TRIMETHAPHAN (BioDeep_00001868299)

Main id: BioDeep_00000006435

 


代谢物信息卡片


TRIMETHAPHAN

化学式: C22H25N2OS+ (365.1688)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC2C3C(C[S+]2C1)N(C(=O)N3CC4=CC=CC=C4)CC5=CC=CC=C5
InChI: InChI=1S/C22H25N2OS/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18/h1-6,8-11,19-21H,7,12-16H2/q+1

描述信息

C - Cardiovascular system > C02 - Antihypertensives > C02B - Antiadrenergic agents, ganglion-blocking > C02BA - Sulfonium derivatives
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C66886 - Nicotinic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D005730 - Ganglionic Blockers
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002491 - Central Nervous System Agents

同义名列表

2 个代谢物同义名

TRIMETHAPHAN; Trimethaphan



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 AXIN2, CA1, POMC, PPY, SNCA
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 1 SLC33A1
Nucleus 3 ACHE, AXIN2, SNCA
cytosol 6 AVP, AXIN2, CA1, GPT, SNCA, SST
dendrite 1 AVP
centrosome 1 AXIN2
Cell membrane 4 ACHE, ADRB3, AGTR2, GPRC5A
Cell projection, axon 1 SNCA
Multi-pass membrane protein 5 ADRB3, AGTR2, CACNA1I, GPRC5A, SLC33A1
Synapse 2 ACHE, SNCA
cell cortex 1 SNCA
cell surface 1 ACHE
glutamatergic synapse 1 ICAM5
Golgi apparatus 1 ACHE
Golgi membrane 2 INS, SLC33A1
growth cone 1 SNCA
neuromuscular junction 1 ACHE
neuronal cell body 3 GIP, SNCA, SST
postsynapse 2 ICAM5, SNCA
Lysosome 1 SNCA
plasma membrane 12 ACHE, ADRB3, AGTR2, AXIN2, BCHE, CACNA1I, GCG, GPRC5A, ICAM5, REN, SLC33A1, SNCA
synaptic vesicle membrane 1 SNCA
Membrane 6 ACHE, CACNA1I, ICAM5, REN, SLC33A1, SNCA
axon 1 SNCA
extracellular exosome 3 CA1, GPRC5A, GPT
extracellular space 11 ACHE, AVP, BCHE, GCG, GIP, INS, POMC, PPY, REN, SNCA, SST
perinuclear region of cytoplasm 2 ACHE, SNCA
mitochondrion 1 SNCA
protein-containing complex 1 SNCA
intracellular membrane-bounded organelle 1 GPRC5A
Single-pass type I membrane protein 1 ICAM5
Secreted 10 ACHE, AVP, BCHE, GCG, INS, POMC, PPY, REN, SNCA, SST
extracellular region 11 ACHE, AVP, BCHE, GCG, GIP, INS, POMC, PPY, REN, SNCA, SST
Extracellular side 1 ACHE
actin cytoskeleton 1 SNCA
beta-catenin destruction complex 1 AXIN2
nucleolus 1 GPRC5A
apical part of cell 1 REN
vesicle 1 GPRC5A
GABA-ergic synapse 1 SST
basement membrane 1 ACHE
secretory granule 2 AVP, POMC
receptor complex 2 ADRB3, GPRC5A
supramolecular fiber 1 SNCA
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 GPRC5A
side of membrane 1 ACHE
secretory granule lumen 4 GCG, GIP, INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 BCHE, GCG, GIP, INS
axon terminus 1 SNCA
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 2 AVP, SST
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 1 AVP
synaptic cleft 1 ACHE
[Glucagon-like peptide 1]: Secreted 1 GCG
inclusion body 1 SNCA
[Isoform H]: Cell membrane 1 ACHE


文献列表

  • Jens Jordan, Cyndya Shibao, Italo Biaggioni. Multiple system atrophy: using clinical pharmacology to reveal pathophysiology. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2015 Feb; 25(1):53-9. doi: 10.1007/s10286-015-0271-4. [PMID: 25757803]
  • Alfredo Gamboa, Luis E Okamoto, Amy C Arnold, Rocio A Figueroa, André Diedrich, Satish R Raj, Sachin Y Paranjape, Ginnie Farley, Naji Abumrad, Italo Biaggioni. Autonomic blockade improves insulin sensitivity in obese subjects. Hypertension (Dallas, Tex. : 1979). 2014 Oct; 64(4):867-74. doi: 10.1161/hypertensionaha.114.03738. [PMID: 25001269]
  • David A Mitchell, Gavin Lambert, Niels H Secher, Peter B Raven, Johannes van Lieshout, Murray D Esler. Jugular venous overflow of noradrenaline from the brain: a neurochemical indicator of cerebrovascular sympathetic nerve activity in humans. The Journal of physiology. 2009 Jun; 587(Pt 11):2589-97. doi: 10.1113/jphysiol.2008.167999. [PMID: 19403604]
  • Melissa Li, Xiaoling Dai, Stephanie Watts, David Kreulen, Gregory Fink. Increased superoxide levels in ganglia and sympathoexcitation are involved in sarafotoxin 6c-induced hypertension. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 Nov; 295(5):R1546-54. doi: 10.1152/ajpregu.00783.2007. [PMID: 18768769]
  • Yehonatan Sharabi, David S Goldstein, Oladi Bentho, Ahmed Saleem, Sandra Pechnik, Marilla F Geraci, Courtney Holmes, Karel Pacak, Graeme Eisenhofer. Sympathoadrenal function in patients with paroxysmal hypertension: pseudopheochromocytoma. Journal of hypertension. 2007 Nov; 25(11):2286-95. doi: 10.1097/hjh.0b013e3282ef5fac. [PMID: 17921824]
  • Frans H H Leenen, Anne Fourney, Elizabeth Coletta, Roselyn White. Effects of hypertension on cardiovascular responses to epinephrine in humans. American journal of physiology. Heart and circulatory physiology. 2007 Jun; 292(6):H3025-31. doi: 10.1152/ajpheart.01200.2006. [PMID: 17307999]
  • R K Crowley, M Sherlock, A Agha, D Smith, C J Thompson. Clinical insights into adipsic diabetes insipidus: a large case series. Clinical endocrinology. 2007 Apr; 66(4):475-82. doi: 10.1111/j.1365-2265.2007.02754.x. [PMID: 17371462]
  • Yehonatan Sharabi, Basil Eldadah, Sheng-Ting Li, Rhaguveer Dendi, Sandra Pechnik, Courtney Holmes, David S Goldstein. Neuropharmacologic distinction of neurogenic orthostatic hypotension syndromes. Clinical neuropharmacology. 2006 May; 29(3):97-105. doi: 10.1097/01.wnf.0000220822.80640.0d. [PMID: 16772807]
  • Demetra D Christou, Pamela Parker Jones, Jens Jordan, André Diedrich, David Robertson, Douglas R Seals. Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men. Circulation. 2005 Feb; 111(4):494-8. doi: 10.1161/01.cir.0000153864.24034.a6. [PMID: 15687139]
  • Cees J Tack, Petra J van Gurp, Courtney Holmes, David S Goldstein. Local sympathetic denervation in painful diabetic neuropathy. Diabetes. 2002 Dec; 51(12):3545-53. doi: 10.2337/diabetes.51.12.3545. [PMID: 12453912]
  • D Smith, K McKenna, K Moore, W Tormey, J Finucane, J Phillips, P Baylis, C J Thompson. Baroregulation of vasopressin release in adipsic diabetes insipidus. The Journal of clinical endocrinology and metabolism. 2002 Oct; 87(10):4564-8. doi: 10.1210/jc.2002-020090. [PMID: 12364435]
  • Simon Bruce, Cees Tack, Jigisha Patel, Karel Pacak, David S Goldstein. Local sympathetic function in human skeletal muscle and adipose tissue assessed by microdialysis. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2002 Feb; 12(1):13-9. doi: 10.1007/s102860200005. [PMID: 12102443]
  • Jens Jordan, John R Shannon, Andre Diedrich, Bonnie K Black, David Robertson. Increased sympathetic activation in idiopathic orthostatic intolerance: role of systemic adrenoreceptor sensitivity. Hypertension (Dallas, Tex. : 1979). 2002 Jan; 39(1):173-8. doi: 10.1161/hy1201.097202. [PMID: 11799098]
  • D A D'Alessio, T J Kieffer, G J Taborsky, P J Havel. Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques. The Journal of clinical endocrinology and metabolism. 2001 Mar; 86(3):1253-9. doi: 10.1210/jcem.86.3.7367. [PMID: 11238517]
  • B Nellgård, G B Mackensen, G Massey, R D Pearlstein, D S Warner. The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat. Anesthesia and analgesia. 2000 Jul; 91(1):145-51. doi: 10.1097/00000539-200007000-00027. [PMID: 10866902]
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  • J R Shannon, J Jordan, A Diedrich, B Pohar, B K Black, D Robertson, I Biaggioni. Sympathetically mediated hypertension in autonomic failure. Circulation. 2000 Jun; 101(23):2710-5. doi: 10.1161/01.cir.101.23.2710. [PMID: 10851208]
  • J Jordan, J R Shannon, G Jacob, B Pohar, D Robertson. Interaction of genetic predisposition and environmental factors in the pathogenesis of idiopathic orthostatic intolerance. The American journal of the medical sciences. 1999 Nov; 318(5):298-303. doi: 10.1097/00000441-199911000-00003. [PMID: 10555091]
  • D S Goldstein, K J Swoboda, J M Miles, S W Coppack, A Aneman, C Holmes, I Lamensdorf, G Eisenhofer. Sources and physiological significance of plasma dopamine sulfate. The Journal of clinical endocrinology and metabolism. 1999 Jul; 84(7):2523-31. doi: 10.1210/jcem.84.7.5864. [PMID: 10404831]
  • G B Mackensen, B Nellgård, Y Miura, C T Chu, F Dexter, R D Pearlstein, D S Warner. Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat. Anesthesiology. 1999 Mar; 90(3):873-81. doi: 10.1097/00000542-199903000-00031. [PMID: 10078690]
  • J Jordan, J R Shannon, B K Black, R H Lance, M D Squillante, F Costa, D Robertson. N(N)-nicotinic blockade as an acute human model of autonomic failure. Hypertension (Dallas, Tex. : 1979). 1998 May; 31(5):1178-84. doi: 10.1161/01.hyp.31.5.1178. [PMID: 9576132]
  • P J Havel, B Ahren. Activation of autonomic nerves and the adrenal medulla contributes to increased glucagon secretion during moderate insulin-induced hypoglycemia in women. Diabetes. 1997 May; 46(5):801-7. doi: 10.2337/diab.46.5.801. [PMID: 9133547]
  • J S Petersen, W Liu, D R Kapusta, K J Varner. Metformin inhibits ganglionic neurotransmission in renal nerves. Hypertension (Dallas, Tex. : 1979). 1997 May; 29(5):1173-7. doi: 10.1161/01.hyp.29.5.1173. [PMID: 9149683]
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  • N Nagata, T Matsukado, M Takeshita, G Yoshikawa, M Takasaki. [Effect of deliberate hypotension on renal functions during epidural block plus inhalation anesthesia: a comparison of prostaglandin E1 and trimethaphan]. Masui. The Japanese journal of anesthesiology. 1994 Oct; 43(10):1472-7. doi: . [PMID: 7815696]
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  • M Takasaki, S Sakimura, M Takeshita, T Hamakawa. [Pharmacokinetics of epidurally administered bupivacaine during prostaglandin E1- or trimetaphan-induced hypotension]. Masui. The Japanese journal of anesthesiology. 1992 May; 41(5):779-84. doi: NULL. [PMID: 1608154]
  • M Horiuchi. [Effects of hypotensive anesthesia with prostaglandin E1 or trimethaphan on renal microstructure]. Masui. The Japanese journal of anesthesiology. 1992 May; 41(5):785-90. doi: NULL. [PMID: 1608155]
  • T G Monk, M Mueller, P F White. Treatment of stress response during balanced anesthesia. Comparative effects of isoflurane, alfentanil, and trimethaphan. Anesthesiology. 1992 Jan; 76(1):39-45. doi: 10.1097/00000542-199201000-00006. [PMID: 1346082]
  • Y Nomura, M Nomura, H Koizumi, K Ozaki, M Kawamata, M Fujita. [Effects of induced hypotensive anesthesia on the blood coagulation-fibrinolysis system measured by thrombelastography--comparison between prostaglandin E1 and trimethaphan]. Masui. The Japanese journal of anesthesiology. 1992 Jan; 41(1):86-91. doi: . [PMID: 1545507]
  • K Abe, A Demizu, K Kamada, T Morimoto, T Sakaki, I Yoshiya. Local cerebral blood flow with prostaglandin E1 or trimethaphan during cerebral aneurysm clip ligation. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 1991 Oct; 38(7):831-6. doi: 10.1007/bf03036956. [PMID: 1742816]
  • E Grossman, P C Chang, A Hoffman, M Tamrat, D S Goldstein. Evidence for functional alpha 2-adrenoceptors on vascular sympathetic nerve endings in the human forearm. Circulation research. 1991 Oct; 69(4):887-97. doi: 10.1161/01.res.69.4.887. [PMID: 1657439]
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  • M A Takiyyuddin, A D Baron, J H Cervenka, J A Barbosa, H P Neumann, R J Parmer, P A Sullivan, D T O'Connor. Suppression of chromogranin-A release from neuroendocrine sources in man: pharmacological studies. The Journal of clinical endocrinology and metabolism. 1991 Mar; 72(3):616-22. doi: 10.1210/jcem-72-3-616. [PMID: 1671783]
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  • S Takeda, Y Inada, T Tomaru, T Ikeda, N Tashiro, F Morimoto, F Shibata. [Plasma and red blood cell cyanide concentrations during hypotension induced by sodium nitroprusside or by a nitroprusside-trimetaphan mixture in rabbits]. Masui. The Japanese journal of anesthesiology. 1990 Jun; 39(6):701-7. doi: . [PMID: 2388388]
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  • Y Tanifuji, K Kageyama, N Yasuda, K Kobayashi. [Effect of controlled hypotension on inorganic fluoride and renal function after enflurane anesthesia. Difference between trimetaphan and sodium nitroprusside]. Masui. The Japanese journal of anesthesiology. 1985 Jul; 34(7):953-9. doi: . [PMID: 4057545]
  • N R Fahmy, N A Soter. Effects of trimethaphan on arterial blood histamine and systemic hemodynamics in humans. Anesthesiology. 1985 May; 62(5):562-6. doi: 10.1097/00000542-198505000-00003. [PMID: 2581479]
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