Caroverine (BioDeep_00000177051)
human metabolite blood metabolite
代谢物信息卡片
化学式: C22H27N3O2 (365.2103162)
中文名称: 卡维琳
谱图信息:
最多检出来源 Homo sapiens(blood) 95.45%
分子结构信息
SMILES: CCN(CC)CCN1C(=O)C(CC2=CC=C(OC)C=C2)=NC2=CC=CC=C12
InChI: InChI=1S/C22H27N3O2/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17/h6-13H,4-5,14-16H2,1-3H3
描述信息
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
C78272 - Agent Affecting Nervous System > C29698 - Antispasmodic Agent
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135541
- PubChem: 65709
- HMDB: HMDB0249687
- DrugBank: DB13835
- ChEMBL: CHEMBL1729803
- Wikipedia: Caroverine
- chemspider: 59135
- CAS: 23465-76-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jesada Kanjanaumporn, Songklot Aeumjaturapat, Kornkiat Snidvongs, Kachorn Seresirikachorn, Supinda Chusakul. Smell and taste dysfunction in patients with SARS-CoV-2 infection: A review of epidemiology, pathogenesis, prognosis, and treatment options.
Asian Pacific journal of allergy and immunology.
2020 Jun; 38(2):69-77. doi:
10.12932/ap-030520-0826. [PMID: 32563234] - Lucas Harless, Jonathan Liang. Pharmacologic treatment for postviral olfactory dysfunction: a systematic review.
International forum of allergy & rhinology.
2016 07; 6(7):760-7. doi:
10.1002/alr.21727. [PMID: 26879592] - S V Logvinov, E Yu Varakuta, A A Zhdankina, A V Potapov, M B Plotnikov. Changes in the synaptoarchitectonics of the retina after light-induced damage and their correction with antioxidants of plant origin.
Neuroscience and behavioral physiology.
2009 Feb; 39(2):217-21. doi:
10.1007/s11055-009-9103-0. [PMID: 19140007] - S V Logvinov, E Iu Varakuta, A A Zhdankina, A V Potapov, M B Plotnikov. [Changes of synaptoarchitecture of the retina after the light-induced damage and their correction by plant antioxidants].
Morfologiia (Saint Petersburg, Russia).
2008; 133(1):46-50. doi:
". [PMID: 19069415] - Hans Nohl, Natalia Rohr-Udilova, Lars Gille, Werner Bieberschulte, Daniela Jurek, Brigitte Marian, Rolf Schulte-Herman. Suppression of tumour-promoting factors in fat-induced colon carcinogenesis by the antioxidants caroverine and ubiquinone.
Anticancer research.
2005 Jul; 25(4):2793-800. doi:
". [PMID: 16080529] - Hans Nohl, Natalia Rohr-Udilova, Lars Gille, Werner Bieberschulte, Daniela Jurek, Brigitte Marian, Rolf Schulte-Hermann. Ubiquinol and the papaverine derivative caroverine prevent the expression of tumour- promoting factors in adenoma and carcinoma colon cancer cells induced by dietary fat.
BioFactors (Oxford, England).
2005; 25(1-4):87-95. doi:
10.1002/biof.5520250110. [PMID: 16873933] - Zhiqiang Chen, Maoli Duan, Howsung Lee, Runsheng Ruan, Mats Ulfendahl. Pharmacokinetics of caroverine in the inner ear and its effects on cochlear function after systemic and local administrations in Guinea pigs.
Audiology & neuro-otology.
2003 Jan; 8(1):49-56. doi:
10.1159/000067893. [PMID: 12566692] - Natalia Udilova, Andrey V Kozlov, Werner Bieberschulte, Klemens Frei, Klaus Ehrenberger, Hans Nohl. The antioxidant activity of caroverine.
Biochemical pharmacology.
2003 Jan; 65(1):59-65. doi:
10.1016/s0006-2952(02)01452-1. [PMID: 12473379] - Hans Nohl, Werner Bieberschulte, Barbara Dietrich, Natalia Udilova, Andrey V Kozlov. Caroverine, a multifunctional drug with antioxidant functions.
BioFactors (Oxford, England).
2003; 19(1-2):79-85. doi:
10.1002/biof.5520190110. [PMID: 14757980] - Xiaoyan Chen, Dafang Zhong, Haiyan Xu, Barbara Schug, Henning Blume. Sensitive and specific liquid chromatographic-tandem mass spectrometric assay for dihydroergotamine and its major metabolite in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2002 Mar; 768(2):267-75. doi:
10.1016/s1570-0232(01)00601-8. [PMID: 11888055] - Klaus Ehrenberger. Clinical experience with caroverine in inner ear diseases.
Advances in oto-rhino-laryngology.
2002; 59(?):156-62. doi:
10.1159/000059252. [PMID: 11885656]