ritodrine (BioDeep_00001868490)
Main id: BioDeep_00000002698
代谢物信息卡片
ritodrine
化学式: C17H21NO3 (287.1521)
中文名称: 4-[2-[[1-羟基-1-（4-羟基苯基）丙-2-基]氨基]乙基]苯酚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(C1=CC=C(C=C1)O)O)NCCC2=CC=C(C=C2)O
InChI: InChI=1S/C17H21NO3/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13/h2-9,12,17-21H,10-11H2,1H3/t12-,17-/m0/s1
描述信息
G - Genito urinary system and sex hormones > G02 - Other gynecologicals > G02C - Other gynecologicals > G02CA - Sympathomimetics, labour repressants
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D012102 - Reproductive Control Agents > D015149 - Tocolytic Agents
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:8872
- KEGG: C07239
- KEGGdrug: D02359
- PubChem: 33572
- DrugBank: DB00867
- ChEMBL: CHEMBL785
- MeSH: Ritodrine
- CAS: 154095-90-6
- PubChem: 9448
- CAS: 26652-09-5
- PDB-CCD: YIF
- NIKKAJI: J243.804F
- KNApSAcK: 8872
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ichiro Yamauchi, Yoriko Sakane, Yukiko Okuno, Taku Sugawa, Takuro Hakata, Haruka Fujita, Kentaro Okamoto, Daisuke Taura, Takafumi Yamashita, Keisho Hirota, Yohei Ueda, Toshihito Fujii, Akihiro Yasoda, Nobuya Inagaki. High-throughput Screening in Combination With a Cohort Study for Iodothyronine Deiodinases.
Endocrinology.
2022 08; 163(8):. doi:
10.1210/endocr/bqac090. [PMID: 35695766] - Manabu Ogoyama, Hironori Takahashi, Yukako Kobayashi, Rie Usui, Shigeki Matsubara. Ritodrine-induced rhabdomyolysis, infantile myotonic dystrophy, and maternal myotonic dystrophy unveiled.
The journal of obstetrics and gynaecology research.
2017 Feb; 43(2):403-407. doi:
10.1111/jog.13211. [PMID: 27987333] - Hiraku Onishi, Kei Yumoto, Osamu Sakata. Oral Biodisposition Study of Ritodrine after Its Buccal Administration in Rats.
Current drug delivery.
2017; 14(5):634-640. doi:
10.2174/1567201814666170126112108. [PMID: 28128069] - Hiraku Onishi, Osamu Sakata, Kei Yumoto. In vitro and in vivo evaluations of buccal tablet formulations of ritodrine hydrochloride.
Biological & pharmaceutical bulletin.
2015; 38(6):919-25. doi:
10.1248/bpb.b14-00833. [PMID: 26027834] - Hiraku Onishi, Kei Yumoto, Osamu Sakata. Preparation and evaluation of ritodrine buccal tablets for rational therapeutic use.
International journal of pharmaceutics.
2014 Jul; 468(1-2):207-13. doi:
10.1016/j.ijpharm.2014.04.009. [PMID: 24709218] - Hiroshi Kimura, Hiroyoshi Yuki. [A case of swelling of salivary gland due to drug treatment for threatened premature labor].
Nihon Jibiinkoka Gakkai kaiho.
2014 Jul; 117(7):928-31. doi:
10.3950/jibiinkoka.117.928. [PMID: 25158563] - Osamu Sakata, Hiraku Onishi. In vivo absorption study of ritodrine hydrochloride in the buccal administration to rats.
Drug development and industrial pharmacy.
2013 Sep; 39(9):1414-20. doi:
10.3109/03639045.2012.704044. [PMID: 22779426] - Hiroyoshi Tsuchiya, Junji Sato, Hidetoshi Tsuda, Yoko Fujiwara, Toshiyuki Yamada, Akio Fujimura, Taka-Aki Koshimizu. Serum amyloid A upsurge precedes standard biomarkers of hepatotoxicity in ritodrine-injected mice.
Toxicology.
2013 Mar; 305(?):79-88. doi:
10.1016/j.tox.2013.01.012. [PMID: 23370008] - Hiroyoshi Tsuchiya, Kentarou Ushijima, Yoko Fujiwara, Akio Fujimura, Taka-aki Koshimizu. Chronic ritodrine treatment induces refractoriness of glucose-lowering β2 adrenoceptor signal in female mice.
Regulatory toxicology and pharmacology : RTP.
2012 Apr; 62(3):561-7. doi:
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Urological research.
2012 Apr; 40(2):163-9. doi:
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Frontiers in pharmacology.
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Kidney international.
2011 Jul; 80(1):119-23. doi:
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Critical reviews in toxicology.
2011 Apr; 41(4):263-91. doi:
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Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2011 Jan; 131(1):139-52. doi:
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Journal of clinical research in pediatric endocrinology.
2011; 3(3):144-8. doi:
10.4274/jcrpe.v3i3.28. [PMID: 21911328] - Ainari Konda, Mayuko Soma, Taku Ito, Yuriko Yakeuchi, Takaki Toda, Toru Hayakawa, Nobuo Inotsume. Stereoselective analysis of ritodrine diastereomers in human serum using HPLC.
Journal of chromatographic science.
2010 Jul; 48(6):503-6. doi:
10.1093/chromsci/48.6.503. [PMID: 20822668] - Daniele Di Corcia, Veronica Morra, Marco Pazzi, Marco Vincenti. Simultaneous determination of beta2-agonists in human urine by fast-gas chromatography/mass spectrometry: method validation and clinical application.
Biomedical chromatography : BMC.
2010 Apr; 24(4):358-66. doi:
10.1002/bmc.1300. [PMID: 19642085] - Antonio Marzo, Katrin Coa, Elena Fontana, Simona Tavazzi, Lorenzo Dal Bo, Shefqet Ismaili, Dario Zava, Vittorio Cantoni, Andrea Bertolini. Pharmacokinetics and pharmacodynamics of ritodrine hydrochloride administered orally and intramuscularly to female healthy volunteers.
Arzneimittel-Forschung.
2010; 60(8):510-8. doi:
10.1055/s-0031-1296320. [PMID: 20863008] - A Konda, T Ito, H Yoshida, T Toda, T Hayakawa, N Inotsume. Pharmacokinetics of ritodrine diastereomers in patients pregnant with singletons and twins.
European journal of clinical pharmacology.
2009 Sep; 65(9):913-7. doi:
10.1007/s00228-009-0665-0. [PMID: 19471911] - Marie Nagai, Takahiro Fukamachi, Masayuki Tsujimoto, Kenichiro Ogura, Akira Hiratsuka, Hisakazu Ohtani, Satoko Hori, Yasufumi Sawada. Inhibitory effects of herbal extracts on the activity of human sulfotransferase isoform sulfotransferase 1A3 (SULT1A3).
Biological & pharmaceutical bulletin.
2009 Jan; 32(1):105-9. doi:
10.1248/bpb.32.105. [PMID: 19122289] - Aixiang Liu, Fei Liu, Yu Xu, Fang Xu, Wanqun Hu, Qingxiang Guo. Determination of ritodrine in human plasma by high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 May; 867(1):144-8. doi:
10.1016/j.jchromb.2008.03.007. [PMID: 18378197] - A Konda, A Nodai, M Soma, Y Koga, H Yoshida, T Toda, T Hayakawa, N Inotsume. Ritodrine pharmacokinetics in twin pregnancy patients.
European journal of clinical pharmacology.
2008 Apr; 64(4):399-404. doi:
10.1007/s00228-007-0423-0. [PMID: 18087698] - Tomofumi Ohmori, Mitsuhiro Nakamura, Shin Tada, Tadashi Sugiyama, Yoshinori Itoh, Yasuhiro Udagawa, Kazuyuki Hirano. A highly sensitive assay for ritodrine in human serum by hydrophilic interaction chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2008 Jan; 861(1):95-100. doi:
10.1016/j.jchromb.2007.11.010. [PMID: 18054846] - Jerry Chan, Dominique Cabrol, Ingemar Ingemarsson, Karel Marsal, Jean-Marie Moutquin, Nicholas M Fisk. Pragmatic comparison of beta2-agonist side effects within the Worldwide Atosiban versus Beta Agonists study.
European journal of obstetrics, gynecology, and reproductive biology.
2006 Sep; 128(1-2):135-41. doi:
10.1016/j.ejogrb.2006.01.030. [PMID: 16504369] - Yoshio Furihata, Mamoru Kobayashi, Masami Kojima, Kaoru Kobayashi, Tatsuhiko Kawarabayashi, Toshinori Yamamoto. Effects of KUR-1246, a selective uterine relaxant, on transplacental passage and transmigration to milk.
The journal of obstetrics and gynaecology research.
2006 Feb; 32(1):4-9. doi:
10.1111/j.1447-0756.2006.00363.x. [PMID: 16445519] - Kaei Nasu, Terumasa Sugano, Jun Yoshimatsu, Hisashi Narahara. Rhabdomyolysis caused by tocolysis with oral ritodrine hydrochloride in a pregnant patient with myotonic dystrophy.
Gynecologic and obstetric investigation.
2006; 61(1):53-5. doi:
10.1159/000088531. [PMID: 16192734] - Gian Maria Pacifici. Sulfation of drugs and hormones in mid-gestation human fetus.
Early human development.
2005 Jul; 81(7):573-81. doi:
10.1016/j.earlhumdev.2004.10.021. [PMID: 16009282] - Leslie C Dickson, James D MacNeil, Stephen Lee, Adrian C E Fesser. Determination of beta-agonist residues in bovine urine using liquid chromatography-tandem mass spectrometry.
Journal of AOAC International.
2005 Jan; 88(1):46-56. doi:
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Journal of analytical toxicology.
2004 Jan; 28(1):27-34. doi:
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Obstetrics and gynecology.
2002 Sep; 100(3):487-94. doi:
10.1016/s0029-7844(02)02141-5. [PMID: 12220768] - Naoko Ohta, Hirokazu Tsukahara, Nobuko Yamashita, Ritsuyo Kobata, Masahiro Hiraoka, Kenichi Shukunami, Kumiko Hosokawa, Fumikazu Kotsuji, Mitsufumi Mayumi. Infantile renal dysfunction associated with intrauterine exposure to ritodrine and magnesium sulfate.
Nephron.
2002 Jun; 91(2):352-3. doi:
10.1159/000058420. [PMID: 12053081] - A J Douglas, G Leng, J A Russell. The importance of oxytocin mechanisms in the control of mouse parturition.
Reproduction (Cambridge, England).
2002 Apr; 123(4):543-52. doi:
10.1530/rep.0.1230543. [PMID: 11914117] - Yoshio Matsuda, Yumiko Nagayoshi, Nami Kirihara. Evaluation of creatine kinase level during long-term tocolysis.
Journal of perinatal medicine.
2002; 30(6):476-9. doi:
10.1515/jpm.2002.074. [PMID: 12530103] - Akihisa Taniguchi, Hidehiro Kakizaki, Masashi Murakumo, Katsuya Nonomura, Tomohiko Koyanagi. [Management of pregnancy and delivery after augmentation cystoplasty].
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2002 Jan; 93(1):39-43. doi:
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2001 Aug; 759(1):27-32. doi:
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Journal of perinatal medicine.
2000; 28(3):228-31. doi:
10.1515/jpm.2000.031. [PMID: 10923307] - S Bertini, G Coruzzi, L Intorre, G Soldani. Effects of beta3-adrenoceptor agonist SR 58611A on gastric acid secretion and histamine release in the dog: comparison with ritodrine.
General pharmacology.
1998 Oct; 31(4):625-31. doi:
10.1016/s0306-3623(98)00068-8. [PMID: 9792227] - F Plenge-Tellechea, F Soler, F Fernandez-Belda. Ritodrine inhibition of the plasma membrane Ca2+-ATPase from human erythrocyte.
Archives of biochemistry and biophysics.
1998 Sep; 357(2):179-84. doi:
10.1006/abbi.1998.0812. [PMID: 9735158] - T Watanabe, H Minakami, S Matsubara, Y Honma, A Uchida, I Sato. Effect of daily vaginal disinfection on duration of gestation after premature rupture of the membranes and on infant outcome.
The journal of obstetrics and gynaecology research.
1998 Aug; 24(4):285-90. doi:
10.1111/j.1447-0756.1998.tb00091.x. [PMID: 9798359] - J M Bassett, M E Symonds. Beta2-agonist ritodrine, unlike natural catecholamines, activates thermogenesis prematurely in fetal sheep.
The American journal of physiology.
1998 07; 275(1):R112-9. doi:
10.1152/ajpregu.1998.275.1.r112. [PMID: 9688968] - H Minakami, I Sato, Y Gunj, Y Taniguchi. Idiopathic hyperamylasemia.
Hepato-gastroenterology.
1998 Jul; 45(22):1148-9. doi:
NULL. [PMID: 9756023] - N Kaga, Y Katsuki, S Kajikawa, Y Shibutani. Preventive effect of ritodrine hydrochloride and/or urinary trypsin inhibitor against lipopolysaccharide-induced preterm delivery in mice.
Acta obstetricia et gynecologica Scandinavica.
1997 Oct; 76(9):811-6. doi:
10.3109/00016349709024357. [PMID: 9351404] - G L Braden, P T von Oeyen, M J Germain, D J Watson, B L Haag. Ritodrine- and terbutaline-induced hypokalemia in preterm labor: mechanisms and consequences.
Kidney international.
1997 Jun; 51(6):1867-75. doi:
10.1038/ki.1997.255. [PMID: 9186877] - F Marques, M P Bicho. Activation of a NADH dehydrogenase in the human erythrocyte by beta-adrenergic agonists: possible involvement of a G protein in enzyme activation.
Biological signals.
1997 Mar; 6(2):52-61. doi:
10.1159/000109109. [PMID: 9266092] - T Takahashi, H Minakami, T Tamada, I Sato. Hyperamylasemia in response to ritodrine or ephedrine administered to pregnant women.
Journal of the American College of Surgeons.
1997 Jan; 184(1):31-6. doi:
NULL. [PMID: 8989297] - P Hantson, J Y Lambermont, P Mahieu. Methanol poisoning during late pregnancy.
Journal of toxicology. Clinical toxicology.
1997; 35(2):187-91. doi:
10.3109/15563659709001191. [PMID: 9120889] - M Hirai, I Yasuhi, T Ishimaru, T Yamabe, K Kubota. [Effect of prolonged intravenous ritodrine tocolysis on diurnal glucose profiles in pregnant women with normal carbohydrate tolerance].
Nihon Sanka Fujinka Gakkai zasshi.
1996 Jul; 48(7):488-94. doi:
NULL. [PMID: 8754389] - A Daftary, J P Chiao, S N Caritis. Alterations in ovine myometrial beta-adrenergic cascade do not mediate tachyphylaxis to ritodrine.
The Journal of maternal-fetal medicine.
1996 May; 5(3):155-60. doi:
10.1002/(sici)1520-6661(199605/06)5:3<155::aid-mfm11>3.0.co;2-i. [PMID: 8796787] - F De Arcos, E Gratacós, M Palacio, V Cararach. Toxic hepatitis: a rare complication associated with the use of ritodrine during pregnancy.
Acta obstetricia et gynecologica Scandinavica.
1996 Apr; 75(4):340-2. doi:
10.3109/00016349609033327. [PMID: 8638452] - O Shen, O Lavie, S Grisaru, Y Aboulafia, Y Z Diamant. Elevated serum liver enzyme concentrations during ritodrine therapy.
Acta obstetricia et gynecologica Scandinavica.
1996 Feb; 75(2):183-4. doi:
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Journal of perinatal medicine.
1996; 24(3):283-5. doi:
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Life sciences.
1995 Mar; 56(17):PL325-31. doi:
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Annals of the New York Academy of Sciences.
1994 Sep; 732(?):495-6. doi:
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Biochemical medicine and metabolic biology.
1994 Aug; 52(2):128-31. doi:
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European journal of obstetrics, gynecology, and reproductive biology.
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Masui. The Japanese journal of anesthesiology.
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European journal of obstetrics, gynecology, and reproductive biology.
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Gynecologic and obstetric investigation.
1994; 37(1):10-3. doi:
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British journal of obstetrics and gynaecology.
1993 Dec; 100(12):1107-10. doi:
10.1111/j.1471-0528.1993.tb15174.x. [PMID: 8297844] - S A Laifer, P N Rauk. Ritodrine increases leukotriene B4 concentrations in pregnant sheep.
American journal of obstetrics and gynecology.
1993 Oct; 169(4):956-60. doi:
10.1016/0002-9378(93)90034-g. [PMID: 8238156] - E Schiff, E Sivan, S Terry, M Dulitzky, S A Friedman, S Mashiach, B M Sibai. Currently recommended oral regimens for ritodrine tocolysis result in extremely low plasma levels.
American journal of obstetrics and gynecology.
1993 Oct; 169(4):1059-64. doi:
10.1016/0002-9378(93)90054-m. [PMID: 8238120] - P N Rauk, S A Laifer. The prostaglandin synthesis inhibitor ketorolac blocks ritodrine-stimulated production of prostaglandin F2 alpha in pregnant sheep.
Obstetrics and gynecology.
1993 Mar; 81(3):323-6. doi:
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American journal of obstetrics and gynecology.
1993 Feb; 168(2):693-7. doi:
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European journal of clinical pharmacology.
1993; 44(3):259-64. doi:
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Acta medica Okayama.
1992 Dec; 46(6):443-8. doi:
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American journal of obstetrics and gynecology.
1992 Sep; 167(3):758-65. doi:
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Magnesium research.
1992 Sep; 5(3):179-81. doi:
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Experimental physiology.
1992 Jul; 77(4):637-40. doi:
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The Journal of pharmacology and experimental therapeutics.
1992 Jul; 262(1):48-59. doi:
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Journal of perinatal medicine.
1992; 20(4):289-95. doi:
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Obstetrics and gynecology.
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The Journal of pharmacology and experimental therapeutics.
1991 Sep; 258(3):897-902. doi:
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1991 Jul; 37(7):1305-6. doi:
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American journal of obstetrics and gynecology.
1991 Apr; 164(4):1005-11; discussion 1011. doi:
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European journal of obstetrics, gynecology, and reproductive biology.
1991 Jan; 38(1):15-8. doi:
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1991; 4(1):32-6. doi:
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Pediatric research.
1990 Oct; 28(4):388-93. doi:
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1990 Jul; 18(4):488-93. doi:
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1990 Jul; 149(10):730-3. doi:
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American journal of obstetrics and gynecology.
1990 May; 162(5):1215-9. doi:
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Southern medical journal.
1990 May; 83(5):503-6. doi:
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European journal of obstetrics, gynecology, and reproductive biology.
1990 May; 35(2-3):179-82. doi:
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1990 Apr; 70(4):400-6. doi:
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American journal of obstetrics and gynecology.
1990 Apr; 162(4):1048-53. doi:
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American journal of obstetrics and gynecology.
1990 Feb; 162(2):429-37. doi:
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1989 Oct; 74(4):567-72. doi:
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American journal of obstetrics and gynecology.
1989 Sep; 161(3):788-95. doi:
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American journal of obstetrics and gynecology.
1989 Aug; 161(2):318-21. doi:
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American journal of obstetrics and gynecology.
1989 Jul; 161(1):32-5. doi:
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Clinical chemistry.
1989 Jul; 35(7):1542-3. doi:
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Nihon Sanka Fujinka Gakkai zasshi.
1989 Mar; 41(3):321-7. doi:
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Gynecologic and obstetric investigation.
1989; 27(1):10-3. doi:
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Gynecologic and obstetric investigation.
1989; 28(3):132-7. doi:
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Obstetrics and gynecology.
1989 Jan; 73(1):117-22. doi:
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American journal of obstetrics and gynecology.
1988 Dec; 159(6):1467-73. doi:
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Investigative radiology.
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