Methaqualone (BioDeep_00000018024)

 

Secondary id: BioDeep_00000002035

human metabolite Chemicals and Drugs


代谢物信息卡片


2-methyl-3-(2-methylphenyl)-3,4-dihydroquinazolin-4-one

化学式: C16H14N2O (250.1106)
中文名称: 海米那
谱图信息: 最多检出来源 Homo sapiens(not specific) 7.69%

分子结构信息

SMILES: CC1=CC=CC=C1N1C(C)=NC2=CC=CC=C2C1=O
InChI: InChI=1S/C16H14N2O/c1-11-7-3-6-10-15(11)18-12(2)17-14-9-5-4-8-13(14)16(18)19/h3-10H,1-2H3

描述信息

Methaqualone, also known as optimil or ortonal, belongs to the class of organic compounds known as quinazolines. Quinazolines are compounds containing a quinazoline moiety, which is made up of two fused six-member aromatic rings, a benzene ring and a pyrimidine ring. Methaqualone is a drug which is used for the treatment of insomnia, and as a sedative and muscle relaxant. Methaqualone exists as a solid and is considered to be practically insoluble (in water) and relatively neutral.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic

同义名列表

13 个代谢物同义名

2-methyl-3-(2-methylphenyl)-3,4-dihydroquinazolin-4-one; Wallace brand OF methaqualone hydrochloride; Hydrochloride, methaqualone; Methaqualone hydrochloride; Metolquizolone; Methaqualonum; METHAQUALONE; Metacualona; Quaalude; Optimil; Ortonal; Sonal; Methaqualone



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ALB, ANG, APOB, AXIN2, CAT, CENPJ, CYP2C19, CYP2D6, CYP3A4, PTP4A2, TAOK3
Peripheral membrane protein 1 TAOK3
Endosome membrane 1 APOB
Endoplasmic reticulum membrane 4 APOB, CYP2C19, CYP2D6, CYP3A4
Nucleus 4 ALB, ANG, AXIN2, PTP4A2
cytosol 11 ACACA, ALB, ANG, APOB, AXIN2, CAT, CENPJ, GPT, LIPE, MTTP, PTP4A2
centrosome 3 ALB, AXIN2, CENPJ
Cell membrane 2 LIPE, TAOK3
Multi-pass membrane protein 1 CACNA1I
Synapse 1 CRH
Golgi apparatus 2 ALB, MTTP
Golgi membrane 1 INS
growth cone 1 ANG
neuronal cell body 2 ANG, APOB
smooth endoplasmic reticulum 1 APOB
Cytoplasm, cytosol 2 ACACA, LIPE
plasma membrane 6 APOB, AXIN2, CACNA1I, CYP2C19, PTP4A2, TAOK3
Membrane 5 CACNA1I, CAT, CYP2D6, CYP3A4, LIPE
basolateral plasma membrane 1 MTTP
caveola 1 LIPE
extracellular exosome 5 ALB, APOB, CAT, GPT, LYZ
endoplasmic reticulum 3 ALB, CYP2D6, MTTP
extracellular space 6 ALB, ANG, APOB, CRH, INS, LYZ
lysosomal lumen 1 APOB
mitochondrion 3 ACACA, CAT, CYP2D6
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 5 APOB, CAT, CYP2C19, CYP2D6, CYP3A4
Microsome membrane 2 CYP2D6, CYP3A4
Secreted 5 ALB, ANG, APOB, CRH, INS
extracellular region 7 ALB, ANG, APOB, CAT, CRH, INS, LYZ
Single-pass membrane protein 1 CYP2D6
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CENPJ
varicosity 1 CRH
chylomicron 1 APOB
low-density lipoprotein particle 1 APOB
very-low-density lipoprotein particle 1 APOB
actin cytoskeleton 2 ACACA, ANG
neuronal dense core vesicle lumen 1 CRH
perikaryon 1 CRH
beta-catenin destruction complex 1 AXIN2
nucleolus 1 ANG
Early endosome 2 APOB, PTP4A2
vesicle 1 MTTP
focal adhesion 1 CAT
microtubule 1 CENPJ
Peroxisome 1 CAT
basement membrane 1 ANG
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
receptor complex 1 MTTP
ciliary basal body 2 ALB, CENPJ
Chromosome 1 ANG
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole 1 CENPJ
centriole 2 ALB, CENPJ
brush border membrane 1 MTTP
Nucleus, nucleolus 1 ANG
spindle pole 1 ALB
blood microparticle 1 ALB
microvillus membrane 1 MTTP
fibrillar center 1 ACACA
endosome lumen 2 APOB, INS
Lipid droplet 2 APOB, LIPE
Membrane, caveola 1 LIPE
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, APOB, INS, MTTP
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
procentriole replication complex 1 CENPJ
endocytic vesicle 1 ANG
transport vesicle 1 INS
azurophil granule lumen 1 LYZ
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 APOB
clathrin-coated endocytic vesicle membrane 1 APOB
endocytic vesicle lumen 1 APOB
chylomicron remnant 1 APOB
intermediate-density lipoprotein particle 1 APOB
angiogenin-PRI complex 1 ANG
catalase complex 1 CAT
mature chylomicron 1 APOB
ciliary transition fiber 1 ALB
gamma-tubulin small complex 1 CENPJ


文献列表

  • Xinlv Chen, Shuqin Liu, Ruifen Jiang, Tiangang Luan, Gangfeng Ouyang. Rapid detection and speciation of illicit drugs via a thin-film microextraction approach for wastewater-based epidemiology study. The Science of the total environment. 2022 Oct; 842(?):156888. doi: 10.1016/j.scitotenv.2022.156888. [PMID: 35753476]
  • Tara Carney, Jennifer A Rooney, Nandi Niemand, Bronwyn Myers, Danie Theron, Robin Wood, Laura F White, Christina S Meade, Novel N Chegou, Elizabeth Ragan, Gerhard Walzl, Robert Horsburgh, Robin M Warren, Karen R Jacobson. Transmission Of Tuberculosis Among illicit drug use Linkages (TOTAL): A cross-sectional observational study protocol using respondent driven sampling. PloS one. 2022; 17(2):e0262440. doi: 10.1371/journal.pone.0262440. [PMID: 35167586]
  • Katrin Romanek, Helena Fels, Torsten Dame, Gisela Skopp, Frank Musshoff, Hans Eiglmeier, Florian Eyer. Return of the Quaaludes? Prolonged agitated delirium after intentional ingestion of the methaqualone analog SL-164 - a case report. Substance abuse. 2021; 42(4):503-505. doi: 10.1080/08897077.2021.1903648. [PMID: 33760714]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • A Ceschi, G Giardelli, D M Müller, S Elavumkudy, A F Manini, C Rauber-Lüthy, K E Hofer. Acute neurotoxicity associated with recreational use of methylmethaqualone confirmed by liquid chromatography tandem mass spectrometry. Clinical toxicology (Philadelphia, Pa.). 2013 Jan; 51(1):54-7. doi: 10.3109/15563650.2012.758855. [PMID: 23298217]
  • Michael S Kostapanos, Evangelos C Rizos, Nikolaos Papanas, Efstratios Maltezos, Moses S Elisaf. Mitochondrial triglyceride transfer protein inhibition: new achievements in the treatment of dyslipidemias. Current pharmaceutical design. 2013; 19(17):3150-60. doi: 10.2174/1381612811319170023. [PMID: 23317403]
  • Elżbieta Miller, Małgorzata Mrowicka, Joanna Saluk-Juszczak, Majsterek Ireneusz. The level of isoprostanes as a non-invasive marker for in vivo lipid peroxidation in secondary progressive multiple sclerosis. Neurochemical research. 2011 Jun; 36(6):1012-6. doi: 10.1007/s11064-011-0442-1. [PMID: 21399906]
  • Martin Prøven Bogsrud, Leiv Ose, Gisle Langslet, Inger Ottestad, Ellen Charlotte Strøm, Tor-Arne Hagve, Kjetil Retterstøl. HypoCol (red yeast rice) lowers plasma cholesterol - a randomized placebo controlled study. Scandinavian cardiovascular journal : SCJ. 2010 Aug; 44(4):197-200. doi: 10.3109/14017431003624123. [PMID: 20636227]
  • Jianping Liu, Jing Zhang, Yi Shi, Sameline Grimsgaard, Terje Alraek, Vinjar Fønnebø. Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials. Chinese medicine. 2006 Nov; 1(?):4. doi: 10.1186/1749-8546-1-4. [PMID: 17302963]
  • Stanley Scheindlin. Antimalarials: shortages and searches. Molecular interventions. 2005 Oct; 5(5):268-72. doi: 10.1124/mi.5.5.2. [PMID: 16249521]
  • Reinhard A Uebel, Cherylynn A Wium. Toxicological screening for drugs of abuse in samples adulterated with household chemicals. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 2002 Jul; 92(7):547-9. doi: . [PMID: 12197198]
  • Meihui Pan, Jun-shan Liang Js, Edward A Fisher, Henry N Ginsberg. The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both microsomal triglyceride transfer protein activity and new triglyceride synthesis. The Journal of biological chemistry. 2002 Feb; 277(6):4413-21. doi: 10.1074/jbc.m107460200. [PMID: 11704664]
  • F Prost, W Thormann. Enantiomeric analysis of the five major monohydroxylated metabolites of methaqualone in human urine by chiral capillary electrophoresis. Electrophoresis. 2001 Sep; 22(15):3270-80. doi: 10.1002/1522-2683(200109)22:15<3270::aid-elps3270>3.0.co;2-k. [PMID: 11589290]
  • O Plaut, C Girod, C Staub. Analysis of methaqualone in biological matrices by micellar electrokinetic capillary chromatography. Comparison with gas chromatography-mass spectrometry. Forensic science international. 1998 Apr; 92(2-3):219-27. doi: 10.1016/s0379-0738(98)00018-8. [PMID: 9627981]
  • F Benoist, E Nicodeme, T Grand-Perret. Microsomal triacylglycerol transfer protein prevents presecretory degradation of apolipoprotein B-100. A dithiothreitol-sensitive protease is involved. European journal of biochemistry. 1996 Sep; 240(3):713-20. doi: 10.1111/j.1432-1033.1996.0713h.x. [PMID: 8856075]
  • M Haghpassand, D Wilder, J B Moberly. Inhibition of apolipoprotein B and triglyceride secretion in human hepatoma cells (HepG2). Journal of lipid research. 1996 Jul; 37(7):1468-80. doi: . [PMID: 8827519]
  • C Brenner, R Hui, J Passarelli, R Wu, R Brenneisen, K Bracher, M A ElSohly, V D Ghodoussi, S J Salamone. Comparison of methaqualone excretion patterns using Abuscreen ONLINE and EMIT II immunoassays and GC/MS. Forensic science international. 1996 May; 79(1):31-41. doi: 10.1016/0379-0738(96)01888-9. [PMID: 8635771]
  • R W Kurz, R Hainz, F Gremmel, W Grisold, K Hruby, P Dellert, W Vycudilik. [Dangerous intoxication from extreme serum concentrations of methaqualone metabolites. Detection and quantification of biosynthesis with gas chromatography-mass spectrometry]. Der Anaesthesist. 1995 Dec; 44(12):863-8. doi: 10.1007/s001010050223. [PMID: 8594961]
  • F Liu, Y T Liu, C L Feng, Y Luo. Determination of methaqualone and its metabolites in urine and blood by UV, GC/FID and GC/MS. Yao xue xue bao = Acta pharmaceutica Sinica. 1994; 29(8):610-6. doi: NULL. [PMID: 7985519]
  • G Kauert, I Herrle, M Wermeille. Quantification of dimethindene in plasma by gas chromatography-mass fragmentography using ammonia chemical ionization. Journal of chromatography. 1993 Aug; 617(2):318-23. doi: 10.1016/0378-4347(93)80506-y. [PMID: 8408399]
  • R Pocci, V Dixit, V M Dixit. Solid-phase extraction and GC/MS confirmation of barbiturates from human urine. Journal of analytical toxicology. 1992 Jan; 16(1):45-7. doi: 10.1093/jat/16.1.45. [PMID: 1353548]
  • R A Klinger, L M Blum, F Rieders. Direct automated EMIT d.a.u. analysis of N,N-dimethylformamide-modified serum, plasma, and postmortem blood for amphetamines, barbiturates, methadone, methaqualone, phencyclidine, and propoxyphene. Journal of analytical toxicology. 1990 Sep; 14(5):288-91. doi: 10.1093/jat/14.5.288. [PMID: 2263063]
  • P Kintz, A Tracqui, P Mangin, A A Lugnier, A A Chaumont. Simultaneous determination of dextropropoxyphene, norpropoxyphene and methaqualone in plasma by gas chromatography with selective nitrogen detection. Journal de toxicologie clinique et experimentale. 1990 Mar; 10(2):89-94. doi: . [PMID: 2388178]
  • P P Rop, J Spinazzola, A Zahra, M Bresson, J Quicke, A Viala. Column liquid chromatographic analysis of barbiturates in biological fluids. Journal of chromatography. 1988 May; 427(1):172-80. doi: 10.1016/0378-4347(88)80118-x. [PMID: 3410899]
  • K Wilson, M Oram, D Burnett. The effect of age on the competitive C- and N-oxidative pathways of methaqualone in women. European journal of drug metabolism and pharmacokinetics. 1984 Oct; 9(4):301-6. doi: 10.1007/bf03189680. [PMID: 6532802]
  • D R Jarvie, D Simpson. Gas chromatographic screening for drugs and metabolites in plasma and urine. Annals of clinical biochemistry. 1984 Mar; 21 ( Pt 2)(?):92-101. doi: 10.1177/000456328402100203. [PMID: 6143530]
  • S Kaur, B Ali. Selective induction of xenobiotic metabolizing esterases/amidases of liver by methaqualone consumption. Toxicology and applied pharmacology. 1983 Aug; 70(1):156-9. doi: 10.1016/0041-008x(83)90189-8. [PMID: 6612732]
  • C A Sutheimer, B R Hepler, I Sunshine. EMIT-st screening for drugs of abuse: methaqualone. Journal of analytical toxicology. 1983 Mar; 7(2):83-5. doi: 10.1093/jat/7.2.83. [PMID: 6343724]
  • N E Gary, O Tresznewsky. Clinical aspects of drug intoxication: barbiturates and a potpourri of other sedatives, hypnotics, and tranquilizers. Heart & lung : the journal of critical care. 1983 Mar; 12(2):122-7. doi: NULL. [PMID: 6550044]
  • K W Hindmarsh, S M Wallace, C B Schneider, E D Korchinski. Methaqualone-diphenhydramine interaction study in humans. Journal of pharmaceutical sciences. 1983 Feb; 72(2):176-80. doi: 10.1002/jps.2600720220. [PMID: 6834256]
  • M E Sharp, S M Wallace, K W Hindmarsh, H W Peel. Monitoring saliva concentrations of methaqualone, codeine, secobarbital, diphenhydramine and diazepam after single oral doses. Journal of analytical toxicology. 1983 Jan; 7(1):11-4. doi: 10.1093/jat/7.1.11. [PMID: 6834790]
  • M Van Boven, P Daenens. Biotransformation and excretion of nitromethaqualone in rats and humans. Journal of pharmaceutical sciences. 1982 Oct; 71(10):1152-7. doi: 10.1002/jps.2600711019. [PMID: 7143214]
  • M Oram, K Wilson, D Burnett. The influence of oral contraceptives on the metabolism of methaqualone in man. British journal of clinical pharmacology. 1982 Sep; 14(3):341-5. doi: 10.1111/j.1365-2125.1982.tb01989.x. [PMID: 7126411]
  • K Wilson, M Oram, C E Horth, D Burnett. The influence of the menstrual cycle on the metabolism and clearance of methaqualone. British journal of clinical pharmacology. 1982 Sep; 14(3):333-9. doi: 10.1111/j.1365-2125.1982.tb01988.x. [PMID: 7126410]
  • W O Boggan, J S Meyer. Effect of methaqualone on plasma corticosterone in rats: possible sites of action. Pharmacology, biochemistry, and behavior. 1982 Jun; 16(6):925-7. doi: 10.1016/0091-3057(82)90046-6. [PMID: 6287502]
  • R A Hux, H Y Mohammed, F F Cantwell. Precolumns of amberlite XAD-2 for direct injection liquid chromatographic determination of methaqualone in blood plasma. Analytical chemistry. 1982 Jan; 54(1):113-7. doi: 10.1021/ac00238a032. [PMID: 7065406]
  • D N Bailey. Methaqualone ingestion: evaluation of present status. Journal of analytical toxicology. 1981 Nov; 5(6):279-82. doi: 10.1093/jat/5.6.279. [PMID: 7339211]
  • J M Bonicamp, D L King, B A O'Brien, D W Jones. A simple procedure for separating drugs from interfering lipids on special thin layer chromatographic media. Journal of analytical toxicology. 1981 Nov; 5(6):261-3. doi: 10.1093/jat/5.6.261. [PMID: 7339206]
  • D Baggish, S Gray, P Jatlow, M J Bia. Treatment of Methaqualone overdose with resin hemoperfusion. The Yale journal of biology and medicine. 1981 Mar; 54(2):147-50. doi: . [PMID: 7269641]
  • N S Shah, E Gerling. Age-dependent variations in the distribution of methaqualone in rat. Developmental pharmacology and therapeutics. 1981; 2(2):127-36. doi: 10.1159/000481038. [PMID: 7472107]
  • K Wilson, D Burnett, M Oram, C T Reynolds. The kinetics of the urinary excretion of the N-oxide and glucuronides of methaqualone in man. European journal of drug metabolism and pharmacokinetics. 1981; 6(4):289-95. doi: 10.1007/bf03189528. [PMID: 7333329]
  • M A Peat, B S Finkle. Determination of methaqualone and its major metabolite in plasma and saliva after single oral doses. Journal of analytical toxicology. 1980 May; 4(3):114-8. doi: 10.1093/jat/4.3.114. [PMID: 7421144]
  • R D Budd, F C Yang, W J Leung. Mass screening and confirmation of methaqualone and its metabolites in urine by radioimmunoassay-thin-layer chromatography. Journal of chromatography. 1980 Mar; 190(1):129-32. doi: 10.1016/s0021-9673(00)85519-3. [PMID: 7380944]
  • L F Jaramillo, J N Driscoll. Analysis of therapeutic and commonly abused drugs in serum and urine by gas-liquid chromatography using a photoionization detector. Journal of chromatography. 1979 Dec; 186(?):637-44. doi: 10.1016/s0021-9673(00)95284-1. [PMID: 44717]
  • M Werner, R J Mohrbacher, C J Riendeau. Gas-liquid chromatography of undervatized drugs after chromatographic extraction from blood. Clinical chemistry. 1979 Dec; 25(12):2020-5. doi: NULL. [PMID: 41649]
  • L Giuliani, G Carmignani, E Belgrano, P Puppo. Transcatheter arterial embolization in urological tumors: the use of isobutyl-2-cyanoacrylate. The Journal of urology. 1979 May; 121(5):630-4. doi: 10.1016/s0022-5347(17)56913-x. [PMID: 439260]
  • E K Jeffer. Deterrence of methaqualone abuse through mass urinalysis. The International journal of the addictions. 1979 Apr; 14(3):445-50. doi: 10.3109/10826087909054593. [PMID: 468434]
  • G Peiker, B Müller, H Nöschel, A Bonow. [Studies on the kinetics of methaqualone during the late stage of pregnancy (author's transl)]. Die Pharmazie. 1979 Apr; 34(4):244-6. doi: NULL. [PMID: 482333]
  • K Harstick, C J Holloway, G Brunner, W R Külpmann, K Petry. The removal of hypnotic drugs from human serum. A comparative investigation of the adsorptive properties of native and agarose-encapsulated resins and charcoal. The International journal of artificial organs. 1979 Mar; 2(2):87-95. doi: . [PMID: 38209]
  • D Burnett, C N Reynolds, K Wilson. The metabolism of methaqualone in patients with biliary cirrhosis or secondary carcinoma of the liver. European journal of clinical pharmacology. 1979 Feb; 15(1):57-61. doi: 10.1007/bf00563558. [PMID: 421729]
  • A Poklis, M A Mackell, W K Drake. Fatal intoxication from 3,4-methylenedioxyamphetamine. Journal of forensic sciences. 1979 Jan; 24(1):70-5. doi: . [PMID: 512617]
  • M Van Boven. [Metabolism of nitromethaqualone]. Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie. 1979; 41(4):275-86. doi: NULL. [PMID: 532318]
  • M Eichelbaum, B Sonntag, G von Unruh. Determination of monoureides in biological fluids by high-pressure-liquid-chromatography. Archives of toxicology. 1978 Dec; 41(3):187-93. doi: 10.1007/bf00354090. [PMID: 32863]
  • R G Stoll, G C Chao, H J Hoyt, A Yacobi. Comparison of in vitro dissolution and in vivo bioavailability of methaqualone tablets in humans. Journal of pharmaceutical sciences. 1978 Sep; 67(9):1328-9. doi: 10.1002/jps.2600670940. [PMID: 690848]
  • S J Mulé, M Kogan, D Jukofsky. Radioimmunoassay of methaqualone in human urine compared with chromatographic methods. Clinical chemistry. 1978 Sep; 24(9):1473-6. doi: NULL. [PMID: 688604]
  • K J Kogan, D Jukofsky, K Verebey, S J Mulé. Detection of methaqualone in human urine by radioimmunoassay and gas-liquid chromatography after a therapeutic dose. Clinical chemistry. 1978 Aug; 24(8):1425-6. doi: NULL. [PMID: 679471]
  • C N Reynolds, K Wilson, D Burnett. Metabolism of methaqualone in geriatric patients. European journal of clinical pharmacology. 1978 Jun; 13(4):285-9. doi: 10.1007/bf00716364. [PMID: 668786]
  • D G Mills. Effects of methaqualone on blood platelet function. Clinical pharmacology and therapeutics. 1978 Jun; 23(6):685-91. doi: 10.1002/cpt1978236685. [PMID: 648081]
  • H D Heck, K Maloney, M Anbar. Long-term urinary excretion of methaqualone in a human subject. Journal of pharmacokinetics and biopharmaceutics. 1978 Apr; 6(2):111-22. doi: 10.1007/bf01117446. [PMID: 671218]
  • W J Tilstone, P C Reavey. Interaction of ethanol with amylobarbitone, phenobarbitone and methaqualone. Research communications in chemical pathology and pharmacology. 1978 Feb; 19(2):233-42. doi: . [PMID: 644120]
  • J Breiter, R Helger, E Interschick, H Wüst. Thin layer chromatographic screening for methaqualone, phenothiazines, opiates and benzodiazepines. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 1978 Feb; 16(2):127-34. doi: 10.1515/cclm.1978.16.2.127. [PMID: 24081]
  • L Kazyak, J A Kelley, J A Cella, R E Droege, L R Hilpert, R C Permisohn. Methaqualone metabolites in human urine after therapeutic doses. Clinical chemistry. 1977 Nov; 23(11):2001-6. doi: 10.1093/clinchem/23.11.2001. [PMID: 912864]
  • O Ericsson, B Danielsson. Urinary excretion pattern of methaqualone metabolites in man. Drug metabolism and disposition: the biological fate of chemicals. 1977 Nov; 5(6):497-502. doi: NULL. [PMID: 21773]
  • K W Hindmarsh, N W Hamon, D F LeGatt. Simultaneous identification and quantitation of diphenhydramine and methaqualone. Clinical toxicology. 1977 Sep; 11(2):245-55. doi: 10.3109/15563657708989837. [PMID: 891115]
  • W O Boggan, J S Meyer, R M Steinberg, C Worthington. The effects of methaqualone on the seizure susceptibility of mice. Psychopharmacology. 1977 Aug; 54(1):45-9. doi: 10.1007/bf00426540. [PMID: 410059]
  • J S Meyer, W O Boggan. The effects of methaqualone on pituitary-adrenocortical activity in mice. Psychopharmacology. 1977 Aug; 54(1):51-5. doi: 10.1007/bf00426541. [PMID: 410060]
  • N S Shah, E Hixson, O D Gulati, D Kuhn, P P Mathur. Maternal-fetal distribution of methaqualone in control and SKF 525-A-pretreated pregnant mice. Toxicology and applied pharmacology. 1977 Jun; 40(3):497-509. doi: 10.1016/0041-008x(77)90076-x. [PMID: 882984]
  • S Roden, P Harvey, M Mitchard. The effect of ethanol on residual plasma methaqualone concentrations and behaviour in volunteers who have taken Mandrax. British journal of clinical pharmacology. 1977 Apr; 4(2):245-7. doi: 10.1111/j.1365-2125.1977.tb00705.x. [PMID: 861141]
  • R Goulding. Experience with hemoperfusion in drug abuse. Kidney international. Supplement. 1976 Dec; ?(7):S338-40. doi: NULL. [PMID: 1070558]
  • J L Rosenbaum, M S Kramer, R Raja, S Winsten, F Dalal. Hemoperfusion for acute drug intoxication. Kidney international. Supplement. 1976 Dec; ?(7):S341-2. doi: NULL. [PMID: 1070559]
  • C White, E Doyle, L F Chasseaud, T Taylor. Serum concentrations of methaqualone after repeated oral doses of a combination formulation to human subjects. European journal of clinical pharmacology. 1976 Sep; 10(5):343-7. doi: 10.1007/bf00565624. [PMID: 10165]
  • A F Delong, R D Smyth, A Polk, R K Nayak, N H Reavey-Cantwell. Blood levels in methaqualone in man following chronic therapeutic doses. Archives internationales de pharmacodynamie et de therapie. 1976 Aug; 222(2):322-31. doi: NULL. [PMID: 984982]
  • A Zune, P Dobberstein, K H Maurer, U Rapp. Identification of drugs using a gas chromatography-mass spectrometry system equipped with electron impact-chemical ionization and electron impact-field ionizationfield desorption combination sources. Journal of chromatography. 1976 Jul; 122(?):365-71. doi: 10.1016/s0021-9673(00)82259-1. [PMID: 932159]
  • S Okonek. [Hemoperfusion with coated activated charcoal for treating acute poisoning by remedies, plant protectants, and fungi. I. Remedies (author's transl)]. Medizinische Klinik. 1976 Jun; 71(26):1120-4. doi: . [PMID: 934007]
  • J Anweiler, G Bender, M Höbel. Simultaneous determination of glutethimide, methyprylon, and methaqualone in serum by gas liquid chromatography. Archives of toxicology. 1976 Jun; 35(3):187-93. doi: 10.1007/bf00293566. [PMID: 9049]
  • R Cleeland, J Christenson, M Usategui-Gomez, J Heveran, R Davis, E Grunberg. Detection of drugs of abuse by radioimmunoassay: a summary of published data and some new information. Clinical chemistry. 1976 Jun; 22(6):712-25. doi: 10.1093/clinchem/22.6.712. [PMID: 776447]
  • K Wiener, C H Foot. Letter: Methaqualone and urinary steroids. British medical journal. 1976 May; 1(6017):1072. doi: 10.1136/bmj.1.6017.1072. [PMID: 1268559]
  • D Burnett, C N Reynolds, K Wilson, J R Francis. Urinary excretion of c-hydroxy derivatives of methaqualone in man. Xenobiotica; the fate of foreign compounds in biological systems. 1976 Feb; 6(2):125-34. doi: 10.3109/00498257609151621. [PMID: 1274374]
  • C N Reynolds, K Wilson, D Burnett. Urinary excretion of methaqualone-N-oxide in man. Xenobiotica; the fate of foreign compounds in biological systems. 1976 Feb; 6(2):113-24. doi: 10.3109/00498257609151620. [PMID: 1274373]
  • N L Rock, R J Moore. Methaqualone (Mandrax) abuse, urine testing, and identification: clinical correlation between a new mass urinalysis test and a military drug abuse program. The International journal of the addictions. 1976; 11(2):237-44. doi: 10.3109/10826087609058796. [PMID: 1262091]
  • P P Mathur, R D Smyth, T Herczeg, N H Reavey-Cantwell. Induction of hepatic enzymes by methaqualone and effect on warfarin-induced hypoprothrombinemia. The Journal of pharmacology and experimental therapeutics. 1976 Jan; 196(1):204-12. doi: . [PMID: 1246011]
  • R C Permisohn, L R Hilpert, L Kazyak. Determination of methaqualone in urine by metabolite detection via gas chromatography. Journal of forensic sciences. 1976 Jan; 21(1):98-107. doi: NULL. [PMID: 765430]
  • N C Jain, W J Leung, R D Budd, T C Sneath. Thin-layer chromatographic screening and confirmation of basic drugs of abuse in urine. Journal of chromatography. 1975 Dec; 115(2):519-26. doi: 10.1016/s0021-9673(01)98955-1. [PMID: 1206062]
  • A R Berman, J P McGrath, R C Permisohn, J A Cella. Radioimmunoassay of methaqualone and its monohydroxy metabolites in urine. Clinical chemistry. 1975 Dec; 21(13):1878-81. doi: 10.1093/clinchem/21.13.1878. [PMID: 1192579]
  • K W Hindmarsh, N W Hamon, D F LeGatt. Letter: Use of a charcoal cartridge in isolating basic drugs from urine. Clinical chemistry. 1975 Nov; 21(12):1852, 1854. doi: NULL. [PMID: 1183016]
  • J M Christensen, S Holfort. Methaqualone in human serum and cerebrospinal fluid after oral intake. The Journal of pharmacy and pharmacology. 1975 Jul; 27(7):538-9. doi: 10.1111/j.2042-7158.1975.tb09501.x. [PMID: 239164]
  • W G Stillwell, P A Gregory, M G Horning. Metabolism of methaqualone by the epoxide-diol pathway in man and the rat. Drug metabolism and disposition: the biological fate of chemicals. 1975 Jul; 3(4):287-96. doi: NULL. [PMID: 240659]
  • R Khodjet el Khil, A M Batt, G Siest, P Tridon, M Weber. Method for diphenylhydantoin and phenobarbital assay by gas chromatography. Pathologie-biologie. 1975 May; 23(5):409-16. doi: . [PMID: 1105335]
  • C Kerde. [Spectrophotometric determination of methaqualone in biologic material]. Arzneimittel-Forschung. 1975 Mar; 25(3):363-5. doi: NULL. [PMID: 1174032]
  • W J Tilstone, P C Reavey. Letter: Concentration of morphine equivalent in urine. Clinical pharmacology and therapeutics. 1975 Jan; 17(1):119. doi: NULL. [PMID: 1122666]
  • H K Sleeman, J A Cella, J L Harvey, D J Beach. Thin-layer chromatographic detection and identification of methaqualone metabolites in urine. Clinical chemistry. 1975 Jan; 21(1):76-80. doi: 10.1093/clinchem/21.1.76. [PMID: 1116281]
  • G Alván, O Ericsson, S Levander, J E Lindgren. Plasma concentrations and effects of methaqualone after single and multiple oral doses in man. European journal of clinical pharmacology. 1974 Oct; 7(6):449-54. doi: 10.1007/bf00560357. [PMID: 4439868]
  • D Chin, E Fastlich. Letter: Improved extraction technique for gas-liquid chromatographic determination of methaqualone in serum. Clinical chemistry. 1974 Oct; 20(10):1382. doi: NULL. [PMID: 4414267]
  • K Tokunaga. [A sensitive method to prove the administration of methaqualone upon hydrolysis of urine (author's transl)]. Fukuoka igaku zasshi = Hukuoka acta medica. 1974 Oct; 65(10):746-63. doi: NULL. [PMID: 4477103]
  • T N Higgins, J D Taylor. Optimization of extraction and separation of narcotics from urine. Clinical biochemistry. 1974 Sep; 7(3):280-9. doi: 10.1016/s0009-9120(74)92378-9. [PMID: 4426123]
  • H J Hinze, G Bedessem. [A sensitive spray reagent for methaqualone and its metabolites]. Journal of chromatography. 1974 Jul; 94(0):347-8. doi: 10.1016/s0021-9673(01)92397-0. [PMID: 4844619]
  • A W Missen, J F Lewin. A non-ionic resin extraction of drugs in blood. Clinica chimica acta; international journal of clinical chemistry. 1974 Jun; 53(3):389-90. doi: 10.1016/0009-8981(74)90282-4. [PMID: 4847115]
  • G Norheim. Abnormal drug distribution in fatal intoxications. Forensic science. 1974 Jun; 3(3):271-4. doi: 10.1016/0300-9432(74)90055-7. [PMID: 4842026]
  • J M White, M H Graves. The detection of sedative-hypnotic drugs in the impaired driver. Journal of chromatographic science. 1974 May; 12(5):219-24. doi: 10.1093/chromsci/12.5.219. [PMID: 4833005]