2-Amino-3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxaline (BioDeep_00000024548)

   

human metabolite


代谢物信息卡片


3,4,8-Trimethyl-3H-imidazo[4,5-F]quinoxalin-2-amine, 9ci

化学式: C12H13N5 (227.11708980000003)
中文名称: 2-氨基-3,4,8-三甲基-3H-咪唑[4,5-F]喹喔啉-D3, 2-氨基-3,4,8-三甲基-3H-咪唑[4,5-F]喹喔啉
谱图信息: 最多检出来源 Rattus norvegicus(not specific) 18.7%

分子结构信息

SMILES: CC1=CC2=NC=C(N=C2C3=C1N(C(=N3)N)C)C
InChI: InChI=1S/C12H13N5/c1-6-4-8-9(15-7(2)5-14-8)10-11(6)17(3)12(13)16-10/h4-5H,1-3H3,(H2,13,16)

描述信息

Pyrolysis production from creatine, threonine and glucose in cooked food.
Pyrolysis produced from creatine, threonine and glucose in cooked food.
D009676 - Noxae > D002273 - Carcinogens
D009676 - Noxae > D009153 - Mutagens

同义名列表

17 个代谢物同义名

3,4,8-Trimethyl-3H-imidazo[4,5-F]quinoxalin-2-amine, 9ci; 2-Amino-3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxaline-D3; 2-Amino-3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxaline; 3,4,8-Trimethyl-3H-imidazo(4,5-F)quinoxalin-2-amine; 3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine; 2-amino-3,4,8-trimethylimidazo[4,5-F ]Quinoxaline; 2-amino-3,4,8-trimethylimidazo(4,5-F)Quinoxaline; 3,4,8-trimethylimidazo[4,5-f]quinoxalin-2-amine; 3,4,8-trimethylimidazo(4,5-F)Quinoxalin-2-amine; 4,8-Dimethyl iqx; 4,8-Dimethyl-iqx; 4-Methyl meiqx; 4,8-Di-meiqx; Dimethyl-iqx; 3,4,8-MeIQX; 4,8-DiMeIQx; Di-meiqx



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Renato Tavares dos Santos Pereira, Felipe Augusto Dörr, Ernani Pinto, Marina Yazigi Solis, Guilherme Giannini Artioli, Alan Lins Fernandes, Igor Hisashi Murai, Wagner Silva Dantas, Antônio Carlos Seguro, Mirela Aparecida Rodrigues Santinho, Hamilton Roschel, Alain Carpentier, Jacques Remi Poortmans, Bruno Gualano. Can creatine supplementation form carcinogenic heterocyclic amines in humans?. The Journal of physiology. 2015 Sep; 593(17):3959-71. doi: 10.1113/jp270861. [PMID: 26148133]
  • Kevin M Cooper, Natcha Jankhaikhot, Geraldine Cuskelly. Optimised extraction of heterocyclic aromatic amines from blood using hollow fibre membrane liquid-phase microextraction and triple quadrupole mass spectrometry. Journal of chromatography. A. 2014 Sep; 1358(?):20-8. doi: 10.1016/j.chroma.2014.06.061. [PMID: 25037778]
  • Yan Zhang, Chundi Yu, Jingbo Mei, Shuo Wang. Formation and mitigation of heterocyclic aromatic amines in fried pork. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2013; 30(9):1501-7. doi: 10.1080/19440049.2013.809627. [PMID: 23862679]
  • Fernando De Andrés, Mohammed Zougagh, Gregorio Castañeda, Angel Ríos. Determination of heterocyclic amines in urine samples by capillary liquid chromatography with evaporated light-scattering detection. Analytical and bioanalytical chemistry. 2010 May; 397(1):223-231. doi: 10.1007/s00216-009-3370-z. [PMID: 20396988]
  • Volker Mai, Quintece M McCrary, Rashmi Sinha, Michael Glei. Associations between dietary habits and body mass index with gut microbiota composition and fecal water genotoxicity: an observational study in African American and Caucasian American volunteers. Nutrition journal. 2009 Oct; 8(?):49. doi: 10.1186/1475-2891-8-49. [PMID: 19845958]
  • Monika Gibis. Effect of oil marinades with garlic, onion, and lemon juice on the formation of heterocyclic aromatic amines in fried beef patties. Journal of agricultural and food chemistry. 2007 Dec; 55(25):10240-7. doi: 10.1021/jf071720t. [PMID: 17988088]
  • Ka-Wing Cheng, Qingli Wu, Zong Ping Zheng, Xiaofang Peng, James E Simon, Feng Chen, Mingfu Wang. Inhibitory effect of fruit extracts on the formation of heterocyclic amines. Journal of agricultural and food chemistry. 2007 Dec; 55(25):10359-65. doi: 10.1021/jf071820z. [PMID: 18004801]
  • Robert J Turesky, Jian-Min Yuan, Renwei Wang, Sabrina Peterson, Mimi C Yu. Tobacco smoking and urinary levels of 2-amino-9H-pyrido[2,3-b]indole in men of Shanghai, China. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2007 Aug; 16(8):1554-60. doi: 10.1158/1055-9965.epi-07-0132. [PMID: 17684128]
  • Ricky D Holland, Jason Taylor, Laura Schoenbachler, Richard C Jones, James P Freeman, Dwight W Miller, Brian G Lake, Nigel J Gooderham, Robert J Turesky. Rapid biomonitoring of heterocyclic aromatic amines in human urine by tandem solvent solid phase extraction liquid chromatography electrospray ionization mass spectrometry. Chemical research in toxicology. 2004 Aug; 17(8):1121-36. doi: 10.1021/tx049910a. [PMID: 15310244]
  • Markus Zsivkovits, Kassie Fekadu, Gerhard Sontag, Ursula Nabinger, Wolfgang W Huber, Michael Kundi, Asima Chakraborty, Helmuth Foissy, Siegfried Knasmüller. Prevention of heterocyclic amine-induced DNA damage in colon and liver of rats by different lactobacillus strains. Carcinogenesis. 2003 Dec; 24(12):1913-8. doi: 10.1093/carcin/bgg167. [PMID: 12970070]
  • R Reistad, O J Rossland, K J Latva-Kala, T Rasmussen, R Vikse, G Becher, J Alexander. Heterocyclic aromatic amines in human urine following a fried meat meal. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1997 Oct; 35(10-11):945-55. doi: 10.1016/s0278-6915(97)00112-9. [PMID: 9463528]
  • H Frandsen. Excretion of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline, PhIP-dG, PhIP-DNA and DiMeIQx-DNA from the rat. Carcinogenesis. 1997 Aug; 18(8):1555-60. doi: 10.1093/carcin/18.8.1555. [PMID: 9276630]
  • L O Dragsted, S Grivas, H Frandsen, J C Larsen. Antibodies to the food mutagens, 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline: useful for immunoassay and immunoaffinity chromatography of biological samples. Carcinogenesis. 1995 Nov; 16(11):2795-806. doi: 10.1093/carcin/16.11.2795. [PMID: 7586201]
  • I S Kim, K Wakabayashi, R Kurosaka, Z Yamaizumi, F Jinno, S Koyota, A Tada, H Nukaya, M Takahashi, T Sugimura. Isolation and identification of a new mutagen, 2-amino-4-hydroxy-methyl-3,8-dimethylimidazo[4,5-f]quinoxaline (4-CH2OH-8-MeIQx), from beef extract. Carcinogenesis. 1994 Jan; 15(1):21-6. doi: 10.1093/carcin/15.1.21. [PMID: 8293543]
  • M G Knize, E Overik, T Midtvedt, K W Turteltaub, J A Happe, J A Gustafsson, J S Felton. The metabolism of 4,8-DiMeIQx in conventional and germ-free rats. Carcinogenesis. 1989 Aug; 10(8):1479-84. doi: 10.1093/carcin/10.8.1479. [PMID: 2665968]