Levothyroxine (BioDeep_00000873025)
Main id: BioDeep_00000001625
PANOMIX_OTCML-2023 BioNovoGene_Lab2019 natural product
代谢物信息卡片
Levothyroxine
化学式: C15H11I4NO4 (776.6867)
中文名称: 左旋甲状腺素, L-甲状腺素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N
InChI: InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)
描述信息
H - Systemic hormonal preparations, excl. sex hormones and insulins > H03 - Thyroid therapy > H03A - Thyroid preparations > H03AA - Thyroid hormones
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1553 - Thyroid Agent
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
The thyronamines function via some unknown mechanism to inhibit neuronal activity; this plays an important role in the hibernation cycles of mammals. One effect of administering the thyronamines is a severe drop in body temperature.; Iodide is actively absorbed from the bloodstream and concentrated in the thyroid follicles. (If there is a deficiency of dietary iodine, the thyroid enlarges in an attempt to trap more iodine, resulting in goitre.) Via a reaction with the enzyme thyroperoxidase, iodine is covalently bound to tyrosine residues in the thyroglobulin molecules, forming monoiodotyrosine (MIT) and diiodotyrosine (DIT). Linking two moieties of DIT produces thyroxine. Combining one particle of MIT and one particle of DIT produces triiodothyronine.; Both T3 and T4 are used to treat thyroid hormone deficiency (hypothyroidism). They are both absorbed well by the gut, so can be given orally. Levothyroxine, the most commonly used synthetic thyroxine form, is a stereoisomer of physiological thyroxine, which is metabolized more slowly and hence usually only needs once-daily administration. Natural desiccated thyroid hormones, which are derived from pig thyroid glands, are a "natural" hypothyroid treatment containing 20\\\% T3 and traces of T2, T1 and calcitonin.; this plays an important role in the hibernation cycles of mammals. One effect of administering the thyronamines is a severe drop in body temperature.; The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines (diiodotyrosine) in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine which exerts a broad spectrum of stimulatory effects on cell metabolism.; The thyronamines function via some unknown mechanism to inhibit neuronal activity [HMDB]
L-Thyroxine (Levothyroxine; T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[1].
同义名列表
4 个代谢物同义名
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:18332
- KEGG: C01829
- KEGGdrug: D78141
- KEGGdrug: D08125
- PubChem: 5819
- DrugBank: DB00451
- ChEMBL: CHEMBL1624
- MeSH: Thyroxine
- foodb: FDB021829
- CAS: 51-48-9
- PubChem: 4950
- PDB-CCD: T44
- 3DMET: B01505
- NIKKAJI: J4.118A
- medchemexpress: HY-18341
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-598
- KNApSAcK: 18332
- LOTUS: LTS0233381
分类词条
相关代谢途径
Reactome(4)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
12 个相关的物种来源信息
- 7711 - Chordata: LTS0233381
- 2759 - Eukaryota: LTS0233381
- 9604 - Hominidae: LTS0233381
- 9605 - Homo: LTS0233381
- 9606 - Homo sapiens: 10.1038/NBT.2488
- 9606 - Homo sapiens: LTS0233381
- 40674 - Mammalia: LTS0233381
- 33208 - Metazoa: LTS0233381
- 10066 - Muridae: LTS0233381
- 10088 - Mus: LTS0233381
- 10090 - Mus musculus: LTS0233381
- 10090 - Mus musculus: NA
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Meng-Yuan Sheng, De-Wei Peng, Hui-Ming Peng, Ya-Li Zhang, Ling Xiao, Meng-Ru Zhang, Si-Yu Wang, Chuan-Peng Zhao, Si-Ying Zhu, Jian-Kang Lu, Li Lin, Rong Huang, Jing Nie, Jin-Bo Fang. Effective substances and molecular mechanisms guided by network pharmacology: An example study of Scrophulariae Radix treatment of hyperthyroidism and thyroid hormone-induced liver and kidney injuries.
Journal of ethnopharmacology.
2024 May; 326(?):117965. doi:
10.1016/j.jep.2024.117965. [PMID: 38423410] - Yang Li, Wen Yang, Xuewei Yang, Aijia Ma, Xuepeng Zhang, Hongxia Li, Hui Wu. Quemeiteng granule relieves goiter by suppressing thyroid microvascular endothelial cell proliferation and angiogenesis via miR-217-5p-mediated targeting of FGF2-induced regulation of the ERK pathway.
Journal of ethnopharmacology.
2024 May; 326(?):117908. doi:
10.1016/j.jep.2024.117908. [PMID: 38367931] - Lin-Na Xie, Xiao-Chen Wang, Li-Qin Su, Sai-Sai Ji, Wen Gu, Holly Barrett, Xiao-Jie Dong, Hui-Juan Zhu, Sha-Sha Hou, Zhen-Huan Li, Yi-Lin Liu, Ling Zhang, Ying Zhu. The association between per-/polyfluoroalkyl substances in serum and thyroid function parameters: A cross-sectional study on teenagers living near a Chinese fluorochemical industrial plant.
The Science of the total environment.
2024 Apr; 920(?):170985. doi:
10.1016/j.scitotenv.2024.170985. [PMID: 38367719] - Xin Tian, Yajuan Xu, Yanjie Ban, Jingjing Li, Lin Hu, Dong Liu, Lulu Hu, Zongzong Sun, Miao Zhang, Chenchen Zhang, Yixin Wang, Pengkun Lin. Evaluation of the therapeutic efficacy of different doses of LT4 in pregnant women with high-normal TSH levels and TPOAb positivity in the first half of pregnancy.
Lipids in health and disease.
2024 Apr; 23(1):101. doi:
10.1186/s12944-024-02099-9. [PMID: 38600581] - James C Fazioli, Margaret K Mulligan, Erin K Ison, J Alex Pasternak. Impact of methimazole-induced hypothyroidism on postnatal swine.
Physiological reports.
2024 Apr; 12(8):e16007. doi:
10.14814/phy2.16007. [PMID: 38658325] - Fereshteh Badini, Abolfazl Bayrami, Mohammad Ali Mirshekar, Samira Shahraki, Hamed Fanaei. Levothyroxine attenuates behavioral impairment and improves oxidative stress and histological alteration 3-nitropropionic acid induced experimental Huntington's disease in rats.
Behavioural brain research.
2024 Mar; 461(?):114864. doi:
10.1016/j.bbr.2024.114864. [PMID: 38220060] - Benjamin J Gigliotti, Sina Jasim. Differentiated thyroid cancer: a focus on post-operative thyroid hormone replacement and thyrotropin suppression therapy.
Endocrine.
2024 Feb; 83(2):251-258. doi:
10.1007/s12020-023-03548-8. [PMID: 37824045] - Guangwei Pan, Guoyuan Zhao, Lin Li, Lu Yu, Yijia Liu, Rongrong Yang, Tong Yang, Yang Wang, Jinyu Su, Zhu Li, Fengmin Liu, Chunquan Yu. Association of thyroid hormone sensitivity index with stroke in patients with coronary artery disease.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2024 Feb; 33(2):107482. doi:
10.1016/j.jstrokecerebrovasdis.2023.107482. [PMID: 38061182] - Ragaa Sm Kawara, Fatma Sm Moawed, Yakout Elsenosi, Hussein Abd Elmaksoud, Esraa S A Ahmed, Omayma Ar Abo-Zaid. Melissa officinalis extract palliates redox imbalance and inflammation associated with hyperthyroidism-induced liver damage by regulating Nrf-2/ Keap-1 gene expression in γ-irradiated rats.
BMC complementary medicine and therapies.
2024 Feb; 24(1):71. doi:
10.1186/s12906-024-04370-z. [PMID: 38303002] - Minji Yu, Yongling Long, Yuanyuan Wang, Rulan Zhang, Lili Tao. Effect of levothyroxine on the pregnancy outcomes in recurrent pregnancy loss women with subclinical hypothyroidism and thyroperoxidase antibody positivity: a systematic review and meta-analysis.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2023 Dec; 36(2):2233039. doi:
10.1080/14767058.2023.2233039. [PMID: 37433649] - Issac Sachmechi, Kathryn Jean Lucas, Larry D Stonesifer, John Fitzgerald Ansley, Paul Sack, Francesco S Celi, Claudia Scarsi, Gabriele Lanzi, Leonard Wartofsky, Kenneth D Burman. Efficacy of Levothyroxine Sodium Soft Gelatin Capsules in Thyroidectomized Patients Taking Proton Pump Inhibitors: An Open-Label Study.
Thyroid : official journal of the American Thyroid Association.
2023 Nov; ?(?):. doi:
10.1089/thy.2023.0382. [PMID: 37885233] - Muyun Li, Linlin Xiu, Wenyong Liao, Yuna Ren, Min Huo, Haiyan Liu, Shaohong Chen, Na Li, Yuan Gao, Xue Yu, Angran Fan, Gansheng Zhong. Exploring the effect and mechanism of Haizao Yuhu decoction containing three variants of glycyrrhiza on goiter using an integrated strategy of network pharmacology and RNA sequencing.
Journal of ethnopharmacology.
2023 Nov; 316(?):116750. doi:
10.1016/j.jep.2023.116750. [PMID: 37295576] - V Calcaterra, A Gazzarri, A De Silvestri, C Madia, P Baldassarre, V Rossi, V Garella, G Zuccotti. Thyroid function, sensitivity to thyroid hormones, and metabolic syndrome in euthyroid children and adolescents with Down syndrome.
Journal of endocrinological investigation.
2023 Nov; 46(11):2319-2325. doi:
10.1007/s40618-023-02086-4. [PMID: 37040064] - Michal Mazaki-Tovi, Omer Shachar, Tzachi Even Zur. Alterations in serum concentrations of visfatin and betatrophin in dogs with hypothyroidism.
Journal of veterinary internal medicine.
2023 Oct; ?(?):. doi:
10.1111/jvim.16904. [PMID: 37864301] - Anzar Alam, Ghulamuddin Sofi, Aleemuddin Quamri. The Perspective of Unani Medicine in Understanding Hyperthyroidism.
Alternative therapies in health and medicine.
2023 Oct; 29(7):262-267. doi:
". [PMID: 36455141] - Alireza Ostadrahimi, Taher Manzari, Sahar Gohari-Lasaki, Helda Tutunchi, Majid Mobasseri, Vahideh Sadra, Farzad Najafipour. Effects of levothyroxine replacement therapy on insulin resistance in patients with untreated primary hypothyroidism.
BMC research notes.
2023 Sep; 16(1):237. doi:
10.1186/s13104-023-06516-7. [PMID: 37773140] - Abid Ali, Kiryl Zhaliazka, Tianyi Dou, Aidan P Holman, Dmitry Kurouski. Role of Saturation and Length of Fatty Acids of Phosphatidylserine in the Aggregation of Transthyretin.
ACS chemical neuroscience.
2023 Sep; ?(?):. doi:
10.1021/acschemneuro.3c00357. [PMID: 37676231] - Guocheng Wang, Feng Jin, Limin Xie, Xiaofen Zhang, Yawei Zhang, Xin Ni, Wei Li, Guojun Zhang. Thyroid-Stimulating Hormone Levels within the Trimester-Specific Reference Intervals Are Correlated with Non-High-Density Lipoprotein Cholesterol and Remnant Cholesterol Concentrations in Pregnant Women.
Laboratory medicine.
2023 Sep; 54(5):449-456. doi:
10.1093/labmed/lmac150. [PMID: 36573791] - Ranran Shi, Jie Jiang, Baohong Wang, Fengmin Liu, Xinjian Liu, Dejuan Yang, Zhongliang Li, Haiying He, Xuemei Sun, Qiongyu Liu, Huimin Li, Jinrong He, Jiabi Yu, Ming Zhang, Simmy Reddy, Yonghui Yu, Jiajun Zhao. Dynamic Screening of Thyroid Function for the Timely Diagnosis of Congenital Hypothyroidism in Very Preterm Infants: A Prospective Multicenter Cohort Study.
Thyroid : official journal of the American Thyroid Association.
2023 09; 33(9):1055-1063. doi:
10.1089/thy.2023.0100. [PMID: 37566523] - Ahmad Mahdi Ahmad, Zahra Hassan Serry, Heba Ali Abd Elghaffar, Hossam Arafa Ghazi, Saher Lotfy El Gayar. Effects of aerobic, resistance, and combined training on thyroid function and quality of life in hypothyroidism. A randomized controlled trial.
Complementary therapies in clinical practice.
2023 Aug; 53(?):101795. doi:
10.1016/j.ctcp.2023.101795. [PMID: 37659172] - Sigrun Henjum, Synne Groufh-Jacobsen, Inger Aakre, Elin Lovise Folven Gjengedal, Mina Marthinsen Langfjord, Espen Heen, Veronika Sele, Maria Andersson. Thyroid function and urinary concentrations of iodine, selenium, and arsenic in vegans, lacto-ovo vegetarians and pescatarians.
European journal of nutrition.
2023 Aug; ?(?):. doi:
10.1007/s00394-023-03218-5. [PMID: 37592132] - Selin Kir, Suheyla Gorar, Isilay Kalan Sari, Hamit Yasar Ellidag, Ayhan Hilmi Cekin, Esin Yilmaz. Omentin-1 Levels in Hypothyroid Patients with Autoimmune Thyroiditis.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2023 Aug; 33(8):842-846. doi:
10.29271/jcpsp.2023.08.842. [PMID: 37553919] - Yanchun Lin, Amy E Riek, Ann M Gronowski, Christopher W Farnsworth. Limited Utility of Free Triiodothyronine Testing.
The journal of applied laboratory medicine.
2023 Jul; ?(?):. doi:
10.1093/jalm/jfad032. [PMID: 37473430] - Xiao-Ya Zhang, Jin-Di Xu, Yao Wang, Cheng-Ying Wu, Jing Zhou, Hong Shen, Ye-Ting Zou, Jin-Hao Zhu, Shan-Shan Zhou, Song-Lin Li, Jun Xu, Fang Long. Comparing steamed and wine-stewed Rehmanniae Radix in terms of Yin-nourishing effects via metabolomics and microbiome analysis.
Journal of ethnopharmacology.
2023 Jul; 311(?):116424. doi:
10.1016/j.jep.2023.116424. [PMID: 37003400] - F B Rahman, M H Zubery, S Y Moni, S Ara, Z Sultana, M N Islam. Impact of Levothyroxine on Lipid Profile in Patients with Hypothyroidism.
Mymensingh medical journal : MMJ.
2023 Jul; 32(3):727-731. doi:
. [PMID: 37391966] - Jinqi Zhang, Ya Xing, Fangbo Li, Ji'an Mu, Tongjun Liu, Jing Ge, Minmeng Zhao, Long Liu, Daoqing Gong, Tuoyu Geng. Study on the Mechanism of MC5R Participating in Energy Metabolism of Goose Liver.
International journal of molecular sciences.
2023 May; 24(10):. doi:
10.3390/ijms24108648. [PMID: 37239994] - Yan Zhang, Hua-Li Wang, Chao-Qiong Zhou, Da-Hai He, Feng Wu, Hong-Chuan Li, Qian-Rong Xie, Yu Luo, Li-Rui Kong. Intraday Changes and Clinical Applications of Thyroid Function Biomarkers in Healthy Subjects.
Laboratory medicine.
2023 May; 54(3):282-286. doi:
10.1093/labmed/lmac105. [PMID: 36222001] - Anand Kar, Durgesh Mahar, Sagarika Biswas, Debolina Chakraborty, Thomas Efferth, Sunanda Panda. Phytochemical profiling of polyphenols and thyroid stimulatory activity of Ficus religiosa leaf extract in 6-propyl-thiouracil-induced hypothyroid rats.
Journal of ethnopharmacology.
2023 Apr; ?(?):116479. doi:
10.1016/j.jep.2023.116479. [PMID: 37062529] - Zhifeng Chen, Binaya Wasti, Yulin Shang, Aijun Jia, Xudong Xiang, Ruoyun Ouyang. Clinical characteristics and risk factors of patients with eosinophilic fasciitis associated with pleural effusion.
Scientific reports.
2023 Apr; 13(1):5452. doi:
10.1038/s41598-023-32678-2. [PMID: 37012347] - Mei Qiu, Fangjun Luo, Lixin Du. Serum total and free T3 and CSF total T3 levels are significantly lower in Alzheimer Disease?.
Endocrine.
2023 04; 80(1):231. doi:
10.1007/s12020-022-03255-w. [PMID: 36378244] - Jose Vinoth Raja Antony Samy, Rajeswari Ranga Anantha Sayanam, Chitra Balasubramanian, Natesan Vijayakumar, Sung-Jin Kim, Sekar Vijayakumar, Mansour K Gatasheh, Mohammad Shamsul Ola, Omar Ahmed Basudan, Mohamed Saad Daoud, Moneera Saud Al-Bagmi, Badr Tayeb Hazazi. Effect of a polyherbal formulation on L-thyroxine induced hyperthyroidism in a rat model: In vitro and in vivo analysis and identification of bioactive phytochemicals.
International journal of biological macromolecules.
2023 Mar; 237(?):124140. doi:
10.1016/j.ijbiomac.2023.124140. [PMID: 36965568] - Yijia Liu, Mei Ma, Lin Li, Fanfan Liu, Zhu Li, Lu Yu, Tong Yang, Yang Wang, Shan Gao, Sheng Gao, Rongrong Yang, Chunquan Yu. Association between sensitivity to thyroid hormones and dyslipidemia in patients with coronary heart disease.
Endocrine.
2023 03; 79(3):459-468. doi:
10.1007/s12020-022-03254-x. [PMID: 36434323] - Li-Mei Li, Yan Song, Yong-Quan Shi, Liang-Liang Sun. Thyroid hormone receptor-beta agonists in NAFLD therapy: possibilities and challenges.
The Journal of clinical endocrinology and metabolism.
2023 Feb; ?(?):. doi:
10.1210/clinem/dgad072. [PMID: 36746649] - A Tropeano, D Corica, S Curatola, A Li Pomi, C Casto, A Alibrandi, G Pepe, T Aversa, M Wasniewska. The effect of obesity-related allostatic changes on cardio-metabolic risk in euthyroid children.
Journal of endocrinological investigation.
2023 Feb; 46(2):285-295. doi:
10.1007/s40618-022-01899-z. [PMID: 35986868] - Wenxian Xu, Yizhou Huang, Linjuan Ma, Peiqiong Chen, Saisai Li, Ketan Chu, Yibing Lan, Chunming Li, Yang Song, Qian Ying, Jianhong Zhou. Clinical observation of menopause hormone therapy in postmenopausal women with euthyroid and mild subclinical hypothyroidism.
BMC endocrine disorders.
2023 Jan; 23(1):21. doi:
10.1186/s12902-023-01269-7. [PMID: 36691016] - Xueqi Zhang, Yang Li, Jing Jin, Huangman Wang, Bozun Zhao, Songwen Wang, Zhongyan Shan, Weiping Teng, Xiaochun Teng. The different outcomes in the elderly with subclinical hypothyroidism diagnosed by age-specific and non-age-specific TSH reference intervals: a prospectively observational study protocol.
Frontiers in endocrinology.
2023; 14(?):1242110. doi:
10.3389/fendo.2023.1242110. [PMID: 38075041] - Łukasz Szczerbiński, Michał Andrzej Okruszko, Maciej Szabłowski, Sebastian Sołomacha, Paweł Sowa, Łukasz Kiszkiel, Joanna Gościk, Adam Jacek Krętowski, Anna Moniuszko-Malinowska, Karol Kamiński. Long-term effects of COVID-19 on the endocrine system - a pilot case-control study.
Frontiers in endocrinology.
2023; 14(?):1192174. doi:
10.3389/fendo.2023.1192174. [PMID: 37790604] - Sara Safari, Maryam Rafraf, Mahsa Malekian, Roghayeh Molani-Gol, Mohammad Asghari-Jafarabadi, Majid Mobasseri. Effects of vitamin D supplementation on metabolic parameters, serum irisin and obesity values in women with subclinical hypothyroidism: a double-blind randomized controlled trial.
Frontiers in endocrinology.
2023; 14(?):1306470. doi:
10.3389/fendo.2023.1306470. [PMID: 38179303] - Chengfei Zhang, Qiue Zhang, Lingling Qin, Zhiyi Yan, Lili Wu, Tonghua Liu. Dioscin Ameliorates Experimental Autoimmune Thyroiditis via the mTOR and TLR4/NF-κB Signaling.
Drug design, development and therapy.
2023; 17(?):2273-2285. doi:
10.2147/dddt.s410901. [PMID: 37551407] - Jinming Yao, Junyu Zhao, Jing Liu, Shan Jiang, Siyi Guo, Lusi Xu, Xinzhong Zhang, Qiqi Sheng, Kaili Wang, Lin Liao, Jianjun Dong. The relationships between thyroid functions of short-term rapid hypothyroidism and blood lipid levels in post-thyroidectomy patients of differentiated thyroid cancer.
Frontiers in endocrinology.
2023; 14(?):1114344. doi:
10.3389/fendo.2023.1114344. [PMID: 37181036] - Mei Liu, An Li, Lingling Meng, Gaoxin Zhang, Xiaoling Guan, Jiang Zhu, Yingming Li, Qinghua Zhang, Guibin Jiang. Exposure to Novel Brominated Flame Retardants and Organophosphate Esters and Associations with Thyroid Cancer Risk: A Case-Control Study in Eastern China.
Environmental science & technology.
2022 12; 56(24):17825-17835. doi:
10.1021/acs.est.2c04759. [PMID: 36468700] - Yunyi Xu, Yiqi Zhao, Xiaoqin Xu, Qiqi Yan, Liwei Yang. Serum lipid profile in relation to free thyroxine and the effect of levothyroxine treatment on lipids in patients with isolated hypothyroxinemia during pregnancy: a single-center retrospective study.
Lipids in health and disease.
2022 Dec; 21(1):142. doi:
10.1186/s12944-022-01744-5. [PMID: 36536397] - Jaehoon Choi, Kanghee Lee, Junhyung Kim, Woonhyeok Jeong, Taehee Jo, Hyoun Wook Lee, Young Sook Park, Sang Woo Park. Thyroid Hormone Ameliorates Lymphedema by Suppressing Adipogenesis in a Murine Lymphedema Model.
Lymphatic research and biology.
2022 12; 20(6):585-592. doi:
10.1089/lrb.2021.0079. [PMID: 35333603] - Rashika Srivastava, Saurabh Tiwari, P S Banakar, Mukesh Bhakat, Veena Mani, T K Mohanty, Goutam Mondal. Iodine Supplementation Improved Antioxidant Status, Hormonal Status, Sexual Behavior, and Semen Production Performance of Bos indicus Bulls Under Tropical Climatic Condition.
Biological trace element research.
2022 Nov; 200(11):4690-4703. doi:
10.1007/s12011-021-03066-6. [PMID: 35048268] - Grigorios Panagiotou, Peter N Taylor, D Aled Rees, Onyebuchi E Okosieme. Late offspring effects of antenatal thyroid screening.
British medical bulletin.
2022 09; 143(1):16-29. doi:
10.1093/bmb/ldac018. [PMID: 35868487] - Menglong Geng, Hui Gao, Baolin Wang, Kun Huang, Xiaoyan Wu, Chunmei Liang, Shuangqin Yan, Yan Han, Peng Ding, Wei Wang, Sheng Wang, Peng Zhu, Kaiyong Liu, Yunxia Cao, Fangbiao Tao. Urinary tetracycline antibiotics exposure during pregnancy and maternal thyroid hormone parameters: A repeated measures study.
The Science of the total environment.
2022 Sep; 838(Pt 2):156146. doi:
10.1016/j.scitotenv.2022.156146. [PMID: 35605876] - Fa-Zhi Su, Chen-Xi Bai, Wen-Sen Zhang, Jing Yang, Jian-Ping Hu, Yan-Ping Sun, Bing-You Yang, Hai-Xue Kuang, Qiu-Hong Wang. [Study on drug properties of Arisaematis Rhizoma and Arisaema Cum Bile based on substance and energy metabolism in normal and cold/heat syndrome model rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Sep; 47(17):4682-4690. doi:
10.19540/j.cnki.cjcmm.20220524.402. [PMID: 36164875] - Kaihong Xu, Zichen Feng, Francis Kojo Afrim, Jun Ma, Shuo Yang, Xuanyin Zhang, Zeyuan Niu, Ning An, Yuhui Du, Fangfang Yu, Guoyu Zhou, Yue Ba. Interaction of fluoride exposure and CREB1 gene polymorphisms on thyroid function in school-age children.
Chemosphere.
2022 Sep; 303(Pt 2):135156. doi:
10.1016/j.chemosphere.2022.135156. [PMID: 35640685] - Richard Christian Jensen, Dorte Glintborg, Clara Amalie Gade Timmermann, Flemming Nielsen, Henriette Boye, Jeppe Buur Madsen, Niels Bilenberg, Philippe Grandjean, Tina Kold Jensen, Marianne S Andersen. Higher free thyroxine associated with PFAS exposure in first trimester. The Odense Child Cohort.
Environmental research.
2022 Sep; 212(Pt D):113492. doi:
10.1016/j.envres.2022.113492. [PMID: 35597289] - Kyeezu Kim, Maria Argos, Victoria W Persky, Sally Freels, Robert M Sargis, Mary E Turyk. Associations of exposure to metal and metal mixtures with thyroid hormones: Results from the NHANES 2007-2012.
Environmental research.
2022 Sep; 212(Pt C):113413. doi:
10.1016/j.envres.2022.113413. [PMID: 35537494] - Yousef Baghcheghi, Farimah Beheshti, Mahmoud Hosseini, Arezoo Gowhari-Shabgah, Mohammad Ali-Hassanzadeh, Mahdiyeh Hedayati-Moghadam. Cardiovascular protective effects of PPARγ agonists in hypothyroid rats: protection against oxidative stress.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2022 Aug; 44(6):539-547. doi:
10.1080/10641963.2022.2079669. [PMID: 35722928] - Man Liang, Huimin Wang, Chunlong Liu, Yabo Li, Shuqi An, Yanlin Han. A new method for the evaluation of measurement uncertainty in strict accordance with measurement model: Determination of total thyroxine in human serum by triple isotope dilution mass spectrometry.
Talanta.
2022 Aug; 246(?):123494. doi:
10.1016/j.talanta.2022.123494. [PMID: 35523020] - Yuxi Yang, Huabing Yuan, Xueran Wang, Zheng Zhang, Ruixia Liu, Chenghong Yin. Significance of levothyroxine treatment on serum lipid in pregnant women with subclinical hypothyroidism.
BMC pregnancy and childbirth.
2022 Aug; 22(1):623. doi:
10.1186/s12884-022-04950-2. [PMID: 35933361] - Govinthasamy Prabakar, Marappan Gopi, Gautham Kolluri, Jaydip Jaywant Rokade, Selvaraj Pavulraj, Beulah V Pearlin, Gautham Sudamrao Khillare, Velusamy Madhupriya, Jagbir Singh Tyagi, Jag Mohan. Seasonal variations on semen quality attributes in turkey and egg type chicken male breeders.
International journal of biometeorology.
2022 Aug; 66(8):1547-1560. doi:
10.1007/s00484-022-02299-x. [PMID: 35567622] - Ichiro Yamauchi, Yoriko Sakane, Yukiko Okuno, Taku Sugawa, Takuro Hakata, Haruka Fujita, Kentaro Okamoto, Daisuke Taura, Takafumi Yamashita, Keisho Hirota, Yohei Ueda, Toshihito Fujii, Akihiro Yasoda, Nobuya Inagaki. High-throughput Screening in Combination With a Cohort Study for Iodothyronine Deiodinases.
Endocrinology.
2022 08; 163(8):. doi:
10.1210/endocr/bqac090. [PMID: 35695766] - Elisa Merchan-Ramirez, Guillermo Sanchez-Delgado, Cristina Arrizabalaga-Arriazu, Francisco M Acosta, Maria Jose Arias-Tellez, Manuel Muñoz-Torres, Jose V Garcia-Lario, Jose M Llamas-Elvira, Jonatan R Ruiz. Circulating concentrations of free triiodothyronine are associated with central adiposity and cardiometabolic risk factors in young euthyroid adults.
Journal of physiology and biochemistry.
2022 Aug; 78(3):629-640. doi:
10.1007/s13105-022-00881-w. [PMID: 35381950] - Min Wu, Cheng Chi, Yuxi Yang, Shan Guo, Tianhe Li, Muqing Gu, Tingting Zhang, Huimin Gao, Ruixia Liu, Chenghong Yin. Dynamics of gut microbiota during pregnancy in women with TPOAb-positive subclinical hypothyroidism: a prospective cohort study.
BMC pregnancy and childbirth.
2022 Jul; 22(1):592. doi:
10.1186/s12884-022-04923-5. [PMID: 35883066] - Shuai Chen, Xiaohe Sun, Guowei Zhou, Jie Jin, Zhiwei Li. Association between sensitivity to thyroid hormone indices and the risk of osteoarthritis: an NHANES study.
European journal of medical research.
2022 Jul; 27(1):114. doi:
10.1186/s40001-022-00749-1. [PMID: 35820977] - Klara Gustin, Marie Vahter, Malin Barman, Bo Jacobsson, Helena Skröder, Helena Filipsson Nyström, Anna Sandin, Ann-Sofie Sandberg, Agnes E Wold, Maria Kippler. Assessment of Joint Impact of Iodine, Selenium, and Zinc Status on Women's Third-Trimester Plasma Thyroid Hormone Concentrations.
The Journal of nutrition.
2022 Jul; 152(7):1737-1746. doi:
10.1093/jn/nxac081. [PMID: 35383840] - Elizabeth N Pearce. Management of Hypothyroidism and Hypothyroxinemia During Pregnancy.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2022 Jul; 28(7):711-718. doi:
10.1016/j.eprac.2022.05.004. [PMID: 35569735] - Ekim Comert, Ulufer Celebi, Bilge Piri Cinar, Mustafa Acikgoz, Esra Aciman Demirel, Huseyin Tugrul Atasoy. Thyroid functions as a parameter in monitoring of antiepileptic drugs.
Neurological research.
2022 Jul; 44(7):614-621. doi:
10.1080/01616412.2021.2025317. [PMID: 35019830] - Gilad Karavani, Lina Daoud-Sabag, Cherut Chay, David Gillis, David Strich. Is TSH a Reliable Indicator of Thyroid Hormone Status in Pregnancy?.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2022 Jul; 54(7):435-441. doi:
10.1055/a-1872-0246. [PMID: 35835143] - Yushu Liu, Yanyi Huang, Guoheng Mo, Tao Zhou, Qian Hou, Chaoqun Shi, Jichun Yu, Yunxia Lv. Combined prognostic value of preoperative serum thyrotrophin and thyroid hormone concentration in papillary thyroid cancer.
Journal of clinical laboratory analysis.
2022 Jul; 36(7):e24503. doi:
10.1002/jcla.24503. [PMID: 35666615] - Janice N Thai, Ingrid Rymer De Marchena, Vijeyaluxmy Motilal Nehru, Elliot Landau, Seleshi Demissie, Raina Josemon, Steven Peti, Arnold I Brenner. Low correlation between serum thyroglobulin and 131I radioiodine whole body scintigraphy: implication for postoperative disease surveillance in differentiated thyroid cancer.
Clinical imaging.
2022 Jul; 87(?):1-4. doi:
10.1016/j.clinimag.2022.04.003. [PMID: 35439719] - Rebecca Geddes, Joana Aguiar. Feline Comorbidities: Balancing hyperthyroidism and concurrent chronic kidney disease.
Journal of feline medicine and surgery.
2022 Jul; 24(7):641-650. doi:
10.1177/1098612x221090390. [PMID: 35481810] - Sibel Demiral Sezer, Omercan Topaloglu. Effects of thyroid hormones in women with gestational diabetes.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2022 Jul; 38(7):588-591. doi:
10.1080/09513590.2022.2076832. [PMID: 35604060] - Güldeniz Şekerci, Yavuz Erden, Suat Tekin. Effects of meteorin-like hormone on endocrine function of hypothalamo-hypophysial system and peripheral uncoupling proteins in rats.
Molecular biology reports.
2022 Jul; 49(7):5919-5925. doi:
10.1007/s11033-022-07374-5. [PMID: 35332411] - Sachiko Nakamura, Nozomi Kido, Miki Watanabe, Yuka Ohmachi, Yuko Inayama, Yuya Kashitani, Keiko Ishii, Ikuhiro Ishida, Naho Goda, Yasunori Fujita, Keiji Iida. Analysis of thyroid function in Japanese patients with coronavirus disease 2019.
Endocrine journal.
2022 Jun; 69(6):643-648. doi:
10.1507/endocrj.ej21-0609. [PMID: 34955465] - Jinfeng Xiao, Chonggui Zhu, Xinxin Zhang, Longhao Sun, Chang Gao, Xiaoyu Liang, Qing He, Ming Liu. Associations among FT4 level, FT3/FT4 ratio, and non-alcoholic fatty liver disease in Chinese patients with hypopituitarism.
Endocrine journal.
2022 Jun; 69(6):659-667. doi:
10.1507/endocrj.ej21-0536. [PMID: 35034938] - Adeleh Esform, Tahereh Farkhondeh, Saeed Samarghandian, Maryam Rezaei, Ali Naghizadeh. Environmental arsenic exposure and its toxicological effect on thyroid function: a systematic review.
Reviews on environmental health.
2022 Jun; 37(2):281-289. doi:
10.1515/reveh-2021-0025. [PMID: 34090316] - Ceyhun Bereketoglu, Ajay Pradhan. Plasticizers: negative impacts on the thyroid hormone system.
Environmental science and pollution research international.
2022 Jun; 29(26):38912-38927. doi:
10.1007/s11356-022-19594-0. [PMID: 35303231] - H Salman Jasim, N Khalid Shafeeq, E A A Abass. Vitamin D Level and its Relation with the Newly Diagnosed Diabetic Neuropathy in Women with Hypothyroidism.
Archives of Razi Institute.
2022 06; 77(3):1139-1145. doi:
10.22092/ari.2022.357389.2029. [PMID: 36618309] - Meng Rao, Longda Wang, Gaofeng Yan, Mengxiang Chen, Li Tang, Shuhua Zhao. Normal-Range Paternal Serum-Free Thyroxine Concentrations and Outcomes of Assisted Reproductive Technologies.
Thyroid : official journal of the American Thyroid Association.
2022 06; 32(6):705-713. doi:
10.1089/thy.2022.0049. [PMID: 35286181] - Ya Zhang, Ruijie Xie, Jun Ou. A U-shaped association between serum albumin with total triiodothyronine in adults.
Journal of clinical laboratory analysis.
2022 Jun; 36(6):e24473. doi:
10.1002/jcla.24473. [PMID: 35524426] - Emre Urhan, Zuleyha Karaca, Canan Sehit Kara, Zeynep Ture Yuce, Kursad Unluhizarci. The potential impact of COVID-19 on thyroid gland volumes among COVID-19 survivors.
Endocrine.
2022 Jun; 76(3):635-641. doi:
10.1007/s12020-022-03019-6. [PMID: 35239124] - Georgios K Markantes, Dimitrios Daoussis, Irene Mamali, Neoklis A Georgopoulos, Marina A Michalaki. Differences in thyroid function tests after administration of a single supraphysiological dose of ACTH or a high dose of a synthetic steroid.
Steroids.
2022 06; 182(?):109009. doi:
10.1016/j.steroids.2022.109009. [PMID: 35283116] - Philippe Caron, Solange Grunenwald, Luca Persani, Françoise Borson-Chazot, Remy Leroy, Leonidas Duntas. Factors influencing the levothyroxine dose in the hormone replacement therapy of primary hypothyroidism in adults.
Reviews in endocrine & metabolic disorders.
2022 06; 23(3):463-483. doi:
10.1007/s11154-021-09691-9. [PMID: 34671932] - Yuanyuan Zhang, Juyi Li, Huaizhen Liu. Correlation between the thyroid hormone levels and nonalcoholic fatty liver disease in type 2 diabetic patients with normal thyroid function.
BMC endocrine disorders.
2022 May; 22(1):144. doi:
10.1186/s12902-022-01050-2. [PMID: 35641932] - Rosalie B T M Sterenborg, Tessel E Galesloot, Alexander Teumer, Romana T Netea-Maier, Doug Speed, Marcel E Meima, W Edward Visser, Johannes W A Smit, Robin P Peeters, Marco Medici. The Effects of Common Genetic Variation in 96 Genes Involved in Thyroid Hormone Regulation on TSH and FT4 Concentrations.
The Journal of clinical endocrinology and metabolism.
2022 05; 107(6):e2276-e2283. doi:
10.1210/clinem/dgac136. [PMID: 35262175] - Zhiyuan Wu, Yue Jiang, Di Zhou, Shuo Chen, Yu Zhao, Haiping Zhang, Yue Liu, Xia Li, Wei Wang, Jingbo Zhang, Xiaoping Kang, Lixin Tao, Bo Gao, Xiuhua Guo. Sex-specific Association of Subclinical Hypothyroidism With Incident Metabolic Syndrome: A Population-based Cohort Study.
The Journal of clinical endocrinology and metabolism.
2022 05; 107(6):e2365-e2372. doi:
10.1210/clinem/dgac110. [PMID: 35213715] - Yen-Ju Chen, Wei-Ying Chu, Yu-Wen Pan, Chen-Yueh Wang, Yen-Yin Chou, Chyi-Her Lin, Kennosuke Tsuda, Osuke Iwata, Wen-Hao Yu, Yung-Chieh Lin. Postnatal Serum Total Thyroxine Level Associated with Short- and Long-Term Anthropometric Outcomes in Very Preterm Infants.
Nutrients.
2022 May; 14(10):. doi:
10.3390/nu14102056. [PMID: 35631197] - Shi Dong, Qunying Liu, Miao Jiang, Qihong Ma, Qianqian Huang, Tianhua Liu, Yuan Li, Lei Ni, Yuanyuan Shi. Xiao-Luo-Wan treats propylthiouracil-induced goiter with hypothyroidism in rats through the PI3K-AKT/RAS pathways based on UPLC/MS and network pharmacology.
Journal of ethnopharmacology.
2022 May; 289(?):115045. doi:
10.1016/j.jep.2022.115045. [PMID: 35101570] - Hongxiao Yang, Juncai Bai, Chengchuang Zhan, Shuang Liu, Yunan Gao, Lihua Zhong, Yajing Lv, Jing Chi, Jiaren Liu, Xinrui Yang, Wei Yang. Hydrogen Attenuates Thyroid Hormone-Induced Cardiac Hypertrophy in Rats by regulating angiotensin II type 1 receptor and NADPH oxidase 2 mediated oxidative stress.
European journal of pharmacology.
2022 May; 922(?):174917. doi:
10.1016/j.ejphar.2022.174917. [PMID: 35341785] - Zeynep Cetin, Arzu Kosem, Merve Catak, Bulent Can, Ozden Baser, Serdar Guler. The Relationship of Thyroid Functions with ADMA, IMA, and Metabolic Laboratory Parameters in Euthyroid Adults with and without Autoimmune Thyroiditis.
Laboratory medicine.
2022 May; 53(3):290-295. doi:
10.1093/labmed/lmab098. [PMID: 34792122] - Mohamed M Elgebaly, Asmaa R Abdel-Hamed, Noha M Mesbah, Dina M Abo-Elmatty, Amr Abouzid, Mohamed A Abdelrazek. Hypothyroidism affect progression and worse outcomes of breast cancer but not ovarian cancer.
Journal of immunoassay & immunochemistry.
2022 May; 43(3):288-298. doi:
10.1080/15321819.2021.2001003. [PMID: 34787075] - Eleonora Nicolai, Marzia Nuccetelli, Serena Sarubbi, Valerio Basile, Marco Alfonso Perrone, Alessandro Terrinoni, Marilena Minieri, Massimo Pieri, Sergio Bernardini. Performance evaluation of the new Chemiluminescence Immunoassay CL-1200i Thyroid Panel.
Journal of immunoassay & immunochemistry.
2022 May; 43(3):333-345. doi:
10.1080/15321819.2021.2017301. [PMID: 34927566] - Josh M Evron, Scott L Hummel, David Reyes-Gastelum, Megan R Haymart, Mousumi Banerjee, Maria Papaleontiou. Association of Thyroid Hormone Treatment Intensity With Cardiovascular Mortality Among US Veterans.
JAMA network open.
2022 05; 5(5):e2211863. doi:
10.1001/jamanetworkopen.2022.11863. [PMID: 35552725] - Dayamin Martínez Brito, Patrizia Leogrande, Xavier de la Torre, Francesco Botrè. Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry.
Journal of pharmacological and toxicological methods.
2022 May; 115(?):107169. doi:
10.1016/j.vascn.2022.107169. [PMID: 35351644] - Patrick Quinlan, Alexandra Horvath, Carl Eckerström, Anders Wallin, Johan Svensson. Higher thyroid function is associated with accelerated hippocampal volume loss in Alzheimer's disease.
Psychoneuroendocrinology.
2022 05; 139(?):105710. doi:
10.1016/j.psyneuen.2022.105710. [PMID: 35278981] - Janice Kritchevsky, Carla Olave, Stacy Tinkler, Melissa Tropf, Kathleen Ivester, Lauren Forsythe, Laurent Couetil. A randomised, controlled trial to determine the effect of levothyroxine on Standardbred racehorses.
Equine veterinary journal.
2022 May; 54(3):584-591. doi:
10.1111/evj.13480. [PMID: 34101895] - Kellie A Fecteau, Luca Giori, Andrew Cushing, Joshua M Price, Xiaojuan Zhu. Comparison of steroid and thyroid hormone concentrations in blood serum and plasma of captive tigers.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.
2022 May; 34(3):547-551. doi:
10.1177/10406387221090538. [PMID: 35404190] - Tina Mosaferi, Karen Tsai, Samantha Sovich, Holly Wilhalme, Nikhita Kathuria-Prakash, Stephanie S Praw, Alexandra Drakaki, Trevor E Angell, Melissa G Lechner. Optimal Thyroid Hormone Replacement Dose in Immune Checkpoint Inhibitor-Associated Hypothyroidism Is Distinct from Hashimoto's Thyroiditis.
Thyroid : official journal of the American Thyroid Association.
2022 05; 32(5):496-504. doi:
10.1089/thy.2021.0685. [PMID: 35199588] - Nalan Okuroglu, Elif Sakci, Meltem Sertbas, Yasar Sertbas, Seda Sancak, Ali Ozdemir. Normalisation of serum TSH doesn't represent true euthyroidism for patients on levothyroxine treatment.
JPMA. The Journal of the Pakistan Medical Association.
2022 May; 72(5):827-831. doi:
10.47391/jpma.0588. [PMID: 35713039] - Domenico Salvatore, Tommaso Porcelli, Matthew D Ettleson, Antonio C Bianco. The relevance of T3 in the management of hypothyroidism.
The lancet. Diabetes & endocrinology.
2022 05; 10(5):366-372. doi:
10.1016/s2213-8587(22)00004-3. [PMID: 35240052] - Naruhiko Sunada, Yoshihisa Hanayama, Koichiro Yamamoto, Yasuhiro Nakano, Takahiro Nada, Hiroyuki Honda, Kou Hasegawa, Hideharu Hagiya, Fumio Otsuka. Clinical utility of urinary levels of catecholamines and their fraction ratios related to heart rate and thyroid function.
Endocrine journal.
2022 Apr; 69(4):417-425. doi:
10.1507/endocrj.ej21-0488. [PMID: 34732615] - Rosaria Sciarrillo, Alessandra Falzarano, Vito Gallicchio, Aldo Mileo, Maria De Falco. Toxic Effects on Thyroid Gland of Male Adult Lizards (Podarcis Siculus) in Contact with PolyChlorinated Biphenyls (PCBs)-Contaminated Soil.
International journal of molecular sciences.
2022 Apr; 23(9):. doi:
10.3390/ijms23094790. [PMID: 35563180] - Li Wang, Youde Liu, Haifeng Yu, Kun Ding, Zhiqiang Zou. Low serum free triiodothyronineis level predicts worse outcome of patients with severe fever with thrombocytopenia syndrome.
BMC infectious diseases.
2022 Apr; 22(1):391. doi:
10.1186/s12879-022-07367-6. [PMID: 35443632] - Adrian Post, Erwin Garcia, Eke G Gruppen, Daan Kremer, Margery A Connelly, Stephan J L Bakker, Robin P F Dullaart. Higher Free Triiodothyronine Is Associated With Higher HDL Particle Concentration and Smaller HDL Particle Size.
The Journal of clinical endocrinology and metabolism.
2022 04; 107(5):e1807-e1815. doi:
10.1210/clinem/dgac044. [PMID: 35106588] - Hindole Ghosh, Seema Rai, Md Dilshad Manzar, Seithikurippu R Pandi-Perumal, Gregory M Brown, Russel J Reiter, Daniel P Cardinali. Differential expression and interaction of melatonin and thyroid hormone receptors with estrogen receptor α improve ovarian functions in letrozole-induced rat polycystic ovary syndrome.
Life sciences.
2022 Apr; 295(?):120086. doi:
10.1016/j.lfs.2021.120086. [PMID: 34710445]
