Ciadox (BioDeep_00000177771)
human metabolite blood metabolite
代谢物信息卡片
2-Cyano-N-[(1,4-dioxo-1,4-quinoxalin-2-yl)methylidene]ethanehydrazonate
化学式: C12H9N5O3 (271.07053640000004)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 80%
分子结构信息
SMILES: [O-][N+]1=CC(C=NNC(=O)CC#N)=[N+]([O-])C2=CC=CC=C12
InChI: InChI=1S/C12H9N5O3/c13-6-5-12(18)15-14-7-9-8-16(19)10-3-1-2-4-11(10)17(9)20/h1-4,7-8H,5H2,(H,15,18)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chongyang Huang, Hehua Lei, Chaoyang Liu, Yulan Wang. Acute and subchronic exposure of cyadox induced metabolic and transcriptomic disturbances in Wistar rats.
Toxicology.
2022 12; 482(?):153367. doi:
10.1016/j.tox.2022.153367. [PMID: 36330926] - Sechenchogt Harnud, Shishan Fu, Yulian Wang, Yuanhu Pan, Aiqun Zhang, Lingli Huang. Pharmacokinetics of cyadox and its main metabolites in rats, pigs, chickens, and carps following oral administration at three dosage.
Regulatory toxicology and pharmacology : RTP.
2021 Aug; 124(?):104971. doi:
10.1016/j.yrtph.2021.104971. [PMID: 34119601] - Ju Guo, Huanhuan Zhao, Luqing Cui, Qirong Lu, Xu Wang, Yulian Wang, Guyue Cheng, Zhenli Liu, Menghong Dai. Transcriptional regulation of seven cyadox-related genes mainly activated by PI3K and NF-кB signaling pathways in PK-15 cells.
Research in veterinary science.
2020 Aug; 131(?):232-243. doi:
10.1016/j.rvsc.2020.04.024. [PMID: 32417693] - Adeel Sattar, Mian Abdul Hafeez, Qin Wu, Adnan Hassan Tahir, Muhammad Abu Bakr Shabbir, Dongmei Chen, Lingli Huang, Shuyu Xie, Zonghui Yuan. Disposition of cyadox in domesticated cats following oral, intramuscular, and intravenous administration.
Journal of veterinary pharmacology and therapeutics.
2020 Mar; 43(2):97-107. doi:
10.1111/jvp.12836. [PMID: 31912519] - L L Huang, Y M Qiu, L L Sun, J Li, Y H Pan, Y L Wang, Z H Yuan. Dietary exposure assessment of cyadox based on tissue depletion of cyadox and its major metabolites in pigs, chickens, and carp.
Journal of veterinary pharmacology and therapeutics.
2018 Feb; 41(1):125-136. doi:
10.1111/jvp.12440. [PMID: 29194660] - Qianying Liu, Zhixin Lei, Luqing Cui, Jianwu Zhang, Ihsan Awais, Menghong Dai, Xu Wang, Zonghui Yuan. A two-year dietary carcinogenicity study of cyadox in Sprague-Dawley rats.
Regulatory toxicology and pharmacology : RTP.
2017 Jul; 87(?):9-22. doi:
10.1016/j.yrtph.2017.04.011. [PMID: 28454720] - Adeel Sattar, Dongmei Chen, Lishun Jiang, Yuanhu Pan, Yanfei Tao, Lingli Huang, Zhenli Liu, Shuyu Xie, Zonghui Yuan. Preparation, characterization and pharmacokinetics of cyadox nanosuspension.
Scientific reports.
2017 05; 7(1):2289. doi:
10.1038/s41598-017-02523-4. [PMID: 28536446] - Mayada Ragab Farag, Mahmoud Alagawany, Vincenzo Tufarelli. In vitro antioxidant activities of resveratrol, cinnamaldehyde and their synergistic effect against cyadox-induced cytotoxicity in rabbit erythrocytes.
Drug and chemical toxicology.
2017 Apr; 40(2):196-205. doi:
10.1080/01480545.2016.1193866. [PMID: 27314888] - Qin Huang, Awais Ihsan, Pu Guo, Xun Luo, Guyue Cheng, Haihong Hao, Dongmei Chen, Farrukh Jamil, Yanfei Tao, Xu Wang, Zonghui Yuan. Evaluation of the safety of primary metabolites of cyadox: Acute and sub-chronic toxicology studies and genotoxicity assessment.
Regulatory toxicology and pharmacology : RTP.
2016 Feb; 74(?):123-36. doi:
10.1016/j.yrtph.2015.11.011. [PMID: 26617409] - Xu Wang, Wen Zhou, Awais Ihsan, Dongmei Chen, Guyue Cheng, Haihong Hao, Zhenli Liu, Yulian Wang, Zonghui Yuan. Assessment of thirteen-week subchronic oral toxicity of cyadox in Beagle dogs.
Regulatory toxicology and pharmacology : RTP.
2015 Nov; 73(2):652-9. doi:
10.1016/j.yrtph.2015.09.023. [PMID: 26408151] - Huang Lingli, Xu Ning, Sechenchogt Harnud, Pan Yuanhu, Chen Dongmei, Tao Yanfei, Liu Zhenli, Yuan Zonghui. Metabolic Disposition and Elimination of Cyadox in Pigs, Chickens, Carp, and Rats.
Journal of agricultural and food chemistry.
2015 Jun; 63(22):5557-69. doi:
10.1021/acs.jafc.5b01745. [PMID: 25973850] - Lingli Huang, Zhoumeng Lin, Xuan Zhou, Meiling Zhu, Ronette Gehring, Jim E Riviere, Zonghui Yuan. Estimation of residue depletion of cyadox and its marker residue in edible tissues of pigs using physiologically based pharmacokinetic modelling.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2015; 32(12):2002-17. doi:
10.1080/19440049.2015.1100330. [PMID: 26414219] - Haihong Hao, Weige Guo, Zahid Iqbal, Guyue Cheng, Xu Wang, Menghong Dai, Lingli Huang, Yulian Wang, Dapeng Peng, Zhenli Liu, Zonghui Yuan. Impact of cyadox on human colonic microflora in chemostat models.
Regulatory toxicology and pharmacology : RTP.
2013 Dec; 67(3):335-43. doi:
10.1016/j.yrtph.2013.08.011. [PMID: 23973379] - Yafei Li, Ning Zhao, Zhenling Zeng, Xiaoyan Gu, Binghu Fang, Fan Yang, Bingxu Zhang, Huanzhong Ding. Tissue deposition and residue depletion of cyadox and its three major metabolites in pigs after oral administration.
Journal of agricultural and food chemistry.
2013 Oct; 61(39):9510-5. doi:
10.1021/jf4028602. [PMID: 24050441] - Chongyang Huang, Hehua Lei, Xiuju Zhao, Huiru Tang, Yulan Wang. Metabolic influence of acute cyadox exposure on Kunming mice.
Journal of proteome research.
2013 Jan; 12(1):537-45. doi:
10.1021/pr301033a. [PMID: 23234330] - Wentao Guo, Haihong Hao, Menghong Dai, Yulian Wang, Lingli Huang, Dapeng Peng, Xu Wang, Hailan Wang, Min Yao, Yawei Sun, Zhenli Liu, Zonghui Yuan. Development of quinoxaline 1, 4-dioxides resistance in Escherichia coli and molecular change under resistance selection.
PloS one.
2012; 7(8):e43322. doi:
10.1371/journal.pone.0043322. [PMID: 22952665] - Limin He, Kaiyong Liu, Yijuan Su, Jiahui Zhang, Yahong Liu, Zhenling Zeng, Binghu Fang, Guijun Zhang. Simultaneous determination of cyadox and its metabolites in plasma by high-performance liquid chromatography tandem mass spectrometry.
Journal of separation science.
2011 Aug; 34(15):1755-62. doi:
10.1002/jssc.201000822. [PMID: 21721120] - Xu Wang, Qing-Hua He, Yu-Lian Wang, Awais Ihsan, Ling-Li Huang, Wen Zhou, Shi-Jia Su, Zhen-Li Liu, Zong-Hui Yuan. A chronic toxicity study of cyadox in Wistar rats.
Regulatory toxicology and pharmacology : RTP.
2011 Mar; 59(2):324-33. doi:
10.1016/j.yrtph.2010.11.004. [PMID: 21129430] - Lingli Huang, Yulian Wang, Yanfei Tao, Dongmei Chen, Zonghui Yuan. Development of high performance liquid chromatographic methods for the determination of cyadox and its metabolites in plasma and tissues of chicken.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Oct; 874(1-2):7-14. doi:
10.1016/j.jchromb.2008.08.013. [PMID: 18838344] - M X Ding, Y L Wang, H L Zhu, Z H Yuan. Effects of cyadox and olaquindox on intestinal mucosal immunity and on fecal shedding of Escherichia coli in piglets.
Journal of animal science.
2006 Sep; 84(9):2367-73. doi:
10.2527/jas.2005-564. [PMID: 16908639] - Guijie Fang, Qinghua He, Shiqi Zhou, Daju Wang, Yanling Zhang, Zonghui Yuan. Subchronic oral toxicity study with cyadox in Wistar rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2006 Jan; 44(1):36-41. doi:
10.1016/j.fct.2005.06.003. [PMID: 16024154] - Yanling Zhang, Lingli Huang, Dongmei Chen, Shengxian Fan, Yulian Wang, Yanfei Tao, Zonghui Yuan. Development of HPLC methods for the determination of cyadox and its main metabolites in goat tissues.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2005 Dec; 21(12):1495-9. doi:
10.2116/analsci.21.1495. [PMID: 16379393] - H de Vries, J Bojarski, A A Donker, A Bakri, G M Beyersbergen van Henegouwen. Photochemical reactions of quindoxin, olaquindox, carbadox and cyadox with protein, indicating photoallergic properties.
Toxicology.
1990 Jul; 63(1):85-95. doi:
10.1016/0300-483x(90)90071-n. [PMID: 2382272] - M J Nabuurs, E J van der Molen, G J de Graaf, L P Jager. Clinical signs and performance of pigs treated with different doses of carbadox, cyadox and olaquindox.
Zentralblatt fur Veterinarmedizin. Reihe A.
1990 Feb; 37(1):68-76. doi:
10.1111/j.1439-0442.1990.tb00877.x. [PMID: 2110404] - E J van der Molen, A J Baars, G J de Graaf, L P Jager. Comparative study of the effect of the effect of carbadox, olaquindox and cyadox on aldosterone, sodium and potassium plasma levels in weaned pigs.
Research in veterinary science.
1989 Jul; 47(1):11-6. doi:
10.1016/s0034-5288(18)31224-4. [PMID: 2772398] - M Tokosová. [The effect of growth stimulators on the levels of various trace elements in chickens].
Veterinarni medicina.
1989 Feb; 34(2):107-12. doi:
NULL. [PMID: 2494789] - M Tokosová. [The effect of growth stimulators on the levels of various macroelements in chickens].
Veterinarni medicina.
1989 Jan; 34(1):51-7. doi:
NULL. [PMID: 2494786] - M Dvorák. [Increasing the effectiveness of feed mixtures for the early weaning of piglets with the addition of fats or growth stimulators].
Veterinarni medicina.
1984 Mar; 29(3):151-62. doi:
NULL. [PMID: 6426127]