1h-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one (BioDeep_00000173041)
human metabolite blood metabolite
代谢物信息卡片
1h-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
化学式: C9H5N3O2 (187.03817500000002)
中文名称: 1H-[1,2,4]恶二唑并[4,3-a]喹喔啉-1-酮
谱图信息:
最多检出来源 Homo sapiens(blood) 85.71%
分子结构信息
SMILES: C1=CC=C2C(=C1)N=CC3=NOC(=O)N23
InChI: InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
描述信息
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:91215
- PubChem: 1456
- HMDB: HMDB0244864
- ChEMBL: CHEMBL598952
- chemspider: 1412
- CAS: 41443-28-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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2007 Jun; 39(5):1350-3. doi:
10.1016/j.transproceed.2007.02.079. [PMID: 17580137] - Sunny Sun-Kin Chan, Tin-Yan Cheng, Ge Lin. Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta.
Journal of ethnopharmacology.
2007 May; 111(3):677-80. doi:
10.1016/j.jep.2006.12.018. [PMID: 17222996] - Madhu Chauhan, Gracious R Ross, Uma Yallampalli, Chandra Yallampalli. Adrenomedullin-2, a novel calcitonin/calcitonin-gene-related peptide family peptide, relaxes rat mesenteric artery: influence of pregnancy.
Endocrinology.
2007 Apr; 148(4):1727-35. doi:
10.1210/en.2006-1105. [PMID: 17218418] - Hai-Bin Xu, Zhao-Quan Huang. Vasorelaxant effects of icariin on isolated canine coronary artery.
Journal of cardiovascular pharmacology.
2007 Apr; 49(4):207-13. doi:
10.1097/fjc.0b013e3180325abe. [PMID: 17438405] - Carlos R Tirapelli, Claudia R de Andrade, Adriano O Cassano, Fernando A De Souza, Sergio R Ambrosio, Fernando B da Costa, Ana M de Oliveira. Antispasmodic and relaxant effects of the hidroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle.
Journal of ethnopharmacology.
2007 Mar; 110(1):23-9. doi:
10.1016/j.jep.2006.08.031. [PMID: 17027208] - Jingang Gui, Yan Song, Nian-Lin Reena Han, Fwu-Shan Sheu. Characterization of transcriptional regulation of neurogranin by nitric oxide and the role of neurogranin in SNP-induced cell death: implication of neurogranin in an increased neuronal susceptibility to oxidative stress.
International journal of biological sciences.
2007 Feb; 3(4):212-24. doi:
10.7150/ijbs.3.212. [PMID: 17389928] - Kim E Wever, Rosalinde Masereeuw, David S Miller, Xiao M Hang, Gert Flik. Endothelin and calciotropic hormones share regulatory pathways in multidrug resistance protein 2-mediated transport.
American journal of physiology. Renal physiology.
2007 Jan; 292(1):F38-46. doi:
10.1152/ajprenal.00479.2005. [PMID: 16912062] - Bahjat Al-Ani, Peter W Hewett, Suborna Ahmed, Melissa Cudmore, Takeshi Fujisawa, Shakil Ahmad, Asif Ahmed. The release of nitric oxide from S-nitrosothiols promotes angiogenesis.
PloS one.
2006 Dec; 1(?):e25. doi:
10.1371/journal.pone.0000025. [PMID: 17183652] - Fady T Botros, L Gabriel Navar. Interaction between endogenously produced carbon monoxide and nitric oxide in regulation of renal afferent arterioles.
American journal of physiology. Heart and circulatory physiology.
2006 Dec; 291(6):H2772-8. doi:
10.1152/ajpheart.00528.2006. [PMID: 16844915] - Hyun-Jung An, Oky Maeng, Kyoung-Hee Kang, Jie-Oh Lee, Young-Sang Kim, Sang-Gi Paik, Hayyoung Lee. Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death.
The Journal of biological chemistry.
2006 Nov; 281(45):33939-48. doi:
10.1074/jbc.m605819200. [PMID: 16954213] - Takashi Yoshida, Ryuji Inoue, Takashi Morii, Nobuaki Takahashi, Shinichiro Yamamoto, Yuji Hara, Makoto Tominaga, Shunichi Shimizu, Yoji Sato, Yasuo Mori. Nitric oxide activates TRP channels by cysteine S-nitrosylation.
Nature chemical biology.
2006 Nov; 2(11):596-607. doi:
10.1038/nchembio821. [PMID: 16998480] - Francis Fu Yuen Lam, Sai Wang Seto, Yiu Wa Kwan, John Hok Keung Yeung, Paul Chan. Activation of the iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells.
European journal of pharmacology.
2006 Sep; 546(1-3):28-35. doi:
10.1016/j.ejphar.2006.07.038. [PMID: 16928370] - Francisco Aguirre-Crespo, Jorge Vergara-Galicia, Rafael Villalobos-Molina, Juan Javier López-Guerrero, Gabriel Navarrete-Vázquez, Samuel Estrada-Soto. Ursolic acid mediates the vasorelaxant activity of Lepechinia caulescens via NO release in isolated rat thoracic aorta.
Life sciences.
2006 Aug; 79(11):1062-8. doi:
10.1016/j.lfs.2006.03.006. [PMID: 16630635] - Ruriko Koto, Masatoshi Imamura, Chie Watanabe, Satoshi Obayashi, Mitsuya Shiraishi, Yasuharu Sasaki, Hiroshi Azuma. Linalyl acetate as a major ingredient of lavender essential oil relaxes the rabbit vascular smooth muscle through dephosphorylation of myosin light chain.
Journal of cardiovascular pharmacology.
2006 Jul; 48(1):850-6. doi:
10.1097/01.fjc.0000238589.00365.42. [PMID: 16891914] - Michael J Ryan, Nikki L Jernigan, Heather A Drummond, Gerald R McLemore, John M Rimoldi, Sambasiva R Poreddy, Rama S V Gadepalli, David E Stec. Renal vascular responses to CORM-A1 in the mouse.
Pharmacological research.
2006 Jul; 54(1):24-9. doi:
10.1016/j.phrs.2006.01.012. [PMID: 16524742] - J-H Chiu, K-K Chen, T-M Chien, W-F Chiou, C-C Chen, J-Y Wang, W-Y Lui, C-W Wu. Epimedium brevicornum Maxim extract relaxes rabbit corpus cavernosum through multitargets on nitric oxide/cyclic guanosine monophosphate signaling pathway.
International journal of impotence research.
2006 Jul; 18(4):335-42. doi:
10.1038/sj.ijir.3901437. [PMID: 16395327] - Carola Buccellati, Angelo Sala, Giuseppe Rossoni, Valérie Capra, G Enrico Rovati, Antonio Di Gennaro, Giancarlo Folco, Susanna Colli, Cesare Casagrande. Pharmacological characterization of 2NTX-99 [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide], a potential antiatherothrombotic agent with antithromboxane and nitric oxide donor activity in platelet and vascular preparations.
The Journal of pharmacology and experimental therapeutics.
2006 May; 317(2):830-7. doi:
10.1124/jpet.105.097170. [PMID: 16399881] - Keiko Iwasaki-Kurashige, Renzo Y Loyaga-Rendon, Hitoshi Matsumoto, Takahisa Tokunaga, Hiroshi Azuma. Possible mediators involved in decreasing peripheral vascular resistance with blackcurrant concentrate (BC) in hind-limb perfusion model of the rat.
Vascular pharmacology.
2006 Apr; 44(4):215-23. doi:
10.1016/j.vph.2005.12.001. [PMID: 16448858] - Roman E Perri, Daniel A Langer, Suvro Chatterjee, Simon J Gibbons, Jay Gadgil, Sheng Cao, Gianrico Farrugia, Vijay H Shah. Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation.
American journal of physiology. Gastrointestinal and liver physiology.
2006 Mar; 290(3):G535-42. doi:
10.1152/ajpgi.00297.2005. [PMID: 16269521] - Cheng-Dean Shih, Jih-Jung Chen, Hsinn-Hsing Lee. Activation of nitric oxide signaling pathway mediates hypotensive effect of Muntingia calabura L. (Tiliaceae) leaf extract.
The American journal of Chinese medicine.
2006; 34(5):857-72. doi:
10.1142/s0192415x0600434x. [PMID: 17080550] - A Sandouka, B J Fuller, B E Mann, C J Green, R Foresti, R Motterlini. Treatment with CO-RMs during cold storage improves renal function at reperfusion.
Kidney international.
2006 Jan; 69(2):239-47. doi:
10.1038/sj.ki.5000016. [PMID: 16408112] - Dae Gill Kang, Mi Kyoung Moon, Deok Ho Choi, Jun Kyoung Lee, Tae Oh Kwon, Ho Sub Lee. Vasodilatory and anti-inflammatory effects of the 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) via a nitric oxide-cGMP pathway.
European journal of pharmacology.
2005 Nov; 524(1-3):111-9. doi:
10.1016/j.ejphar.2005.08.061. [PMID: 16253226] - Andrew C Skinn, Wallace K MacNaughton. Nitric oxide inhibits cAMP-dependent CFTR trafficking in intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology.
2005 Oct; 289(4):G739-44. doi:
10.1152/ajpgi.00425.2004. [PMID: 15994425] - Paloma Alonso-Magdalena, Ouahiba Laribi, Ana B Ropero, Esther Fuentes, Cristina Ripoll, Bernat Soria, Angel Nadal. Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans.
Environmental health perspectives.
2005 Aug; 113(8):969-77. doi:
10.1289/ehp.8002. [PMID: 16079065] - Aliye Uc, Russell F Husted, Radhamma L Giriyappa, Bradley E Britigan, John B Stokes. Hemin induces active chloride secretion in Caco-2 cells.
American journal of physiology. Gastrointestinal and liver physiology.
2005 Aug; 289(2):G202-8. doi:
10.1152/ajpgi.00518.2004. [PMID: 15805100] - Chinnasamy Thirunavukkarasu, Tadahiro Uemura, Lian Fu Wang, Simon C Watkins, Chandrashekhar R Gandhi. Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes.
Journal of cellular physiology.
2005 Aug; 204(2):654-65. doi:
10.1002/jcp.20366. [PMID: 15828022] - Seung-Soo Chung, Duck-Sun Ahn, Hong-Ghi Lee, Young-Ho Lee, Taick-Sang Nam. Inhibition of carbachol-evoked oscillatory currents by the NO donor sodium nitroprusside in guinea-pig ileal myocytes.
Experimental physiology.
2005 Jul; 90(4):577-86. doi:
10.1113/expphysiol.2004.029611. [PMID: 15833757] - Emmanouil Karteris, Manu Vatish, Edward W Hillhouse, Dimitris K Grammatopoulos. Preeclampsia is associated with impaired regulation of the placental nitric oxide-cyclic guanosine monophosphate pathway by corticotropin-releasing hormone (CRH) and CRH-related peptides.
The Journal of clinical endocrinology and metabolism.
2005 Jun; 90(6):3680-7. doi:
10.1210/jc.2004-2210. [PMID: 15784708] - K Sathishkumar, R Gracious Ross, Dnyaneshwar U Bawankule, Kautuk K Sardar, Vellanki Ravi Prakash, Santosh K Mishra. Segmental heterogeneity in the mechanism of sodium nitroprusside-induced relaxation in ovine pulmonary artery.
Journal of cardiovascular pharmacology.
2005 Jun; 45(6):491-8. doi:
10.1097/01.fjc.0000159043.50488.ac. [PMID: 15897774] - Chong-Bin Zhu, Ana M Carneiro, Wolfgang R Dostmann, William A Hewlett, Randy D Blakely. p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process.
The Journal of biological chemistry.
2005 Apr; 280(16):15649-58. doi:
10.1074/jbc.m410858200. [PMID: 15728187] - Shiu-Jen Chen, Kao-Hsiang Chen, Chin-Chen Wu. Nitric oxide-cyclic GMP contributes to abnormal activation of Na+-K+-ATPase in the aorta from rats with endotoxic shock.
Shock (Augusta, Ga.).
2005 Feb; 23(2):179-85. doi:
10.1097/01.shk.0000148071.73975.38. [PMID: 15665735] - Robin E Gandley, Vladimir A Tyurin, Wan Huang, Antonio Arroyo, Ashi Daftary, Gail Harger, Jianfei Jiang, Bruce Pitt, Robert N Taylor, Carl A Hubel, Valerian E Kagan. S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper: effects in pregnancy and preeclampsia plasma.
Hypertension (Dallas, Tex. : 1979).
2005 Jan; 45(1):21-7. doi:
10.1161/01.hyp.0000150158.42620.3e. [PMID: 15569857] - Ana Paula Sendão Oliveira, Lusiane M Bendhack. Relaxation induced by acetylcholine involves endothelium-derived hyperpolarizing factor in 2-kidney 1-clip hypertensive rat carotid arteries.
Pharmacology.
2004 Dec; 72(4):231-9. doi:
10.1159/000080378. [PMID: 15539883] - Lesley J Bryan-Lluka, Marisa H Papacostas, Filip A Paczkowski, Janet C Wanstall. Nitric oxide donors inhibit 5-hydroxytryptamine (5-HT) uptake by the human 5-HT transporter (SERT).
British journal of pharmacology.
2004 Sep; 143(1):63-70. doi:
10.1038/sj.bjp.0705904. [PMID: 15302679] - Kazuyoshi Nakamura, Junko Hirano, Manabu Kubokawa. Regulation of an inwardly rectifying K+ channel by nitric oxide in cultured human proximal tubule cells.
American journal of physiology. Renal physiology.
2004 Sep; 287(3):F411-7. doi:
10.1152/ajprenal.00014.2004. [PMID: 15140759] - Chong-Bin Zhu, William A Hewlett, Igor Feoktistov, Italo Biaggioni, Randy D Blakely. Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation.
Molecular pharmacology.
2004 Jun; 65(6):1462-74. doi:
10.1124/mol.65.6.1462. [PMID: 15155839] - Julia M Orshal, Raouf A Khalil. Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2004 Jun; 286(6):R1013-23. doi:
10.1152/ajpregu.00729.2003. [PMID: 15142856] - Carlos R Tirapelli, Sergio R Ambrosio, Fernando B da Costa, Silvia T Coutinho, Dionéia C R de Oliveira, Ana M de Oliveira. Analysis of the mechanisms underlying the vasorelaxant action of kaurenoic acid in the isolated rat aorta.
European journal of pharmacology.
2004 May; 492(2-3):233-41. doi:
10.1016/j.ejphar.2004.04.003. [PMID: 15178370] - Xiao-Hong Jin, Helen E McGrath, John J Gildea, Helmy M Siragy, Robin A Felder, Robert M Carey. Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-natriuresis via protein kinase G.
Hypertension (Dallas, Tex. : 1979).
2004 May; 43(5):1133-9. doi:
10.1161/01.hyp.0000123574.60586.7d. [PMID: 15007031]