Trimethaphan (BioDeep_00000006435)

human metabolite blood metabolite Chemicals and Drugs

代谢物信息卡片

3,5-dibenzyl-4-oxo-8λ⁴-thia-3,5-diazatricyclo[6.3.0.0²,⁶]undecan-8-ylium

化学式: C22H25N2OS+ (365.1688)
中文名称:
谱图信息: 最多检出来源 Mentha canadensis(plant) 85.71%

分子结构信息

SMILES: C1CC2C3C(C[S+]2C1)N(C(=O)N3CC4=CC=CC=C4)CC5=CC=CC=C5
InChI: InChI=1S/C22H25N2OS/c25-22-23(14-17-8-3-1-4-9-17)19-16-26-13-7-12-20(26)21(19)24(22)15-18-10-5-2-6-11-18/h1-6,8-11,19-21H,7,12-16H2/q+1

描述信息

Trimethaphan is only found in individuals that have used or taken this drug. It is a nicotinic antagonist that has been used as a ganglionic blocker in hypertension, as an adjunct to anesthesia, and to induce hypotension during surgery. [PubChem]Trimethaphan is a ganglionic blocking agent prevents stimulation of postsynaptic receptors by competing with acetylcholine for these receptor sites. Additional effects may include direct peripheral vasodilation and release of histamine. Trimethaphans hypotensive effect is due to reduction in sympathetic tone and vasodilation, and is primarily postural.
C - Cardiovascular system > C02 - Antihypertensives > C02B - Antiadrenergic agents, ganglion-blocking > C02BA - Sulfonium derivatives
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C66886 - Nicotinic Antagonist
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D005730 - Ganglionic Blockers
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002491 - Central Nervous System Agents

同义名列表

6 个代谢物同义名

3,5-dibenzyl-4-oxo-8λ⁴-thia-3,5-diazatricyclo[6.3.0.0²,⁶]undecan-8-ylium; Trimetaphanum; TRIMETHAPHAN; Thimethaphan; Trimetaphan; Trimethaphan

数据库引用编号

16 个数据库交叉引用编号

ChEBI: CHEBI:9728
KEGG: C07174
PubChem: 23576
HMDB: HMDB0015248
DrugBank: DB01116
ChEMBL: CHEMBL1201329
Wikipedia: Trimetaphan camsilate
MeSH: Trimethaphan
chemspider: 22044
CAS: 7187-66-8
CAS: 7728-39-4
PMhub: MS000019472
PubChem: 9383
NIKKAJI: J209.355C
RefMet: Trimethaphan
KNApSAcK: 9728

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 - Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位		关联基因列表
Cytoplasm	5	AXIN2, CA1, POMC, PPY, SNCA
Peripheral membrane protein	1	ACHE
Endoplasmic reticulum membrane	1	SLC33A1
Nucleus	3	ACHE, AXIN2, SNCA
cytosol	6	AVP, AXIN2, CA1, GPT, SNCA, SST
dendrite	1	AVP
centrosome	1	AXIN2
Cell membrane	4	ACHE, ADRB3, AGTR2, GPRC5A
Cell projection, axon	1	SNCA
Multi-pass membrane protein	5	ADRB3, AGTR2, CACNA1I, GPRC5A, SLC33A1
Synapse	2	ACHE, SNCA
cell cortex	1	SNCA
cell surface	1	ACHE
glutamatergic synapse	1	ICAM5
Golgi apparatus	1	ACHE
Golgi membrane	2	INS, SLC33A1
growth cone	1	SNCA
neuromuscular junction	1	ACHE
neuronal cell body	3	GIP, SNCA, SST
postsynapse	2	ICAM5, SNCA
Lysosome	1	SNCA
plasma membrane	12	ACHE, ADRB3, AGTR2, AXIN2, BCHE, CACNA1I, GCG, GPRC5A, ICAM5, REN, SLC33A1, SNCA
synaptic vesicle membrane	1	SNCA
Membrane	6	ACHE, CACNA1I, ICAM5, REN, SLC33A1, SNCA
axon	1	SNCA
extracellular exosome	3	CA1, GPRC5A, GPT
extracellular space	11	ACHE, AVP, BCHE, GCG, GIP, INS, POMC, PPY, REN, SNCA, SST
perinuclear region of cytoplasm	2	ACHE, SNCA
mitochondrion	1	SNCA
protein-containing complex	1	SNCA
intracellular membrane-bounded organelle	1	GPRC5A
Single-pass type I membrane protein	1	ICAM5
Secreted	10	ACHE, AVP, BCHE, GCG, INS, POMC, PPY, REN, SNCA, SST
extracellular region	11	ACHE, AVP, BCHE, GCG, GIP, INS, POMC, PPY, REN, SNCA, SST
Extracellular side	1	ACHE
actin cytoskeleton	1	SNCA
beta-catenin destruction complex	1	AXIN2
nucleolus	1	GPRC5A
apical part of cell	1	REN
vesicle	1	GPRC5A
GABA-ergic synapse	1	SST
basement membrane	1	ACHE
secretory granule	2	AVP, POMC
receptor complex	2	ADRB3, GPRC5A
supramolecular fiber	1	SNCA
blood microparticle	1	BCHE
Lipid-anchor, GPI-anchor	1	ACHE
endosome lumen	1	INS
Cytoplasmic vesicle membrane	1	GPRC5A
side of membrane	1	ACHE
secretory granule lumen	4	GCG, GIP, INS, POMC
Golgi lumen	1	INS
endoplasmic reticulum lumen	4	BCHE, GCG, GIP, INS
axon terminus	1	SNCA
voltage-gated calcium channel complex	1	CACNA1I
transport vesicle	1	INS
Endoplasmic reticulum-Golgi intermediate compartment membrane	1	INS
neuronal dense core vesicle	2	AVP, SST
nuclear envelope lumen	1	BCHE
clathrin-coated endocytic vesicle membrane	1	AVP
synaptic cleft	1	ACHE
[Glucagon-like peptide 1]: Secreted	1	GCG
inclusion body	1	SNCA
[Isoform H]: Cell membrane	1	ACHE

文献列表

Jens Jordan, Cyndya Shibao, Italo Biaggioni. Multiple system atrophy: using clinical pharmacology to reveal pathophysiology. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2015 Feb; 25(1):53-9. doi: 10.1007/s10286-015-0271-4. [PMID: 25757803]
Alfredo Gamboa, Luis E Okamoto, Amy C Arnold, Rocio A Figueroa, André Diedrich, Satish R Raj, Sachin Y Paranjape, Ginnie Farley, Naji Abumrad, Italo Biaggioni. Autonomic blockade improves insulin sensitivity in obese subjects. Hypertension (Dallas, Tex. : 1979). 2014 Oct; 64(4):867-74. doi: 10.1161/hypertensionaha.114.03738. [PMID: 25001269]
David A Mitchell, Gavin Lambert, Niels H Secher, Peter B Raven, Johannes van Lieshout, Murray D Esler. Jugular venous overflow of noradrenaline from the brain: a neurochemical indicator of cerebrovascular sympathetic nerve activity in humans. The Journal of physiology. 2009 Jun; 587(Pt 11):2589-97. doi: 10.1113/jphysiol.2008.167999. [PMID: 19403604]
Melissa Li, Xiaoling Dai, Stephanie Watts, David Kreulen, Gregory Fink. Increased superoxide levels in ganglia and sympathoexcitation are involved in sarafotoxin 6c-induced hypertension. American journal of physiology. Regulatory, integrative and comparative physiology. 2008 Nov; 295(5):R1546-54. doi: 10.1152/ajpregu.00783.2007. [PMID: 18768769]
Yehonatan Sharabi, David S Goldstein, Oladi Bentho, Ahmed Saleem, Sandra Pechnik, Marilla F Geraci, Courtney Holmes, Karel Pacak, Graeme Eisenhofer. Sympathoadrenal function in patients with paroxysmal hypertension: pseudopheochromocytoma. Journal of hypertension. 2007 Nov; 25(11):2286-95. doi: 10.1097/hjh.0b013e3282ef5fac. [PMID: 17921824]
Frans H H Leenen, Anne Fourney, Elizabeth Coletta, Roselyn White. Effects of hypertension on cardiovascular responses to epinephrine in humans. American journal of physiology. Heart and circulatory physiology. 2007 Jun; 292(6):H3025-31. doi: 10.1152/ajpheart.01200.2006. [PMID: 17307999]
R K Crowley, M Sherlock, A Agha, D Smith, C J Thompson. Clinical insights into adipsic diabetes insipidus: a large case series. Clinical endocrinology. 2007 Apr; 66(4):475-82. doi: 10.1111/j.1365-2265.2007.02754.x. [PMID: 17371462]
Yehonatan Sharabi, Basil Eldadah, Sheng-Ting Li, Rhaguveer Dendi, Sandra Pechnik, Courtney Holmes, David S Goldstein. Neuropharmacologic distinction of neurogenic orthostatic hypotension syndromes. Clinical neuropharmacology. 2006 May; 29(3):97-105. doi: 10.1097/01.wnf.0000220822.80640.0d. [PMID: 16772807]
Demetra D Christou, Pamela Parker Jones, Jens Jordan, André Diedrich, David Robertson, Douglas R Seals. Women have lower tonic autonomic support of arterial blood pressure and less effective baroreflex buffering than men. Circulation. 2005 Feb; 111(4):494-8. doi: 10.1161/01.cir.0000153864.24034.a6. [PMID: 15687139]
Cees J Tack, Petra J van Gurp, Courtney Holmes, David S Goldstein. Local sympathetic denervation in painful diabetic neuropathy. Diabetes. 2002 Dec; 51(12):3545-53. doi: 10.2337/diabetes.51.12.3545. [PMID: 12453912]
D Smith, K McKenna, K Moore, W Tormey, J Finucane, J Phillips, P Baylis, C J Thompson. Baroregulation of vasopressin release in adipsic diabetes insipidus. The Journal of clinical endocrinology and metabolism. 2002 Oct; 87(10):4564-8. doi: 10.1210/jc.2002-020090. [PMID: 12364435]
Simon Bruce, Cees Tack, Jigisha Patel, Karel Pacak, David S Goldstein. Local sympathetic function in human skeletal muscle and adipose tissue assessed by microdialysis. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. 2002 Feb; 12(1):13-9. doi: 10.1007/s102860200005. [PMID: 12102443]
Jens Jordan, John R Shannon, Andre Diedrich, Bonnie K Black, David Robertson. Increased sympathetic activation in idiopathic orthostatic intolerance: role of systemic adrenoreceptor sensitivity. Hypertension (Dallas, Tex. : 1979). 2002 Jan; 39(1):173-8. doi: 10.1161/hy1201.097202. [PMID: 11799098]
D A D'Alessio, T J Kieffer, G J Taborsky, P J Havel. Activation of the parasympathetic nervous system is necessary for normal meal-induced insulin secretion in rhesus macaques. The Journal of clinical endocrinology and metabolism. 2001 Mar; 86(3):1253-9. doi: 10.1210/jcem.86.3.7367. [PMID: 11238517]
B Nellgård, G B Mackensen, G Massey, R D Pearlstein, D S Warner. The effects of anesthetics on stress responses to forebrain ischemia and reperfusion in the rat. Anesthesia and analgesia. 2000 Jul; 91(1):145-51. doi: 10.1097/00000539-200007000-00027. [PMID: 10866902]
D S Goldstein, C Tack, S T Li. Sympathetic innervation and function in reflex sympathetic dystrophy. Annals of neurology. 2000 Jul; 48(1):49-59. doi: 10.1002/1531-8249(200007)48:1<49::aid-ana8>3.0.co;2-t. [PMID: 10894215]
J R Shannon, J Jordan, A Diedrich, B Pohar, B K Black, D Robertson, I Biaggioni. Sympathetically mediated hypertension in autonomic failure. Circulation. 2000 Jun; 101(23):2710-5. doi: 10.1161/01.cir.101.23.2710. [PMID: 10851208]
J Jordan, J R Shannon, G Jacob, B Pohar, D Robertson. Interaction of genetic predisposition and environmental factors in the pathogenesis of idiopathic orthostatic intolerance. The American journal of the medical sciences. 1999 Nov; 318(5):298-303. doi: 10.1097/00000441-199911000-00003. [PMID: 10555091]
D S Goldstein, K J Swoboda, J M Miles, S W Coppack, A Aneman, C Holmes, I Lamensdorf, G Eisenhofer. Sources and physiological significance of plasma dopamine sulfate. The Journal of clinical endocrinology and metabolism. 1999 Jul; 84(7):2523-31. doi: 10.1210/jcem.84.7.5864. [PMID: 10404831]
G B Mackensen, B Nellgård, Y Miura, C T Chu, F Dexter, R D Pearlstein, D S Warner. Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat. Anesthesiology. 1999 Mar; 90(3):873-81. doi: 10.1097/00000542-199903000-00031. [PMID: 10078690]
J Jordan, J R Shannon, B K Black, R H Lance, M D Squillante, F Costa, D Robertson. N(N)-nicotinic blockade as an acute human model of autonomic failure. Hypertension (Dallas, Tex. : 1979). 1998 May; 31(5):1178-84. doi: 10.1161/01.hyp.31.5.1178. [PMID: 9576132]
P J Havel, B Ahren. Activation of autonomic nerves and the adrenal medulla contributes to increased glucagon secretion during moderate insulin-induced hypoglycemia in women. Diabetes. 1997 May; 46(5):801-7. doi: 10.2337/diab.46.5.801. [PMID: 9133547]
J S Petersen, W Liu, D R Kapusta, K J Varner. Metformin inhibits ganglionic neurotransmission in renal nerves. Hypertension (Dallas, Tex. : 1979). 1997 May; 29(5):1173-7. doi: 10.1161/01.hyp.29.5.1173. [PMID: 9149683]
M White, F H Leenen. Effects of age on cardiovascular responses to adrenaline in man. British journal of clinical pharmacology. 1997 Apr; 43(4):407-14. doi: 10.1046/j.1365-2125.1997.00561.x. [PMID: 9146853]
P J Havel, C Valverde. Autonomic mediation of glucagon secretion during insulin-induced hypoglycemia in rhesus monkeys. Diabetes. 1996 Jul; 45(7):960-6. doi: 10.2337/diab.45.7.960. [PMID: 8666149]
M C Newton, G D Chadd, B O'Donoghue, S M Sapsed-Byrne, G M Hall. Metabolic and hormonal responses to induced hypotension for middle ear surgery. British journal of anaesthesia. 1996 Mar; 76(3):352-7. doi: 10.1093/bja/76.3.352. [PMID: 8785132]
M Endoh, T Takamura, T Shiga, R Ogawa. [Effect of intra-operative fluid on renal function during hypotensive anesthesia with trimethaphan]. Masui. The Japanese journal of anesthesiology. 1996 Jan; 45(1):15-20. doi: NULL. [PMID: 8865719]
P C Chang, E Grossman, I J Kopin, D S Goldstein, C J Folio, C Holmes. On the existence of functional angiotensin II receptors on vascular sympathetic nerve terminals in the human forearm. Journal of hypertension. 1995 Nov; 13(11):1275-84. doi: 10.1097/00004872-199511000-00009. [PMID: 8984125]
M H Khadra, P M Satchell, C W Vaughan. Sympathetic nervous system effects on feline bladder wall compliance throughout continence. Acta physiologica Scandinavica. 1995 Sep; 155(1):31-9. doi: 10.1111/j.1748-1716.1995.tb09945.x. [PMID: 8553875]
J N Barendregt, L L van Nispen tot Pannerden, P C Chang. Interactions between sodium balance, intrarenal dopamine synthesis, and sympathetic activity in HLA-identical kidney donors and recipients. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 1995; 10(3):341-8. doi: . [PMID: 7792028]
N Nagata, T Matsukado, M Takeshita, G Yoshikawa, M Takasaki. [Effect of deliberate hypotension on renal functions during epidural block plus inhalation anesthesia: a comparison of prostaglandin E1 and trimethaphan]. Masui. The Japanese journal of anesthesiology. 1994 Oct; 43(10):1472-7. doi: . [PMID: 7815696]
P C Chang, E Grossman, I J Kopin, D S Goldstein. On the existence of functional beta-adrenoceptors on vascular sympathetic nerve endings in the human forearm. Journal of hypertension. 1994 Jun; 12(6):681-90. doi: NULL. [PMID: 7963493]
L H Mortensen, L E Ohman, J R Haywood. Effects of lateral parabrachial nucleus lesions in chronic renal hypertensive rats. Hypertension (Dallas, Tex. : 1979). 1994 Jun; 23(6 Pt 1):774-80. doi: 10.1161/01.hyp.23.6.774. [PMID: 8206576]
N Nagata, T Agune, M Takeshita, G Yoshikawa, M Takasaki. [Effects of induced hypotension on perioperative renal and hepatic functions]. Masui. The Japanese journal of anesthesiology. 1993 Aug; 42(8):1157-61. doi: . [PMID: 8366555]
M Takasaki, S Sakimura, M Takeshita, T Hamakawa. [Pharmacokinetics of epidurally administered bupivacaine during prostaglandin E1- or trimetaphan-induced hypotension]. Masui. The Japanese journal of anesthesiology. 1992 May; 41(5):779-84. doi: NULL. [PMID: 1608154]
M Horiuchi. [Effects of hypotensive anesthesia with prostaglandin E1 or trimethaphan on renal microstructure]. Masui. The Japanese journal of anesthesiology. 1992 May; 41(5):785-90. doi: NULL. [PMID: 1608155]
T G Monk, M Mueller, P F White. Treatment of stress response during balanced anesthesia. Comparative effects of isoflurane, alfentanil, and trimethaphan. Anesthesiology. 1992 Jan; 76(1):39-45. doi: 10.1097/00000542-199201000-00006. [PMID: 1346082]
Y Nomura, M Nomura, H Koizumi, K Ozaki, M Kawamata, M Fujita. [Effects of induced hypotensive anesthesia on the blood coagulation-fibrinolysis system measured by thrombelastography--comparison between prostaglandin E1 and trimethaphan]. Masui. The Japanese journal of anesthesiology. 1992 Jan; 41(1):86-91. doi: . [PMID: 1545507]
K Abe, A Demizu, K Kamada, T Morimoto, T Sakaki, I Yoshiya. Local cerebral blood flow with prostaglandin E1 or trimethaphan during cerebral aneurysm clip ligation. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 1991 Oct; 38(7):831-6. doi: 10.1007/bf03036956. [PMID: 1742816]
E Grossman, P C Chang, A Hoffman, M Tamrat, D S Goldstein. Evidence for functional alpha 2-adrenoceptors on vascular sympathetic nerve endings in the human forearm. Circulation research. 1991 Oct; 69(4):887-97. doi: 10.1161/01.res.69.4.887. [PMID: 1657439]
B F Cox, V S Bishop. Neural and humoral mechanisms of angiotensin-dependent hypertension. The American journal of physiology. 1991 Oct; 261(4 Pt 2):H1284-91. doi: 10.1152/ajpheart.1991.261.4.h1284. [PMID: 1681742]
R J Nelson, S Perry, A C Burns, J Roberts, J D Pickard. The effects of hyponatraemia and subarachnoid haemorrhage on the cerebral vasomotor responses of the rabbit. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 1991 Jul; 11(4):661-6. doi: 10.1038/jcbfm.1991.118. [PMID: 2050754]
K Nakazawa, C Taneyama, K T Benson, G K Unruh, H Goto. Mixtures of sodium nitroprusside and trimethaphan for induction of hypotension. Anesthesia and analgesia. 1991 Jul; 73(1):59-63. doi: 10.1213/00000539-199107000-00012. [PMID: 1858992]
K Hirota, M Muraoka, S Takahashi, E Ogasawara, H Ishihara, A Matsuki. [Effect of induced hypotension with prostaglandin E1 or trimetaphan on endocrine functions in surgical patients]. Masui. The Japanese journal of anesthesiology. 1991 May; 40(5):763-8. doi: NULL. [PMID: 2072520]
M A Takiyyuddin, A D Baron, J H Cervenka, J A Barbosa, H P Neumann, R J Parmer, P A Sullivan, D T O'Connor. Suppression of chromogranin-A release from neuroendocrine sources in man: pharmacological studies. The Journal of clinical endocrinology and metabolism. 1991 Mar; 72(3):616-22. doi: 10.1210/jcem-72-3-616. [PMID: 1671783]
E Grossman, R F Rea, A Hoffman, D S Goldstein. Yohimbine increases sympathetic nerve activity and norepinephrine spillover in normal volunteers. The American journal of physiology. 1991 Jan; 260(1 Pt 2):R142-7. doi: 10.1152/ajpregu.1991.260.1.r142. [PMID: 1847020]
S Takeda, Y Inada, T Tomaru, T Ikeda, N Tashiro, F Morimoto, F Shibata. [Plasma and red blood cell cyanide concentrations during hypotension induced by sodium nitroprusside or by a nitroprusside-trimetaphan mixture in rabbits]. Masui. The Japanese journal of anesthesiology. 1990 Jun; 39(6):701-7. doi: . [PMID: 2388388]
J P Desborough, G M Hall, G R Hart, J M Burrin, S R Bloom. Hormonal responses to cardiac surgery: effects of sufentanil, somatostatin and ganglion block. British journal of anaesthesia. 1990 Jun; 64(6):688-95. doi: 10.1093/bja/64.6.688. [PMID: 1974142]
L A Corr, R M Grounds, J L Beacham, J G Whitwam, M J Brown. Effects of circulating endogenous catecholamines on plasma glucose, potassium and magnesium. Clinical science (London, England : 1979). 1990 Feb; 78(2):185-91. doi: 10.1042/cs0780185. [PMID: 2155747]
K Kumagai, K Nakada, K Kikuchi, H Mori. [Effect of induced hypotension on damage to renal tubular cells]. Masui. The Japanese journal of anesthesiology. 1989 Oct; 38(10):1317-22. doi: . [PMID: 2573742]
S Takeda, Y Inada, T Tomaru, T Kagawa, T Ikeda, N Mozawa, F Morimoto. [Comparison of endocrine effects of hypotension induced by sodium nitroprusside, trimetaphan camsylate and a nitroprusside-trimetaphan mixture in rabbits]. Masui. The Japanese journal of anesthesiology. 1989 Sep; 38(9):1135-41. doi: . [PMID: 2681862]
C J Thompson, J Charlton, S Walford, J Baird, J Hearnshaw, A McCulloch, W Kelly, P H Baylis. Vasopressin secretion in the DIDMOAD (Wolfram) syndrome. The Quarterly journal of medicine. 1989 Apr; 71(264):333-45. doi: . [PMID: 2687931]
P Chiodera, A Gnudi, G Rossi, L Camellini, A Caiazza, C Marchesi, L Bianconi, R Volpi, V Coiro. Dopaminergic, but not cholinergic, involvement in regulation of hypoglycemia-induced oxytocin release in man. Psychoneuroendocrinology. 1989; 14(3):203-8. doi: 10.1016/0306-4530(89)90018-8. [PMID: 2667016]
H Hashemzadeh-Gargari, A J Baertschi, P G Guyenet. Baroreceptor-independent medullary mechanism for release of vasopressin during hypotension in rats. The Journal of endocrinology. 1988 Jul; 118(1):101-11. doi: 10.1677/joe.0.1180101. [PMID: 2842427]
M R Sury, M D Donaldson, M Stringer, C J Vesey, P V Cole. Cardiovascular actions of trimetaphan nitroprusside. Comparison with sodium nitroprusside in greyhounds. British journal of anaesthesia. 1988 Jun; 60(7):797-802. doi: 10.1093/bja/60.7.797. [PMID: 3395539]
Y Tanifuji, H Shima, K Mishima, N Yasuda, K Kobayashi, J Kimura. [The effect of urinastatin on renal blood flow and urine volume in deliberate hypotension anesthesia]. Masui. The Japanese journal of anesthesiology. 1988 May; 37(5):577-82. doi: NULL. [PMID: 3411781]
D S Goldstein, R Zimlichman, G D Kelly, R Stull, J D Bacher, H R Keiser. Effect of ganglion blockade on cerebrospinal fluid norepinephrine. Journal of neurochemistry. 1987 Nov; 49(5):1484-90. doi: 10.1111/j.1471-4159.1987.tb01018.x. [PMID: 3668535]
D S Goldstein, R Udelsman, G Eisenhofer, R Stull, H R Keiser, I J Kopin. Neuronal source of plasma dihydroxyphenylalanine. The Journal of clinical endocrinology and metabolism. 1987 Apr; 64(4):856-61. doi: 10.1210/jcem-64-4-856. [PMID: 3102548]
J Shimada, M Okitsu, Y Ri, Y Yamamoto, H Sumida, T Arima, T Hori. Effect of enflurane on renal function. III. Comparison with hypotensive-anesthetized group. Josai Shika Daigaku kiyo. The Bulletin of the Josai Dental University. 1987; 16(2):434-40. doi: NULL. [PMID: 3146392]
J Kastrup, J H Henriksen, J H Pedersen, J Fahrenkrug, O B Schaffalitzky de Muckadell, T Schwartz, H H Parving, N J Christensen. Effect of ganglionic blockade on endogenous circulating pancreatic polypeptide, vasoactive intestinal polypeptide, substance P, neurotensin and noradrenaline in healthy controls and long-term insulin-dependent diabetic patients. Clinical science (London, England : 1979). 1986 Oct; 71(4):411-9. doi: 10.1042/cs0710411. [PMID: 2428557]
L Corr, R M Grounds, M J Brown, J G Whitwam. Plasma catecholamine changes during cardiopulmonary bypass: a randomised double blind comparison of trimetaphan camsylate and sodium nitroprusside. British heart journal. 1986 Jul; 56(1):89-93. doi: 10.1136/hrt.56.1.89. [PMID: 3524635]
D S Goldstein, R Zimlichman, R Stull, H R Keiser, I J Kopin. Estimation of intrasynaptic norepinephrine concentrations in humans. Hypertension (Dallas, Tex. : 1979). 1986 Jun; 8(6):471-5. doi: 10.1161/01.hyp.8.6.471. [PMID: 3710555]
J H Henriksen, J Kastrup, O B Schaffalitzky De Muckadell. Arterial blood-pressure change and endogenous circulating substance P in man. Clinical physiology (Oxford, England). 1985 Aug; 5(4):377-81. doi: 10.1111/j.1475-097x.1985.tb00758.x. [PMID: 2412752]
Y Tanifuji, K Kageyama, N Yasuda, K Kobayashi. [Effect of controlled hypotension on inorganic fluoride and renal function after enflurane anesthesia. Difference between trimetaphan and sodium nitroprusside]. Masui. The Japanese journal of anesthesiology. 1985 Jul; 34(7):953-9. doi: . [PMID: 4057545]
N R Fahmy, N A Soter. Effects of trimethaphan on arterial blood histamine and systemic hemodynamics in humans. Anesthesiology. 1985 May; 62(5):562-6. doi: 10.1097/00000542-198505000-00003. [PMID: 2581479]
J E Redgrave, S L Swartz. Diagnosis and management of malignant hypertension. Comprehensive therapy. 1985 Mar; 11(3):6-10. doi: NULL. [PMID: 3979024]
R Behnia, E Koushanpour, T K Goldstick, H W Linde, R Osborn. Renal tissue oxygenation following induced hypotension in dogs. British journal of anaesthesia. 1984 Sep; 56(9):1037-43. doi: 10.1093/bja/56.9.1037. [PMID: 6466528]
J R Sowers, F W Beck, P Eggena. Effect of ganglionic blockade with trimethaphan on corticosteroid responses to metoclopramide in rhesus monkeys. Journal of hypertension. 1984 Aug; 2(4):367-70. doi: . [PMID: 6152278]
L A Newberg, J H Milde, J D Michenfelder. Systemic and cerebral effects of isoflurane-induced hypotension in dogs. Anesthesiology. 1984 Jun; 60(6):541-6. doi: 10.1097/00000542-198406000-00004. [PMID: 6731908]
M Hamaji, C Tashiro, N Oka, T Seki, Y Kawashima, I Yoshiya. Plasma catecholamine response to hypotension induced by trimethaphan and by sodium nitroprusside during nitrous oxide-oxygen-fentanyl anesthesia. Medical journal of Osaka University. 1983 Sep; 34(1-2):37-41. doi: . [PMID: 6669139]
T A Wilson, D L Kaiser, M J Peach, E M Wright, R M Carey. Possible mechanism of action of metoclopramide-induced aldosterone secretion: in vivo and in vitro studies in the sheep. Endocrinology. 1983 Sep; 113(3):887-92. doi: 10.1210/endo-113-3-887. [PMID: 6307670]
T A Wilson, D L Kaiser, R M Carey. Dopaminergic inhibition of aldosterone secretion in man is independent of the autonomic nervous system. The Journal of clinical endocrinology and metabolism. 1983 Jul; 57(1):200-3. doi: 10.1210/jcem-57-1-200. [PMID: 6853677]
W K Dong, S W Bledsoe, D Y Eng, J E Heavner, C M Shaw, T F Hornbein, J L Anderson. Profound arterial hypotension in dogs: brain electrical activity and organ integrity. Anesthesiology. 1983 Jan; 58(1):61-71. doi: 10.1097/00000542-198301000-00010. [PMID: 6848019]
S Julius, R Sanchez, S Malayan, M Hamlin, M Elkins, D Brant, D F Bohr. Sustained blood pressure elevation to lower body compression in pigs and dogs. Hypertension (Dallas, Tex. : 1979). 1982 Nov; 4(6):782-8. doi: 10.1161/01.hyp.4.6.782. [PMID: 7141604]
R Behnia, A Martin, E Koushanpour, E A Brunner. Trimethaphan-induced hypotension: effect on renal function. Canadian Anaesthetists' Society journal. 1982 Nov; 29(6):581-6. doi: 10.1007/bf03007745. [PMID: 7139398]
Z Hochberg, A M Moses, M Miller, A Benderli, R A Richman. Altered osmotic threshold for vasopressin release and impaired thirst sensation: additional abnormalities in Kallmann's syndrome. The Journal of clinical endocrinology and metabolism. 1982 Oct; 55(4):779-82. doi: 10.1210/jcem-55-4-779. [PMID: 7107821]
F Goto, E Otani, S Kato, T Fujita. Prostaglandin E1 as a hypotensive drug during general anaesthesia. Anaesthesia. 1982 May; 37(5):530-5. doi: 10.1111/j.1365-2044.1982.tb01222.x. [PMID: 7200736]
P M Kotliarov, I M Goncharova. [Pharmacoangiorheography of the kidney]. Urologiia i nefrologiia. 1981 Nov; ?(6):12-5. doi: NULL. [PMID: 7314305]
N Matsumoto, T Hori, T Miyazaki, T Goto, M Matsumoto, Y Maruno, I Sato, I Matsumoto. [Effects of halothane and trimethaphan on hepatic blood flow, oxygen consumption and serum enzyme leakage in the dog (author's transl)]. Masui. The Japanese journal of anesthesiology. 1981 Jul; 30(7):709-14. doi: NULL. [PMID: 7321160]
N R Fahmy. Consumption of vitamin B12 during sodium nitroprusside administration in humans. Anesthesiology. 1981 Apr; 54(4):305-9. doi: 10.1097/00000542-198104000-00009. [PMID: 7212330]
P H Baylis, M B Gaskill, G L Robertson. Vasopressin secretion in primary polydipsia and cranial diabetes insipidus. The Quarterly journal of medicine. 1981; 50(199):345-58. doi: 10.1093/oxfordjournals.qjmed.a067692. [PMID: 7036200]
Y Wada, K Iijima, T Yonezawa. [Tissue blood flow in brain, myocardium, liver, renal cortex and renal medulla in trimethaphan-induced hypotension (author's transl)]. Masui. The Japanese journal of anesthesiology. 1979 Nov; 28(12):1521-7. doi: NULL. [PMID: 529391]
Y Furuya, Y Ooe, S Tanaka, M Nagara, Y Yamamura, M Fujita. [Effects of vasoactive drugs on renal circulation. III. Hypotensive agents (author's transl)]. Masui. The Japanese journal of anesthesiology. 1979 Oct; 28(10):1046-53. doi: NULL. [PMID: 117155]
D T Lowenthal. Hypertensive crisis and postcrisis management. Comprehensive therapy. 1978 Dec; 4(12):32-9. doi: NULL. [PMID: 738010]
M Miyazaki, S Yokono. Comparison of various kinds of hypotensive anesthesia, especially on the influences on renal blood flow and catecholamine (preliminary report). Medical journal of Osaka University. 1978 Dec; 29(3-4):229-39. doi: NULL. [PMID: 752760]
A H Anton, S Czinn, J Jazwa, L Tam, L Amaranath. Trimethaphan camsylate (Arfonad) and human plasma cholinesterase. Research communications in chemical pathology and pharmacology. 1978 Nov; 22(2):375-83. doi: NULL. [PMID: 734220]
G Vargha, A Simay, P Vargha, S Bacsa. [Estimation of the arfonad effect by angiography and flow examination (author's transl)]. Radiologia diagnostica. 1978 Oct; 19(5):571-83. doi: NULL. [PMID: 734105]
M Takiguchi, H Ishihara, K Ishita, S Wakayama, M Yamashita, K Toyooka, M Kudo, T Oyama. [Plasma cortisol response to trimethaphan (Arfonad) induced hypotension anesthesia (author's transl)]. Masui. The Japanese journal of anesthesiology. 1978 Aug; 27(8):829-34. doi: NULL. [PMID: 691246]
J B Halter, A P Goldberg, G L Robertson, D Porte. Selective osmoreceptor dysfunction in the syndrome of chronic hypernatremia. The Journal of clinical endocrinology and metabolism. 1977 Apr; 44(4):609-16. doi: 10.1210/jcem-44-4-609. [PMID: 849975]
O G Galvez, B W Roberts, M H Mishkind, W H Bay, T F Ferris. Studies of the mechanism of contralateral polyuria after renal artery stenosis. The Journal of clinical investigation. 1977 Apr; 59(4):609-15. doi: 10.1172/jci108678. [PMID: 845253]
I J Russell, J Smith, R R Dozois, H W Wahner, L G Bartholomew. Menetrier's disease. Effect of medical and surgical vagotomy. Mayo Clinic proceedings. 1977 Feb; 52(2):91-6. doi: NULL. [PMID: 609291]
N R Fahmy. Changes in serum potassium and blood glucose concentrations after trimethaphan administration in man. The Journal of laboratory and clinical medicine. 1976 Jun; 87(6):999-1004. doi: . [PMID: 932527]
B E Sobel. Applications and limitations of estimation of infarct size from serial changes in plasma creatine phosphokinase activity. Acta medica Scandinavica. Supplementum. 1976; 587(?):151-67. doi: 10.1111/j.0954-6820.1976.tb05877.x. [PMID: 1062124]
H Schad, H Seller. A method for recording autonomic nerve activity in unanesthetized, freely moving cats. Brain research. 1975 Dec; 100(2):425-30. doi: 10.1016/0006-8993(75)90495-3. [PMID: 1192186]
S A Kenawy, A M El Masry, S F Saad, M T Khayyal, M T Abdel Aziz. Comparative study on the effect of neostigmine, trimetaphan an oxyphenonium on some aspects of 5-hydroxytryptamine metabolism in rats. The Journal of pharmacy and pharmacology. 1975 Nov; 27(11):871-3. doi: 10.1111/j.2042-7158.1975.tb10235.x. [PMID: 1501]
M Boulanger, B Paiement, J G Maillé. [Conservation of the blood]. Canadian Anaesthetists' Society journal. 1975 Jul; 22(4):387-98. doi: 10.1007/bf03004853. [PMID: 1139383]
R J Gordon, M Ravin, G R Daicoff, R E Rawitscher. Effects of hemodilution on hypotention during cardiopulmonary bypass. Anesthesia and analgesia. 1975 Jul; 54(4):482-8. doi: 10.1213/00000539-197554040-00019. [PMID: 1170785]
F W Gamache, R E Myers. Effects of hypotension on rhesus monkeys. Archives of neurology. 1975 Jun; 32(6):374-80. doi: 10.1001/archneur.1975.00490480040004. [PMID: 1169051]
J Kiersz, L Hryniewiecki, R Bernat. The effect of arfonad on blood proteins and nitrogen components in experimental shock. Acta physiologica Polonica. 1975 May; 26(3):229-39. doi: NULL. [PMID: 52282]