Tetrahydrodeoxycortisol (BioDeep_00000010004)
Secondary id: BioDeep_00001874177
human metabolite Endogenous blood metabolite
代谢物信息卡片
化学式: C21H34O4 (350.2457)
中文名称: 5β-Pregnane-3α,17α,21-triol-20-one
谱图信息:
最多检出来源 Homo sapiens(lipidomics) 39.42%
分子结构信息
SMILES: CC12CCC(CC1CCC3C2CCC4(C3CCC4(C(=O)CO)O)C)O
InChI: InChI=1S/C21H34O4/c1-19-8-5-14(23)11-13(19)3-4-15-16(19)6-9-20(2)17(15)7-10-21(20,25)18(24)12-22/h13-17,22-23,25H,3-12H2,1-2H3/t13-,14-,15-,16+,17+,19+,20+,21+/m1/s1
描述信息
Tetrahydrodeoxycortisol (THS) is a mineralocorticoid, the main urinary metabolite of 11-deoxycortisol. THS excretion is significantly associated with tetrahydroaldosterone excretion, total androgen excretion, and cortisol metabolites. Aldosterone synthesis is highly heritable and is affected by genotype at CYP11B1. Variation in the region of chromosome 8 including the genes steroid 11-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) influences mineralocorticoid and glucocorticoid metabolism; differences in 11-hydroxylation efficiency can have downstream effects on mineralocorticoid synthesis. Such effects may be of relevance to the development of low-renin essential hypertension. Genotype differences in CYP11B1 explains approx. 5\\% of the variance in urinary THS excretion in the population. Excretion of THS is heritable (19.4\\%) and the T-allele of the −344 C/T polymorphism of CYP11B2 is more strongly assocd. with higher THS levels than the C-allele. (PMID: 16984984, 15522937, 15272911) [HMDB]
Tetrahydrodeoxycortisol (THS) is a mineralocorticoid, the main urinary metabolite of 11-deoxycortisol. THS excretion is significantly associated with tetrahydroaldosterone excretion, total androgen excretion, and cortisol metabolites. Aldosterone synthesis is highly heritable and is affected by genotype at CYP11B1. Variation in the region of chromosome 8 including the genes steroid 11-beta-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) influences mineralocorticoid and glucocorticoid metabolism; differences in 11-hydroxylation efficiency can have downstream effects on mineralocorticoid synthesis. Such effects may be of relevance to the development of low-renin essential hypertension. Genotype differences in CYP11B1 explains approximately 5\\% of the variance in urinary THS excretion in the population. Excretion of THS is heritable (19.4\\%) and the T-allele of the -344 C/T polymorphism of CYP11B2 is more strongly associated with higher THS levels than the C-allele. (PMID: 16984984, 15522937, 15272911).
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
17 个代谢物同义名
1-[(1S,2S,5R,7R,10R,11S,14R,15S)-5,14-dihydroxy-2,15-dimethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl]-2-hydroxyethan-1-one; 3alpha,17alpha,21-Trihydroxy-5beta-pregnan-20-one; 3 alpha, 17,21-Trihydroxy-5 beta-pregnan-20-one; 5 beta-Pregnane-3alpha,17alpha,21-triol-20-one; 5beta-Pregnane-3alpha,17alpha,21-triol-20-one; tetrahydro-Reichsteins substance S; Tetrahydro-11-deoxy Cortisol; Tetrahydro-11-deoxycortisol; 11-Deoxytetrahydrocortisol; Tetrahydrodeoxycortisol; tetrahydro Compound S; Tetrahydrocortexolone; Trihydroxypregnanone; ALLOTETRAHYDRO S; 3alpha,5beta-THS; tetrahydro-S; 3alpha,17alpha,21-Trihydroxy-5beta-pregnan-20-one
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:34352
- KEGG: C14594
- PubChem: 4141504
- PubChem: 65555
- HMDB: HMDB0005972
- Metlin: METLIN57990
- LipidMAPS: LMST05030014
- foodb: FDB023794
- chemspider: 58998
- CAS: 68-60-0
- PMhub: MS000023833
- PubChem: 17395594
- NIKKAJI: J39.545E
- RefMet: Tetrahydrodeoxycortisol
- KNApSAcK: 34352
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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