrospray mass spectrometry detection. Talanta. 2004 Sep; 64(1):87-100. doi: 10.1016/j.talanta.2004.02.038. [PMID: 18969572]
  • Craig D C Salisbury, Jason C Sweet, Roger Munro. Determination of sulfonamide residues in the tissues of food animals using automated precolumn derivatization and liquid chromatography with fluorescence detection. Journal of AOAC International. 2004 Sep; 87(5):1264-8. doi: . [PMID: 15493686]
  • B Shaikh, N Rummel, D Smith. Determination of 14C residue in eggs of laying hens administered orally with [14C] sulfaquinoxaline. Food additives and contaminants. 2004 Jun; 21(6):545-54. doi: 10.1080/02652030410001687672. [PMID: 15204532]
  • Sara Bogialli, Roberta Curini, Antonio Di Corcia, Manuela Nazzari, Manuel Sergi. Confirmatory analysis of sulfonamide antibacterials in bovine liver and kidney: extraction with hot water and liquid chromatography coupled to a single- or triple-quadrupole mass spectrometer. Rapid communications in mass spectrometry : RCM. 2003; 17(11):1146-56. doi: 10.1002/rcm.1031. [PMID: 12772270]
  • N Furusawa. Binding profile of spiramycin to oviducal proteins of laying hens. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine. 2000 Dec; 47(10):585-91. doi: 10.1046/j.1439-0442.2000.00319.x. [PMID: 11199206]
  • A H Atta, el-Zeni, A Samia. Tissue residues of some sulphonamides in normal and Eimeria stiedai infected rabbits. DTW. Deutsche tierarztliche Wochenschrift. 1999 Jul; 106(7):295-8. doi: NULL. [PMID: 10481374]
  • N Furusawa, Y Tsuzukida. Tissue concentrations of sulphaquinoxaline administered in the food of laying hens. British poultry science. 1998 Dec; 39(5):683-5. doi: 10.1080/00071669888575. [PMID: 9925323]
  • M G el-Sayed, M I Abd el-Aziz, M H el-Kholy. Kinetic behaviour of sulphaquinoxaline and amprolium in chickens. DTW. Deutsche tierarztliche Wochenschrift. 1995 Dec; 102(12):481-5. doi: NULL. [PMID: 8591749]
  • T Li, G L Qiao, G Z Hu, F D Meng, Y S Qiu, X Y Zhang, W X Guo, H L Yie, S F Li, S Y Li. Comparative plasma and tissue pharmacokinetics and drug residue profiles of different chemotherapeutants in fowls and rabbits. Journal of veterinary pharmacology and therapeutics. 1995 Aug; 18(4):260-73. doi: 10.1111/j.1365-2885.1995.tb00590.x. [PMID: 8583539]
  • S Porter. Confirmation of sulfonamide residues in kidney tissue by liquid chromatography-mass spectrometry. The Analyst. 1994 Dec; 119(12):2753-6. doi: 10.1039/an9941902753. [PMID: 7879889]
  • M Atef, S A Youssef, A Ramadan, N A Afifi, A A Muity. Interaction between lead toxicity and some sulphonamides in rabbits: effect on certain blood constituents and serum enzymes. DTW. Deutsche tierarztliche Wochenschrift. 1994 May; 101(5):187-90. doi: NULL. [PMID: 8013295]
  • R L Epstein, R B Ashworth. Tissue sulfonamide concentration and correlation in turkeys. American journal of veterinary research. 1989 Jun; 50(6):926-8. doi: NULL. [PMID: 2764344]
  • J G Eppel, J J Thiessen. Liquid chromatographic analysis of sulfaquinoxaline and its application to pharmacokinetic studies in rabbits. Journal of pharmaceutical sciences. 1984 Nov; 73(11):1635-8. doi: 10.1002/jps.2600731136. [PMID: 6520769]
  • E Goren, W A de Jong, P Doornenbal. Some pharmacokinetic aspects of four sulphonamides and trimethoprim, and their therapeutic efficacy in experimental Escherichia coli infection in poultry. The veterinary quarterly. 1984 Jul; 6(3):134-40. doi: 10.1080/01652176.1984.9693927. [PMID: 6385459]
  • L P Joyner, J Catchpole, S Berrett. Eimeria stiedai in rabbits: the demonstration of responses to chemotherapy. Research in veterinary science. 1983 Jan; 34(1):64-7. doi: 10.1016/s0034-5288(18)32285-9. [PMID: 6132429]
  • A Hobson-Frohock, H A Johnson. Coccidiostat residues in poultry excreta. Journal of the science of food and agriculture. 1983 Jan; 34(1):37-44. doi: 10.1002/jsfa.2740340107. [PMID: 6843092]
  • T Sakano, S Masuda, T Amano. Determination of residual diaveridine and sulfaquinoxaline in Hen's egg, chicken plasma and tissues by high-performance liquid chromatography. Chemical & pharmaceutical bulletin. 1981 Aug; 29(8):2290-5. doi: 10.1248/cpb.29.2290. [PMID: 7318037]
  • S Weiner. Control of fowl cholera in Hungary. Poultry science. 1980 Jun; 59(6):1345-9. doi: 10.3382/ps.0591345. [PMID: 7403000]
  • J Catchpole, C C Norton. The species of Eimeria in rabbits for meat production in Britain. Parasitology. 1979 Oct; 79(2):249-57. doi: 10.1017/s0031182000053324. [PMID: 537836]
  • H W Smith, J F Tucker. The effect of feeding diets containing permitted antibiotics on the faecal excretion of Salmonella typhimurium by experimentally infected chickens. The Journal of hygiene. 1975 Oct; 75(2):293-301. doi: 10.1017/s0022172400047318. [PMID: 1100715]
  • M Mitrovic, E G Schildknecht. Lasalocid: resistance and cross-resistance studies in Eimeria tenella-infected chicks. Poultry science. 1975 May; 54(3):750-6. doi: 10.3382/ps.0540750. [PMID: 1153374]
  • N C Banerjee, K P Yadava, H N Jha. Distribution of sulphaquinoxaline in tissues of poultry. Indian journal of physiology and pharmacology. 1974 Oct; 18(4):361-3. doi: NULL. [PMID: 4466796]
  • H F Righter, J M Worthington, H E Zimmerman, H D Mercer. Tissue-residue depletion of sulfaquinoxaline in poultry. American journal of veterinary research. 1970 Jun; 31(6):1051-4. doi: NULL. [PMID: 5430695]