BW619c89 (BioDeep_00001875813)

Main id: BioDeep_00000009622

 


代谢物信息卡片


Sipatrigine

化学式: C15H16Cl3N5 (371.0471)
中文名称: 西帕曲近
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1CCN(CC1)C2=NC=C(C(=N2)N)C3=C(C(=CC(=C3)Cl)Cl)Cl
InChI: InChI=1S/C15H16Cl3N5/c1-22-2-4-23(5-3-22)15-20-8-11(14(19)21-15)10-6-9(16)7-12(17)13(10)18/h6-8H,2-5H2,1H3,(H2,19,20,21)

描述信息

D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors
D002491 - Central Nervous System Agents > D018696 - Neuroprotective Agents
C26170 - Protective Agent > C1509 - Neuroprotective Agent
D049990 - Membrane Transport Modulators
D020011 - Protective Agents

同义名列表

3 个代谢物同义名

Sipatrigine; BW619c89; Sipatrigine



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 AXIN2, CA1, EDN1, KCNK2, NPPB
Peripheral membrane protein 1 KCNK2
Endoplasmic reticulum membrane 1 KCNK2
Nucleus 2 AXIN2, KRT76
cytosol 4 AXIN2, CA1, KCNK2, KRT76
dendrite 1 KCNK2
centrosome 1 AXIN2
nucleoplasm 1 SCNN1G
Cell membrane 5 KCNK10, KCNK18, KCNK2, KCNK4, SLC1A2
Cytoplasmic side 1 KCNK2
Cell projection, axon 2 KCNK2, KCNK4
Multi-pass membrane protein 9 CACNA1E, CACNA1I, KCNA3, KCNK10, KCNK18, KCNK2, KCNK4, SCNN1G, SLC1A2
Synapse 2 CACNA1E, KCNK2
cell surface 2 KCNK2, SLC1A2
glutamatergic synapse 2 KCNA3, SLC1A2
neuronal cell body 2 CACNA1E, KCNK2
presynaptic membrane 2 KCNA3, SLC1A2
sarcolemma 1 KCNK2
plasma membrane 10 AXIN2, CACNA1E, CACNA1I, KCNA3, KCNK10, KCNK18, KCNK2, KCNK4, SCNN1G, SLC1A2
Membrane 7 CACNA1E, CACNA1I, KCNA3, KCNK10, KCNK2, KCNK4, SLC1A2
apical plasma membrane 2 KCNK2, SCNN1G
axon 1 KCNA3
extracellular exosome 3 CA1, KRT76, SCNN1G
endoplasmic reticulum 1 KCNK2
extracellular space 2 EDN1, NPPB
perinuclear region of cytoplasm 1 KCNA3
Schaffer collateral - CA1 synapse 1 KCNK2
protein-containing complex 1 NPPB
Secreted 1 EDN1
extracellular region 2 EDN1, NPPB
cytoplasmic side of plasma membrane 1 KCNK2
basal part of cell 1 EDN1
external side of plasma membrane 1 SCNN1G
beta-catenin destruction complex 1 AXIN2
vesicle 1 SLC1A2
postsynaptic membrane 1 KCNA3
Apical cell membrane 1 SCNN1G
Cell membrane, sarcolemma 1 KCNK2
Membrane raft 2 KCNA3, SLC1A2
Cytoplasm, cytoskeleton 1 KCNK2
axolemma 1 SLC1A2
intermediate filament 1 KRT76
cytoskeleton 1 KCNK2
[Isoform 2]: Cell membrane 2 KCNA3, KCNK2
monoatomic ion channel complex 2 CACNA1E, KCNK10
sodium channel complex 1 SCNN1G
Cell projection, dendrite 1 KCNK2
specific granule membrane 1 KCNK2
tertiary granule membrane 1 KCNK2
cell body 1 SLC1A2
potassium channel complex 1 KCNK4
voltage-gated potassium channel complex 2 KCNA3, KCNK2
voltage-gated calcium channel complex 2 CACNA1E, CACNA1I
transport vesicle 1 EDN1
node of Ranvier 2 KCNK2, KCNK4
postsynaptic density membrane 1 KCNK2
calyx of Held 2 KCNA3, KCNK2
Synapse, synaptosome 1 KCNK2
[Isoform 1]: Cell membrane 1 KCNA3
keratin filament 1 KRT76
[Isoform 3]: Cell membrane 1 KCNK2
[Isoform 4]: Endoplasmic reticulum membrane 1 KCNK2
astrocyte projection 2 KCNK2, SLC1A2
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
neuron projection terminus 1 SLC1A2
juxtaparanode region of axon 1 KCNK2
[NT-proBNP]: Secreted 1 NPPB
[proBNP(3-108)]: Secreted 1 NPPB
[Brain natriuretic peptide 32]: Secreted 1 NPPB
[BNP(3-32)]: Secreted 1 NPPB
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
membrane protein complex 1 SLC1A2
pinceau fiber 1 KCNK2


文献列表

  • Atticus H Hainsworth, Nicolle C L McNaughton, Alexey Pereverzev, Toni Schneider, Andrew D Randall. Actions of sipatrigine, 202W92 and lamotrigine on R-type and T-type Ca2+ channel currents. European journal of pharmacology. 2003 Apr; 467(1-3):77-80. doi: 10.1016/s0014-2999(03)01625-x. [PMID: 12706458]
  • K W Muir, L Holzapfel, K R Lees. Phase II clinical trial of sipatrigine (619C89) by continuous infusion in acute stroke. Cerebrovascular diseases (Basel, Switzerland). 2000 Nov; 10(6):431-6. doi: 10.1159/000016103. [PMID: 11070372]
  • N C McNaughton, A H Hainsworth, P J Green, A D Randall. Inhibition of recombinant low-voltage-activated Ca(2+) channels by the neuroprotective agent BW619C89 (Sipatrigine). Neuropharmacology. 2000 Apr; 39(7):1247-53. doi: 10.1016/s0028-3908(99)00201-4. [PMID: 10760366]
  • Z Hussein, I J Fraser, K R Lees, K W Muir, M W Lunnon, S F Hobbiger, J Posner. Pharmacokinetics of 619C89, a novel neuronal sodium channel inhibitor, in acute stroke patients after loading and discrete maintenance infusions. British journal of clinical pharmacology. 1996 Jun; 41(6):505-11. doi: 10.1046/j.1365-2125.1996.03625.x. [PMID: 8799514]
  • A L Sheffer, D T Fearon, K F Austen. Methyltestosterone therapy in hereditary angioedema. Annals of internal medicine. 1977 Mar; 86(3):306-8. doi: 10.7326/0003-4819-86-3-306. [PMID: 320930]